CY1124861T1 - Παραγωγη ανασυνδυασμενης λουμπρικινης - Google Patents
Παραγωγη ανασυνδυασμενης λουμπρικινηςInfo
- Publication number
- CY1124861T1 CY1124861T1 CY20211100872T CY211100872T CY1124861T1 CY 1124861 T1 CY1124861 T1 CY 1124861T1 CY 20211100872 T CY20211100872 T CY 20211100872T CY 211100872 T CY211100872 T CY 211100872T CY 1124861 T1 CY1124861 T1 CY 1124861T1
- Authority
- CY
- Cyprus
- Prior art keywords
- lubricin
- production
- recombined
- human
- manufacture
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4725—Proteoglycans, e.g. aggreccan
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Dermatology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Marine Sciences & Fisheries (AREA)
- Toxicology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Ophthalmology & Optometry (AREA)
- Inorganic Chemistry (AREA)
- Pulmonology (AREA)
- Otolaryngology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Αποκαλύπτονται νέες ανασυνδυασμένες ισομορφές λουμπρικίνης όμοιας με ανθρώπινη ή γλυκοπρωτεΐνης PRG4 που έχουν εξαιρετικές ιδιότητες λίπανσης και ένα νέο πρότυπο γλυκοσυλίωσης και μέθοδοι για την κατασκευή τους σε υψηλά επίπεδα που επιτρέπουν την εμπορική παραγωγή.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361894366P | 2013-10-22 | 2013-10-22 | |
PCT/US2014/061827 WO2015061488A1 (en) | 2013-10-22 | 2014-10-22 | Production of recombinant lubricin |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1124861T1 true CY1124861T1 (el) | 2022-11-25 |
Family
ID=52993344
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20211100872T CY1124861T1 (el) | 2013-10-22 | 2021-10-06 | Παραγωγη ανασυνδυασμενης λουμπρικινης |
Country Status (22)
Country | Link |
---|---|
US (5) | US9982027B2 (el) |
EP (2) | EP3971203A1 (el) |
JP (2) | JP6669649B2 (el) |
KR (1) | KR102488928B1 (el) |
CN (1) | CN105899527A (el) |
AU (2) | AU2014340080B2 (el) |
BR (1) | BR112016008923A2 (el) |
CA (1) | CA2927949A1 (el) |
CY (1) | CY1124861T1 (el) |
DK (1) | DK3060577T3 (el) |
ES (1) | ES2891331T3 (el) |
HR (1) | HRP20211497T1 (el) |
HU (1) | HUE056397T2 (el) |
IL (2) | IL245236B (el) |
LT (1) | LT3060577T (el) |
MX (2) | MX2016005302A (el) |
PL (1) | PL3060577T3 (el) |
PT (1) | PT3060577T (el) |
RU (1) | RU2758115C2 (el) |
SG (2) | SG11201603151VA (el) |
SI (1) | SI3060577T1 (el) |
WO (2) | WO2015060935A1 (el) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3110817C (en) | 2009-05-22 | 2023-08-15 | Lubris, Llc | Application and uses of prg4 and therapeutic modulation thereof |
DK2948553T3 (da) * | 2013-01-25 | 2020-06-29 | Baylor College Medicine | Hjælper-afhængigt afgivelses- og ekspressionssystem til adenoviral genterapi |
US9982027B2 (en) | 2013-10-22 | 2018-05-29 | Lubris Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
AU2014354859B2 (en) | 2013-11-26 | 2020-04-09 | Lubris Llc | Compositions and methods for inhibiting intercellular interactions |
JP6758299B2 (ja) | 2015-01-26 | 2020-09-23 | ルブリス,エルエルシー. | 抗炎症剤としてのprg4の使用 |
DK3300482T3 (da) | 2015-05-19 | 2021-10-18 | Lubris Llc | Brug af prg4 til at forbedre dynamisk synsstyrke og højere ordens aberrationer |
CN109055426B (zh) * | 2018-08-06 | 2021-06-25 | 智享生物(苏州)有限公司 | 一种在中华仓鼠卵巢细胞中表达生产类人润滑素的方法 |
EP3976085A4 (en) * | 2019-06-03 | 2023-04-05 | Lubris LLC | USING PRG4 TO TREAT CANCER |
MX2022010334A (es) | 2020-02-24 | 2022-09-19 | Novartis Ag | Purificacion de polipeptidos producidos recombinantemente. |
WO2023212598A1 (en) | 2022-04-27 | 2023-11-02 | Lubris Llc | Methods of making polymer films |
CN115154667A (zh) * | 2022-06-27 | 2022-10-11 | 天津大学 | 一种基于重组润滑素蛋白修饰的胶原蛋白基质的制备方法 |
CN115177790A (zh) * | 2022-06-27 | 2022-10-14 | 天津大学 | 透明质酸和润滑素蛋白协同修饰胶原蛋白基质的制备方法 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2243827B2 (en) | 1996-08-30 | 2017-11-22 | Life Technologies Corporation | Serum-free mammalian cell culture medium, and uses thereof |
US6530956B1 (en) * | 1998-09-10 | 2003-03-11 | Kevin A. Mansmann | Resorbable scaffolds to promote cartilage regeneration |
US6743774B1 (en) | 1999-04-23 | 2004-06-01 | Rhode Island Hospital | Tribonectins |
US6960562B2 (en) | 1999-04-23 | 2005-11-01 | Rhode Island Hospital, A Lifespan Partner | Tribonectin polypeptides and uses thereof |
US7001881B1 (en) | 1999-04-23 | 2006-02-21 | Rhode Island Hospital | Tribonectins |
DK1395669T3 (da) | 2001-01-26 | 2009-11-16 | Selexis Sa | Matriks bindingsregioner og fremgangsmåder til anvendelse af disse |
TW200307011A (en) | 2002-04-18 | 2003-12-01 | Chugai Pharmaceutical Co Ltd | Hyaluronic acid modifier |
US7415381B2 (en) | 2003-01-09 | 2008-08-19 | Rhode Island Hospital, A Lifespan Partner | Joint friction sensing |
WO2005000331A2 (en) | 2003-06-04 | 2005-01-06 | Mucosal Therapeutics, Inc. | Compositions for the treatment and prevention of degenerative joint disorders |
NZ545021A (en) * | 2003-08-14 | 2009-03-31 | Wyeth Corp | Recombinant lubricin molecules and uses thereof |
AU2004284220B2 (en) | 2003-10-24 | 2010-10-14 | Selexis S.A. | High efficiency gene transfer and expression in mammalian cells by a multiple transfection procedure of matrix attachment region sequences |
WO2005102363A2 (en) | 2004-04-20 | 2005-11-03 | Mucosal Therapeutics Llc | Methods of promoting cartilage healing or cartilage integration |
JP2008507553A (ja) | 2004-07-23 | 2008-03-13 | ミューコサル セラピューティクス リミテッド ライアビリディ カンパニー | 粘性補給のための組成物および方法 |
US20080139458A1 (en) | 2004-12-03 | 2008-06-12 | Jay Gregory D | Methods of Treatment For Injured or Diseased Joints |
US20070111327A1 (en) | 2005-05-05 | 2007-05-17 | Jay Gregory D | Methods of detecting lubricin |
PL1931346T3 (pl) | 2005-09-09 | 2013-01-31 | Angelini Labopharm Llc | Kompozycja trazodonu do podawania raz na dobę |
WO2008023247A2 (en) | 2006-08-23 | 2008-02-28 | Selexis S.A. | Matrix attachment regions (mars) for increasing transcription and uses thereof |
CN101541308B (zh) * | 2006-09-28 | 2012-02-01 | 哈达斯特医疗研究服务和开发有限公司 | 甘油磷脂用于关节润滑的用途 |
WO2008143816A1 (en) | 2007-05-15 | 2008-11-27 | Mucosal Therapeutics | Compositions and methods for reducing friction between the surface of tendons or other soft tissues |
US20090068247A1 (en) | 2007-09-12 | 2009-03-12 | Mucosal Therapeutics | Biocompatible devices coated with a tribonectin and methods for their production |
US20090104148A1 (en) * | 2007-09-18 | 2009-04-23 | Jay Gregory D | Treatment and prevention of joint disease |
US8506944B2 (en) * | 2008-05-07 | 2013-08-13 | The Regents Of The University Of California | Replenishment and enrichment of ocular surface lubrication |
RU2510274C2 (ru) | 2008-05-07 | 2014-03-27 | Дзе Реджентс Оф Дзе Юниверсити Оф Калифорния | Терапевтическое восстановление и усиление увлажнения поверхности глаза |
CN102438645A (zh) | 2009-01-13 | 2012-05-02 | 卢布里斯有限责任公司 | 阴道上皮界面润滑的治疗调节 |
CA3110817C (en) | 2009-05-22 | 2023-08-15 | Lubris, Llc | Application and uses of prg4 and therapeutic modulation thereof |
WO2011019963A2 (en) | 2009-08-13 | 2011-02-17 | Singularis, Inc. | Prg4 treatment for interstitial cystitis |
US20120231449A1 (en) | 2009-09-18 | 2012-09-13 | Selexis S.A. | Products and methods for enhanced transgene expression and processing |
ES2627103T3 (es) | 2010-01-19 | 2017-07-26 | Lubris Llc | Composiciones de cuidado bucal y métodos |
US20130116186A1 (en) | 2011-10-04 | 2013-05-09 | Rhode Island Hospital, A Lifespan Partner | Lubricin injections to maintain cartilage health |
US9982027B2 (en) | 2013-10-22 | 2018-05-29 | Lubris Llc | Control of rheological properties of mixed hyaluronate/lubricin solutions |
AU2014354859B2 (en) | 2013-11-26 | 2020-04-09 | Lubris Llc | Compositions and methods for inhibiting intercellular interactions |
JP6758299B2 (ja) | 2015-01-26 | 2020-09-23 | ルブリス,エルエルシー. | 抗炎症剤としてのprg4の使用 |
US20180161393A1 (en) | 2015-01-26 | 2018-06-14 | Lubris Llc | Prg4 for treating gout and its symptoms |
DK3300482T3 (da) | 2015-05-19 | 2021-10-18 | Lubris Llc | Brug af prg4 til at forbedre dynamisk synsstyrke og højere ordens aberrationer |
US20170312335A1 (en) | 2015-12-30 | 2017-11-02 | Lubris Llc | Topical use of prg4 for treatment of allergy and symptoms of inflammation |
-
2014
- 2014-08-22 US US15/028,752 patent/US9982027B2/en active Active
- 2014-08-22 WO PCT/US2014/052272 patent/WO2015060935A1/en active Application Filing
- 2014-10-22 EP EP21183527.7A patent/EP3971203A1/en not_active Withdrawn
- 2014-10-22 ES ES14856188T patent/ES2891331T3/es active Active
- 2014-10-22 MX MX2016005302A patent/MX2016005302A/es unknown
- 2014-10-22 US US15/030,825 patent/US10125180B2/en active Active
- 2014-10-22 SI SI201431882T patent/SI3060577T1/sl unknown
- 2014-10-22 HR HRP20211497TT patent/HRP20211497T1/hr unknown
- 2014-10-22 EP EP14856188.9A patent/EP3060577B1/en active Active
- 2014-10-22 PL PL14856188T patent/PL3060577T3/pl unknown
- 2014-10-22 AU AU2014340080A patent/AU2014340080B2/en active Active
- 2014-10-22 HU HUE14856188A patent/HUE056397T2/hu unknown
- 2014-10-22 PT PT14856188T patent/PT3060577T/pt unknown
- 2014-10-22 BR BR112016008923A patent/BR112016008923A2/pt not_active Application Discontinuation
- 2014-10-22 WO PCT/US2014/061827 patent/WO2015061488A1/en active Application Filing
- 2014-10-22 DK DK14856188.9T patent/DK3060577T3/da active
- 2014-10-22 CN CN201480065482.7A patent/CN105899527A/zh active Pending
- 2014-10-22 SG SG11201603151VA patent/SG11201603151VA/en unknown
- 2014-10-22 LT LTEPPCT/US2014/061827T patent/LT3060577T/lt unknown
- 2014-10-22 RU RU2016119532A patent/RU2758115C2/ru active
- 2014-10-22 JP JP2016525090A patent/JP6669649B2/ja active Active
- 2014-10-22 KR KR1020167013154A patent/KR102488928B1/ko active IP Right Grant
- 2014-10-22 SG SG10201913598TA patent/SG10201913598TA/en unknown
- 2014-10-22 CA CA2927949A patent/CA2927949A1/en active Pending
-
2016
- 2016-04-20 IL IL245236A patent/IL245236B/en unknown
- 2016-04-22 MX MX2021003243A patent/MX2021003243A/es unknown
-
2018
- 2018-11-07 US US16/183,497 patent/US10723773B2/en active Active
-
2019
- 2019-03-04 AU AU2019201478A patent/AU2019201478B2/en active Active
- 2019-11-18 JP JP2019207908A patent/JP6970164B2/ja active Active
-
2020
- 2020-06-18 US US16/904,978 patent/US11485764B2/en active Active
-
2021
- 2021-05-25 IL IL283447A patent/IL283447A/en unknown
- 2021-10-06 CY CY20211100872T patent/CY1124861T1/el unknown
-
2022
- 2022-10-27 US US17/975,572 patent/US20230234999A1/en active Pending
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