DK2948553T3 - Hjælper-afhængigt afgivelses- og ekspressionssystem til adenoviral genterapi - Google Patents

Hjælper-afhængigt afgivelses- og ekspressionssystem til adenoviral genterapi Download PDF

Info

Publication number
DK2948553T3
DK2948553T3 DK14708933.8T DK14708933T DK2948553T3 DK 2948553 T3 DK2948553 T3 DK 2948553T3 DK 14708933 T DK14708933 T DK 14708933T DK 2948553 T3 DK2948553 T3 DK 2948553T3
Authority
DK
Denmark
Prior art keywords
helper
gene therapy
expression system
adenoviral gene
dependent delivery
Prior art date
Application number
DK14708933.8T
Other languages
English (en)
Inventor
Zhechao Ruan
Kilian Guse
Brendan Lee
Original Assignee
Baylor College Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baylor College Medicine filed Critical Baylor College Medicine
Application granted granted Critical
Publication of DK2948553T3 publication Critical patent/DK2948553T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10041—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/24—Vectors characterised by the absence of particular element, e.g. selectable marker, viral origin of replication

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
DK14708933.8T 2013-01-25 2014-01-27 Hjælper-afhængigt afgivelses- og ekspressionssystem til adenoviral genterapi DK2948553T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361756516P 2013-01-25 2013-01-25
PCT/IB2014/000071 WO2014115022A1 (en) 2013-01-25 2014-01-27 A helper-dependent adenoviral gene therapy delivery and expression system

Publications (1)

Publication Number Publication Date
DK2948553T3 true DK2948553T3 (da) 2020-06-29

Family

ID=50239686

Family Applications (1)

Application Number Title Priority Date Filing Date
DK14708933.8T DK2948553T3 (da) 2013-01-25 2014-01-27 Hjælper-afhængigt afgivelses- og ekspressionssystem til adenoviral genterapi

Country Status (6)

Country Link
US (4) US20150361452A1 (da)
EP (1) EP2948553B1 (da)
DK (1) DK2948553T3 (da)
ES (1) ES2802878T3 (da)
PL (1) PL2948553T3 (da)
WO (1) WO2014115022A1 (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6758299B2 (ja) 2015-01-26 2020-09-23 ルブリス，エルエルシー． 抗炎症剤としてのｐｒｇ４の使用
CN108697813B (zh) 2016-01-13 2024-01-16 勃林格殷格翰动物保健美国公司 用于治疗哺乳动物内骨关节炎和相关关节病症的表达骨保护性基因、包括has2和润滑素的重组aav载体
EP3500279A4 (en) * 2016-08-19 2020-04-22 Calimmune, Inc. METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANINE CONDITIONS USING A RECOMBINANT SELF-COMPLEMENTARY ADENO-ASSOCIATED VIRUS.
AU2017313844B2 (en) 2016-08-19 2023-10-12 University Of Florida Research Foundation, Incorporated Methods and compositions for treating conditions using recombinant self-complementary adeno-associated virus
WO2018035441A1 (en) * 2016-08-19 2018-02-22 Colorado State University Research Foundation Methods and compositions for treating equine conditions using recombinant self-complementary adeno-associated virus
US11958886B2 (en) 2016-12-07 2024-04-16 University Of Florida Research Foundation, Incorporated IL-1RA cDNAs
NZ758626A (en) 2017-04-21 2023-09-29 Baylor College Medicine Oncolytic virotherapy and immunotherapy
CN114616001A (zh) * 2019-09-18 2022-06-10 帕西拉制药有限公司 用于治疗人骨关节炎的基于腺病毒的生物递送和表达系统的有效剂量以及包含其的组合物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5747072A (en) * 1993-07-30 1998-05-05 University Of Michigan Adenoviral-mediated gene transfer to synovial cells in vivo
US6743774B1 (en) 1999-04-23 2004-06-01 Rhode Island Hospital Tribonectins
US6960562B2 (en) * 1999-04-23 2005-11-01 Rhode Island Hospital, A Lifespan Partner Tribonectin polypeptides and uses thereof
WO2002083080A2 (en) * 2001-04-17 2002-10-24 Genetix Pharmaceuticals, Inc. Method of treating arthritis using lentiviral vectors in gene therapy
ATE464068T1 (de) 2001-06-26 2010-04-15 Amgen Fremont Inc Antikörper gegen opgl
NZ545021A (en) * 2003-08-14 2009-03-31 Wyeth Corp Recombinant lubricin molecules and uses thereof
EP2034025A1 (en) * 2007-09-04 2009-03-11 Freie Universität Berlin Inflammation-induced anti-inflammatory gene expression
US20090104148A1 (en) * 2007-09-18 2009-04-23 Jay Gregory D Treatment and prevention of joint disease
CN101918018B (zh) * 2007-11-14 2012-12-05 再生医药有限公司 使用白介素-1受体拮抗剂作为骨髓保护剂的方法
US20100215731A1 (en) * 2009-02-20 2010-08-26 Maastricht University Method for improving cartilage repair and/or preventing cartilage degeneration in a joint
DK2623604T3 (da) * 2012-02-02 2015-06-01 Baylor College Medicine Adenovirusbaseret biologisk afgivelses- og ekspressionssystem til anvendelse ved behandling af osteoartrose
US9982027B2 (en) * 2013-10-22 2018-05-29 Lubris Llc Control of rheological properties of mixed hyaluronate/lubricin solutions

Also Published As

Publication number Publication date
US20220017923A1 (en) 2022-01-20
WO2014115022A1 (en) 2014-07-31
EP2948553A1 (en) 2015-12-02
US20220282280A1 (en) 2022-09-08
US20240102049A1 (en) 2024-03-28
US11746359B2 (en) 2023-09-05
US20150361452A1 (en) 2015-12-17
PL2948553T3 (pl) 2020-11-16
ES2802878T3 (es) 2021-01-21
EP2948553B1 (en) 2020-04-01

Similar Documents

Publication Publication Date Title
HK1222135A1 (zh) 透皮遞送系統
HK1222814A1 (zh) 便携式流體輸送系統
EP2954422A4 (en) DEMOGRAPHIC CONTEXTING SYSTEM
DK3082926T3 (da) Forbindelser til befugtningssystem
DK3404106T3 (da) Ekspressionssystem til selektiv genterapi
DK2908905T3 (da) System til at kontrollere elektriske forhold i væv
DK2869889T3 (da) Flowsystem til medicinske ledninger
DK2948553T3 (da) Hjælper-afhængigt afgivelses- og ekspressionssystem til adenoviral genterapi
DK2914540T3 (da) Styresystem til kabler eller lignende
DK2764881T3 (da) System til medicinsk behandling
LT2908873T (lt) Transderminio įvedimo sistema
EP2987504A4 (en) NON-VIRAL GENE DELIVERY SYSTEM FOR TARGETING ADIPOSE CELLS
EP2967709A4 (en) THERAPEUTIC CRYOABLATION SYSTEM
DE112014004954T8 (de) Abgabesystem
DK3206733T3 (da) Leveringssystem og driftsmodus
FI20126284A (fi) Valvontajärjestelmä ja -menetelmä
DE112014004938T8 (de) Abgabesystem
EP3017043A4 (en) Gene expression or activity enhancing elements
DK2887956T3 (da) Neisseria-meningitidis-fhbp-variant og dens anvendelse til vaccination
IL239580A0 (en) electrophoresis system
GB201306981D0 (en) Delivery system
FI20126169A (fi) Lääkejakelujärjestelmä
EP2960784A4 (en) VIRTUALIZATION SYSTEM
DK2842006T3 (da) System og fremgangsmåde til kontrollerende koblede leverings spiraler
GB201316687D0 (en) Computer controlled inhaler system