MX2020001875A - Forma polimorfica de tg02. - Google Patents
Forma polimorfica de tg02.Info
- Publication number
- MX2020001875A MX2020001875A MX2020001875A MX2020001875A MX2020001875A MX 2020001875 A MX2020001875 A MX 2020001875A MX 2020001875 A MX2020001875 A MX 2020001875A MX 2020001875 A MX2020001875 A MX 2020001875A MX 2020001875 A MX2020001875 A MX 2020001875A
- Authority
- MX
- Mexico
- Prior art keywords
- acid addition
- addition salts
- free base
- polymorphic forms
- crystalline polymorphic
- Prior art date
Links
- 239000002253 acid Substances 0.000 abstract 3
- 239000012458 free base Substances 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/529—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5169—Proteins, e.g. albumin, gelatin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nanotechnology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762547157P | 2017-08-18 | 2017-08-18 | |
| PCT/US2018/000264 WO2019035985A1 (en) | 2017-08-18 | 2018-08-17 | POLYMORPHIC FORM OF TG02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2020001875A true MX2020001875A (es) | 2020-07-29 |
Family
ID=65359869
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020001875A MX2020001875A (es) | 2017-08-18 | 2018-08-17 | Forma polimorfica de tg02. |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10544162B2 (enExample) |
| EP (2) | EP3668876B1 (enExample) |
| JP (1) | JP7250764B2 (enExample) |
| KR (1) | KR102758037B1 (enExample) |
| CN (1) | CN111372934B (enExample) |
| AU (1) | AU2018317865B2 (enExample) |
| CA (1) | CA3073270A1 (enExample) |
| ES (1) | ES2977589T3 (enExample) |
| IL (1) | IL272697B2 (enExample) |
| MX (1) | MX2020001875A (enExample) |
| RU (1) | RU2020111019A (enExample) |
| SG (1) | SG11202001441WA (enExample) |
| TW (1) | TWI785098B (enExample) |
| WO (1) | WO2019035985A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11865116B2 (en) | 2016-03-24 | 2024-01-09 | Cothera Bioscience, Inc. | Treatment of cancer with TG02 |
| ES2977589T3 (es) | 2017-08-18 | 2024-08-27 | Cothera Bioscience Inc | Forma polimórfica de TG02 |
| ES3034869T3 (en) * | 2019-04-22 | 2025-08-25 | Univ Pittsburgh Commonwealth Sys Higher Education | Tg02 for use in treating gliomas in pediatric subjects |
| CN110664760B (zh) * | 2019-10-28 | 2020-10-23 | 浙江大学 | 一种负载vegfr靶向抑制剂的药物载体及其制备方法和应用 |
| WO2024031406A1 (en) * | 2022-08-10 | 2024-02-15 | Xiang Li | Idh mutations as biomarkers for zotiraciclib therapy |
| CN115429793A (zh) * | 2022-08-15 | 2022-12-06 | 复旦大学附属中山医院 | 一种化合物在制备治疗肝细胞癌药物中的应用 |
| CN115305251B (zh) * | 2022-08-30 | 2023-06-27 | 中国农业科学院北京畜牧兽医研究所 | Ap2-mybl2分子模块在调控原花色素生物合成中的应用 |
Family Cites Families (48)
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| EP0084796B1 (en) | 1982-01-22 | 1990-05-02 | Cetus Corporation | Hla typing method and cdna probes used therein |
| US4683194A (en) | 1984-05-29 | 1987-07-28 | Cetus Corporation | Method for detection of polymorphic restriction sites and nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| CA1338457C (en) | 1986-08-22 | 1996-07-16 | Henry A. Erlich | Purified thermostable enzyme |
| US5093330A (en) | 1987-06-15 | 1992-03-03 | Ciba-Geigy Corporation | Staurosporine derivatives substituted at methylamino nitrogen |
| US6605712B1 (en) | 1990-12-20 | 2003-08-12 | Arch Development Corporation | Gene transcription and ionizing radiation: methods and compositions |
| WO1998042752A1 (en) | 1997-03-21 | 1998-10-01 | Brigham And Women's Hospital Inc. | Immunotherapeutic ctla-4 binding peptides |
| EP2360254A1 (en) | 1999-08-23 | 2011-08-24 | Dana-Farber Cancer Institute, Inc. | Assays for screening anti-pd-1 antibodies and uses thereof |
| WO2001014424A2 (en) | 1999-08-24 | 2001-03-01 | Medarex, Inc. | Human ctla-4 antibodies and their uses |
| AU2003213054A1 (en) | 2002-02-20 | 2003-09-09 | Sirna Therapeutics, Inc. | RNA INTERFERENCE MEDIATED INHIBITION OF POLYCOMB GROUP PROTEIN EZH2 GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| US7595048B2 (en) | 2002-07-03 | 2009-09-29 | Ono Pharmaceutical Co., Ltd. | Method for treatment of cancer by inhibiting the immunosuppressive signal induced by PD-1 |
| CN103285395A (zh) * | 2005-02-18 | 2013-09-11 | 阿布拉科斯生物科学有限公司 | 治疗剂的组合和给予方式以及联合治疗 |
| DK2161336T4 (en) | 2005-05-09 | 2017-04-24 | Ono Pharmaceutical Co | Human monoclonal antibodies for programmed death 1 (PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapies |
| DK1951730T3 (da) | 2005-11-16 | 2010-09-27 | S Bio Pte Ltd | Heteroalkylbundne pyrimidinderivater |
| CA2682356C (en) | 2007-04-16 | 2016-06-14 | Abbott Laboratories | 7-substituted indole mcl-1 inhibitors |
| NZ582150A (en) | 2007-06-18 | 2012-08-31 | Msd Oss Bv | Antibodies to human programmed death receptor pd-1 |
| GB0806652D0 (en) | 2008-04-11 | 2008-05-14 | Glaxo Group Ltd | Anhydrous crystal form of orvepitant maleate |
| AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
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| HRP20170908T1 (hr) | 2008-12-09 | 2017-09-22 | F. Hoffmann - La Roche Ag | Protutijela anti-pd-l1 i njihova uporaba za poboljšanje funkcije t-stanice |
| EP2418955A4 (en) * | 2009-04-15 | 2012-11-21 | Poniard Pharmaceuticals Inc | ORBIOTIC ANTICANCER THERAPY BASED ON HIGH BIODISIBILITY PICOPLATIN |
| JP4965623B2 (ja) | 2009-09-30 | 2012-07-04 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 所定のソフトウェアの実行パラメータを入力フィールドへ入力することを支援するための方法、システム、およびプログラム |
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| WO2011103016A2 (en) | 2010-02-19 | 2011-08-25 | The Regents Of The University Of Michigan | Compositions and methods for inhibiting ezh2 |
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| US20150252434A1 (en) | 2014-03-07 | 2015-09-10 | University Health Network | Methods and compositions for detection of targets involved in cancer metastasis |
| LT3116909T (lt) | 2014-03-14 | 2020-02-10 | Novartis Ag | Antikūno molekulės prieš lag-3 ir jų panaudojimas |
| KR20220070066A (ko) | 2014-03-14 | 2022-05-27 | 아지오스 파마슈티컬스 아이엔씨. | 치료적으로 활성인 화합물의 약제학적 조성물 |
| US11865116B2 (en) | 2016-03-24 | 2024-01-09 | Cothera Bioscience, Inc. | Treatment of cancer with TG02 |
| ES2977589T3 (es) | 2017-08-18 | 2024-08-27 | Cothera Bioscience Inc | Forma polimórfica de TG02 |
-
2018
- 2018-08-17 ES ES18846214T patent/ES2977589T3/es active Active
- 2018-08-17 JP JP2020508985A patent/JP7250764B2/ja active Active
- 2018-08-17 AU AU2018317865A patent/AU2018317865B2/en active Active
- 2018-08-17 WO PCT/US2018/000264 patent/WO2019035985A1/en not_active Ceased
- 2018-08-17 SG SG11202001441WA patent/SG11202001441WA/en unknown
- 2018-08-17 CN CN201880065266.0A patent/CN111372934B/zh active Active
- 2018-08-17 KR KR1020207007701A patent/KR102758037B1/ko active Active
- 2018-08-17 TW TW107128900A patent/TWI785098B/zh active
- 2018-08-17 RU RU2020111019A patent/RU2020111019A/ru unknown
- 2018-08-17 CA CA3073270A patent/CA3073270A1/en active Pending
- 2018-08-17 US US15/998,872 patent/US10544162B2/en active Active
- 2018-08-17 EP EP18846214.7A patent/EP3668876B1/en active Active
- 2018-08-17 EP EP24152903.1A patent/EP4364741A3/en active Pending
- 2018-08-17 IL IL272697A patent/IL272697B2/en unknown
- 2018-08-17 MX MX2020001875A patent/MX2020001875A/es unknown
-
2020
- 2020-01-24 US US16/751,969 patent/US12043630B2/en active Active
-
2023
- 2023-12-06 US US18/530,765 patent/US20240254142A1/en active Pending
- 2023-12-06 US US18/530,745 patent/US20240254141A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA3073270A1 (en) | 2019-02-21 |
| EP3668876A1 (en) | 2020-06-24 |
| US10544162B2 (en) | 2020-01-28 |
| IL272697A (en) | 2020-04-30 |
| IL272697B2 (en) | 2023-12-01 |
| EP3668876A4 (en) | 2021-04-28 |
| SG11202001441WA (en) | 2020-03-30 |
| AU2018317865A1 (en) | 2020-03-19 |
| US20190055263A1 (en) | 2019-02-21 |
| KR20200078481A (ko) | 2020-07-01 |
| RU2020111019A3 (enExample) | 2022-03-18 |
| EP4364741A3 (en) | 2024-07-03 |
| IL272697B1 (en) | 2023-08-01 |
| CN111372934B (zh) | 2024-04-26 |
| TWI785098B (zh) | 2022-12-01 |
| US12043630B2 (en) | 2024-07-23 |
| CN111372934A (zh) | 2020-07-03 |
| JP2020531463A (ja) | 2020-11-05 |
| US20240254141A1 (en) | 2024-08-01 |
| ES2977589T3 (es) | 2024-08-27 |
| AU2018317865B2 (en) | 2023-03-16 |
| RU2020111019A (ru) | 2021-09-20 |
| TW201920199A (zh) | 2019-06-01 |
| EP4364741A2 (en) | 2024-05-08 |
| EP3668876B1 (en) | 2024-01-24 |
| WO2019035985A1 (en) | 2019-02-21 |
| JP7250764B2 (ja) | 2023-04-03 |
| US20240254142A1 (en) | 2024-08-01 |
| US20200262843A1 (en) | 2020-08-20 |
| KR102758037B1 (ko) | 2025-01-22 |
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