MX2016005302A - Produccion de lubricina recombinante. - Google Patents

Produccion de lubricina recombinante.

Info

Publication number
MX2016005302A
MX2016005302A MX2016005302A MX2016005302A MX2016005302A MX 2016005302 A MX2016005302 A MX 2016005302A MX 2016005302 A MX2016005302 A MX 2016005302A MX 2016005302 A MX2016005302 A MX 2016005302A MX 2016005302 A MX2016005302 A MX 2016005302A
Authority
MX
Mexico
Prior art keywords
production
recombinant lubricin
lubricin
human
manufacture
Prior art date
Application number
MX2016005302A
Other languages
English (en)
Inventor
Schmidt Tannin
D Jay Gregory
Original Assignee
Lubris Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lubris Llc filed Critical Lubris Llc
Publication of MX2016005302A publication Critical patent/MX2016005302A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Toxicology (AREA)
  • Biotechnology (AREA)
  • Ophthalmology & Optometry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Inorganic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Se divulgan nuevas isoformas recombinantes de lubricina tipo humana o glicoproteína de PRG4 que tiene excelentes propiedades de lubricación y un novedoso patrón de glicosilación, y métodos para su fabricación en niveles altos que permiten la producción comercial.
MX2016005302A 2013-10-22 2014-10-22 Produccion de lubricina recombinante. MX2016005302A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361894366P 2013-10-22 2013-10-22
PCT/US2014/061827 WO2015061488A1 (en) 2013-10-22 2014-10-22 Production of recombinant lubricin

Publications (1)

Publication Number Publication Date
MX2016005302A true MX2016005302A (es) 2017-02-15

Family

ID=52993344

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2016005302A MX2016005302A (es) 2013-10-22 2014-10-22 Produccion de lubricina recombinante.
MX2021003243A MX2021003243A (es) 2013-10-22 2016-04-22 Produccion de lubricina recombinante.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2021003243A MX2021003243A (es) 2013-10-22 2016-04-22 Produccion de lubricina recombinante.

Country Status (22)

Country Link
US (5) US9982027B2 (es)
EP (2) EP3060577B1 (es)
JP (2) JP6669649B2 (es)
KR (1) KR102488928B1 (es)
CN (1) CN105899527A (es)
AU (2) AU2014340080B2 (es)
BR (1) BR112016008923A2 (es)
CA (1) CA2927949A1 (es)
CY (1) CY1124861T1 (es)
DK (1) DK3060577T3 (es)
ES (1) ES2891331T3 (es)
HR (1) HRP20211497T1 (es)
HU (1) HUE056397T2 (es)
IL (2) IL245236B (es)
LT (1) LT3060577T (es)
MX (2) MX2016005302A (es)
PL (1) PL3060577T3 (es)
PT (1) PT3060577T (es)
RU (1) RU2758115C2 (es)
SG (2) SG11201603151VA (es)
SI (1) SI3060577T1 (es)
WO (2) WO2015060935A1 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2012527485A (ja) 2009-05-22 2012-11-08 ルブリス，エルエルシー． Ｐｒｇ４及びその治療調節作用の応用及び使用
EP2948553B1 (en) * 2013-01-25 2020-04-01 Baylor College Of Medicine A helper-dependent adenoviral gene therapy delivery and expression system
WO2015060935A1 (en) 2013-10-22 2015-04-30 Lubris, Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
JP6571101B2 (ja) 2013-11-26 2019-09-04 ルブリス，エルエルシー． 細胞間相互作用を阻害するための組成物及び方法
ES2808199T3 (es) 2015-01-26 2021-02-25 Lubris Llc Uso de PRG4 como un agente antiinflamatorio
SI3300482T1 (sl) * 2015-05-19 2021-11-30 Lubris Llc Uporaba prg4 za izboljšanje dinamične ostrine vide in aberacij višjega reda
CN109055426B (zh) * 2018-08-06 2021-06-25 智享生物(苏州)有限公司 一种在中华仓鼠卵巢细胞中表达生产类人润滑素的方法
US20220332839A1 (en) * 2019-06-03 2022-10-20 Lubris Llc Use of prg4 to treat cancer
KR20220145361A (ko) 2020-02-24 2022-10-28 노파르티스 아게 재조합적으로 생성된 폴리펩타이드의 정제
WO2023212598A1 (en) 2022-04-27 2023-11-02 Lubris Llc Methods of making polymer films
CN115177790A (zh) * 2022-06-27 2022-10-14 天津大学 透明质酸和润滑素蛋白协同修饰胶原蛋白基质的制备方法
CN115154667A (zh) * 2022-06-27 2022-10-11 天津大学 一种基于重组润滑素蛋白修饰的胶原蛋白基质的制备方法

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EP1482031B1 (en) * 1996-08-30 2015-10-28 Life Technologies Corporation Serum-free mammalian cell culture medium, and uses thereof
US6530956B1 (en) * 1998-09-10 2003-03-11 Kevin A. Mansmann Resorbable scaffolds to promote cartilage regeneration
US6960562B2 (en) 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
US6743774B1 (en) 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
US7001881B1 (en) 1999-04-23 2006-02-21 Rhode Island Hospital Tribonectins
EP1395669B1 (en) 2001-01-26 2009-07-22 Selexis S.A. Matrix attachment regions and methods for use thereof
TW200307011A (en) 2002-04-18 2003-12-01 Chugai Pharmaceutical Co Ltd Hyaluronic acid modifier
US7415381B2 (en) 2003-01-09 2008-08-19 Rhode Island Hospital, A Lifespan Partner Joint friction sensing
US20060240037A1 (en) 2003-06-04 2006-10-26 Edward Fey Methods and compositions for the treatment and prevention of degenerative joint disorders
RU2376313C2 (ru) 2003-08-14 2009-12-20 Уайт Рекомбинантные молекулы лубрицина и их использование
PL2292754T3 (pl) 2003-10-24 2013-06-28 Selexis Sa Wysokowydajny transfer genu i ekspresja w komórkach ssaczych przez procedurę wielokrotnej transfekcji sekwencji regionu przylegania do macierzy
US20090155200A1 (en) 2004-04-20 2009-06-18 Jay Gregory D Methods of promoting cartilage healing or cartilage integration
US20080287369A1 (en) 2004-07-23 2008-11-20 Jay Gregory D Compositions and Methods for Viscosupplementation
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DK1940467T3 (da) 2005-09-09 2017-02-13 Paladin Labs Inc Lægemiddelsammensætning med langvarig frigivelse
AU2007287327B2 (en) * 2006-08-23 2012-11-22 Selexis S.A. Matrix attachment regions (MARs) for increasing transcription and uses thereof
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US8506944B2 (en) 2008-05-07 2013-08-13 The Regents Of The University Of California Replenishment and enrichment of ocular surface lubrication
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JP2012527485A (ja) 2009-05-22 2012-11-08 ルブリス，エルエルシー． Ｐｒｇ４及びその治療調節作用の応用及び使用
EP2464375B1 (en) 2009-08-13 2017-06-14 Lubris LLC Prg4 treatment for interstitial cystitis
WO2011033375A2 (en) 2009-09-18 2011-03-24 Selexis S.A. Products and methods for enhanced transgene expression and processing
EP2525805B1 (en) 2010-01-19 2017-03-15 Lubris LLC Oral care compositions and methods
US20130116186A1 (en) 2011-10-04 2013-05-09 Rhode Island Hospital, A Lifespan Partner Lubricin injections to maintain cartilage health
WO2015060935A1 (en) 2013-10-22 2015-04-30 Lubris, Llc Control of rheological properties of mixed hyaluronate/lubricin solutions
JP6571101B2 (ja) 2013-11-26 2019-09-04 ルブリス，エルエルシー． 細胞間相互作用を阻害するための組成物及び方法
US20180161393A1 (en) 2015-01-26 2018-06-14 Lubris Llc Prg4 for treating gout and its symptoms
ES2808199T3 (es) 2015-01-26 2021-02-25 Lubris Llc Uso de PRG4 como un agente antiinflamatorio
SI3300482T1 (sl) 2015-05-19 2021-11-30 Lubris Llc Uporaba prg4 za izboljšanje dinamične ostrine vide in aberacij višjega reda
US20170312335A1 (en) 2015-12-30 2017-11-02 Lubris Llc Topical use of prg4 for treatment of allergy and symptoms of inflammation

Also Published As

Publication number Publication date
CY1124861T1 (el) 2022-11-25
US20160304572A1 (en) 2016-10-20
PT3060577T (pt) 2021-10-01
AU2019201478B2 (en) 2021-07-08
CN105899527A (zh) 2016-08-24
KR102488928B1 (ko) 2023-01-13
RU2016119532A (ru) 2017-11-28
US20190270783A1 (en) 2019-09-05
WO2015061488A1 (en) 2015-04-30
JP2016535590A (ja) 2016-11-17
PL3060577T3 (pl) 2022-01-24
IL283447A (en) 2021-07-29
US20210130427A1 (en) 2021-05-06
AU2014340080B2 (en) 2018-12-06
HRP20211497T1 (hr) 2021-12-24
RU2016119532A3 (es) 2018-05-16
US20230234999A1 (en) 2023-07-27
EP3060577B1 (en) 2021-07-07
KR20160086843A (ko) 2016-07-20
JP6970164B2 (ja) 2021-11-24
WO2015060935A1 (en) 2015-04-30
RU2758115C2 (ru) 2021-10-26
CA2927949A1 (en) 2015-04-30
LT3060577T (lt) 2021-12-27
SG11201603151VA (en) 2016-05-30
ES2891331T3 (es) 2022-01-27
IL245236A0 (en) 2016-06-30
AU2019201478A1 (en) 2019-03-28
EP3060577A1 (en) 2016-08-31
JP6669649B2 (ja) 2020-03-18
DK3060577T3 (da) 2021-10-04
IL245236B (en) 2021-12-01
US10125180B2 (en) 2018-11-13
US10723773B2 (en) 2020-07-28
SG10201913598TA (en) 2020-02-27
US11485764B2 (en) 2022-11-01
SI3060577T1 (sl) 2021-12-31
BR112016008923A2 (pt) 2017-09-19
US9982027B2 (en) 2018-05-29
HUE056397T2 (hu) 2022-02-28
AU2014340080A1 (en) 2016-06-02
MX2021003243A (es) 2021-05-12
US20160250286A1 (en) 2016-09-01
EP3060577A4 (en) 2017-05-17
JP2020039348A (ja) 2020-03-19
EP3971203A1 (en) 2022-03-23

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