MX2021002742A - Terapia combinada con un inhibidor de la fosfoinositida 3-quinasa con un resto de unión a zinc. - Google Patents

Terapia combinada con un inhibidor de la fosfoinositida 3-quinasa con un resto de unión a zinc.

Info

Publication number
MX2021002742A
MX2021002742A MX2021002742A MX2021002742A MX2021002742A MX 2021002742 A MX2021002742 A MX 2021002742A MX 2021002742 A MX2021002742 A MX 2021002742A MX 2021002742 A MX2021002742 A MX 2021002742A MX 2021002742 A MX2021002742 A MX 2021002742A
Authority
MX
Mexico
Prior art keywords
phosphoinositide
pharmaceutically acceptable
combination therapy
kinase inhibitor
binding moiety
Prior art date
Application number
MX2021002742A
Other languages
English (en)
Inventor
Jing Wang
Troy David Patterson
Ze Tian
Original Assignee
Curis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Curis Inc filed Critical Curis Inc
Publication of MX2021002742A publication Critical patent/MX2021002742A/es

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La invención proporciona un método para tratar el cáncer en un sujeto que lo necesita, que comprende administrar al sujeto: (a) un compuesto de Fórmula I: (ver formula I) o una sal farmacéuticamente aceptable de este, en donde R es hidrógeno o un grupo acilo; y (b) un inhibidor de la señalización de PD-1; en donde el compuesto de Fórmula I o una sal farmacéuticamente aceptable de este y el inhibidor de la señalización de PD-1 se administran en cantidades que en combinación son terapéuticamente efectivos. La invención proporciona además una composición farmacéutica que comprende un compuesto de Fórmula I o una sal farmacéuticamente aceptable de este, un inhibidor de la señalización de PD-1 y un portador o excipiente farmacéuticamente aceptable.
MX2021002742A 2018-09-11 2019-09-10 Terapia combinada con un inhibidor de la fosfoinositida 3-quinasa con un resto de unión a zinc. MX2021002742A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201862729648P 2018-09-11 2018-09-11
PCT/US2019/050373 WO2020055840A1 (en) 2018-09-11 2019-09-10 Combination therapy with a phosphoinositide 3-kinase inhibitor with a zinc binding moiety

Publications (1)

Publication Number Publication Date
MX2021002742A true MX2021002742A (es) 2021-08-11

Family

ID=69721106

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021002742A MX2021002742A (es) 2018-09-11 2019-09-10 Terapia combinada con un inhibidor de la fosfoinositida 3-quinasa con un resto de unión a zinc.

Country Status (15)

Country Link
US (2) US11234986B2 (es)
EP (1) EP3849554A4 (es)
JP (1) JP7467423B2 (es)
KR (1) KR20210087438A (es)
CN (1) CN113164466A (es)
AU (1) AU2019340376A1 (es)
BR (1) BR112021004371A2 (es)
CA (1) CA3112177A1 (es)
EA (1) EA202190748A1 (es)
IL (1) IL281303A (es)
MA (1) MA53619A (es)
MX (1) MX2021002742A (es)
PH (1) PH12021550471A1 (es)
SG (1) SG11202102343QA (es)
WO (1) WO2020055840A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112778212B (zh) * 2021-01-28 2022-03-15 苏州莱克施德药业有限公司 库潘尼西中间体2-胺基嘧啶-5-羧酸甲酯的合成方法

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Also Published As

Publication number Publication date
WO2020055840A1 (en) 2020-03-19
EP3849554A4 (en) 2022-06-01
AU2019340376A1 (en) 2021-04-08
US20220249502A1 (en) 2022-08-11
KR20210087438A (ko) 2021-07-12
JP7467423B2 (ja) 2024-04-15
SG11202102343QA (en) 2021-04-29
CN113164466A (zh) 2021-07-23
MA53619A (fr) 2021-12-15
US11234986B2 (en) 2022-02-01
EP3849554A1 (en) 2021-07-21
JP2022500374A (ja) 2022-01-04
US20200078364A1 (en) 2020-03-12
EA202190748A1 (ru) 2021-07-22
CA3112177A1 (en) 2020-03-19
IL281303A (en) 2021-04-29
BR112021004371A2 (pt) 2021-05-25
PH12021550471A1 (en) 2021-11-22

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