MX2021003243A - Produccion de lubricina recombinante. - Google Patents

Produccion de lubricina recombinante.

Info

Publication number
MX2021003243A
MX2021003243A MX2021003243A MX2021003243A MX2021003243A MX 2021003243 A MX2021003243 A MX 2021003243A MX 2021003243 A MX2021003243 A MX 2021003243A MX 2021003243 A MX2021003243 A MX 2021003243A MX 2021003243 A MX2021003243 A MX 2021003243A
Authority
MX
Mexico
Prior art keywords
production
recombinant lubricin
lubricin
human
manufacture
Prior art date
Application number
MX2021003243A
Other languages
English (en)
Inventor
Tannin Schmidt
Gregory Jay
Original Assignee
Lubris Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lubris Llc filed Critical Lubris Llc
Publication of MX2021003243A publication Critical patent/MX2021003243A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se divulgan nuevas isoformas recombinantes de lubricina tipo humana o glicoproteína de PRG4 que tiene excelentes propiedades de lubricación y un novedoso patrón de glicosilación, y métodos para su fabricación en niveles altos que permiten la producción comercial.
MX2021003243A 2013-10-22 2016-04-22 Produccion de lubricina recombinante. MX2021003243A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201361894366P 2013-10-22 2013-10-22

Publications (1)

Publication Number Publication Date
MX2021003243A true MX2021003243A (es) 2021-05-12

Family

ID=52993344

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016005302A MX2016005302A (es) 2013-10-22 2014-10-22 Produccion de lubricina recombinante.
MX2021003243A MX2021003243A (es) 2013-10-22 2016-04-22 Produccion de lubricina recombinante.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2016005302A MX2016005302A (es) 2013-10-22 2014-10-22 Produccion de lubricina recombinante.

Country Status (22)

Country Link
US (5) US9982027B2 (es)
EP (2) EP3060577B1 (es)
JP (2) JP6669649B2 (es)
KR (1) KR102488928B1 (es)
CN (1) CN105899527A (es)
AU (2) AU2014340080B2 (es)
BR (1) BR112016008923A2 (es)
CA (1) CA2927949A1 (es)
CY (1) CY1124861T1 (es)
DK (1) DK3060577T3 (es)
ES (1) ES2891331T3 (es)
HR (1) HRP20211497T1 (es)
HU (1) HUE056397T2 (es)
IL (2) IL245236B (es)
LT (1) LT3060577T (es)
MX (2) MX2016005302A (es)
PL (1) PL3060577T3 (es)
PT (1) PT3060577T (es)
RU (1) RU2758115C2 (es)
SG (2) SG10201913598TA (es)
SI (1) SI3060577T1 (es)
WO (2) WO2015060935A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9730865B2 (en) 2009-05-22 2017-08-15 Lubris, Llc Application and uses of PRG4 and therapeutic modulation thereof
EP2948553B1 (en) * 2013-01-25 2020-04-01 Baylor College Of Medicine A helper-dependent adenoviral gene therapy delivery and expression system
US9982027B2 (en) 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
EP3074022B1 (en) 2013-11-26 2022-03-30 Lubris LLC Compositions and methods for inhibiting intercellular interactions
SG11201705636SA (en) 2015-01-26 2017-08-30 Lubris Llc Use of prg4 as an anti-inflammatory agent
LT3300482T (lt) 2015-05-19 2021-10-25 Lubris Llc Prg4 panaudojimas dinaminio regos aštrumo pagerinimui ir aukštesnės eilės aberacijų sumažinimui
CN109055426B (zh) * 2018-08-06 2021-06-25 智享生物(苏州)有限公司 一种在中华仓鼠卵巢细胞中表达生产类人润滑素的方法
WO2020247440A1 (en) * 2019-06-03 2020-12-10 Lubris Llc Use of prg4 to treat cancer
US20230127949A1 (en) 2020-02-24 2023-04-27 Novartis Ag Purification of recombinantly produced polypeptides
WO2023212598A1 (en) 2022-04-27 2023-11-02 Lubris Llc Methods of making polymer films
CN115154667A (zh) * 2022-06-27 2022-10-11 天津大学 一种基于重组润滑素蛋白修饰的胶原蛋白基质的制备方法
CN115177790A (zh) * 2022-06-27 2022-10-14 天津大学 透明质酸和润滑素蛋白协同修饰胶原蛋白基质的制备方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000517188A (ja) 1996-08-30 2000-12-26 ライフ テクノロジーズ，インコーポレイテッド 無血清哺乳動物細胞培養培地およびその使用
US6530956B1 (en) * 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
US7001881B1 (en) 1999-04-23 2006-02-21 Rhode Island Hospital Tribonectins
US6960562B2 (en) 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
US6743774B1 (en) * 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
SG141239A1 (en) 2001-01-26 2008-04-28 Selexis Sa Matrix attachment regions and methods for use thereof
TW200307011A (en) 2002-04-18 2003-12-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modifier
US7415381B2 (en) 2003-01-09 2008-08-19 Rhode Island Hospital, A Lifespan Partner Joint friction sensing
WO2005000331A2 (en) 2003-06-04 2005-01-06 Mucosal Therapeutics, Inc. Compositions for the treatment and prevention of degenerative joint disorders
US7642236B2 (en) 2003-08-14 2010-01-05 Wyeth Recombinant lubricin molecules and uses thereof
KR101229989B1 (ko) 2003-10-24 2013-02-06 셀렉시스 에스. 에이. Ｍａｒ 서열의 복합 트랜스펙션 방법에 의한 포유동물 세포에서의 고효율 유전자 전달 및 발현
US20090155200A1 (en) 2004-04-20 2009-06-18 Jay Gregory D Methods of promoting cartilage healing or cartilage integration
EP1778360A2 (en) * 2004-07-23 2007-05-02 Mucosal Therapeutics LLC Compositions and methods for viscosupplementation
EP1827478A4 (en) 2004-12-03 2009-08-05 Mucosal Therapeutics Llc METHODS OF TREATING JOINED OR SICK JOINTS
US20070111327A1 (en) 2005-05-05 2007-05-17 Jay Gregory D Methods of detecting lubricin
UA94916C2 (ru) 2005-09-09 2011-06-25 Лабофарм Инк. Композиция тразодона для введения один раз в день
EP2061883A2 (en) * 2006-08-23 2009-05-27 Selexis S.A. Matrix attachment regions (mars) for increasing transcription and uses thereof
JP5660561B2 (ja) 2006-09-28 2015-01-28 ハダシット メディカルリサーチサービセス アンド ディベロップメント リミテッド ジョイント部の潤滑に関するグリセロリン脂質の使用
WO2008143816A1 (en) 2007-05-15 2008-11-27 Mucosal Therapeutics Compositions and methods for reducing friction between the surface of tendons or other soft tissues
US20090068247A1 (en) 2007-09-12 2009-03-12 Mucosal Therapeutics Biocompatible devices coated with a tribonectin and methods for their production
US20090104148A1 (en) 2007-09-18 2009-04-23 Jay Gregory D Treatment and prevention of joint disease
US8506944B2 (en) 2008-05-07 2013-08-13 The Regents Of The University Of California Replenishment and enrichment of ocular surface lubrication
PT2285364E (pt) 2008-05-07 2015-02-24 Univ California Reposição e enriquecimento terapêutico de lubrificação da superficie ocular
US8980840B2 (en) 2009-01-13 2015-03-17 Schepens Eye Research Institute Therapeutic modulation of vaginal epithelium boundary lubrication
US9730865B2 (en) 2009-05-22 2017-08-15 Lubris, Llc Application and uses of PRG4 and therapeutic modulation thereof
EP2464375B1 (en) 2009-08-13 2017-06-14 Lubris LLC Prg4 treatment for interstitial cystitis
JP2013505013A (ja) * 2009-09-18 2013-02-14 セレクシス エス．エー． 強化導入遺伝子発現およびプロセッシングの産物および方法
US11213566B2 (en) 2010-01-19 2022-01-04 Lubris Llc Oral care compositions and methods
US20130116186A1 (en) 2011-10-04 2013-05-09 Rhode Island Hospital, A Lifespan Partner Lubricin injections to maintain cartilage health
US9982027B2 (en) 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
EP3074022B1 (en) 2013-11-26 2022-03-30 Lubris LLC Compositions and methods for inhibiting intercellular interactions
SG11201705636SA (en) 2015-01-26 2017-08-30 Lubris Llc Use of prg4 as an anti-inflammatory agent
US20180161393A1 (en) 2015-01-26 2018-06-14 Lubris Llc Prg4 for treating gout and its symptoms
LT3300482T (lt) 2015-05-19 2021-10-25 Lubris Llc Prg4 panaudojimas dinaminio regos aštrumo pagerinimui ir aukštesnės eilės aberacijų sumažinimui
US20170312335A1 (en) 2015-12-30 2017-11-02 Lubris Llc Topical use of prg4 for treatment of allergy and symptoms of inflammation

Also Published As

Publication number Publication date
SG10201913598TA (en) 2020-02-27
IL245236A0 (en) 2016-06-30
RU2758115C2 (ru) 2021-10-26
US20210130427A1 (en) 2021-05-06
IL283447A (en) 2021-07-29
LT3060577T (lt) 2021-12-27
US11485764B2 (en) 2022-11-01
SG11201603151VA (en) 2016-05-30
JP2020039348A (ja) 2020-03-19
MX2016005302A (es) 2017-02-15
WO2015061488A1 (en) 2015-04-30
HUE056397T2 (hu) 2022-02-28
IL245236B (en) 2021-12-01
EP3060577A4 (en) 2017-05-17
US20190270783A1 (en) 2019-09-05
AU2019201478B2 (en) 2021-07-08
US20230234999A1 (en) 2023-07-27
DK3060577T3 (da) 2021-10-04
US20160250286A1 (en) 2016-09-01
JP2016535590A (ja) 2016-11-17
JP6970164B2 (ja) 2021-11-24
CN105899527A (zh) 2016-08-24
EP3971203A1 (en) 2022-03-23
ES2891331T3 (es) 2022-01-27
EP3060577A1 (en) 2016-08-31
CY1124861T1 (el) 2022-11-25
KR102488928B1 (ko) 2023-01-13
AU2014340080A1 (en) 2016-06-02
AU2019201478A1 (en) 2019-03-28
SI3060577T1 (sl) 2021-12-31
RU2016119532A (ru) 2017-11-28
JP6669649B2 (ja) 2020-03-18
US10723773B2 (en) 2020-07-28
HRP20211497T1 (hr) 2021-12-24
PL3060577T3 (pl) 2022-01-24
AU2014340080B2 (en) 2018-12-06
WO2015060935A1 (en) 2015-04-30
BR112016008923A2 (pt) 2017-09-19
KR20160086843A (ko) 2016-07-20
US20160304572A1 (en) 2016-10-20
RU2016119532A3 (es) 2018-05-16
US9982027B2 (en) 2018-05-29
US10125180B2 (en) 2018-11-13
PT3060577T (pt) 2021-10-01
EP3060577B1 (en) 2021-07-07
CA2927949A1 (en) 2015-04-30

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