MX2020003383A - Compuesto de griseofulvina y uso farmacéutico de este. - Google Patents

Compuesto de griseofulvina y uso farmacéutico de este.

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Publication number
MX2020003383A
MX2020003383A MX2020003383A MX2020003383A MX2020003383A MX 2020003383 A MX2020003383 A MX 2020003383A MX 2020003383 A MX2020003383 A MX 2020003383A MX 2020003383 A MX2020003383 A MX 2020003383A MX 2020003383 A MX2020003383 A MX 2020003383A
Authority
MX
Mexico
Prior art keywords
sup
alkyl group
compound
pharmaceutical use
acceptable salt
Prior art date
Application number
MX2020003383A
Other languages
English (en)
Inventor
Keiji Saito
Yasuyuki Ogawa
Katsuyoshi Nakajima
Kaori Ito
Seiko Nagata
Mitsuhiro Makino
Makoto Hirasawa
Original Assignee
Daiichi Sankyo Co Ltd
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Filing date
Publication date
Application filed by Daiichi Sankyo Co Ltd filed Critical Daiichi Sankyo Co Ltd
Publication of MX2020003383A publication Critical patent/MX2020003383A/es

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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/424—Oxazoles condensed with heterocyclic ring systems, e.g. clavulanic acid
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
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  • Rheumatology (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Hospice & Palliative Care (AREA)
  • Diabetes (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Furan Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención aborda el problema de proporcionar un compuesto para la profilaxis y/o tratamiento de enfermedades inflamatorias centrales, o una sal farmacológicamente aceptable de este. La presente invención aborda un compuesto de una fórmula general (I) o una sal farmacológicamente aceptable de este como un medio para resolver el problema. [R1: un grupo alquilo C1-C6 o similar, R2: un grupo alquilo C1-C6 o similar, A: un heteroanillo aromático de 5 miembros o similar, R3, R3': un grupo alquilo C1-C6 o similar].
MX2020003383A 2017-09-29 2018-09-28 Compuesto de griseofulvina y uso farmacéutico de este. MX2020003383A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2017191690 2017-09-29
PCT/JP2018/036160 WO2019065928A1 (ja) 2017-09-29 2018-09-28 グリセオフルビン化合物と医薬用途

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MX2020003383A true MX2020003383A (es) 2020-10-01

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US (1) US11407746B2 (es)
EP (1) EP3689857A4 (es)
JP (1) JP7102426B2 (es)
KR (1) KR20200062243A (es)
CN (1) CN111295378A (es)
AU (1) AU2018342423B2 (es)
BR (1) BR112020006239A2 (es)
CA (1) CA3076885A1 (es)
IL (1) IL273339B1 (es)
MX (1) MX2020003383A (es)
PH (1) PH12020550168A1 (es)
SG (1) SG11202002973WA (es)
TW (1) TWI811243B (es)
WO (1) WO2019065928A1 (es)

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WO2017170623A1 (ja) 2016-03-30 2017-10-05 第一三共株式会社 グリセオフルビン化合物
TWI811243B (zh) 2017-09-29 2023-08-11 日商第一三共股份有限公司 灰黃黴素化合物及醫藥用途
CN114585360A (zh) * 2019-09-05 2022-06-03 特维娜有限公司 使用其治疗癫痫的方法
CA3168026A1 (en) * 2020-04-02 2021-10-07 Michael Friedrich ACKERMANN Compositions and methods for treating age-related diseases and premature aging disorders
CN114656363A (zh) * 2022-03-28 2022-06-24 南京林业大学 一种钯催化芳香酯类化合物的合成方法
WO2024026443A1 (en) * 2022-07-28 2024-02-01 Sirtsei Pharmaceuticals, Inc. Compositions and methods for improving memory and cognition

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JPH03255081A (ja) 1990-03-01 1991-11-13 Mect Corp ｄｌ―グリセオフルビン、ｄｌ―グリセオフルビン誘導体およびそれらの中間体の製造方法
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TWI811243B (zh) 2017-09-29 2023-08-11 日商第一三共股份有限公司 灰黃黴素化合物及醫藥用途

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