CA3073270A1 - Polymorphic form of tg02 - Google Patents

Info

Publication number

CA3073270A1

CA3073270A1 CA3073270A CA3073270A CA3073270A1 CA 3073270 A1 CA3073270 A1 CA 3073270A1 CA 3073270 A CA3073270 A CA 3073270A CA 3073270 A CA3073270 A CA 3073270A CA 3073270 A1 CA3073270 A1 CA 3073270A1

Authority

CA

Canada

Prior art keywords

cancer

tgo2

patient

inhibitor

protein

Prior art date

2017-08-18

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
• Global Dossier
• CIPO
• Discuss

• 206010028980 Neoplasm Diseases 0.000 claims abstract description 118
• 201000011510 cancer Diseases 0.000 claims abstract description 88
• 238000000034 method Methods 0.000 claims abstract description 55
• 239000012458 free base Substances 0.000 claims abstract description 50
• 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 40
• VXBAJLGYBMTJCY-NSCUHMNNSA-N sb1317 Chemical compound N=1C2=CC=NC=1NC(C=1)=CC=CC=1CN(C)C\C=C\CCOC1=CC=CC2=C1 VXBAJLGYBMTJCY-NSCUHMNNSA-N 0.000 claims abstract description 24
• 239000003814 drug Substances 0.000 claims description 66
• 229940076838 Immune checkpoint inhibitor Drugs 0.000 claims description 57
• 102000037984 Inhibitory immune checkpoint proteins Human genes 0.000 claims description 57
• 108091008026 Inhibitory immune checkpoint proteins Proteins 0.000 claims description 57
• 239000012274 immune-checkpoint protein inhibitor Substances 0.000 claims description 57
• 229940124597 therapeutic agent Drugs 0.000 claims description 56
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 39
• 230000002018 overexpression Effects 0.000 claims description 25
• 102100038895 Myc proto-oncogene protein Human genes 0.000 claims description 23
• 101001030211 Homo sapiens Myc proto-oncogene protein Proteins 0.000 claims description 22
• 238000011282 treatment Methods 0.000 claims description 22
• 201000001441 melanoma Diseases 0.000 claims description 16
• 239000000546 pharmaceutical excipient Substances 0.000 claims description 16
• 238000000634 powder X-ray diffraction Methods 0.000 claims description 15
• 101001056180 Homo sapiens Induced myeloid leukemia cell differentiation protein Mcl-1 Proteins 0.000 claims description 14
• 102100026539 Induced myeloid leukemia cell differentiation protein Mcl-1 Human genes 0.000 claims description 14
• 239000002245 particle Substances 0.000 claims description 11
• 239000000945 filler Substances 0.000 claims description 10
• 238000004519 manufacturing process Methods 0.000 claims description 9
• 239000011230 binding agent Substances 0.000 claims description 8
• 239000000314 lubricant Substances 0.000 claims description 8
• 206010006187 Breast cancer Diseases 0.000 claims description 7
• 208000026310 Breast neoplasm Diseases 0.000 claims description 7
• 208000032612 Glial tumor Diseases 0.000 claims description 7
• 206010018338 Glioma Diseases 0.000 claims description 7
• 206010009944 Colon cancer Diseases 0.000 claims description 6
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 6
• 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
• 206010060862 Prostate cancer Diseases 0.000 claims description 6
• 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 6
• 239000007884 disintegrant Substances 0.000 claims description 6
• 238000009826 distribution Methods 0.000 claims description 6
• 208000005017 glioblastoma Diseases 0.000 claims description 6
• 201000010536 head and neck cancer Diseases 0.000 claims description 6
• 208000014829 head and neck neoplasm Diseases 0.000 claims description 6
• 206010073071 hepatocellular carcinoma Diseases 0.000 claims description 6
• 231100000844 hepatocellular carcinoma Toxicity 0.000 claims description 6
• 201000005202 lung cancer Diseases 0.000 claims description 6
• 208000020816 lung neoplasm Diseases 0.000 claims description 6
• 229940100198 alkylating agent Drugs 0.000 claims description 5
• 239000002168 alkylating agent Substances 0.000 claims description 5
• 208000002250 Hematologic Neoplasms Diseases 0.000 claims description 4
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 4
• 206010066476 Haematological malignancy Diseases 0.000 claims description 3
• 208000034578 Multiple myelomas Diseases 0.000 claims description 3
• 206010035226 Plasma cell myeloma Diseases 0.000 claims description 3
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 4
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 3
• NWYDRHSNEATNRI-SQQVDAMQSA-N 2-hydroxypropane-1,2,3-tricarboxylic acid (16E)-14-methyl-20-oxa-5,7,14,27-tetrazatetracyclo[19.3.1.12,6.18,12]heptacosa-1(25),2(27),3,5,8,10,12(26),16,21,23-decaene Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.N=1C2=CC=NC=1NC(C=1)=CC=CC=1CN(C)C\C=C\CCOC1=CC=CC2=C1 NWYDRHSNEATNRI-SQQVDAMQSA-N 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• 150000001860 citric acid derivatives Chemical class 0.000 claims 1
• 238000001816 cooling Methods 0.000 claims 1
• 238000010438 heat treatment Methods 0.000 claims 1
• 150000003839 salts Chemical class 0.000 abstract description 15
• 239000002253 acid Substances 0.000 abstract description 7
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 7
• 201000010099 disease Diseases 0.000 abstract description 5
• -1 platin compound Chemical class 0.000 description 94
• 150000001875 compounds Chemical class 0.000 description 59
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical group Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 47
• 239000003112 inhibitor Substances 0.000 description 39
• 238000001144 powder X-ray diffraction data Methods 0.000 description 36
• 230000000694 effects Effects 0.000 description 32
• 239000000090 biomarker Substances 0.000 description 30
• 108090000623 proteins and genes Proteins 0.000 description 29
• 210000004027 cell Anatomy 0.000 description 27
• 238000002560 therapeutic procedure Methods 0.000 description 27
• 230000005855 radiation Effects 0.000 description 25
• 235000018102 proteins Nutrition 0.000 description 24
• 102000004169 proteins and genes Human genes 0.000 description 24
• 230000002401 inhibitory effect Effects 0.000 description 23
• 108090000765 processed proteins & peptides Proteins 0.000 description 21
• 102100031940 Epithelial cell adhesion molecule Human genes 0.000 description 20
• 239000003795 chemical substances by application Substances 0.000 description 19
• 230000003247 decreasing effect Effects 0.000 description 19
• 239000000203 mixture Substances 0.000 description 19
• 229920001184 polypeptide Polymers 0.000 description 19
• 102000004196 processed proteins & peptides Human genes 0.000 description 19
• 238000001959 radiotherapy Methods 0.000 description 19
• 230000008685 targeting Effects 0.000 description 19
• 239000012472 biological sample Substances 0.000 description 18
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 description 17
• 238000001990 intravenous administration Methods 0.000 description 17
• 102000005962 receptors Human genes 0.000 description 17
• 108020003175 receptors Proteins 0.000 description 17
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 16
• 230000001225 therapeutic effect Effects 0.000 description 16
• 239000000427 antigen Substances 0.000 description 15
• 102000036639 antigens Human genes 0.000 description 15
• 108091007433 antigens Proteins 0.000 description 15
• 230000006907 apoptotic process Effects 0.000 description 15
• 238000001802 infusion Methods 0.000 description 15
• 101000920667 Homo sapiens Epithelial cell adhesion molecule Proteins 0.000 description 14
• 206010025323 Lymphomas Diseases 0.000 description 14
• 102100024458 Cyclin-dependent kinase inhibitor 2A Human genes 0.000 description 13
• 102100026236 Interleukin-8 Human genes 0.000 description 13
• 210000001744 T-lymphocyte Anatomy 0.000 description 12
• 239000002246 antineoplastic agent Substances 0.000 description 12
• 230000027455 binding Effects 0.000 description 12
• 208000032839 leukemia Diseases 0.000 description 12
• 239000003446 ligand Substances 0.000 description 12
• 201000009030 Carcinoma Diseases 0.000 description 11
• 101001055222 Homo sapiens Interleukin-8 Proteins 0.000 description 11
• 102000002938 Thrombospondin Human genes 0.000 description 11
• 108060008245 Thrombospondin Proteins 0.000 description 11
• 239000002775 capsule Substances 0.000 description 11
• 229960003301 nivolumab Drugs 0.000 description 11
• 102100022002 CD59 glycoprotein Human genes 0.000 description 10
• 229940045513 CTLA4 antagonist Drugs 0.000 description 10
• 102100023419 Cystic fibrosis transmembrane conductance regulator Human genes 0.000 description 10
• 101000897400 Homo sapiens CD59 glycoprotein Proteins 0.000 description 10
• 101000907783 Homo sapiens Cystic fibrosis transmembrane conductance regulator Proteins 0.000 description 10
• 102100022883 Nuclear receptor coactivator 3 Human genes 0.000 description 10
• 230000014509 gene expression Effects 0.000 description 10
• GLVAUDGFNGKCSF-UHFFFAOYSA-N mercaptopurine Chemical compound S=C1NC=NC2=C1NC=N2 GLVAUDGFNGKCSF-UHFFFAOYSA-N 0.000 description 10
• 102000029791 ADAM Human genes 0.000 description 9
• 108091022885 ADAM Proteins 0.000 description 9
• 102100023700 C-C motif chemokine 16 Human genes 0.000 description 9
• 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 description 9
• 102100023600 Fibroblast growth factor receptor 2 Human genes 0.000 description 9
• 101000978375 Homo sapiens C-C motif chemokine 16 Proteins 0.000 description 9
• 238000003782 apoptosis assay Methods 0.000 description 9
• 210000003719 b-lymphocyte Anatomy 0.000 description 9
• 230000007423 decrease Effects 0.000 description 9
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 description 9
• 230000005522 programmed cell death Effects 0.000 description 9
• 102100023701 C-C motif chemokine 18 Human genes 0.000 description 8
• 102100028672 C-type lectin domain family 4 member D Human genes 0.000 description 8
• 102100025752 CASP8 and FADD-like apoptosis regulator Human genes 0.000 description 8
• 102100032912 CD44 antigen Human genes 0.000 description 8
• 102100025570 Cancer/testis antigen 1 Human genes 0.000 description 8
• 102100023593 Fibroblast growth factor receptor 1 Human genes 0.000 description 8
• 102100034051 Heat shock protein HSP 90-alpha Human genes 0.000 description 8
• 102100034458 Hepatitis A virus cellular receptor 2 Human genes 0.000 description 8
• 101000766905 Homo sapiens C-type lectin domain family 4 member D Proteins 0.000 description 8
• 101000868273 Homo sapiens CD44 antigen Proteins 0.000 description 8
• 101000827688 Homo sapiens Fibroblast growth factor receptor 2 Proteins 0.000 description 8
• 101001068133 Homo sapiens Hepatitis A virus cellular receptor 2 Proteins 0.000 description 8
• 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 description 8
• 102100025304 Integrin beta-1 Human genes 0.000 description 8
• 101001089112 Mytilus californianus Galactose-binding lectin Proteins 0.000 description 8
• 108091008606 PDGF receptors Proteins 0.000 description 8
• 102000011653 Platelet-Derived Growth Factor Receptors Human genes 0.000 description 8
• XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 8
• 235000018417 cysteine Nutrition 0.000 description 8
• 229940043355 kinase inhibitor Drugs 0.000 description 8
• 235000019359 magnesium stearate Nutrition 0.000 description 8
• 229960002621 pembrolizumab Drugs 0.000 description 8
• 239000003757 phosphotransferase inhibitor Substances 0.000 description 8
• 230000003612 virological effect Effects 0.000 description 8
• GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 description 7
• 102100032306 Aurora kinase B Human genes 0.000 description 7
• 102100022976 B-cell lymphoma/leukemia 11A Human genes 0.000 description 7
• 102100021334 Bcl-2-related protein A1 Human genes 0.000 description 7
• 102100025142 Beta-microseminoprotein Human genes 0.000 description 7
• 102100021943 C-C motif chemokine 2 Human genes 0.000 description 7
• 102100039510 Cancer/testis antigen 2 Human genes 0.000 description 7
• 102100040132 Complement factor H-related protein 1 Human genes 0.000 description 7
• 102100037373 DNA-(apurinic or apyrimidinic site) endonuclease Human genes 0.000 description 7
• 102100032249 Dystonin Human genes 0.000 description 7
• 102100023721 Ephrin-B2 Human genes 0.000 description 7
• 102100031706 Fibroblast growth factor 1 Human genes 0.000 description 7
• GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 7
• 101000903703 Homo sapiens B-cell lymphoma/leukemia 11A Proteins 0.000 description 7
• 101000894929 Homo sapiens Bcl-2-related protein A1 Proteins 0.000 description 7
• 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 description 7
• 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 description 7
• 101000856237 Homo sapiens Cancer/testis antigen 1 Proteins 0.000 description 7
• 101000889345 Homo sapiens Cancer/testis antigen 2 Proteins 0.000 description 7
• 101000890732 Homo sapiens Complement factor H-related protein 1 Proteins 0.000 description 7
• 101000827746 Homo sapiens Fibroblast growth factor receptor 1 Proteins 0.000 description 7
• 101001137987 Homo sapiens Lymphocyte activation gene 3 protein Proteins 0.000 description 7
• 102100024193 Mitogen-activated protein kinase 1 Human genes 0.000 description 7
• 102100023050 Nuclear factor NF-kappa-B p105 subunit Human genes 0.000 description 7
• 102000035195 Peptidases Human genes 0.000 description 7
• 108091005804 Peptidases Proteins 0.000 description 7
• 108060008682 Tumor Necrosis Factor Proteins 0.000 description 7
• 102100040247 Tumor necrosis factor Human genes 0.000 description 7
• 102100022156 Tumor necrosis factor receptor superfamily member 3 Human genes 0.000 description 7
• 230000001028 anti-proliverative effect Effects 0.000 description 7
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 description 7
• 229960001467 bortezomib Drugs 0.000 description 7
• DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 description 7
• 229960004316 cisplatin Drugs 0.000 description 7
• STQGQHZAVUOBTE-VGBVRHCVSA-N daunorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 description 7
• 229960004679 doxorubicin Drugs 0.000 description 7
• 229960002949 fluorouracil Drugs 0.000 description 7
• 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 description 7
• 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 description 7
• 229960001428 mercaptopurine Drugs 0.000 description 7
• 235000019833 protease Nutrition 0.000 description 7
• 230000004044 response Effects 0.000 description 7
• 210000004881 tumor cell Anatomy 0.000 description 7
• STQGQHZAVUOBTE-UHFFFAOYSA-N 7-Cyan-hept-2t-en-4,6-diinsaeure Natural products C1=2C(O)=C3C(=O)C=4C(OC)=CC=CC=4C(=O)C3=C(O)C=2CC(O)(C(C)=O)CC1OC1CC(N)C(O)C(C)O1 STQGQHZAVUOBTE-UHFFFAOYSA-N 0.000 description 6
• 102100028187 ATP-binding cassette sub-family C member 6 Human genes 0.000 description 6
• 102100033350 ATP-dependent translocase ABCB1 Human genes 0.000 description 6
• 102100032187 Androgen receptor Human genes 0.000 description 6
• 102100032311 Aurora kinase A Human genes 0.000 description 6
• 102100021662 Baculoviral IAP repeat-containing protein 3 Human genes 0.000 description 6
• 102100031109 Beta-catenin-like protein 1 Human genes 0.000 description 6
• 102100023705 C-C motif chemokine 14 Human genes 0.000 description 6
• 102100036846 C-C motif chemokine 21 Human genes 0.000 description 6
• 102100032367 C-C motif chemokine 5 Human genes 0.000 description 6
• 102100032366 C-C motif chemokine 7 Human genes 0.000 description 6
• 102100039398 C-X-C motif chemokine 2 Human genes 0.000 description 6
• 102100032887 Clusterin Human genes 0.000 description 6
• 102100033269 Cyclin-dependent kinase inhibitor 1C Human genes 0.000 description 6
• 108020004414 DNA Proteins 0.000 description 6
• 102100030960 DNA replication licensing factor MCM2 Human genes 0.000 description 6
• 102100022204 DNA-dependent protein kinase catalytic subunit Human genes 0.000 description 6
• 102100028072 Fibroblast growth factor 4 Human genes 0.000 description 6
• 102100023374 Forkhead box protein M1 Human genes 0.000 description 6
• 102100035184 General transcription and DNA repair factor IIH helicase subunit XPD Human genes 0.000 description 6
• 102100041003 Glutamate carboxypeptidase 2 Human genes 0.000 description 6
• 102100032530 Glypican-3 Human genes 0.000 description 6
• 102100040896 Growth/differentiation factor 15 Human genes 0.000 description 6
• 102100021866 Hepatocyte growth factor Human genes 0.000 description 6
• 101000986621 Homo sapiens ATP-binding cassette sub-family C member 6 Proteins 0.000 description 6
• 101000798300 Homo sapiens Aurora kinase A Proteins 0.000 description 6
• 101000978381 Homo sapiens C-C motif chemokine 14 Proteins 0.000 description 6
• 101000978371 Homo sapiens C-C motif chemokine 18 Proteins 0.000 description 6
• 101000797762 Homo sapiens C-C motif chemokine 5 Proteins 0.000 description 6
• 101000889128 Homo sapiens C-X-C motif chemokine 2 Proteins 0.000 description 6
• 101000583807 Homo sapiens DNA replication licensing factor MCM2 Proteins 0.000 description 6
• 101000619536 Homo sapiens DNA-dependent protein kinase catalytic subunit Proteins 0.000 description 6
• 101001016186 Homo sapiens Dystonin Proteins 0.000 description 6
• 101000907578 Homo sapiens Forkhead box protein M1 Proteins 0.000 description 6
• 101000876511 Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPD Proteins 0.000 description 6
• 101001038874 Homo sapiens Glycoprotein hormones alpha chain Proteins 0.000 description 6
• 101001014668 Homo sapiens Glypican-3 Proteins 0.000 description 6
• 101001069921 Homo sapiens Growth-regulated alpha protein Proteins 0.000 description 6
• 101000994378 Homo sapiens Integrin alpha-3 Proteins 0.000 description 6
• 101001005719 Homo sapiens Melanoma-associated antigen 3 Proteins 0.000 description 6
• 101001005720 Homo sapiens Melanoma-associated antigen 4 Proteins 0.000 description 6
• 101000974356 Homo sapiens Nuclear receptor coactivator 3 Proteins 0.000 description 6
• 102100032819 Integrin alpha-3 Human genes 0.000 description 6
• 102100040019 Interferon alpha-1/13 Human genes 0.000 description 6
• 102100039062 Interleukin enhancer-binding factor 3 Human genes 0.000 description 6
• 102000017578 LAG3 Human genes 0.000 description 6
• 208000025205 Mantle-Cell Lymphoma Diseases 0.000 description 6
• 102100025082 Melanoma-associated antigen 3 Human genes 0.000 description 6
• 102100025077 Melanoma-associated antigen 4 Human genes 0.000 description 6
• 102100034256 Mucin-1 Human genes 0.000 description 6
• 102100040156 Pappalysin-1 Human genes 0.000 description 6
• 102100034763 Peroxiredoxin-2 Human genes 0.000 description 6
• 102100026884 Pro-interleukin-16 Human genes 0.000 description 6
• 102100032338 Protein ALEX Human genes 0.000 description 6
• 229920002472 Starch Polymers 0.000 description 6
• 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 description 6
• 230000001154 acute effect Effects 0.000 description 6
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 description 6
• 230000002354 daily effect Effects 0.000 description 6
• 229960000975 daunorubicin Drugs 0.000 description 6
• 229940079593 drug Drugs 0.000 description 6
• KTUFNOKKBVMGRW-UHFFFAOYSA-N imatinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 KTUFNOKKBVMGRW-UHFFFAOYSA-N 0.000 description 6
• 210000000987 immune system Anatomy 0.000 description 6
• 238000002360 preparation method Methods 0.000 description 6
• 230000001105 regulatory effect Effects 0.000 description 6
• 229960004964 temozolomide Drugs 0.000 description 6
• WYWHKKSPHMUBEB-UHFFFAOYSA-N tioguanine Chemical compound N1C(N)=NC(=S)C2=C1N=CN2 WYWHKKSPHMUBEB-UHFFFAOYSA-N 0.000 description 6
• 230000014621 translational initiation Effects 0.000 description 6
• FDKXTQMXEQVLRF-ZHACJKMWSA-N (E)-dacarbazine Chemical compound CN(C)\N=N\c1[nH]cnc1C(N)=O FDKXTQMXEQVLRF-ZHACJKMWSA-N 0.000 description 5
• 102100028162 ATP-binding cassette sub-family C member 3 Human genes 0.000 description 5
• 102100021569 Apoptosis regulator Bcl-2 Human genes 0.000 description 5
• 102100021631 B-cell lymphoma 6 protein Human genes 0.000 description 5
• MLDQJTXFUGDVEO-UHFFFAOYSA-N BAY-43-9006 Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=CC(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 MLDQJTXFUGDVEO-UHFFFAOYSA-N 0.000 description 5
• 102100025399 Breast cancer type 2 susceptibility protein Human genes 0.000 description 5
• 102100022595 Broad substrate specificity ATP-binding cassette transporter ABCG2 Human genes 0.000 description 5
• 102100023702 C-C motif chemokine 13 Human genes 0.000 description 5
• 102100036842 C-C motif chemokine 19 Human genes 0.000 description 5
• 102100036850 C-C motif chemokine 23 Human genes 0.000 description 5
• 102100036166 C-X-C chemokine receptor type 1 Human genes 0.000 description 5
• 102100025277 C-X-C motif chemokine 13 Human genes 0.000 description 5
• 102100037904 CD9 antigen Human genes 0.000 description 5
• 102100029968 Calreticulin Human genes 0.000 description 5
• 102100037182 Cation-independent mannose-6-phosphate receptor Human genes 0.000 description 5
• UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytarabine Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 description 5
• 206010061818 Disease progression Diseases 0.000 description 5
• 102100023274 Dual specificity mitogen-activated protein kinase kinase 4 Human genes 0.000 description 5
• 102000001301 EGF receptor Human genes 0.000 description 5
• 102100023226 Early growth response protein 1 Human genes 0.000 description 5
• 102100036448 Endothelial PAS domain-containing protein 1 Human genes 0.000 description 5
• 102100027279 FAS-associated factor 1 Human genes 0.000 description 5
• 102100020760 Ferritin heavy chain Human genes 0.000 description 5
• 102100037813 Focal adhesion kinase 1 Human genes 0.000 description 5
• 102100040510 Galectin-3-binding protein Human genes 0.000 description 5
• 102100021337 Gap junction alpha-1 protein Human genes 0.000 description 5
• 102100036717 Growth hormone variant Human genes 0.000 description 5
• 102100034221 Growth-regulated alpha protein Human genes 0.000 description 5
• 101000986633 Homo sapiens ATP-binding cassette sub-family C member 3 Proteins 0.000 description 5
• 101001017818 Homo sapiens ATP-dependent translocase ABCB1 Proteins 0.000 description 5
• 101000798306 Homo sapiens Aurora kinase B Proteins 0.000 description 5
• 101000971234 Homo sapiens B-cell lymphoma 6 protein Proteins 0.000 description 5
• 101000922061 Homo sapiens Beta-catenin-like protein 1 Proteins 0.000 description 5
• 101000576812 Homo sapiens Beta-microseminoprotein Proteins 0.000 description 5
• 101000934858 Homo sapiens Breast cancer type 2 susceptibility protein Proteins 0.000 description 5
• 101000823298 Homo sapiens Broad substrate specificity ATP-binding cassette transporter ABCG2 Proteins 0.000 description 5
• 101000713085 Homo sapiens C-C motif chemokine 21 Proteins 0.000 description 5
• 101000713081 Homo sapiens C-C motif chemokine 23 Proteins 0.000 description 5
• 101000797758 Homo sapiens C-C motif chemokine 7 Proteins 0.000 description 5
• 101000947174 Homo sapiens C-X-C chemokine receptor type 1 Proteins 0.000 description 5
• 101000858064 Homo sapiens C-X-C motif chemokine 13 Proteins 0.000 description 5
• 101001028831 Homo sapiens Cation-independent mannose-6-phosphate receptor Proteins 0.000 description 5
• 101000944365 Homo sapiens Cyclin-dependent kinase inhibitor 1C Proteins 0.000 description 5
• 101000980932 Homo sapiens Cyclin-dependent kinase inhibitor 2A Proteins 0.000 description 5
• 101001115395 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 4 Proteins 0.000 description 5
• 101001049697 Homo sapiens Early growth response protein 1 Proteins 0.000 description 5
• 101000914654 Homo sapiens FAS-associated factor 1 Proteins 0.000 description 5
• 101001002987 Homo sapiens Ferritin heavy chain Proteins 0.000 description 5
• 101000846416 Homo sapiens Fibroblast growth factor 1 Proteins 0.000 description 5
• 101000878536 Homo sapiens Focal adhesion kinase 1 Proteins 0.000 description 5
• 101000893549 Homo sapiens Growth/differentiation factor 15 Proteins 0.000 description 5
• 101001034652 Homo sapiens Insulin-like growth factor 1 receptor Proteins 0.000 description 5
• 101001078143 Homo sapiens Integrin alpha-IIb Proteins 0.000 description 5
• 101000691574 Homo sapiens Junction plakoglobin Proteins 0.000 description 5
• 101001091385 Homo sapiens Kallikrein-6 Proteins 0.000 description 5
• 101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 5
• 101001000302 Homo sapiens Max-interacting protein 1 Proteins 0.000 description 5
• 101000962131 Homo sapiens Mediator of RNA polymerase II transcription subunit 1 Proteins 0.000 description 5
• 101001052493 Homo sapiens Mitogen-activated protein kinase 1 Proteins 0.000 description 5
• 101001133056 Homo sapiens Mucin-1 Proteins 0.000 description 5
• 101000961071 Homo sapiens NF-kappa-B inhibitor alpha Proteins 0.000 description 5
• 101001109501 Homo sapiens NKG2-D type II integral membrane protein Proteins 0.000 description 5
• 101000918983 Homo sapiens Neutrophil defensin 1 Proteins 0.000 description 5
• 101000979629 Homo sapiens Nucleoside diphosphate kinase A Proteins 0.000 description 5
• 101000693234 Homo sapiens PDZ domain-containing protein 4 Proteins 0.000 description 5
• 101000610206 Homo sapiens Pappalysin-1 Proteins 0.000 description 5
• 101001090065 Homo sapiens Peroxiredoxin-2 Proteins 0.000 description 5
• 101000979748 Homo sapiens Protein NDRG1 Proteins 0.000 description 5
• 101000591211 Homo sapiens Receptor-type tyrosine-protein phosphatase O Proteins 0.000 description 5
• 101000679857 Homo sapiens Tumor necrosis factor receptor superfamily member 3 Proteins 0.000 description 5
• 101000733249 Homo sapiens Tumor suppressor ARF Proteins 0.000 description 5
• 101000823316 Homo sapiens Tyrosine-protein kinase ABL1 Proteins 0.000 description 5
• 102100039688 Insulin-like growth factor 1 receptor Human genes 0.000 description 5
• 102100025306 Integrin alpha-IIb Human genes 0.000 description 5
• 102000014150 Interferons Human genes 0.000 description 5
• 108010050904 Interferons Proteins 0.000 description 5
• 102100030698 Interleukin-12 subunit alpha Human genes 0.000 description 5
• 102100026011 Interleukin-13 Human genes 0.000 description 5
• 102100033101 Interleukin-17B Human genes 0.000 description 5
• 102100026878 Interleukin-2 receptor subunit alpha Human genes 0.000 description 5
• 108090001007 Interleukin-8 Proteins 0.000 description 5
• 102100026153 Junction plakoglobin Human genes 0.000 description 5
• 102100034866 Kallikrein-6 Human genes 0.000 description 5
• 102100020880 Kit ligand Human genes 0.000 description 5
• 239000005517 L01XE01 - Imatinib Substances 0.000 description 5
• 102100039648 Lactadherin Human genes 0.000 description 5
• 102100034724 Lipocalin-1 Human genes 0.000 description 5
• 102100035880 Max-interacting protein 1 Human genes 0.000 description 5
• 102100039204 Mediator of RNA polymerase II transcription subunit 1 Human genes 0.000 description 5
• 102100039373 Membrane cofactor protein Human genes 0.000 description 5
• 102100023482 Mitogen-activated protein kinase 14 Human genes 0.000 description 5
• WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 5
• 102100022365 NAD(P)H dehydrogenase [quinone] 1 Human genes 0.000 description 5
• 102100039337 NF-kappa-B inhibitor alpha Human genes 0.000 description 5
• 102100029494 Neutrophil defensin 1 Human genes 0.000 description 5
• 102100023252 Nucleoside diphosphate kinase A Human genes 0.000 description 5
• 108700020796 Oncogene Proteins 0.000 description 5
• 239000012270 PD-1 inhibitor Substances 0.000 description 5
• 239000012668 PD-1-inhibitor Substances 0.000 description 5
• 102100025653 PDZ domain-containing protein 4 Human genes 0.000 description 5
• 102100037026 Peptidyl-prolyl cis-trans isomerase FKBP5 Human genes 0.000 description 5
• 102100035194 Placenta growth factor Human genes 0.000 description 5
• 102100027467 Pro-opiomelanocortin Human genes 0.000 description 5
• 102100024980 Protein NDRG1 Human genes 0.000 description 5
• 102100034086 Receptor-type tyrosine-protein phosphatase O Human genes 0.000 description 5
• 102100021446 Rho GTPase-activating protein 7 Human genes 0.000 description 5
• 206010039491 Sarcoma Diseases 0.000 description 5
• NKANXQFJJICGDU-QPLCGJKRSA-N Tamoxifen Chemical compound C=1C=CC=CC=1C(/CC)=C(C=1C=CC(OCCN(C)C)=CC=1)/C1=CC=CC=C1 NKANXQFJJICGDU-QPLCGJKRSA-N 0.000 description 5
• BPEGJWRSRHCHSN-UHFFFAOYSA-N Temozolomide Chemical compound O=C1N(C)N=NC2=C(C(N)=O)N=CN21 BPEGJWRSRHCHSN-UHFFFAOYSA-N 0.000 description 5
• 102100031988 Tumor necrosis factor ligand superfamily member 6 Human genes 0.000 description 5
• 208000009956 adenocarcinoma Diseases 0.000 description 5
• 230000000340 anti-metabolite Effects 0.000 description 5
• 229940100197 antimetabolite Drugs 0.000 description 5
• 239000002256 antimetabolite Substances 0.000 description 5
• 229950002916 avelumab Drugs 0.000 description 5
• 229960000913 crospovidone Drugs 0.000 description 5
• 230000006378 damage Effects 0.000 description 5
• 230000005750 disease progression Effects 0.000 description 5
• 239000003623 enhancer Substances 0.000 description 5
• 229960005420 etoposide Drugs 0.000 description 5
• VJJPUSNTGOMMGY-MRVIYFEKSA-N etoposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@H](C)OC[C@H]4O3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 VJJPUSNTGOMMGY-MRVIYFEKSA-N 0.000 description 5
• 239000012634 fragment Substances 0.000 description 5
• 230000006870 function Effects 0.000 description 5
• XGALLCVXEZPNRQ-UHFFFAOYSA-N gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 description 5
• 229960002584 gefitinib Drugs 0.000 description 5
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 5
• 150000002632 lipids Chemical class 0.000 description 5
• 230000010534 mechanism of action Effects 0.000 description 5
• 108091008581 nuclear androgen receptors Proteins 0.000 description 5
• 230000037361 pathway Effects 0.000 description 5
• 229940121655 pd-1 inhibitor Drugs 0.000 description 5
• 239000000825 pharmaceutical preparation Substances 0.000 description 5
• 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 5
• 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 5
• XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 description 5
• 229960003787 sorafenib Drugs 0.000 description 5
• 239000000725 suspension Substances 0.000 description 5
• YJZSUCFGHXQWDM-UHFFFAOYSA-N 1-adamantyl 4-[(2,5-dihydroxyphenyl)methylamino]benzoate Chemical compound OC1=CC=C(O)C(CNC=2C=CC(=CC=2)C(=O)OC23CC4CC(CC(C4)C2)C3)=C1 YJZSUCFGHXQWDM-UHFFFAOYSA-N 0.000 description 4
• 102100033458 26S proteasome non-ATPase regulatory subunit 4 Human genes 0.000 description 4
• 102100026802 72 kDa type IV collagenase Human genes 0.000 description 4
• 102100027400 A disintegrin and metalloproteinase with thrombospondin motifs 4 Human genes 0.000 description 4
• 102100028186 ATP-binding cassette sub-family C member 5 Human genes 0.000 description 4
• 108091006112 ATPases Proteins 0.000 description 4
• 102100034134 Activin receptor type-1B Human genes 0.000 description 4
• 102000057290 Adenosine Triphosphatases Human genes 0.000 description 4
• 102100038910 Alpha-enolase Human genes 0.000 description 4
• 102100034613 Annexin A2 Human genes 0.000 description 4
• 102100029361 Aromatase Human genes 0.000 description 4
• 102100022108 Aspartyl/asparaginyl beta-hydroxylase Human genes 0.000 description 4
• 108091012583 BCL2 Proteins 0.000 description 4
• 102100026596 Bcl-2-like protein 1 Human genes 0.000 description 4
• 102100023932 Bcl-2-like protein 2 Human genes 0.000 description 4
• 102100036301 C-C chemokine receptor type 7 Human genes 0.000 description 4
• 102100031102 C-C motif chemokine 4 Human genes 0.000 description 4
• 102100025248 C-X-C motif chemokine 10 Human genes 0.000 description 4
• 102100028737 CAP-Gly domain-containing linker protein 1 Human genes 0.000 description 4
• 101710100501 CASP8 and FADD-like apoptosis regulator Proteins 0.000 description 4
• 102100032937 CD40 ligand Human genes 0.000 description 4
• 102100021975 CREB-binding protein Human genes 0.000 description 4
• 108010021064 CTLA-4 Antigen Proteins 0.000 description 4
• 239000012275 CTLA-4 inhibitor Substances 0.000 description 4
• 102100025579 Calmodulin-2 Human genes 0.000 description 4
• 102100025475 Carcinoembryonic antigen-related cell adhesion molecule 5 Human genes 0.000 description 4
• 102000014914 Carrier Proteins Human genes 0.000 description 4
• 102100032616 Caspase-2 Human genes 0.000 description 4
• 102100038503 Cellular retinoic acid-binding protein 1 Human genes 0.000 description 4
• 102100038447 Claudin-4 Human genes 0.000 description 4
• 102100031162 Collagen alpha-1(XVIII) chain Human genes 0.000 description 4
• 102100026810 Cyclin-dependent kinase 7 Human genes 0.000 description 4
• 102100026234 Cytokine receptor common subunit gamma Human genes 0.000 description 4
• 102100028843 DNA mismatch repair protein Mlh1 Human genes 0.000 description 4
• 102100024361 Disintegrin and metalloproteinase domain-containing protein 9 Human genes 0.000 description 4
• 102100035087 Ectoderm-neural cortex protein 1 Human genes 0.000 description 4
• 102000004190 Enzymes Human genes 0.000 description 4
• 108090000790 Enzymes Proteins 0.000 description 4
• 102100030324 Ephrin type-A receptor 3 Human genes 0.000 description 4
• 102100040954 Ephrin-A1 Human genes 0.000 description 4
• 102100033946 Ephrin-B1 Human genes 0.000 description 4
• 102100037115 Eukaryotic translation initiation factor 3 subunit H Human genes 0.000 description 4
• 102100027304 Eukaryotic translation initiation factor 4E Human genes 0.000 description 4
• 102100026761 Eukaryotic translation initiation factor 5A-1 Human genes 0.000 description 4
• 102100024513 F-box only protein 6 Human genes 0.000 description 4
• 108091008794 FGF receptors Proteins 0.000 description 4
• 102100030421 Fatty acid-binding protein 5 Human genes 0.000 description 4
• 102000044168 Fibroblast Growth Factor Receptor Human genes 0.000 description 4
• 102100027842 Fibroblast growth factor receptor 3 Human genes 0.000 description 4
• 102100037362 Fibronectin Human genes 0.000 description 4
• 108090000852 Forkhead Transcription Factors Proteins 0.000 description 4
• 102000004315 Forkhead Transcription Factors Human genes 0.000 description 4
• 102100039558 Galectin-3 Human genes 0.000 description 4
• 108010010803 Gelatin Proteins 0.000 description 4
• 102100040796 Glycoprotein hormones alpha chain Human genes 0.000 description 4
• 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 4
• 102100027421 Heat shock cognate 71 kDa protein Human genes 0.000 description 4
• 102100031624 Heat shock protein 105 kDa Human genes 0.000 description 4
• 101710113864 Heat shock protein 90 Proteins 0.000 description 4
• 102100039165 Heat shock protein beta-1 Human genes 0.000 description 4
• 102100022846 Histone acetyltransferase KAT2B Human genes 0.000 description 4
• 102100038970 Histone-lysine N-methyltransferase EZH2 Human genes 0.000 description 4
• 101001135231 Homo sapiens 26S proteasome non-ATPase regulatory subunit 4 Proteins 0.000 description 4
• 101000627872 Homo sapiens 72 kDa type IV collagenase Proteins 0.000 description 4
• 101000799189 Homo sapiens Activin receptor type-1B Proteins 0.000 description 4
• 101000882335 Homo sapiens Alpha-enolase Proteins 0.000 description 4
• 101000924474 Homo sapiens Annexin A2 Proteins 0.000 description 4
• 101000901030 Homo sapiens Aspartyl/asparaginyl beta-hydroxylase Proteins 0.000 description 4
• 101000904691 Homo sapiens Bcl-2-like protein 2 Proteins 0.000 description 4
• 101000716065 Homo sapiens C-C chemokine receptor type 7 Proteins 0.000 description 4
• 101000978379 Homo sapiens C-C motif chemokine 13 Proteins 0.000 description 4
• 101000713106 Homo sapiens C-C motif chemokine 19 Proteins 0.000 description 4
• 101000914211 Homo sapiens CASP8 and FADD-like apoptosis regulator Proteins 0.000 description 4
• 101000868215 Homo sapiens CD40 ligand Proteins 0.000 description 4
• 101000738354 Homo sapiens CD9 antigen Proteins 0.000 description 4
• 101000896987 Homo sapiens CREB-binding protein Proteins 0.000 description 4
• 101000984164 Homo sapiens Calmodulin-1 Proteins 0.000 description 4
• 101000793651 Homo sapiens Calreticulin Proteins 0.000 description 4
• 101000942697 Homo sapiens Clusterin Proteins 0.000 description 4
• 101001055227 Homo sapiens Cytokine receptor common subunit gamma Proteins 0.000 description 4
• 101000832769 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 9 Proteins 0.000 description 4
• 101000966403 Homo sapiens Dynein light chain 1, cytoplasmic Proteins 0.000 description 4
• 101000877456 Homo sapiens Ectoderm-neural cortex protein 1 Proteins 0.000 description 4
• 101000851937 Homo sapiens Endothelial PAS domain-containing protein 1 Proteins 0.000 description 4
• 101001049392 Homo sapiens Ephrin-B2 Proteins 0.000 description 4
• 101001052796 Homo sapiens F-box only protein 6 Proteins 0.000 description 4
• 101001060274 Homo sapiens Fibroblast growth factor 4 Proteins 0.000 description 4
• 101000917148 Homo sapiens Fibroblast growth factor receptor 3 Proteins 0.000 description 4
• 101001027128 Homo sapiens Fibronectin Proteins 0.000 description 4
• 101000894966 Homo sapiens Gap junction alpha-1 protein Proteins 0.000 description 4
• 101000642577 Homo sapiens Growth hormone variant Proteins 0.000 description 4
• 101001014590 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas Proteins 0.000 description 4
• 101001014594 Homo sapiens Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Proteins 0.000 description 4
• 101000866478 Homo sapiens Heat shock protein 105 kDa Proteins 0.000 description 4
• 101001016865 Homo sapiens Heat shock protein HSP 90-alpha Proteins 0.000 description 4
• 101000898034 Homo sapiens Hepatocyte growth factor Proteins 0.000 description 4
• 101000872458 Homo sapiens Huntingtin-interacting protein 1-related protein Proteins 0.000 description 4
• 101001046677 Homo sapiens Integrin alpha-V Proteins 0.000 description 4
• 101000959820 Homo sapiens Interferon alpha-1/13 Proteins 0.000 description 4
• 101001033293 Homo sapiens Interleukin enhancer-binding factor 3 Proteins 0.000 description 4
• 101001076430 Homo sapiens Interleukin-13 Proteins 0.000 description 4
• 101000975496 Homo sapiens Keratin, type II cytoskeletal 8 Proteins 0.000 description 4
• 101000946124 Homo sapiens Lipocalin-1 Proteins 0.000 description 4
• 101000916644 Homo sapiens Macrophage colony-stimulating factor 1 receptor Proteins 0.000 description 4
• 101001057154 Homo sapiens Melanoma-associated antigen D2 Proteins 0.000 description 4
• 101000961414 Homo sapiens Membrane cofactor protein Proteins 0.000 description 4
• 101001014610 Homo sapiens Neuroendocrine secretory protein 55 Proteins 0.000 description 4
• 101000851058 Homo sapiens Neutrophil elastase Proteins 0.000 description 4
• 101000979338 Homo sapiens Nuclear factor NF-kappa-B p100 subunit Proteins 0.000 description 4
• 101000603323 Homo sapiens Nuclear receptor subfamily 0 group B member 1 Proteins 0.000 description 4
• 101000595923 Homo sapiens Placenta growth factor Proteins 0.000 description 4
• 101000777658 Homo sapiens Platelet glycoprotein 4 Proteins 0.000 description 4
• 101001003584 Homo sapiens Prelamin-A/C Proteins 0.000 description 4
• 101001055149 Homo sapiens Pro-interleukin-16 Proteins 0.000 description 4
• 101000797903 Homo sapiens Protein ALEX Proteins 0.000 description 4
• 101001012157 Homo sapiens Receptor tyrosine-protein kinase erbB-2 Proteins 0.000 description 4
• 101000777277 Homo sapiens Serine/threonine-protein kinase Chk2 Proteins 0.000 description 4
• 101000611023 Homo sapiens Tumor necrosis factor receptor superfamily member 6 Proteins 0.000 description 4
• 102100034773 Huntingtin-interacting protein 1-related protein Human genes 0.000 description 4
• XDXDZDZNSLXDNA-TZNDIEGXSA-N Idarubicin Chemical compound C1[C@H](N)[C@H](O)[C@H](C)O[C@H]1O[C@@H]1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2C[C@@](O)(C(C)=O)C1 XDXDZDZNSLXDNA-TZNDIEGXSA-N 0.000 description 4
• XDXDZDZNSLXDNA-UHFFFAOYSA-N Idarubicin Natural products C1C(N)C(O)C(C)OC1OC1C2=C(O)C(C(=O)C3=CC=CC=C3C3=O)=C3C(O)=C2CC(O)(C(C)=O)C1 XDXDZDZNSLXDNA-UHFFFAOYSA-N 0.000 description 4
• 102100037852 Insulin-like growth factor I Human genes 0.000 description 4
• 102100022337 Integrin alpha-V Human genes 0.000 description 4
• 102100032999 Integrin beta-3 Human genes 0.000 description 4
• 102100026018 Interleukin-1 receptor antagonist protein Human genes 0.000 description 4
• 102100020793 Interleukin-13 receptor subunit alpha-2 Human genes 0.000 description 4
• 102000004890 Interleukin-8 Human genes 0.000 description 4
• 102100025837 JNK1/MAPK8-associated membrane protein Human genes 0.000 description 4
• 102100034872 Kallikrein-4 Human genes 0.000 description 4
• 102100034870 Kallikrein-8 Human genes 0.000 description 4
• 102100040487 Keratin, type I cytoskeletal 13 Human genes 0.000 description 4
• 102100023972 Keratin, type II cytoskeletal 8 Human genes 0.000 description 4
• FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 4
• 239000005511 L01XE05 - Sorafenib Substances 0.000 description 4
• 239000002138 L01XE21 - Regorafenib Substances 0.000 description 4
• 102100022275 Leucine-rich glioma-inactivated protein 1 Human genes 0.000 description 4
• 102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 4
• 102000043136 MAP kinase family Human genes 0.000 description 4
• 108091054455 MAP kinase family Proteins 0.000 description 4
• 102100028198 Macrophage colony-stimulating factor 1 receptor Human genes 0.000 description 4
• 102100027754 Mast/stem cell growth factor receptor Kit Human genes 0.000 description 4
• 102100027251 Melanoma-associated antigen D2 Human genes 0.000 description 4
• 241001465754 Metazoa Species 0.000 description 4
• 102000029749 Microtubule Human genes 0.000 description 4
• 108091022875 Microtubule Proteins 0.000 description 4
• 102100037808 Mitogen-activated protein kinase 8 Human genes 0.000 description 4
• NWIBSHFKIJFRCO-WUDYKRTCSA-N Mytomycin Chemical compound C1N2C(C(C(C)=C(N)C3=O)=O)=C3[C@@H](COC(N)=O)[C@@]2(OC)[C@@H]2[C@H]1N2 NWIBSHFKIJFRCO-WUDYKRTCSA-N 0.000 description 4
• 102100022680 NKG2-D type II integral membrane protein Human genes 0.000 description 4
• 102100033174 Neutrophil elastase Human genes 0.000 description 4
• 108090001145 Nuclear Receptor Coactivator 3 Proteins 0.000 description 4
• 102100039019 Nuclear receptor subfamily 0 group B member 1 Human genes 0.000 description 4
• 102000005877 Peptide Initiation Factors Human genes 0.000 description 4
• 108010044843 Peptide Initiation Factors Proteins 0.000 description 4
• 102100038825 Peroxisome proliferator-activated receptor gamma Human genes 0.000 description 4
• 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 4
• 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 4
• 102100031574 Platelet glycoprotein 4 Human genes 0.000 description 4
• 102100026531 Prelamin-A/C Human genes 0.000 description 4
• 108090000708 Proteasome Endopeptidase Complex Proteins 0.000 description 4
• 102000004245 Proteasome Endopeptidase Complex Human genes 0.000 description 4
• 102100026034 Protein BTG2 Human genes 0.000 description 4
• 102100036468 Protein diaphanous homolog 3 Human genes 0.000 description 4
• 102100034911 Pyruvate kinase PKM Human genes 0.000 description 4
• 102100033810 RAC-alpha serine/threonine-protein kinase Human genes 0.000 description 4
• 102100030086 Receptor tyrosine-protein kinase erbB-2 Human genes 0.000 description 4
• 102100020718 Receptor-type tyrosine-protein kinase FLT3 Human genes 0.000 description 4
• 102100031075 Serine/threonine-protein kinase Chk2 Human genes 0.000 description 4
• 102100040403 Tumor necrosis factor receptor superfamily member 6 Human genes 0.000 description 4
• 102100022596 Tyrosine-protein kinase ABL1 Human genes 0.000 description 4
• JXLYSJRDGCGARV-WWYNWVTFSA-N Vinblastine Natural products O=C(O[C@H]1[C@](O)(C(=O)OC)[C@@H]2N(C)c3c(cc(c(OC)c3)[C@]3(C(=O)OC)c4[nH]c5c(c4CCN4C[C@](O)(CC)C[C@H](C3)C4)cccc5)[C@@]32[C@H]2[C@@]1(CC)C=CCN2CC3)C JXLYSJRDGCGARV-WWYNWVTFSA-N 0.000 description 4
• RJURFGZVJUQBHK-UHFFFAOYSA-N actinomycin D Natural products CC1OC(=O)C(C(C)C)N(C)C(=O)CN(C)C(=O)C2CCCN2C(=O)C(C(C)C)NC(=O)C1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)NC4C(=O)NC(C(N5CCCC5C(=O)N(C)CC(=O)N(C)C(C(C)C)C(=O)OC4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-UHFFFAOYSA-N 0.000 description 4
• 230000002280 anti-androgenic effect Effects 0.000 description 4
• 229940046836 anti-estrogen Drugs 0.000 description 4
• 230000001833 anti-estrogenic effect Effects 0.000 description 4
• 239000000051 antiandrogen Substances 0.000 description 4
• 229960003852 atezolizumab Drugs 0.000 description 4
• 230000009286 beneficial effect Effects 0.000 description 4
• 230000008901 benefit Effects 0.000 description 4
• 229960000397 bevacizumab Drugs 0.000 description 4
• 108091008324 binding proteins Proteins 0.000 description 4
• 229960004562 carboplatin Drugs 0.000 description 4
• BLMPQMFVWMYDKT-NZTKNTHTSA-N carfilzomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC(C)C)C(=O)[C@]1(C)OC1)NC(=O)CN1CCOCC1)CC1=CC=CC=C1 BLMPQMFVWMYDKT-NZTKNTHTSA-N 0.000 description 4
• 229960002438 carfilzomib Drugs 0.000 description 4
• 108010021331 carfilzomib Proteins 0.000 description 4
• 229960003957 dexamethasone Drugs 0.000 description 4
• 239000008298 dragée Substances 0.000 description 4
• 229950009791 durvalumab Drugs 0.000 description 4
• 229940088598 enzyme Drugs 0.000 description 4
• 230000001973 epigenetic effect Effects 0.000 description 4
• 229960001904 epirubicin Drugs 0.000 description 4
• 229960001433 erlotinib Drugs 0.000 description 4
• AAKJLRGGTJKAMG-UHFFFAOYSA-N erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 description 4
• 239000000328 estrogen antagonist Substances 0.000 description 4
• 230000006846 excision repair Effects 0.000 description 4
• 239000008273 gelatin Substances 0.000 description 4
• 229920000159 gelatin Polymers 0.000 description 4
• 229940014259 gelatin Drugs 0.000 description 4
• 235000019322 gelatine Nutrition 0.000 description 4
• 235000011852 gelatine desserts Nutrition 0.000 description 4
• 229960000908 idarubicin Drugs 0.000 description 4
• 229960002411 imatinib Drugs 0.000 description 4
• 238000002347 injection Methods 0.000 description 4
• 239000007924 injection Substances 0.000 description 4
• 229940079322 interferon Drugs 0.000 description 4
• 102000003898 interleukin-24 Human genes 0.000 description 4
• 108090000237 interleukin-24 Proteins 0.000 description 4
• 229960005386 ipilimumab Drugs 0.000 description 4
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 description 4
• 229960004942 lenalidomide Drugs 0.000 description 4
• GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 description 4
• 229960000485 methotrexate Drugs 0.000 description 4
• 210000004688 microtubule Anatomy 0.000 description 4
• 229950010895 midostaurin Drugs 0.000 description 4
• BMGQWWVMWDBQGC-IIFHNQTCSA-N midostaurin Chemical compound CN([C@H]1[C@H]([C@]2(C)O[C@@H](N3C4=CC=CC=C4C4=C5C(=O)NCC5=C5C6=CC=CC=C6N2C5=C43)C1)OC)C(=O)C1=CC=CC=C1 BMGQWWVMWDBQGC-IIFHNQTCSA-N 0.000 description 4
• KKZJGLLVHKMTCM-UHFFFAOYSA-N mitoxantrone Chemical compound O=C1C2=C(O)C=CC(O)=C2C(=O)C2=C1C(NCCNCCO)=CC=C2NCCNCCO KKZJGLLVHKMTCM-UHFFFAOYSA-N 0.000 description 4
• 229960001156 mitoxantrone Drugs 0.000 description 4
• 229960001592 paclitaxel Drugs 0.000 description 4
• 229920001223 polyethylene glycol Polymers 0.000 description 4
• 229960004836 regorafenib Drugs 0.000 description 4
• FNHKPVJBJVTLMP-UHFFFAOYSA-N regorafenib Chemical compound C1=NC(C(=O)NC)=CC(OC=2C=C(F)C(NC(=O)NC=3C=C(C(Cl)=CC=3)C(F)(F)F)=CC=2)=C1 FNHKPVJBJVTLMP-UHFFFAOYSA-N 0.000 description 4
• 239000000523 sample Substances 0.000 description 4
• 239000000243 solution Substances 0.000 description 4
• 235000019698 starch Nutrition 0.000 description 4
• 239000000126 substance Substances 0.000 description 4
• 239000003826 tablet Substances 0.000 description 4
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 description 4
• 210000001685 thyroid gland Anatomy 0.000 description 4
• 210000001519 tissue Anatomy 0.000 description 4
• FPVKHBSQESCIEP-UHFFFAOYSA-N (8S)-3-(2-deoxy-beta-D-erythro-pentofuranosyl)-3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol Natural products C1C(O)C(CO)OC1N1C(NC=NCC2O)=C2N=C1 FPVKHBSQESCIEP-UHFFFAOYSA-N 0.000 description 3
• LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 description 3
• 108091032973 (ribonucleotides)n+m Proteins 0.000 description 3
• AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 description 3
• 102100027398 A disintegrin and metalloproteinase with thrombospondin motifs 1 Human genes 0.000 description 3
• 102100028161 ATP-binding cassette sub-family C member 2 Human genes 0.000 description 3
• 102100035623 ATP-citrate synthase Human genes 0.000 description 3
• 102100035785 Acyl-CoA-binding protein Human genes 0.000 description 3
• 102100033312 Alpha-2-macroglobulin Human genes 0.000 description 3
• 102100033972 Amyloid protein-binding protein 2 Human genes 0.000 description 3
• 102000052591 Anaphase-Promoting Complex-Cyclosome Apc6 Subunit Human genes 0.000 description 3
• 241000271566 Aves Species 0.000 description 3
• 108091007065 BIRCs Proteins 0.000 description 3
• 102100031746 Bone sialoprotein 2 Human genes 0.000 description 3
• 102100031092 C-C motif chemokine 3 Human genes 0.000 description 3
• 102100034871 C-C motif chemokine 8 Human genes 0.000 description 3
• 102100028989 C-X-C chemokine receptor type 2 Human genes 0.000 description 3
• 102100036170 C-X-C motif chemokine 9 Human genes 0.000 description 3
• 108091007381 CBL proteins Proteins 0.000 description 3
• 102100027207 CD27 antigen Human genes 0.000 description 3
• 102100025221 CD70 antigen Human genes 0.000 description 3
• 102100027217 CD82 antigen Human genes 0.000 description 3
• 108091007914 CDKs Proteins 0.000 description 3
• 102000008203 CTLA-4 Antigen Human genes 0.000 description 3
• 102100025580 Calmodulin-1 Human genes 0.000 description 3
• 102100021868 Calnexin Human genes 0.000 description 3
• 102100030005 Calpain-6 Human genes 0.000 description 3
• 102100025473 Carcinoembryonic antigen-related cell adhesion molecule 6 Human genes 0.000 description 3
• DLGOEMSEDOSKAD-UHFFFAOYSA-N Carmustine Chemical compound ClCCNC(=O)N(N=O)CCCl DLGOEMSEDOSKAD-UHFFFAOYSA-N 0.000 description 3
• 102100037398 Casein kinase I isoform epsilon Human genes 0.000 description 3
• 102100029855 Caspase-3 Human genes 0.000 description 3
• 102100025597 Caspase-4 Human genes 0.000 description 3
• 102100038902 Caspase-7 Human genes 0.000 description 3
• 102000004091 Caspase-8 Human genes 0.000 description 3
• 102100026548 Caspase-8 Human genes 0.000 description 3
• 108090000538 Caspase-8 Proteins 0.000 description 3
• 102100026550 Caspase-9 Human genes 0.000 description 3
• 108090000566 Caspase-9 Proteins 0.000 description 3
• 102100028914 Catenin beta-1 Human genes 0.000 description 3
• 102100038196 Chitinase-3-like protein 1 Human genes 0.000 description 3
• 102100038215 Chromodomain-helicase-DNA-binding protein 7 Human genes 0.000 description 3
• 102100038423 Claudin-3 Human genes 0.000 description 3
• 102100026098 Claudin-7 Human genes 0.000 description 3
• 108090000197 Clusterin Proteins 0.000 description 3
• 102100037078 Complement component 1 Q subcomponent-binding protein, mitochondrial Human genes 0.000 description 3
• 102100036883 Cyclin-H Human genes 0.000 description 3
• 102100032857 Cyclin-dependent kinase 1 Human genes 0.000 description 3
• 102100033270 Cyclin-dependent kinase inhibitor 1 Human genes 0.000 description 3
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 3
• 102100026891 Cystatin-B Human genes 0.000 description 3
• 102000002004 Cytochrome P-450 Enzyme System Human genes 0.000 description 3
• 108010015742 Cytochrome P-450 Enzyme System Proteins 0.000 description 3
• 102100039208 Cytochrome P450 3A5 Human genes 0.000 description 3
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 3
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 3
• 102100021246 DDIT3 upstream open reading frame protein Human genes 0.000 description 3
• 102100021122 DNA damage-binding protein 2 Human genes 0.000 description 3
• 102100031867 DNA excision repair protein ERCC-6 Human genes 0.000 description 3
• 101710109420 DNA-(apurinic or apyrimidinic site) endonuclease Proteins 0.000 description 3
• 102100035619 DNA-(apurinic or apyrimidinic site) lyase Human genes 0.000 description 3
• 102100027641 DNA-binding protein inhibitor ID-1 Human genes 0.000 description 3
• 102100027642 DNA-binding protein inhibitor ID-2 Human genes 0.000 description 3
• 102100039436 DNA-binding protein inhibitor ID-3 Human genes 0.000 description 3
• 102100034428 Dual specificity protein phosphatase 1 Human genes 0.000 description 3
• 102100027085 Dual specificity protein phosphatase 4 Human genes 0.000 description 3
• 102100040565 Dynein light chain 1, cytoplasmic Human genes 0.000 description 3
• 102100032257 E3 ubiquitin-protein ligase Mdm2 Human genes 0.000 description 3
• 108060006698 EGF receptor Proteins 0.000 description 3
• 102100023794 ETS domain-containing protein Elk-3 Human genes 0.000 description 3
• 102100021977 Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Human genes 0.000 description 3
• 102100037241 Endoglin Human genes 0.000 description 3
• 102100039328 Endoplasmin Human genes 0.000 description 3
• 102100031968 Ephrin type-B receptor 2 Human genes 0.000 description 3
• 102100031982 Ephrin type-B receptor 3 Human genes 0.000 description 3
• 102100033919 Ephrin-A2 Human genes 0.000 description 3
• 102100033941 Ephrin-A5 Human genes 0.000 description 3
• HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 description 3
• 102100038595 Estrogen receptor Human genes 0.000 description 3
• 102100027270 Etoposide-induced protein 2.4 homolog Human genes 0.000 description 3
• 102100029091 Exportin-2 Human genes 0.000 description 3
• 102100026121 Flap endonuclease 1 Human genes 0.000 description 3
• 102100041006 Forkhead box protein J1 Human genes 0.000 description 3
• 102100032863 General transcription factor IIH subunit 3 Human genes 0.000 description 3
• 102100033295 Glial cell line-derived neurotrophic factor Human genes 0.000 description 3
• 102100036534 Glutathione S-transferase Mu 1 Human genes 0.000 description 3
• 102100030943 Glutathione S-transferase P Human genes 0.000 description 3
• PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
• 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 3
• 102000002812 Heat-Shock Proteins Human genes 0.000 description 3
• 108010004889 Heat-Shock Proteins Proteins 0.000 description 3
• 102100022623 Hepatocyte growth factor receptor Human genes 0.000 description 3
• 102100035108 High affinity nerve growth factor receptor Human genes 0.000 description 3
• 102100028999 High mobility group protein HMGI-C Human genes 0.000 description 3
• 102100021453 Histone deacetylase 5 Human genes 0.000 description 3
• 102100024594 Histone-lysine N-methyltransferase PRDM16 Human genes 0.000 description 3
• 101000782969 Homo sapiens ATP-citrate synthase Proteins 0.000 description 3
• 101001060288 Homo sapiens Alpha-2-HS-glycoprotein Proteins 0.000 description 3
• 101000779309 Homo sapiens Amyloid protein-binding protein 2 Proteins 0.000 description 3
• 101000896157 Homo sapiens Baculoviral IAP repeat-containing protein 2 Proteins 0.000 description 3
• 101000896224 Homo sapiens Baculoviral IAP repeat-containing protein 3 Proteins 0.000 description 3
• 101000765923 Homo sapiens Bcl-2-like protein 1 Proteins 0.000 description 3
• 101000777471 Homo sapiens C-C motif chemokine 4 Proteins 0.000 description 3
• 101000916059 Homo sapiens C-X-C chemokine receptor type 2 Proteins 0.000 description 3
• 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 description 3
• 101000767052 Homo sapiens CAP-Gly domain-containing linker protein 1 Proteins 0.000 description 3
• 101000914511 Homo sapiens CD27 antigen Proteins 0.000 description 3
• 101000934356 Homo sapiens CD70 antigen Proteins 0.000 description 3
• 101000943456 Homo sapiens Calcium and integrin-binding family member 2 Proteins 0.000 description 3
• 101000984150 Homo sapiens Calmodulin-2 Proteins 0.000 description 3
• 101000933777 Homo sapiens Calmodulin-3 Proteins 0.000 description 3
• 101000793671 Homo sapiens Calpain-6 Proteins 0.000 description 3
• 101000914326 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 6 Proteins 0.000 description 3
• 101000867612 Homo sapiens Caspase-2 Proteins 0.000 description 3
• 101000793880 Homo sapiens Caspase-3 Proteins 0.000 description 3
• 101001099865 Homo sapiens Cellular retinoic acid-binding protein 1 Proteins 0.000 description 3
• 101000851684 Homo sapiens Chimeric ERCC6-PGBD3 protein Proteins 0.000 description 3
• 101000883515 Homo sapiens Chitinase-3-like protein 1 Proteins 0.000 description 3
• 101000883739 Homo sapiens Chromodomain-helicase-DNA-binding protein 7 Proteins 0.000 description 3
• 101000882908 Homo sapiens Claudin-3 Proteins 0.000 description 3
• 101000882890 Homo sapiens Claudin-4 Proteins 0.000 description 3
• 101000912652 Homo sapiens Claudin-7 Proteins 0.000 description 3
• 101000940068 Homo sapiens Collagen alpha-1(XVIII) chain Proteins 0.000 description 3
• 101000911952 Homo sapiens Cyclin-dependent kinase 7 Proteins 0.000 description 3
• 101000912191 Homo sapiens Cystatin-B Proteins 0.000 description 3
• 101000745710 Homo sapiens Cytochrome P450 3A5 Proteins 0.000 description 3
• 101001041466 Homo sapiens DNA damage-binding protein 2 Proteins 0.000 description 3
• 101000920783 Homo sapiens DNA excision repair protein ERCC-6 Proteins 0.000 description 3
• 101001018431 Homo sapiens DNA replication licensing factor MCM7 Proteins 0.000 description 3
• 101001137256 Homo sapiens DNA-(apurinic or apyrimidinic site) lyase Proteins 0.000 description 3
• 101000897035 Homo sapiens Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Proteins 0.000 description 3
• 101000881679 Homo sapiens Endoglin Proteins 0.000 description 3
• 101000938354 Homo sapiens Ephrin type-A receptor 1 Proteins 0.000 description 3
• 101000938351 Homo sapiens Ephrin type-A receptor 3 Proteins 0.000 description 3
• 101001064458 Homo sapiens Ephrin type-B receptor 3 Proteins 0.000 description 3
• 101000965523 Homo sapiens Ephrin-A1 Proteins 0.000 description 3
• 101000925269 Homo sapiens Ephrin-A2 Proteins 0.000 description 3
• 101001057564 Homo sapiens Etoposide-induced protein 2.4 homolog Proteins 0.000 description 3
• 101001054354 Homo sapiens Eukaryotic translation initiation factor 5A-1 Proteins 0.000 description 3
• 101000770958 Homo sapiens Exportin-2 Proteins 0.000 description 3
• 101000891683 Homo sapiens Fanconi anemia group D2 protein Proteins 0.000 description 3
• 101000608757 Homo sapiens Galectin-3 Proteins 0.000 description 3
• 101000967904 Homo sapiens Galectin-3-binding protein Proteins 0.000 description 3
• 101000920748 Homo sapiens General transcription and DNA repair factor IIH helicase subunit XPB Proteins 0.000 description 3
• 101000666405 Homo sapiens General transcription factor IIH subunit 1 Proteins 0.000 description 3
• 101000655398 Homo sapiens General transcription factor IIH subunit 2 Proteins 0.000 description 3
• 101000655391 Homo sapiens General transcription factor IIH subunit 3 Proteins 0.000 description 3
• 101000892862 Homo sapiens Glutamate carboxypeptidase 2 Proteins 0.000 description 3
• 101001010139 Homo sapiens Glutathione S-transferase P Proteins 0.000 description 3
• 101000746367 Homo sapiens Granulocyte colony-stimulating factor Proteins 0.000 description 3
• 101001080568 Homo sapiens Heat shock cognate 71 kDa protein Proteins 0.000 description 3
• 101000972946 Homo sapiens Hepatocyte growth factor receptor Proteins 0.000 description 3
• 101000986379 Homo sapiens High mobility group protein HMGI-C Proteins 0.000 description 3
• 101001047006 Homo sapiens Histone acetyltransferase KAT2B Proteins 0.000 description 3
• 101000882127 Homo sapiens Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 3
• 101000686942 Homo sapiens Histone-lysine N-methyltransferase PRDM16 Proteins 0.000 description 3
• 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 description 3
• 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 description 3
• 101001076292 Homo sapiens Insulin-like growth factor II Proteins 0.000 description 3
• 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 description 3
• 101001015004 Homo sapiens Integrin beta-3 Proteins 0.000 description 3
• 101001054334 Homo sapiens Interferon beta Proteins 0.000 description 3
• 101001033249 Homo sapiens Interleukin-1 beta Proteins 0.000 description 3
• 101001076407 Homo sapiens Interleukin-1 receptor antagonist protein Proteins 0.000 description 3
• 101001010600 Homo sapiens Interleukin-12 subunit alpha Proteins 0.000 description 3
• 101001003132 Homo sapiens Interleukin-13 receptor subunit alpha-2 Proteins 0.000 description 3
• 101000998181 Homo sapiens Interleukin-17B Proteins 0.000 description 3
• 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 description 3
• 101001002709 Homo sapiens Interleukin-4 Proteins 0.000 description 3
• 101001076408 Homo sapiens Interleukin-6 Proteins 0.000 description 3
• 101001056630 Homo sapiens JNK1/MAPK8-associated membrane protein Proteins 0.000 description 3
• 101001091371 Homo sapiens Kallikrein-8 Proteins 0.000 description 3
• 101000614627 Homo sapiens Keratin, type I cytoskeletal 13 Proteins 0.000 description 3
• 101001050567 Homo sapiens Kinesin-like protein KIF2C Proteins 0.000 description 3
• 101000716729 Homo sapiens Kit ligand Proteins 0.000 description 3
• 101001034314 Homo sapiens Lactadherin Proteins 0.000 description 3
• 101000620451 Homo sapiens Leucine-rich glioma-inactivated protein 1 Proteins 0.000 description 3
• 101000764535 Homo sapiens Lymphotoxin-alpha Proteins 0.000 description 3
• 101000624643 Homo sapiens M-phase inducer phosphatase 3 Proteins 0.000 description 3
• 101001011886 Homo sapiens Matrix metalloproteinase-16 Proteins 0.000 description 3
• 101001036406 Homo sapiens Melanoma-associated antigen C1 Proteins 0.000 description 3
• 101001057156 Homo sapiens Melanoma-associated antigen C2 Proteins 0.000 description 3
• 101001057159 Homo sapiens Melanoma-associated antigen C3 Proteins 0.000 description 3
• 101000976900 Homo sapiens Mitogen-activated protein kinase 14 Proteins 0.000 description 3
• 101000950687 Homo sapiens Mitogen-activated protein kinase 7 Proteins 0.000 description 3
• 101000950695 Homo sapiens Mitogen-activated protein kinase 8 Proteins 0.000 description 3
• 101000957259 Homo sapiens Mitotic spindle assembly checkpoint protein MAD2A Proteins 0.000 description 3
• 101000583811 Homo sapiens Mitotic spindle assembly checkpoint protein MAD2B Proteins 0.000 description 3
• 101001023043 Homo sapiens Myoblast determination protein 1 Proteins 0.000 description 3
• 101000973778 Homo sapiens NAD(P)H dehydrogenase [quinone] 1 Proteins 0.000 description 3
• 101000636823 Homo sapiens Neogenin Proteins 0.000 description 3
• 101000996663 Homo sapiens Neurotrophin-4 Proteins 0.000 description 3
• 101001114052 Homo sapiens P antigen family member 4 Proteins 0.000 description 3
• 101001071230 Homo sapiens PHD finger protein 20 Proteins 0.000 description 3
• 101001135738 Homo sapiens Parathyroid hormone-related protein Proteins 0.000 description 3
• 101000878253 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP5 Proteins 0.000 description 3
• 101001000631 Homo sapiens Peripheral myelin protein 22 Proteins 0.000 description 3
• 101000741790 Homo sapiens Peroxisome proliferator-activated receptor gamma Proteins 0.000 description 3
• 101001120056 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit alpha Proteins 0.000 description 3
• 101001120097 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit beta Proteins 0.000 description 3
• 101000872170 Homo sapiens Polycomb complex protein BMI-1 Proteins 0.000 description 3
• 101000933173 Homo sapiens Pro-cathepsin H Proteins 0.000 description 3
• 101000933604 Homo sapiens Protein BTG2 Proteins 0.000 description 3
• 101000928406 Homo sapiens Protein diaphanous homolog 3 Proteins 0.000 description 3
• 101001051767 Homo sapiens Protein kinase C beta type Proteins 0.000 description 3
• 101000971400 Homo sapiens Protein kinase C eta type Proteins 0.000 description 3
• 101000695187 Homo sapiens Protein patched homolog 1 Proteins 0.000 description 3
• 101001091538 Homo sapiens Pyruvate kinase PKM Proteins 0.000 description 3
• 101000932478 Homo sapiens Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 description 3
• 101000692878 Homo sapiens Regulator of MON1-CCZ1 complex Proteins 0.000 description 3
• 101001106322 Homo sapiens Rho GTPase-activating protein 7 Proteins 0.000 description 3
• 101000638161 Homo sapiens Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 3
• 101000997832 Homo sapiens Tyrosine-protein kinase JAK2 Proteins 0.000 description 3
• 101000808784 Homo sapiens Ubiquitin-conjugating enzyme E2 R1 Proteins 0.000 description 3
• 101000851007 Homo sapiens Vascular endothelial growth factor receptor 2 Proteins 0.000 description 3
• 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 description 3
• 102000037982 Immune checkpoint proteins Human genes 0.000 description 3
• 108091008036 Immune checkpoint proteins Proteins 0.000 description 3
• 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 3
• 102100025947 Insulin-like growth factor II Human genes 0.000 description 3
• 102100022338 Integrin alpha-M Human genes 0.000 description 3
• 102100039457 Inter-alpha-trypsin inhibitor heavy chain H4 Human genes 0.000 description 3
• 102100026720 Interferon beta Human genes 0.000 description 3
• 102000006992 Interferon-alpha Human genes 0.000 description 3
• 108010047761 Interferon-alpha Proteins 0.000 description 3
• 102100039065 Interleukin-1 beta Human genes 0.000 description 3
• 102100039898 Interleukin-18 Human genes 0.000 description 3
• 102000000588 Interleukin-2 Human genes 0.000 description 3
• 108010002350 Interleukin-2 Proteins 0.000 description 3
• 102100020941 Interleukin-4 Human genes 0.000 description 3
• 102100026019 Interleukin-6 Human genes 0.000 description 3
• 102100026871 Interleukin-9 Human genes 0.000 description 3
• 102100040443 Keratin, type I cytoskeletal 15 Human genes 0.000 description 3
• 102100033420 Keratin, type I cytoskeletal 19 Human genes 0.000 description 3
• 102100025758 Keratin, type II cytoskeletal 4 Human genes 0.000 description 3
• 102100023424 Kinesin-like protein KIF2C Human genes 0.000 description 3
• OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 description 3
• 239000005411 L01XE02 - Gefitinib Substances 0.000 description 3
• GQYIWUVLTXOXAJ-UHFFFAOYSA-N Lomustine Chemical compound ClCCN(N=O)C(=O)NC1CCCCC1 GQYIWUVLTXOXAJ-UHFFFAOYSA-N 0.000 description 3
• 102100040947 Lutropin subunit beta Human genes 0.000 description 3
• 102100026238 Lymphotoxin-alpha Human genes 0.000 description 3
• 102100026894 Lymphotoxin-beta Human genes 0.000 description 3
• 102100023330 M-phase inducer phosphatase 3 Human genes 0.000 description 3
• 102100028123 Macrophage colony-stimulating factor 1 Human genes 0.000 description 3
• 102100037791 Macrophage migration inhibitory factor Human genes 0.000 description 3
• 102100030417 Matrilysin Human genes 0.000 description 3
• 102100030201 Matrix metalloproteinase-15 Human genes 0.000 description 3
• 102100030200 Matrix metalloproteinase-16 Human genes 0.000 description 3
• 102100039447 Melanoma-associated antigen C1 Human genes 0.000 description 3
• 102100027252 Melanoma-associated antigen C2 Human genes 0.000 description 3
• 102100027248 Melanoma-associated antigen C3 Human genes 0.000 description 3
• 102100039124 Methyl-CpG-binding protein 2 Human genes 0.000 description 3
• 108060004795 Methyltransferase Proteins 0.000 description 3
• 102100030335 Midkine Human genes 0.000 description 3
• 102100037805 Mitogen-activated protein kinase 7 Human genes 0.000 description 3
• 102100030955 Mitotic spindle assembly checkpoint protein MAD2B Human genes 0.000 description 3
• 241001529936 Murinae Species 0.000 description 3
• 102100035077 Myoblast determination protein 1 Human genes 0.000 description 3
• 102100031900 Neogenin Human genes 0.000 description 3
• 102000048238 Neuregulin-1 Human genes 0.000 description 3
• 108090000556 Neuregulin-1 Proteins 0.000 description 3
• 102100028762 Neuropilin-1 Human genes 0.000 description 3
• 102100033857 Neurotrophin-4 Human genes 0.000 description 3
• 102100028452 Nitric oxide synthase, endothelial Human genes 0.000 description 3
• 102100029438 Nitric oxide synthase, inducible Human genes 0.000 description 3
• 102100023059 Nuclear factor NF-kappa-B p100 subunit Human genes 0.000 description 3
• 102100023240 P antigen family member 4 Human genes 0.000 description 3
• 102100036878 PHD finger protein 20 Human genes 0.000 description 3
• 229930012538 Paclitaxel Natural products 0.000 description 3
• 102100036899 Parathyroid hormone-related protein Human genes 0.000 description 3
• 102100037765 Periostin Human genes 0.000 description 3
• 102100035917 Peripheral myelin protein 22 Human genes 0.000 description 3
• 102100028960 Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Human genes 0.000 description 3
• 108091000080 Phosphotransferase Proteins 0.000 description 3
• 102100033566 Polycomb complex protein BMI-1 Human genes 0.000 description 3
• 102100025974 Pro-cathepsin H Human genes 0.000 description 3
• 102100022668 Pro-neuregulin-2, membrane-bound isoform Human genes 0.000 description 3
• 102100024216 Programmed cell death 1 ligand 1 Human genes 0.000 description 3
• 102100038280 Prostaglandin G/H synthase 2 Human genes 0.000 description 3
• 229940079156 Proteasome inhibitor Drugs 0.000 description 3
• 102100026375 Protein PML Human genes 0.000 description 3
• 102100024923 Protein kinase C beta type Human genes 0.000 description 3
• 102100021556 Protein kinase C eta type Human genes 0.000 description 3
• 102100028680 Protein patched homolog 1 Human genes 0.000 description 3
• 102000004022 Protein-Tyrosine Kinases Human genes 0.000 description 3
• 108090000412 Protein-Tyrosine Kinases Proteins 0.000 description 3
• 102000052575 Proto-Oncogene Human genes 0.000 description 3
• 108700020978 Proto-Oncogene Proteins 0.000 description 3
• 102000055251 Proto-Oncogene Proteins c-cbl Human genes 0.000 description 3
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 3
• 102100020824 Serine-protein kinase ATM Human genes 0.000 description 3
• 208000003874 Simpson-Golabi-Behmel syndrome Diseases 0.000 description 3
• 102100038803 Somatotropin Human genes 0.000 description 3
• 101710123496 Spindolin Proteins 0.000 description 3
• 206010042971 T-cell lymphoma Diseases 0.000 description 3
• 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 description 3
• CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 description 3
• 102100023132 Transcription factor Jun Human genes 0.000 description 3
• 102100033725 Tumor necrosis factor receptor superfamily member 16 Human genes 0.000 description 3
• 102100040245 Tumor necrosis factor receptor superfamily member 5 Human genes 0.000 description 3
• 102100033444 Tyrosine-protein kinase JAK2 Human genes 0.000 description 3
• 102000044159 Ubiquitin Human genes 0.000 description 3
• 108090000848 Ubiquitin Proteins 0.000 description 3
• 102100038466 Ubiquitin-conjugating enzyme E2 R1 Human genes 0.000 description 3
• 102100038234 Vascular endothelial growth factor D Human genes 0.000 description 3
• 102100033179 Vascular endothelial growth factor receptor 3 Human genes 0.000 description 3
• 208000027418 Wounds and injury Diseases 0.000 description 3
• 230000001093 anti-cancer Effects 0.000 description 3
• 230000000692 anti-sense effect Effects 0.000 description 3
• 229940030495 antiandrogen sex hormone and modulator of the genital system Drugs 0.000 description 3
• 229960000997 bicalutamide Drugs 0.000 description 3
• 208000035269 cancer or benign tumor Diseases 0.000 description 3
• 239000000969 carrier Substances 0.000 description 3
• 238000000576 coating method Methods 0.000 description 3
• 229940111134 coxibs Drugs 0.000 description 3
• 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 description 3
• 229960004397 cyclophosphamide Drugs 0.000 description 3
• ODKNJVUHOIMIIZ-RRKCRQDMSA-N floxuridine Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(F)=C1 ODKNJVUHOIMIIZ-RRKCRQDMSA-N 0.000 description 3
• 229960002074 flutamide Drugs 0.000 description 3
• MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 3
• XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 description 3
• 230000012010 growth Effects 0.000 description 3
• 239000003276 histone deacetylase inhibitor Substances 0.000 description 3
• 230000001939 inductive effect Effects 0.000 description 3
• 208000014674 injury Diseases 0.000 description 3
• 102000006495 integrins Human genes 0.000 description 3
• 108010044426 integrins Proteins 0.000 description 3
• 231100000682 maximum tolerated dose Toxicity 0.000 description 3
• 229960004857 mitomycin Drugs 0.000 description 3
• 239000003607 modifier Substances 0.000 description 3
• 230000035772 mutation Effects 0.000 description 3
• FPVKHBSQESCIEP-JQCXWYLXSA-N pentostatin Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC[C@H]2O)=C2N=C1 FPVKHBSQESCIEP-JQCXWYLXSA-N 0.000 description 3
• 102000020233 phosphotransferase Human genes 0.000 description 3
• 229950010773 pidilizumab Drugs 0.000 description 3
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical class [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 3
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 3
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 3
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 3
• 238000012545 processing Methods 0.000 description 3
• 239000003207 proteasome inhibitor Substances 0.000 description 3
• 229940121649 protein inhibitor Drugs 0.000 description 3
• 239000012268 protein inhibitor Substances 0.000 description 3
• 102000016914 ras Proteins Human genes 0.000 description 3
• 108010014186 ras Proteins Proteins 0.000 description 3
• 210000003289 regulatory T cell Anatomy 0.000 description 3
• VHXNKPBCCMUMSW-FQEVSTJZSA-N rubitecan Chemical compound C1=CC([N+]([O-])=O)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VHXNKPBCCMUMSW-FQEVSTJZSA-N 0.000 description 3
• 230000019491 signal transduction Effects 0.000 description 3
• 239000000600 sorbitol Substances 0.000 description 3
• 235000010356 sorbitol Nutrition 0.000 description 3
• 239000003381 stabilizer Substances 0.000 description 3
• 239000008107 starch Substances 0.000 description 3
• 229940032147 starch Drugs 0.000 description 3
• HKSZLNNOFSGOKW-FYTWVXJKSA-N staurosporine Chemical class C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1[C@H]1C[C@@H](NC)[C@@H](OC)[C@]4(C)O1 HKSZLNNOFSGOKW-FYTWVXJKSA-N 0.000 description 3
• 239000000454 talc Substances 0.000 description 3
• 229910052623 talc Inorganic materials 0.000 description 3
• 235000012222 talc Nutrition 0.000 description 3
• 229960000235 temsirolimus Drugs 0.000 description 3
• NRUKOCRGYNPUPR-QBPJDGROSA-N teniposide Chemical compound COC1=C(O)C(OC)=CC([C@@H]2C3=CC=4OCOC=4C=C3[C@@H](O[C@H]3[C@@H]([C@@H](O)[C@@H]4O[C@@H](OC[C@H]4O3)C=3SC=CC=3)O)[C@@H]3[C@@H]2C(OC3)=O)=C1 NRUKOCRGYNPUPR-QBPJDGROSA-N 0.000 description 3
• 229960001278 teniposide Drugs 0.000 description 3
• 238000012360 testing method Methods 0.000 description 3
• 229960003087 tioguanine Drugs 0.000 description 3
• PLHJCIYEEKOWNM-HHHXNRCGSA-N tipifarnib Chemical compound CN1C=NC=C1[C@](N)(C=1C=C2C(C=3C=C(Cl)C=CC=3)=CC(=O)N(C)C2=CC=1)C1=CC=C(Cl)C=C1 PLHJCIYEEKOWNM-HHHXNRCGSA-N 0.000 description 3
• 206010044412 transitional cell carcinoma Diseases 0.000 description 3
• 229950007217 tremelimumab Drugs 0.000 description 3
• 150000003626 triacylglycerols Chemical class 0.000 description 3
• OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 description 3
• 229940121358 tyrosine kinase inhibitor Drugs 0.000 description 3
• JXLYSJRDGCGARV-XQKSVPLYSA-N vincaleukoblastine Chemical compound C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 JXLYSJRDGCGARV-XQKSVPLYSA-N 0.000 description 3
• OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 description 3
• 229960004528 vincristine Drugs 0.000 description 3
• OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 description 3
• WAEXFXRVDQXREF-UHFFFAOYSA-N vorinostat Chemical compound ONC(=O)CCCCCCC(=O)NC1=CC=CC=C1 WAEXFXRVDQXREF-UHFFFAOYSA-N 0.000 description 3
• 229960000237 vorinostat Drugs 0.000 description 3
• ZADWXFSZEAPBJS-SNVBAGLBSA-N (2r)-2-amino-3-(1-methylindol-3-yl)propanoic acid Chemical compound C1=CC=C2N(C)C=C(C[C@@H](N)C(O)=O)C2=C1 ZADWXFSZEAPBJS-SNVBAGLBSA-N 0.000 description 2
• UMGQVUWXNOJOSJ-KMHUVPDISA-N (e)-2-cyano-3-(3,4-dihydroxyphenyl)-n-[(1r)-1-phenylethyl]prop-2-enamide Chemical compound N([C@H](C)C=1C=CC=CC=1)C(=O)C(\C#N)=C\C1=CC=C(O)C(O)=C1 UMGQVUWXNOJOSJ-KMHUVPDISA-N 0.000 description 2
• ZADWXFSZEAPBJS-JTQLQIEISA-N 1-methyl-L-tryptophan Chemical compound C1=CC=C2N(C)C=C(C[C@H](N)C(O)=O)C2=C1 ZADWXFSZEAPBJS-JTQLQIEISA-N 0.000 description 2
• UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 description 2
• NHFDRBXTEDBWCZ-ZROIWOOFSA-N 3-[2,4-dimethyl-5-[(z)-(2-oxo-1h-indol-3-ylidene)methyl]-1h-pyrrol-3-yl]propanoic acid Chemical compound OC(=O)CCC1=C(C)NC(\C=C/2C3=CC=CC=C3NC\2=O)=C1C NHFDRBXTEDBWCZ-ZROIWOOFSA-N 0.000 description 2
• WEVYNIUIFUYDGI-UHFFFAOYSA-N 3-[6-[4-(trifluoromethoxy)anilino]-4-pyrimidinyl]benzamide Chemical compound NC(=O)C1=CC=CC(C=2N=CN=C(NC=3C=CC(OC(F)(F)F)=CC=3)C=2)=C1 WEVYNIUIFUYDGI-UHFFFAOYSA-N 0.000 description 2
• XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 description 2
• NMUSYJAQQFHJEW-KVTDHHQDSA-N 5-azacytidine Chemical compound O=C1N=C(N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 NMUSYJAQQFHJEW-KVTDHHQDSA-N 0.000 description 2
• 102100038222 60 kDa heat shock protein, mitochondrial Human genes 0.000 description 2
• 102100027401 A disintegrin and metalloproteinase with thrombospondin motifs 3 Human genes 0.000 description 2
• 102100032638 A disintegrin and metalloproteinase with thrombospondin motifs 5 Human genes 0.000 description 2
• 102100032635 A disintegrin and metalloproteinase with thrombospondin motifs 8 Human genes 0.000 description 2
• 102100033793 ALK tyrosine kinase receptor Human genes 0.000 description 2
• 102100033347 AP-2 complex subunit beta Human genes 0.000 description 2
• 101710150022 ATP-binding cassette sub-family C member 5 Proteins 0.000 description 2
• 102100021886 Activin receptor type-2A Human genes 0.000 description 2
• 101710106492 Acyl-CoA-binding protein Proteins 0.000 description 2
• 101710169323 Acyl-CoA-binding protein homolog Proteins 0.000 description 2
• 102100022089 Acyl-[acyl-carrier-protein] hydrolase Human genes 0.000 description 2
• 102100027265 Aldo-keto reductase family 1 member B1 Human genes 0.000 description 2
• 102100025683 Alkaline phosphatase, tissue-nonspecific isozyme Human genes 0.000 description 2
• GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 2
• 102100038920 Alpha-S1-casein Human genes 0.000 description 2
• 102100040743 Alpha-crystallin B chain Human genes 0.000 description 2
• 102100023635 Alpha-fetoprotein Human genes 0.000 description 2
• 102100038778 Amphiregulin Human genes 0.000 description 2
• 102100034594 Angiopoietin-1 Human genes 0.000 description 2
• 102100040006 Annexin A1 Human genes 0.000 description 2
• 102100034524 Apoptotic protease-activating factor 1 Human genes 0.000 description 2
• 102100028218 Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Human genes 0.000 description 2
• 108010078554 Aromatase Proteins 0.000 description 2
• 102100026792 Aryl hydrocarbon receptor Human genes 0.000 description 2
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
• 102000004000 Aurora Kinase A Human genes 0.000 description 2
• 108090000461 Aurora Kinase A Proteins 0.000 description 2
• 108090000749 Aurora kinase B Proteins 0.000 description 2
• 102100021570 B-cell lymphoma 3 protein Human genes 0.000 description 2
• 102100037140 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Human genes 0.000 description 2
• 108700003785 Baculoviral IAP Repeat-Containing 3 Proteins 0.000 description 2
• 102100021677 Baculoviral IAP repeat-containing protein 2 Human genes 0.000 description 2
• 102100021663 Baculoviral IAP repeat-containing protein 5 Human genes 0.000 description 2
• 102100027453 Bcl2-associated agonist of cell death Human genes 0.000 description 2
• KXDAEFPNCMNJSK-UHFFFAOYSA-N Benzamide Chemical compound NC(=O)C1=CC=CC=C1 KXDAEFPNCMNJSK-UHFFFAOYSA-N 0.000 description 2
• 102100037674 Bis(5'-adenosyl)-triphosphatase Human genes 0.000 description 2
• 229940122361 Bisphosphonate Drugs 0.000 description 2
• 108010006654 Bleomycin Proteins 0.000 description 2
• 102100027058 Bleomycin hydrolase Human genes 0.000 description 2
• 102100036150 C-X-C motif chemokine 5 Human genes 0.000 description 2
• 102100031168 CCN family member 2 Human genes 0.000 description 2
• 102100024210 CD166 antigen Human genes 0.000 description 2
• FVLVBPDQNARYJU-XAHDHGMMSA-N C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O Chemical compound C[C@H]1CCC(CC1)NC(=O)N(CCCl)N=O FVLVBPDQNARYJU-XAHDHGMMSA-N 0.000 description 2
• 102000000905 Cadherin Human genes 0.000 description 2
• 108050007957 Cadherin Proteins 0.000 description 2
• 102100025805 Cadherin-1 Human genes 0.000 description 2
• 102100024152 Cadherin-17 Human genes 0.000 description 2
• 102100029761 Cadherin-5 Human genes 0.000 description 2
• 108010056891 Calnexin Proteins 0.000 description 2
• 102100028801 Calsyntenin-1 Human genes 0.000 description 2
• KLWPJMFMVPTNCC-UHFFFAOYSA-N Camptothecin Natural products CCC1(O)C(=O)OCC2=C1C=C3C4Nc5ccccc5C=C4CN3C2=O KLWPJMFMVPTNCC-UHFFFAOYSA-N 0.000 description 2
• 102100036375 Carbonic anhydrase-related protein Human genes 0.000 description 2
• 108010022366 Carcinoembryonic Antigen Proteins 0.000 description 2
• 108090000397 Caspase 3 Proteins 0.000 description 2
• 102100032219 Cathepsin D Human genes 0.000 description 2
• 102100038099 Cell division cycle protein 20 homolog Human genes 0.000 description 2
• 102100034231 Cell surface A33 antigen Human genes 0.000 description 2
• 108010082155 Chemokine CCL18 Proteins 0.000 description 2
• 102100034667 Chloride intracellular channel protein 1 Human genes 0.000 description 2
• 208000006332 Choriocarcinoma Diseases 0.000 description 2
• 102100031196 Choriogonadotropin subunit beta 3 Human genes 0.000 description 2
• 108010038447 Chromogranin A Proteins 0.000 description 2
• 102000010792 Chromogranin A Human genes 0.000 description 2
• 102100033601 Collagen alpha-1(I) chain Human genes 0.000 description 2
• 102100033825 Collagen alpha-1(XI) chain Human genes 0.000 description 2
• 102100028256 Collagen alpha-1(XVII) chain Human genes 0.000 description 2
• 102100036213 Collagen alpha-2(I) chain Human genes 0.000 description 2
• 102100033775 Collagen alpha-5(IV) chain Human genes 0.000 description 2
• 102000029816 Collagenase Human genes 0.000 description 2
• 108060005980 Collagenase Proteins 0.000 description 2
• 102100027995 Collagenase 3 Human genes 0.000 description 2
• 108010058546 Cyclin D1 Proteins 0.000 description 2
• 102100025191 Cyclin-A2 Human genes 0.000 description 2
• 108010037462 Cyclooxygenase 2 Proteins 0.000 description 2
• 102100031237 Cystatin-A Human genes 0.000 description 2
• 102100026533 Cytochrome P450 1A2 Human genes 0.000 description 2
• 102100029363 Cytochrome P450 2C19 Human genes 0.000 description 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
• 102100031866 DNA excision repair protein ERCC-5 Human genes 0.000 description 2
• 102100029094 DNA repair endonuclease XPF Human genes 0.000 description 2
• 102100033711 DNA replication licensing factor MCM7 Human genes 0.000 description 2
• 229940123780 DNA topoisomerase I inhibitor Drugs 0.000 description 2
• 229940124087 DNA topoisomerase II inhibitor Drugs 0.000 description 2
• 108010092160 Dactinomycin Proteins 0.000 description 2
• 102100028559 Death domain-associated protein 6 Human genes 0.000 description 2
• 102100035784 Decorin Human genes 0.000 description 2
• 108010039287 Diazepam Binding Inhibitor Proteins 0.000 description 2
• 102100031695 DnaJ homolog subfamily C member 2 Human genes 0.000 description 2
• 102100033996 Double-strand break repair protein MRE11 Human genes 0.000 description 2
• 102100023266 Dual specificity mitogen-activated protein kinase kinase 2 Human genes 0.000 description 2
• 102100037567 Dual specificity protein phosphatase 14 Human genes 0.000 description 2
• 102100035813 E3 ubiquitin-protein ligase CBL Human genes 0.000 description 2
• 102100032353 E3 ubiquitin-protein ligase CHFR Human genes 0.000 description 2
• 102100039578 ETS translocation variant 4 Human genes 0.000 description 2
• 102100039577 ETS translocation variant 5 Human genes 0.000 description 2
• XXPXYPLPSDPERN-UHFFFAOYSA-N Ecteinascidin 743 Natural products COc1cc2C(NCCc2cc1O)C(=O)OCC3N4C(O)C5Cc6cc(C)c(OC)c(O)c6C(C4C(S)c7c(OC(=O)C)c(C)c8OCOc8c37)N5C XXPXYPLPSDPERN-UHFFFAOYSA-N 0.000 description 2
• 102100031334 Elongation factor 2 Human genes 0.000 description 2
• 241000196324 Embryophyta Species 0.000 description 2
• 102100021710 Endonuclease III-like protein 1 Human genes 0.000 description 2
• 102100023688 Eotaxin Human genes 0.000 description 2
• 102100030322 Ephrin type-A receptor 1 Human genes 0.000 description 2
• 102100021616 Ephrin type-A receptor 4 Human genes 0.000 description 2
• 102100021606 Ephrin type-A receptor 7 Human genes 0.000 description 2
• 102100021601 Ephrin type-A receptor 8 Human genes 0.000 description 2
• 102100031983 Ephrin type-B receptor 4 Human genes 0.000 description 2
• 108010044099 Ephrin-B1 Proteins 0.000 description 2
• 108010044090 Ephrin-B2 Proteins 0.000 description 2
• 102100023733 Ephrin-B3 Human genes 0.000 description 2
• 108010066687 Epithelial Cell Adhesion Molecule Proteins 0.000 description 2
• 102100029951 Estrogen receptor beta Human genes 0.000 description 2
• 108010057194 Eukaryotic Initiation Factor-4F Proteins 0.000 description 2
• 102100039735 Eukaryotic translation initiation factor 4 gamma 1 Human genes 0.000 description 2
• 102100022466 Eukaryotic translation initiation factor 4E-binding protein 1 Human genes 0.000 description 2
• 102100026765 Eukaryotic translation initiation factor 4H Human genes 0.000 description 2
• HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 2
• 102100029055 Exostosin-1 Human genes 0.000 description 2
• 108010007457 Extracellular Signal-Regulated MAP Kinases Proteins 0.000 description 2
• 102100026693 FAS-associated death domain protein Human genes 0.000 description 2
• 102100036089 Fascin Human genes 0.000 description 2
• 101710083187 Fatty acid-binding protein 5 Proteins 0.000 description 2
• 102100030431 Fatty acid-binding protein, adipocyte Human genes 0.000 description 2
• 102100021062 Ferritin light chain Human genes 0.000 description 2
• 102100035323 Fibroblast growth factor 18 Human genes 0.000 description 2
• 102100028043 Fibroblast growth factor 3 Human genes 0.000 description 2
• 108090000381 Fibroblast growth factor 4 Proteins 0.000 description 2
• 102100027844 Fibroblast growth factor receptor 4 Human genes 0.000 description 2
• 102100035427 Forkhead box protein O1 Human genes 0.000 description 2
• 102100035421 Forkhead box protein O3 Human genes 0.000 description 2
• 102100027570 Forkhead box protein Q1 Human genes 0.000 description 2
• 102100024165 G1/S-specific cyclin-D1 Human genes 0.000 description 2
• 108010026132 Gelatinases Proteins 0.000 description 2
• 102000013382 Gelatinases Human genes 0.000 description 2
• 102100031885 General transcription and DNA repair factor IIH helicase subunit XPB Human genes 0.000 description 2
• 102100031132 Glucose-6-phosphate isomerase Human genes 0.000 description 2
• 108010070600 Glucose-6-phosphate isomerase Proteins 0.000 description 2
• 102400000932 Gonadoliberin-1 Human genes 0.000 description 2
• 108010069236 Goserelin Proteins 0.000 description 2
• 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 2
• 102100028113 Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Human genes 0.000 description 2
• 102000009465 Growth Factor Receptors Human genes 0.000 description 2
• 108010009202 Growth Factor Receptors Proteins 0.000 description 2
• 102100031154 Growth arrest and DNA damage-inducible protein GADD45 gamma Human genes 0.000 description 2
• 108010042283 HSP40 Heat-Shock Proteins Proteins 0.000 description 2
• 102100028765 Heat shock 70 kDa protein 4 Human genes 0.000 description 2
• 102100032510 Heat shock protein HSP 90-beta Human genes 0.000 description 2
• 108090000100 Hepatocyte Growth Factor Proteins 0.000 description 2
• 102100031465 Hepatocyte growth factor activator Human genes 0.000 description 2
• 102100039999 Histone deacetylase 2 Human genes 0.000 description 2
• 208000017604 Hodgkin disease Diseases 0.000 description 2
• 102100025110 Homeobox protein Hox-A5 Human genes 0.000 description 2
• 102100021090 Homeobox protein Hox-A9 Human genes 0.000 description 2
• 102100028092 Homeobox protein Nkx-3.1 Human genes 0.000 description 2
• 102100030234 Homeobox protein cut-like 1 Human genes 0.000 description 2
• 241000282412 Homo Species 0.000 description 2
• 101000936405 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 1 Proteins 0.000 description 2
• 101000779382 Homo sapiens A-kinase anchor protein 12 Proteins 0.000 description 2
• 101000732341 Homo sapiens AP-2 complex subunit beta Proteins 0.000 description 2
• 101000986637 Homo sapiens ATP-binding cassette sub-family C member 2 Proteins 0.000 description 2
• 101000986622 Homo sapiens ATP-binding cassette sub-family C member 5 Proteins 0.000 description 2
• 101000970954 Homo sapiens Activin receptor type-2A Proteins 0.000 description 2
• 101000824278 Homo sapiens Acyl-[acyl-carrier-protein] hydrolase Proteins 0.000 description 2
• 101000799972 Homo sapiens Alpha-2-macroglobulin Proteins 0.000 description 2
• 101000741048 Homo sapiens Alpha-S1-casein Proteins 0.000 description 2
• 101000891982 Homo sapiens Alpha-crystallin B chain Proteins 0.000 description 2
• 101000924552 Homo sapiens Angiopoietin-1 Proteins 0.000 description 2
• 101000959738 Homo sapiens Annexin A1 Proteins 0.000 description 2
• 101000924629 Homo sapiens Apoptotic protease-activating factor 1 Proteins 0.000 description 2
• 101000724276 Homo sapiens Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1 Proteins 0.000 description 2
• 101000919395 Homo sapiens Aromatase Proteins 0.000 description 2
• 101000971178 Homo sapiens B-cell lymphoma 3 protein Proteins 0.000 description 2
• 101000740545 Homo sapiens BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like Proteins 0.000 description 2
• 101000896234 Homo sapiens Baculoviral IAP repeat-containing protein 5 Proteins 0.000 description 2
• 101000936623 Homo sapiens Bcl2-associated agonist of cell death Proteins 0.000 description 2
• 101000707248 Homo sapiens Bone sialoprotein 2 Proteins 0.000 description 2
• 101000777387 Homo sapiens C-C motif chemokine 3 Proteins 0.000 description 2
• 101000946794 Homo sapiens C-C motif chemokine 8 Proteins 0.000 description 2
• 101000947186 Homo sapiens C-X-C motif chemokine 5 Proteins 0.000 description 2
• 101000824531 Homo sapiens CAAX prenyl protease 1 homolog Proteins 0.000 description 2
• 101000777550 Homo sapiens CCN family member 2 Proteins 0.000 description 2
• 101000914469 Homo sapiens CD82 antigen Proteins 0.000 description 2
• 101000984015 Homo sapiens Cadherin-1 Proteins 0.000 description 2
• 101000794587 Homo sapiens Cadherin-5 Proteins 0.000 description 2
• 101000945318 Homo sapiens Calponin-1 Proteins 0.000 description 2
• 101000916423 Homo sapiens Calsyntenin-1 Proteins 0.000 description 2
• 101000914324 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 5 Proteins 0.000 description 2
• 101000859758 Homo sapiens Cartilage-associated protein Proteins 0.000 description 2
• 101001026376 Homo sapiens Casein kinase I isoform epsilon Proteins 0.000 description 2
• 101000933112 Homo sapiens Caspase-4 Proteins 0.000 description 2
• 101000741014 Homo sapiens Caspase-7 Proteins 0.000 description 2
• 101000983528 Homo sapiens Caspase-8 Proteins 0.000 description 2
• 101000916173 Homo sapiens Catenin beta-1 Proteins 0.000 description 2
• 101000869010 Homo sapiens Cathepsin D Proteins 0.000 description 2
• 101000884317 Homo sapiens Cell division cycle protein 20 homolog Proteins 0.000 description 2
• 101000996823 Homo sapiens Cell surface A33 antigen Proteins 0.000 description 2
• 101000946430 Homo sapiens Chloride intracellular channel protein 1 Proteins 0.000 description 2
• 101000776619 Homo sapiens Choriogonadotropin subunit beta 3 Proteins 0.000 description 2
• 101000710623 Homo sapiens Collagen alpha-1(XI) chain Proteins 0.000 description 2
• 101000860679 Homo sapiens Collagen alpha-1(XVII) chain Proteins 0.000 description 2
• 101000875067 Homo sapiens Collagen alpha-2(I) chain Proteins 0.000 description 2
• 101000710876 Homo sapiens Collagen alpha-2(IV) chain Proteins 0.000 description 2
• 101000740725 Homo sapiens Complement component 1 Q subcomponent-binding protein, mitochondrial Proteins 0.000 description 2
• 101000868333 Homo sapiens Cyclin-dependent kinase 1 Proteins 0.000 description 2
• 101000944380 Homo sapiens Cyclin-dependent kinase inhibitor 1 Proteins 0.000 description 2
• 101000921786 Homo sapiens Cystatin-A Proteins 0.000 description 2
• 101000855342 Homo sapiens Cytochrome P450 1A2 Proteins 0.000 description 2
• 101000916686 Homo sapiens Cytohesin-interacting protein Proteins 0.000 description 2
• 101000920784 Homo sapiens DNA excision repair protein ERCC-5 Proteins 0.000 description 2
• 101000577853 Homo sapiens DNA mismatch repair protein Mlh1 Proteins 0.000 description 2
• 101000806846 Homo sapiens DNA-(apurinic or apyrimidinic site) endonuclease Proteins 0.000 description 2
• 101001081590 Homo sapiens DNA-binding protein inhibitor ID-1 Proteins 0.000 description 2
• 101001081582 Homo sapiens DNA-binding protein inhibitor ID-2 Proteins 0.000 description 2
• 101001036287 Homo sapiens DNA-binding protein inhibitor ID-3 Proteins 0.000 description 2
• 101001000206 Homo sapiens Decorin Proteins 0.000 description 2
• 101000924017 Homo sapiens Dual specificity protein phosphatase 1 Proteins 0.000 description 2
• 101000881116 Homo sapiens Dual specificity protein phosphatase 14 Proteins 0.000 description 2
• 101001057621 Homo sapiens Dual specificity protein phosphatase 4 Proteins 0.000 description 2
• 101000942970 Homo sapiens E3 ubiquitin-protein ligase CHFR Proteins 0.000 description 2
• 101001015963 Homo sapiens E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 description 2
• 101000813747 Homo sapiens ETS translocation variant 4 Proteins 0.000 description 2
• 101000813745 Homo sapiens ETS translocation variant 5 Proteins 0.000 description 2
• 101000970385 Homo sapiens Endonuclease III-like protein 1 Proteins 0.000 description 2
• 101000812663 Homo sapiens Endoplasmin Proteins 0.000 description 2
• 101000898708 Homo sapiens Ephrin type-A receptor 7 Proteins 0.000 description 2
• 101000898676 Homo sapiens Ephrin type-A receptor 8 Proteins 0.000 description 2
• 101001064462 Homo sapiens Ephrin type-B receptor 2 Proteins 0.000 description 2
• 101001064456 Homo sapiens Ephrin type-B receptor 4 Proteins 0.000 description 2
• 101000925251 Homo sapiens Ephrin-A5 Proteins 0.000 description 2
• 101000925219 Homo sapiens Ephrin-B1 Proteins 0.000 description 2
• 101000882584 Homo sapiens Estrogen receptor Proteins 0.000 description 2
• 101001010910 Homo sapiens Estrogen receptor beta Proteins 0.000 description 2
• 101000881778 Homo sapiens Eukaryotic translation initiation factor 3 subunit H Proteins 0.000 description 2
• 101001082055 Homo sapiens Eukaryotic translation initiation factor 4E Proteins 0.000 description 2
• 101001054360 Homo sapiens Eukaryotic translation initiation factor 4H Proteins 0.000 description 2
• 101000918311 Homo sapiens Exostosin-1 Proteins 0.000 description 2
• 101000911074 Homo sapiens FAS-associated death domain protein Proteins 0.000 description 2
• 101001021925 Homo sapiens Fascin Proteins 0.000 description 2
• 101001062855 Homo sapiens Fatty acid-binding protein 5 Proteins 0.000 description 2
• 101001062864 Homo sapiens Fatty acid-binding protein, adipocyte Proteins 0.000 description 2
• 101000818390 Homo sapiens Ferritin light chain Proteins 0.000 description 2
• 101000917134 Homo sapiens Fibroblast growth factor receptor 4 Proteins 0.000 description 2
• 101000913035 Homo sapiens Flap endonuclease 1 Proteins 0.000 description 2
• 101000892910 Homo sapiens Forkhead box protein J1 Proteins 0.000 description 2
• 101000877727 Homo sapiens Forkhead box protein O1 Proteins 0.000 description 2
• 101000877681 Homo sapiens Forkhead box protein O3 Proteins 0.000 description 2
• 101000584612 Homo sapiens GTPase KRas Proteins 0.000 description 2
• 101000655406 Homo sapiens General transcription factor IIH subunit 4 Proteins 0.000 description 2
• 101000655402 Homo sapiens General transcription factor IIH subunit 5 Proteins 0.000 description 2
• 101000997829 Homo sapiens Glial cell line-derived neurotrophic factor Proteins 0.000 description 2
• 101001071694 Homo sapiens Glutathione S-transferase Mu 1 Proteins 0.000 description 2
• 101500026183 Homo sapiens Gonadoliberin-1 Proteins 0.000 description 2
• 101000916625 Homo sapiens Granulocyte-macrophage colony-stimulating factor receptor subunit alpha Proteins 0.000 description 2
• 101001066158 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 alpha Proteins 0.000 description 2
• 101001066163 Homo sapiens Growth arrest and DNA damage-inducible protein GADD45 gamma Proteins 0.000 description 2
• 101001078692 Homo sapiens Heat shock 70 kDa protein 4 Proteins 0.000 description 2
• 101001016856 Homo sapiens Heat shock protein HSP 90-beta Proteins 0.000 description 2
• 101001036709 Homo sapiens Heat shock protein beta-1 Proteins 0.000 description 2
• 101000596894 Homo sapiens High affinity nerve growth factor receptor Proteins 0.000 description 2
• 101001035011 Homo sapiens Histone deacetylase 2 Proteins 0.000 description 2
• 101000899255 Homo sapiens Histone deacetylase 5 Proteins 0.000 description 2
• 101001077568 Homo sapiens Homeobox protein Hox-A5 Proteins 0.000 description 2
• 101000578249 Homo sapiens Homeobox protein Nkx-3.1 Proteins 0.000 description 2
• 101000726740 Homo sapiens Homeobox protein cut-like 1 Proteins 0.000 description 2
• 101001044927 Homo sapiens Insulin-like growth factor-binding protein 3 Proteins 0.000 description 2
• 101001078158 Homo sapiens Integrin alpha-1 Proteins 0.000 description 2
• 101001078133 Homo sapiens Integrin alpha-2 Proteins 0.000 description 2
• 101000994375 Homo sapiens Integrin alpha-4 Proteins 0.000 description 2
• 101000994369 Homo sapiens Integrin alpha-5 Proteins 0.000 description 2
• 101000609413 Homo sapiens Inter-alpha-trypsin inhibitor heavy chain H4 Proteins 0.000 description 2
• 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 description 2
• 101000852870 Homo sapiens Interferon alpha/beta receptor 1 Proteins 0.000 description 2
• 101001011441 Homo sapiens Interferon regulatory factor 4 Proteins 0.000 description 2
• 101001002634 Homo sapiens Interleukin-1 alpha Proteins 0.000 description 2
• 101001076418 Homo sapiens Interleukin-1 receptor type 1 Proteins 0.000 description 2
• 101001076422 Homo sapiens Interleukin-1 receptor type 2 Proteins 0.000 description 2
• 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 description 2
• 101001055145 Homo sapiens Interleukin-2 receptor subunit beta Proteins 0.000 description 2
• 101000853009 Homo sapiens Interleukin-24 Proteins 0.000 description 2
• 101001013150 Homo sapiens Interstitial collagenase Proteins 0.000 description 2
• 101001008919 Homo sapiens Kallikrein-10 Proteins 0.000 description 2
• 101001008922 Homo sapiens Kallikrein-11 Proteins 0.000 description 2
• 101000605518 Homo sapiens Kallikrein-15 Proteins 0.000 description 2
• 101001091376 Homo sapiens Kallikrein-4 Proteins 0.000 description 2
• 101001091379 Homo sapiens Kallikrein-5 Proteins 0.000 description 2
• 101000614436 Homo sapiens Keratin, type I cytoskeletal 14 Proteins 0.000 description 2
• 101000998011 Homo sapiens Keratin, type I cytoskeletal 19 Proteins 0.000 description 2
• 101001056466 Homo sapiens Keratin, type II cytoskeletal 4 Proteins 0.000 description 2
• 101001050577 Homo sapiens Kinesin-like protein KIF2A Proteins 0.000 description 2
• 101001139134 Homo sapiens Krueppel-like factor 4 Proteins 0.000 description 2
• 101001139130 Homo sapiens Krueppel-like factor 5 Proteins 0.000 description 2
• 101001020548 Homo sapiens LIM/homeobox protein Lhx1 Proteins 0.000 description 2
• 101001063370 Homo sapiens Legumain Proteins 0.000 description 2
• 101000764294 Homo sapiens Lymphotoxin-beta Proteins 0.000 description 2
• 101001134216 Homo sapiens Macrophage scavenger receptor types I and II Proteins 0.000 description 2
• 101000990912 Homo sapiens Matrilysin Proteins 0.000 description 2
• 101001011884 Homo sapiens Matrix metalloproteinase-15 Proteins 0.000 description 2
• 101000990902 Homo sapiens Matrix metalloproteinase-9 Proteins 0.000 description 2
• 101001005722 Homo sapiens Melanoma-associated antigen 6 Proteins 0.000 description 2
• 101001036689 Homo sapiens Melanoma-associated antigen B5 Proteins 0.000 description 2
• 101001036675 Homo sapiens Melanoma-associated antigen B6 Proteins 0.000 description 2
• 101001057158 Homo sapiens Melanoma-associated antigen D1 Proteins 0.000 description 2
• 101000694615 Homo sapiens Membrane primary amine oxidase Proteins 0.000 description 2
• 101000576802 Homo sapiens Mesothelin Proteins 0.000 description 2
• 101000587539 Homo sapiens Metallothionein-1A Proteins 0.000 description 2
• 101000615492 Homo sapiens Methyl-CpG-binding domain protein 4 Proteins 0.000 description 2
• 101001033726 Homo sapiens Methyl-CpG-binding protein 2 Proteins 0.000 description 2
• 101000990990 Homo sapiens Midkine Proteins 0.000 description 2
• 101000982010 Homo sapiens Myelin proteolipid protein Proteins 0.000 description 2
• 101000589002 Homo sapiens Myogenin Proteins 0.000 description 2
• 101000998623 Homo sapiens NADH-cytochrome b5 reductase 3 Proteins 0.000 description 2
• 101000830386 Homo sapiens Neutrophil defensin 3 Proteins 0.000 description 2
• 101001124309 Homo sapiens Nitric oxide synthase, endothelial Proteins 0.000 description 2
• 101001124991 Homo sapiens Nitric oxide synthase, inducible Proteins 0.000 description 2
• 101000979623 Homo sapiens Nucleoside diphosphate kinase B Proteins 0.000 description 2
• 101001095308 Homo sapiens Periostin Proteins 0.000 description 2
• 101001123331 Homo sapiens Peroxisome proliferator-activated receptor gamma coactivator 1-alpha Proteins 0.000 description 2
• 101000938567 Homo sapiens Persulfide dioxygenase ETHE1, mitochondrial Proteins 0.000 description 2
• 101001001527 Homo sapiens Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Proteins 0.000 description 2
• 101000582950 Homo sapiens Platelet factor 4 Proteins 0.000 description 2
• 101000692455 Homo sapiens Platelet-derived growth factor receptor beta Proteins 0.000 description 2
• 101001102334 Homo sapiens Pleiotrophin Proteins 0.000 description 2
• 101001109792 Homo sapiens Pro-neuregulin-2, membrane-bound isoform Proteins 0.000 description 2
• 101000983583 Homo sapiens Procathepsin L Proteins 0.000 description 2
• 101000945496 Homo sapiens Proliferation marker protein Ki-67 Proteins 0.000 description 2
• 101000947115 Homo sapiens Protein CASC3 Proteins 0.000 description 2
• 101000761460 Homo sapiens Protein CASP Proteins 0.000 description 2
• 101000912957 Homo sapiens Protein DEK Proteins 0.000 description 2
• 101000979460 Homo sapiens Protein Niban 1 Proteins 0.000 description 2
• 101000597932 Homo sapiens Protein numb homolog Proteins 0.000 description 2
• 101000798007 Homo sapiens RAC-gamma serine/threonine-protein kinase Proteins 0.000 description 2
• 101001062222 Homo sapiens Receptor-binding cancer antigen expressed on SiSo cells Proteins 0.000 description 2
• 101001087372 Homo sapiens Securin Proteins 0.000 description 2
• 101000785063 Homo sapiens Serine-protein kinase ATM Proteins 0.000 description 2
• 101000664737 Homo sapiens Somatotropin Proteins 0.000 description 2
• 101000990915 Homo sapiens Stromelysin-1 Proteins 0.000 description 2
• 101000626125 Homo sapiens Tetranectin Proteins 0.000 description 2
• 101000891649 Homo sapiens Transcription elongation factor A protein-like 1 Proteins 0.000 description 2
• 101000701142 Homo sapiens Transcription factor ATOH1 Proteins 0.000 description 2
• 101000904152 Homo sapiens Transcription factor E2F1 Proteins 0.000 description 2
• 101000801254 Homo sapiens Tumor necrosis factor receptor superfamily member 16 Proteins 0.000 description 2
• 101000760337 Homo sapiens Urokinase plasminogen activator surface receptor Proteins 0.000 description 2
• 101000851018 Homo sapiens Vascular endothelial growth factor receptor 1 Proteins 0.000 description 2
• 101000818517 Homo sapiens Zinc-alpha-2-glycoprotein Proteins 0.000 description 2
• 206010020843 Hyperthermia Diseases 0.000 description 2
• 102100023915 Insulin Human genes 0.000 description 2
• 102100022708 Insulin-like growth factor-binding protein 3 Human genes 0.000 description 2
• 102100025323 Integrin alpha-1 Human genes 0.000 description 2
• 102100025305 Integrin alpha-2 Human genes 0.000 description 2
• 102100032817 Integrin alpha-5 Human genes 0.000 description 2
• 108010042918 Integrin alpha5beta1 Proteins 0.000 description 2
• 108010020950 Integrin beta3 Proteins 0.000 description 2
• 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 description 2
• 101710192051 Interferon alpha-1/13 Proteins 0.000 description 2
• 102100036714 Interferon alpha/beta receptor 1 Human genes 0.000 description 2
• 102100030126 Interferon regulatory factor 4 Human genes 0.000 description 2
• 102000000589 Interleukin-1 Human genes 0.000 description 2
• 108010002352 Interleukin-1 Proteins 0.000 description 2
• 102100020881 Interleukin-1 alpha Human genes 0.000 description 2
• 102100026016 Interleukin-1 receptor type 1 Human genes 0.000 description 2
• 102100026017 Interleukin-1 receptor type 2 Human genes 0.000 description 2
• 102100039068 Interleukin-10 Human genes 0.000 description 2
• 108090000174 Interleukin-10 Proteins 0.000 description 2
• 102100030694 Interleukin-11 Human genes 0.000 description 2
• 108090000176 Interleukin-13 Proteins 0.000 description 2
• 102000003812 Interleukin-15 Human genes 0.000 description 2
• 108090000172 Interleukin-15 Proteins 0.000 description 2
• 101800003050 Interleukin-16 Proteins 0.000 description 2
• 102000013691 Interleukin-17 Human genes 0.000 description 2
• 108050003558 Interleukin-17 Proteins 0.000 description 2
• 108090000171 Interleukin-18 Proteins 0.000 description 2
• 102100026879 Interleukin-2 receptor subunit beta Human genes 0.000 description 2
• 102100036671 Interleukin-24 Human genes 0.000 description 2
• 102000004388 Interleukin-4 Human genes 0.000 description 2
• 108090000978 Interleukin-4 Proteins 0.000 description 2
• 102100039897 Interleukin-5 Human genes 0.000 description 2
• 108010002616 Interleukin-5 Proteins 0.000 description 2
• 108090001005 Interleukin-6 Proteins 0.000 description 2
• 102100037795 Interleukin-6 receptor subunit beta Human genes 0.000 description 2
• 108010002335 Interleukin-9 Proteins 0.000 description 2
• 102000015696 Interleukins Human genes 0.000 description 2
• 108010063738 Interleukins Proteins 0.000 description 2
• 102100027613 Kallikrein-10 Human genes 0.000 description 2
• 102100027612 Kallikrein-11 Human genes 0.000 description 2
• 102100038301 Kallikrein-15 Human genes 0.000 description 2
• 102100034868 Kallikrein-5 Human genes 0.000 description 2
• 102100034867 Kallikrein-7 Human genes 0.000 description 2
• 208000027747 Kennedy disease Diseases 0.000 description 2
• 102100040445 Keratin, type I cytoskeletal 14 Human genes 0.000 description 2
• 102100020677 Krueppel-like factor 4 Human genes 0.000 description 2
• 102100020680 Krueppel-like factor 5 Human genes 0.000 description 2
• 239000005551 L01XE03 - Erlotinib Substances 0.000 description 2
• 229940125563 LAG3 inhibitor Drugs 0.000 description 2
• 102100036133 LIM/homeobox protein Lhx1 Human genes 0.000 description 2
• GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
• 102100030985 Legumain Human genes 0.000 description 2
• 102100032352 Leukemia inhibitory factor Human genes 0.000 description 2
• 108010000817 Leuprolide Proteins 0.000 description 2
• 102100027121 Low-density lipoprotein receptor-related protein 1B Human genes 0.000 description 2
• 108010091221 Lymphotoxin beta Receptor Proteins 0.000 description 2
• 108700012928 MAPK14 Proteins 0.000 description 2
• 229940124761 MMP inhibitor Drugs 0.000 description 2
• 102100027998 Macrophage metalloelastase Human genes 0.000 description 2
• 102100034184 Macrophage scavenger receptor types I and II Human genes 0.000 description 2
• 108700018351 Major Histocompatibility Complex Proteins 0.000 description 2
• 102100038884 Major vault protein Human genes 0.000 description 2
• 229930195725 Mannitol Natural products 0.000 description 2
• 101710087603 Mast/stem cell growth factor receptor Kit Proteins 0.000 description 2
• 102000000380 Matrix Metalloproteinase 1 Human genes 0.000 description 2
• 102000002274 Matrix Metalloproteinases Human genes 0.000 description 2
• 108010000684 Matrix Metalloproteinases Proteins 0.000 description 2
• 108090000560 Matrix metalloproteinase-15 Proteins 0.000 description 2
• 102100030412 Matrix metalloproteinase-9 Human genes 0.000 description 2
• 102100025075 Melanoma-associated antigen 6 Human genes 0.000 description 2
• 102100039475 Melanoma-associated antigen B5 Human genes 0.000 description 2
• 102100039483 Melanoma-associated antigen B6 Human genes 0.000 description 2
• 102100027247 Melanoma-associated antigen D1 Human genes 0.000 description 2
• 102100027159 Membrane primary amine oxidase Human genes 0.000 description 2
• 102100027240 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Human genes 0.000 description 2
• 101000761459 Mesocricetus auratus Calcium-dependent serine proteinase Proteins 0.000 description 2
• 102100029698 Metallothionein-1A Human genes 0.000 description 2
• 101710181812 Methionine aminopeptidase Proteins 0.000 description 2
• 102100027383 Methyl-CpG-binding domain protein 1 Human genes 0.000 description 2
• 102100021290 Methyl-CpG-binding domain protein 4 Human genes 0.000 description 2
• 102000016397 Methyltransferase Human genes 0.000 description 2
• 229930192392 Mitomycin Natural products 0.000 description 2
• 101100335081 Mus musculus Flt3 gene Proteins 0.000 description 2
• 108010026664 MutL Protein Homolog 1 Proteins 0.000 description 2
• 102100034670 Myb-related protein B Human genes 0.000 description 2
• 102100026784 Myelin proteolipid protein Human genes 0.000 description 2
• 102100032970 Myogenin Human genes 0.000 description 2
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 description 2
• 101710095135 NAD(P)H dehydrogenase [quinone] 1 Proteins 0.000 description 2
• 102100033153 NADH-cytochrome b5 reductase 3 Human genes 0.000 description 2
• 102000003729 Neprilysin Human genes 0.000 description 2
• 108090000028 Neprilysin Proteins 0.000 description 2
• 102100027347 Neural cell adhesion molecule 1 Human genes 0.000 description 2
• 102100025247 Neurogenic locus notch homolog protein 3 Human genes 0.000 description 2
• 102100030411 Neutrophil collagenase Human genes 0.000 description 2
• 102100024761 Neutrophil defensin 3 Human genes 0.000 description 2
• DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
• 102100033223 Nicotinamide phosphoribosyltransferase Human genes 0.000 description 2
• 102100022397 Nitric oxide synthase, brain Human genes 0.000 description 2
• 108010010424 Nuclear Factor 90 Proteins Proteins 0.000 description 2
• 102100023258 Nucleoside diphosphate kinase B Human genes 0.000 description 2
• 108091034117 Oligonucleotide Proteins 0.000 description 2
• 239000012271 PD-L1 inhibitor Substances 0.000 description 2
• 108091007960 PI3Ks Proteins 0.000 description 2
• 102100035591 POU domain, class 2, transcription factor 2 Human genes 0.000 description 2
• 102100026844 Pancreatic prohormone Human genes 0.000 description 2
• 102100036893 Parathyroid hormone Human genes 0.000 description 2
• 102100036978 Peptidyl-prolyl cis-trans isomerase FKBP8 Human genes 0.000 description 2
• 102100030940 Persulfide dioxygenase ETHE1, mitochondrial Human genes 0.000 description 2
• 102100026169 Phosphatidylinositol 3-kinase regulatory subunit alpha Human genes 0.000 description 2
• 102000003993 Phosphatidylinositol 3-kinases Human genes 0.000 description 2
• 108090000430 Phosphatidylinositol 3-kinases Proteins 0.000 description 2
• 102100036137 Phosphatidylinositol 5-phosphate 4-kinase type-2 beta Human genes 0.000 description 2
• 102000014750 Phosphorylase Kinase Human genes 0.000 description 2
• 108010064071 Phosphorylase Kinase Proteins 0.000 description 2
• 208000007913 Pituitary Neoplasms Diseases 0.000 description 2
• 102100030304 Platelet factor 4 Human genes 0.000 description 2
• 102000010780 Platelet-Derived Growth Factor Human genes 0.000 description 2
• 108010038512 Platelet-Derived Growth Factor Proteins 0.000 description 2
• 102100030485 Platelet-derived growth factor receptor alpha Human genes 0.000 description 2
• 102100026547 Platelet-derived growth factor receptor beta Human genes 0.000 description 2
• 102100039277 Pleiotrophin Human genes 0.000 description 2
• 239000002202 Polyethylene glycol Substances 0.000 description 2
• 102100033237 Pro-epidermal growth factor Human genes 0.000 description 2
• 102100026534 Procathepsin L Human genes 0.000 description 2
• 102100025803 Progesterone receptor Human genes 0.000 description 2
• 102100034836 Proliferation marker protein Ki-67 Human genes 0.000 description 2
• 108010037522 Promyelocytic Leukemia Protein Proteins 0.000 description 2
• 102100038277 Prostaglandin G/H synthase 1 Human genes 0.000 description 2
• 108090000459 Prostaglandin-endoperoxide synthases Proteins 0.000 description 2
• 102000004005 Prostaglandin-endoperoxide synthases Human genes 0.000 description 2
• 102100038358 Prostate-specific antigen Human genes 0.000 description 2
• 102100035703 Prostatic acid phosphatase Human genes 0.000 description 2
• 102100035601 Protein CASC3 Human genes 0.000 description 2
• 102100026113 Protein DEK Human genes 0.000 description 2
• 102000001253 Protein Kinase Human genes 0.000 description 2
• 108091008611 Protein Kinase B Proteins 0.000 description 2
• 102000003923 Protein Kinase C Human genes 0.000 description 2
• 108090000315 Protein Kinase C Proteins 0.000 description 2
• 102100023076 Protein Niban 1 Human genes 0.000 description 2
• 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 description 2
• 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 description 2
• 102100021557 Protein kinase C iota type Human genes 0.000 description 2
• 102100036985 Protein numb homolog Human genes 0.000 description 2
• 101710113459 RAC-alpha serine/threonine-protein kinase Proteins 0.000 description 2
• 102100032314 RAC-gamma serine/threonine-protein kinase Human genes 0.000 description 2
• 102100029986 Receptor tyrosine-protein kinase erbB-3 Human genes 0.000 description 2
• 102100029165 Receptor-binding cancer antigen expressed on SiSo cells Human genes 0.000 description 2
• 102100026436 Regulator of MON1-CCZ1 complex Human genes 0.000 description 2
• YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 description 2
• 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 description 2
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
• 108020004459 Small interfering RNA Proteins 0.000 description 2
• 208000005718 Stomach Neoplasms Diseases 0.000 description 2
• 102100030416 Stromelysin-1 Human genes 0.000 description 2
• 102100028848 Stromelysin-2 Human genes 0.000 description 2
• 102100028847 Stromelysin-3 Human genes 0.000 description 2
• 230000006044 T cell activation Effects 0.000 description 2
• 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 description 2
• 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 description 2
• 108010017842 Telomerase Proteins 0.000 description 2
• MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
• 102100024554 Tetranectin Human genes 0.000 description 2
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
• 239000000365 Topoisomerase I Inhibitor Substances 0.000 description 2
• 239000000317 Topoisomerase II Inhibitor Substances 0.000 description 2
• 102100029373 Transcription factor ATOH1 Human genes 0.000 description 2
• 102100024026 Transcription factor E2F1 Human genes 0.000 description 2
• 102100024689 Urokinase plasminogen activator surface receptor Human genes 0.000 description 2
• 102100031358 Urokinase-type plasminogen activator Human genes 0.000 description 2
• 108010073919 Vascular Endothelial Growth Factor D Proteins 0.000 description 2
• 108010053096 Vascular Endothelial Growth Factor Receptor-1 Proteins 0.000 description 2
• 102000016548 Vascular Endothelial Growth Factor Receptor-1 Human genes 0.000 description 2
• 108010053099 Vascular Endothelial Growth Factor Receptor-2 Proteins 0.000 description 2
• 108010053100 Vascular Endothelial Growth Factor Receptor-3 Proteins 0.000 description 2
• 102100033178 Vascular endothelial growth factor receptor 1 Human genes 0.000 description 2
• 229940122803 Vinca alkaloid Drugs 0.000 description 2
• 102100021144 Zinc-alpha-2-glycoprotein Human genes 0.000 description 2
• RJURFGZVJUQBHK-IIXSONLDSA-N actinomycin D Chemical compound C[C@H]1OC(=O)[C@H](C(C)C)N(C)C(=O)CN(C)C(=O)[C@@H]2CCCN2C(=O)[C@@H](C(C)C)NC(=O)[C@H]1NC(=O)C1=C(N)C(=O)C(C)=C2OC(C(C)=CC=C3C(=O)N[C@@H]4C(=O)N[C@@H](C(N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)=O)C(C)C)=C3N=C21 RJURFGZVJUQBHK-IIXSONLDSA-N 0.000 description 2
• 239000013543 active substance Substances 0.000 description 2
• 208000021841 acute erythroid leukemia Diseases 0.000 description 2
• 230000001780 adrenocortical effect Effects 0.000 description 2
• 239000000556 agonist Substances 0.000 description 2
• 229930013930 alkaloid Natural products 0.000 description 2
• JKOQGQFVAUAYPM-UHFFFAOYSA-N amifostine Chemical compound NCCCNCCSP(O)(O)=O JKOQGQFVAUAYPM-UHFFFAOYSA-N 0.000 description 2
• 229940024606 amino acid Drugs 0.000 description 2
• 235000001014 amino acid Nutrition 0.000 description 2
• 150000001413 amino acids Chemical class 0.000 description 2
• 229960003437 aminoglutethimide Drugs 0.000 description 2
• ROBVIMPUHSLWNV-UHFFFAOYSA-N aminoglutethimide Chemical compound C=1C=C(N)C=CC=1C1(CC)CCC(=O)NC1=O ROBVIMPUHSLWNV-UHFFFAOYSA-N 0.000 description 2
• 239000003242 anti bacterial agent Substances 0.000 description 2
• 230000001772 anti-angiogenic effect Effects 0.000 description 2
• 230000000259 anti-tumor effect Effects 0.000 description 2
• 229940088710 antibiotic agent Drugs 0.000 description 2
• 229940045719 antineoplastic alkylating agent nitrosoureas Drugs 0.000 description 2
• 239000003886 aromatase inhibitor Substances 0.000 description 2
• 201000000065 autosomal dominant auditory neuropathy 1 Diseases 0.000 description 2
• 229940120638 avastin Drugs 0.000 description 2
• 229960002756 azacitidine Drugs 0.000 description 2
• 239000002585 base Substances 0.000 description 2
• 230000008512 biological response Effects 0.000 description 2
• 229960000074 biopharmaceutical Drugs 0.000 description 2
• 150000004663 bisphosphonates Chemical class 0.000 description 2
• 229960001561 bleomycin Drugs 0.000 description 2
• OYVAGSVQBOHSSS-UAPAGMARSA-O bleomycin A2 Chemical compound N([C@H](C(=O)N[C@H](C)[C@@H](O)[C@H](C)C(=O)N[C@@H]([C@H](O)C)C(=O)NCCC=1SC=C(N=1)C=1SC=C(N=1)C(=O)NCCC[S+](C)C)[C@@H](O[C@H]1[C@H]([C@@H](O)[C@H](O)[C@H](CO)O1)O[C@@H]1[C@H]([C@@H](OC(N)=O)[C@H](O)[C@@H](CO)O1)O)C=1N=CNC=1)C(=O)C1=NC([C@H](CC(N)=O)NC[C@H](N)C(N)=O)=NC(N)=C1C OYVAGSVQBOHSSS-UAPAGMARSA-O 0.000 description 2
• 210000000988 bone and bone Anatomy 0.000 description 2
• 238000002725 brachytherapy Methods 0.000 description 2
• 229960005539 bryostatin 1 Drugs 0.000 description 2
• MJQUEDHRCUIRLF-TVIXENOKSA-N bryostatin 1 Chemical compound C([C@@H]1CC(/[C@@H]([C@@](C(C)(C)/C=C/2)(O)O1)OC(=O)/C=C/C=C/CCC)=C\C(=O)OC)[C@H]([C@@H](C)O)OC(=O)C[C@H](O)C[C@@H](O1)C[C@H](OC(C)=O)C(C)(C)[C@]1(O)C[C@@H]1C\C(=C\C(=O)OC)C[C@H]\2O1 MJQUEDHRCUIRLF-TVIXENOKSA-N 0.000 description 2
• 239000001506 calcium phosphate Substances 0.000 description 2
• 229940127093 camptothecin Drugs 0.000 description 2
• VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical compound C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 description 2
• 239000003560 cancer drug Substances 0.000 description 2
• 150000001720 carbohydrates Chemical class 0.000 description 2
• 239000001768 carboxy methyl cellulose Substances 0.000 description 2
• 229960005243 carmustine Drugs 0.000 description 2
• 210000000845 cartilage Anatomy 0.000 description 2
• 230000003197 catalytic effect Effects 0.000 description 2
• 230000022131 cell cycle Effects 0.000 description 2
• 235000010980 cellulose Nutrition 0.000 description 2
• 229920002678 cellulose Polymers 0.000 description 2
• 239000001913 cellulose Substances 0.000 description 2
• 229960005395 cetuximab Drugs 0.000 description 2
• 239000003153 chemical reaction reagent Substances 0.000 description 2
• 230000000973 chemotherapeutic effect Effects 0.000 description 2
• 229940044683 chemotherapy drug Drugs 0.000 description 2
• 229960002424 collagenase Drugs 0.000 description 2
• 230000000295 complement effect Effects 0.000 description 2
• VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 description 2
• UFULAYFCSOUIOV-UHFFFAOYSA-N cysteamine Chemical compound NCCS UFULAYFCSOUIOV-UHFFFAOYSA-N 0.000 description 2
• 230000001086 cytosolic effect Effects 0.000 description 2
• 229940127089 cytotoxic agent Drugs 0.000 description 2
• 229960003901 dacarbazine Drugs 0.000 description 2
• 229960000640 dactinomycin Drugs 0.000 description 2
• 229960003603 decitabine Drugs 0.000 description 2
• RGLYKWWBQGJZGM-ISLYRVAYSA-N diethylstilbestrol Chemical compound C=1C=C(O)C=CC=1C(/CC)=C(\CC)C1=CC=C(O)C=C1 RGLYKWWBQGJZGM-ISLYRVAYSA-N 0.000 description 2
• 239000001177 diphosphate Substances 0.000 description 2
• 235000011180 diphosphates Nutrition 0.000 description 2
• 208000035475 disorder Diseases 0.000 description 2
• VSJKWCGYPAHWDS-UHFFFAOYSA-N dl-camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)C5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-UHFFFAOYSA-N 0.000 description 2
• 239000002552 dosage form Substances 0.000 description 2
• 229960005167 everolimus Drugs 0.000 description 2
• 239000010685 fatty oil Substances 0.000 description 2
• 230000002349 favourable effect Effects 0.000 description 2
• 206010016629 fibroma Diseases 0.000 description 2
• GIUYCYHIANZCFB-FJFJXFQQSA-N fludarabine phosphate Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@@H]1O GIUYCYHIANZCFB-FJFJXFQQSA-N 0.000 description 2
• 238000009472 formulation Methods 0.000 description 2
• 206010017758 gastric cancer Diseases 0.000 description 2
• 210000004051 gastric juice Anatomy 0.000 description 2
• 239000000499 gel Substances 0.000 description 2
• QTQAWLPCGQOSGP-GBTDJJJQSA-N geldanamycin Chemical class N1C(=O)\C(C)=C/C=C\[C@@H](OC)[C@H](OC(N)=O)\C(C)=C/[C@@H](C)[C@@H](O)[C@H](OC)C[C@@H](C)CC2=C(OC)C(=O)C=C1C2=O QTQAWLPCGQOSGP-GBTDJJJQSA-N 0.000 description 2
• SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 description 2
• 229960005277 gemcitabine Drugs 0.000 description 2
• 102000034356 gene-regulatory proteins Human genes 0.000 description 2
• 108091006104 gene-regulatory proteins Proteins 0.000 description 2
• 229960001442 gonadorelin Drugs 0.000 description 2
• QBKSWRVVCFFDOT-UHFFFAOYSA-N gossypol Chemical compound CC(C)C1=C(O)C(O)=C(C=O)C2=C(O)C(C=3C(O)=C4C(C=O)=C(O)C(O)=C(C4=CC=3C)C(C)C)=C(C)C=C21 QBKSWRVVCFFDOT-UHFFFAOYSA-N 0.000 description 2
• 239000008187 granular material Substances 0.000 description 2
• 239000003481 heat shock protein 90 inhibitor Substances 0.000 description 2
• 201000001657 hereditary nonpolyposis colorectal cancer type 2 Diseases 0.000 description 2
• 229940088597 hormone Drugs 0.000 description 2
• 239000005556 hormone Substances 0.000 description 2
• 229930195733 hydrocarbon Natural products 0.000 description 2
• 150000002430 hydrocarbons Chemical class 0.000 description 2
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 description 2
• XXSMGPRMXLTPCZ-UHFFFAOYSA-N hydroxychloroquine Chemical compound ClC1=CC=C2C(NC(C)CCCN(CCO)CC)=CC=NC2=C1 XXSMGPRMXLTPCZ-UHFFFAOYSA-N 0.000 description 2
• 206010020718 hyperplasia Diseases 0.000 description 2
• 230000036031 hyperthermia Effects 0.000 description 2
• 229960001101 ifosfamide Drugs 0.000 description 2
• HOMGKSMUEGBAAB-UHFFFAOYSA-N ifosfamide Chemical compound ClCCNP1(=O)OCCCN1CCCl HOMGKSMUEGBAAB-UHFFFAOYSA-N 0.000 description 2
• 108010008429 immunoglobulin-binding factors Proteins 0.000 description 2
• 239000000367 immunologic factor Substances 0.000 description 2
• 229940051026 immunotoxin Drugs 0.000 description 2
• 239000002596 immunotoxin Substances 0.000 description 2
• 230000002637 immunotoxin Effects 0.000 description 2
• 231100000608 immunotoxin Toxicity 0.000 description 2
• 229950009034 indoximod Drugs 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 230000003993 interaction Effects 0.000 description 2
• 208000020082 intraepithelial neoplasia Diseases 0.000 description 2
• 238000007913 intrathecal administration Methods 0.000 description 2
• 229960004768 irinotecan Drugs 0.000 description 2
• 229960002014 ixabepilone Drugs 0.000 description 2
• FABUFPQFXZVHFB-CFWQTKTJSA-N ixabepilone Chemical compound C/C([C@@H]1C[C@@H]2O[C@]2(C)CCC[C@@H]([C@@H]([C@H](C)C(=O)C(C)(C)[C@H](O)CC(=O)N1)O)C)=C\C1=CSC(C)=N1 FABUFPQFXZVHFB-CFWQTKTJSA-N 0.000 description 2
• 108010024383 kallikrein 4 Proteins 0.000 description 2
• 210000003734 kidney Anatomy 0.000 description 2
• 239000008101 lactose Substances 0.000 description 2
• 229960001375 lactose Drugs 0.000 description 2
• BCFGMOOMADDAQU-UHFFFAOYSA-N lapatinib Chemical compound O1C(CNCCS(=O)(=O)C)=CC=C1C1=CC=C(N=CN=C2NC=3C=C(Cl)C(OCC=4C=C(F)C=CC=4)=CC=3)C2=C1 BCFGMOOMADDAQU-UHFFFAOYSA-N 0.000 description 2
• GFIJNRVAKGFPGQ-LIJARHBVSA-N leuprolide Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 GFIJNRVAKGFPGQ-LIJARHBVSA-N 0.000 description 2
• 229960004338 leuprorelin Drugs 0.000 description 2
• 239000007788 liquid Substances 0.000 description 2
• 229960002247 lomustine Drugs 0.000 description 2
• DHMTURDWPRKSOA-RUZDIDTESA-N lonafarnib Chemical compound C1CN(C(=O)N)CCC1CC(=O)N1CCC([C@@H]2C3=C(Br)C=C(Cl)C=C3CCC3=CC(Br)=CN=C32)CC1 DHMTURDWPRKSOA-RUZDIDTESA-N 0.000 description 2
• 229950001750 lonafarnib Drugs 0.000 description 2
• 210000004072 lung Anatomy 0.000 description 2
• 230000000527 lymphocytic effect Effects 0.000 description 2
• 229940124302 mTOR inhibitor Drugs 0.000 description 2
• 238000012423 maintenance Methods 0.000 description 2
• 230000007257 malfunction Effects 0.000 description 2
• 230000003211 malignant effect Effects 0.000 description 2
• 239000003628 mammalian target of rapamycin inhibitor Substances 0.000 description 2
• 239000000594 mannitol Substances 0.000 description 2
• 235000010355 mannitol Nutrition 0.000 description 2
• 208000023356 medullary thyroid gland carcinoma Diseases 0.000 description 2
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 description 2
• 229960001924 melphalan Drugs 0.000 description 2
• 206010027191 meningioma Diseases 0.000 description 2
• CFCUWKMKBJTWLW-BKHRDMLASA-N mithramycin Chemical compound O([C@@H]1C[C@@H](O[C@H](C)[C@H]1O)OC=1C=C2C=C3C[C@H]([C@@H](C(=O)C3=C(O)C2=C(O)C=1C)O[C@@H]1O[C@H](C)[C@@H](O)[C@H](O[C@@H]2O[C@H](C)[C@H](O)[C@H](O[C@@H]3O[C@H](C)[C@@H](O)[C@@](C)(O)C3)C2)C1)[C@H](OC)C(=O)[C@@H](O)[C@@H](C)O)[C@H]1C[C@@H](O)[C@H](O)[C@@H](C)O1 CFCUWKMKBJTWLW-BKHRDMLASA-N 0.000 description 2
• HDZGCSFEDULWCS-UHFFFAOYSA-N monomethylhydrazine Chemical class CNN HDZGCSFEDULWCS-UHFFFAOYSA-N 0.000 description 2
• 239000002324 mouth wash Substances 0.000 description 2
• 201000005962 mycosis fungoides Diseases 0.000 description 2
• XGXNTJHZPBRBHJ-UHFFFAOYSA-N n-phenylpyrimidin-2-amine Chemical class N=1C=CC=NC=1NC1=CC=CC=C1 XGXNTJHZPBRBHJ-UHFFFAOYSA-N 0.000 description 2
• 208000027831 neuroepithelial neoplasm Diseases 0.000 description 2
• OSTGTTZJOCZWJG-UHFFFAOYSA-N nitrosourea Chemical compound NC(=O)N=NO OSTGTTZJOCZWJG-UHFFFAOYSA-N 0.000 description 2
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 2
• 102000039446 nucleic acids Human genes 0.000 description 2
• 108020004707 nucleic acids Proteins 0.000 description 2
• 150000007523 nucleic acids Chemical class 0.000 description 2
• 239000002777 nucleoside Substances 0.000 description 2
• 230000002246 oncogenic effect Effects 0.000 description 2
• 230000000174 oncolytic effect Effects 0.000 description 2
• 201000008968 osteosarcoma Diseases 0.000 description 2
• DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 description 2
• 229960001756 oxaliplatin Drugs 0.000 description 2
• HFHZKZSRXITVMK-UHFFFAOYSA-N oxyphenbutazone Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=C(O)C=C1 HFHZKZSRXITVMK-UHFFFAOYSA-N 0.000 description 2
• 239000012188 paraffin wax Substances 0.000 description 2
• 238000007911 parenteral administration Methods 0.000 description 2
• 229940121656 pd-l1 inhibitor Drugs 0.000 description 2
• WVUNYSQLFKLYNI-AATRIKPKSA-N pelitinib Chemical compound C=12C=C(NC(=O)\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC1=CC=C(F)C(Cl)=C1 WVUNYSQLFKLYNI-AATRIKPKSA-N 0.000 description 2
• 229960005079 pemetrexed Drugs 0.000 description 2
• WBXPDJSOTKVWSJ-ZDUSSCGKSA-L pemetrexed(2-) Chemical compound C=1NC=2NC(N)=NC(=O)C=2C=1CCC1=CC=C(C(=O)N[C@@H](CCC([O-])=O)C([O-])=O)C=C1 WBXPDJSOTKVWSJ-ZDUSSCGKSA-L 0.000 description 2
• 229960002340 pentostatin Drugs 0.000 description 2
• 239000003614 peroxisome proliferator Substances 0.000 description 2
• 229940124531 pharmaceutical excipient Drugs 0.000 description 2
• VYMDGNCVAMGZFE-UHFFFAOYSA-N phenylbutazonum Chemical compound O=C1C(CCCC)C(=O)N(C=2C=CC=CC=2)N1C1=CC=CC=C1 VYMDGNCVAMGZFE-UHFFFAOYSA-N 0.000 description 2
• ULSIYEODSMZIPX-UHFFFAOYSA-N phenylethanolamine Chemical compound NCC(O)C1=CC=CC=C1 ULSIYEODSMZIPX-UHFFFAOYSA-N 0.000 description 2
• HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 2
• 229960003171 plicamycin Drugs 0.000 description 2
• 108010056274 polo-like kinase 1 Proteins 0.000 description 2
• 239000002243 precursor Substances 0.000 description 2
• OIGNJSKKLXVSLS-VWUMJDOOSA-N prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 description 2
• 229960004618 prednisone Drugs 0.000 description 2
• CPTBDICYNRMXFX-UHFFFAOYSA-N procarbazine Chemical compound CNNCC1=CC=C(C(=O)NC(C)C)C=C1 CPTBDICYNRMXFX-UHFFFAOYSA-N 0.000 description 2
• 239000000047 product Substances 0.000 description 2
• 150000003180 prostaglandins Chemical class 0.000 description 2
• 210000002307 prostate Anatomy 0.000 description 2
• 108020003519 protein disulfide isomerase Proteins 0.000 description 2
• 239000003528 protein farnesyltransferase inhibitor Substances 0.000 description 2
• 108060006633 protein kinase Proteins 0.000 description 2
• NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical compound CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 description 2
• ZADWXFSZEAPBJS-UHFFFAOYSA-N racemic N-methyl tryptophan Natural products C1=CC=C2N(C)C=C(CC(N)C(O)=O)C2=C1 ZADWXFSZEAPBJS-UHFFFAOYSA-N 0.000 description 2
• 230000003537 radioprotector Effects 0.000 description 2
• 229960004622 raloxifene Drugs 0.000 description 2
• GZUITABIAKMVPG-UHFFFAOYSA-N raloxifene Chemical compound C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 GZUITABIAKMVPG-UHFFFAOYSA-N 0.000 description 2
• 102000027426 receptor tyrosine kinases Human genes 0.000 description 2
• 108091008598 receptor tyrosine kinases Proteins 0.000 description 2
• 230000008439 repair process Effects 0.000 description 2
• 238000012552 review Methods 0.000 description 2
• 201000009410 rhabdomyosarcoma Diseases 0.000 description 2
• 229950009213 rubitecan Drugs 0.000 description 2
• 229960003440 semustine Drugs 0.000 description 2
• 230000035939 shock Effects 0.000 description 2
• 210000003491 skin Anatomy 0.000 description 2
• 239000002904 solvent Substances 0.000 description 2
• 206010041823 squamous cell carcinoma Diseases 0.000 description 2
• 150000003431 steroids Chemical class 0.000 description 2
• 201000011549 stomach cancer Diseases 0.000 description 2
• 229960001052 streptozocin Drugs 0.000 description 2
• ZSJLQEPLLKMAKR-GKHCUFPYSA-N streptozocin Chemical compound O=NN(C)C(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O ZSJLQEPLLKMAKR-GKHCUFPYSA-N 0.000 description 2
• WINHZLLDWRZWRT-ATVHPVEESA-N sunitinib Chemical compound CCN(CC)CCNC(=O)C1=C(C)NC(\C=C/2C3=CC(F)=CC=C3NC\2=O)=C1C WINHZLLDWRZWRT-ATVHPVEESA-N 0.000 description 2
• 239000000829 suppository Substances 0.000 description 2
• 239000002511 suppository base Substances 0.000 description 2
• 230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 2
• 208000024891 symptom Diseases 0.000 description 2
• 229960001603 tamoxifen Drugs 0.000 description 2
• 239000003277 telomerase inhibitor Substances 0.000 description 2
• 229960003433 thalidomide Drugs 0.000 description 2
• 208000008732 thymoma Diseases 0.000 description 2
• 229950009158 tipifarnib Drugs 0.000 description 2
• 231100000419 toxicity Toxicity 0.000 description 2
• 230000001988 toxicity Effects 0.000 description 2
• 239000003053 toxin Substances 0.000 description 2
• 231100000765 toxin Toxicity 0.000 description 2
• 108700012359 toxins Proteins 0.000 description 2
• PKVRCIRHQMSYJX-AIFWHQITSA-N trabectedin Chemical compound C([C@@]1(C(OC2)=O)NCCC3=C1C=C(C(=C3)O)OC)S[C@@H]1C3=C(OC(C)=O)C(C)=C4OCOC4=C3[C@H]2N2[C@@H](O)[C@H](CC=3C4=C(O)C(OC)=C(C)C=3)N(C)[C@H]4[C@@H]21 PKVRCIRHQMSYJX-AIFWHQITSA-N 0.000 description 2
• 229960000977 trabectedin Drugs 0.000 description 2
• QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical class [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 2
• 241000701161 unidentified adenovirus Species 0.000 description 2
• 208000023747 urothelial carcinoma Diseases 0.000 description 2
• 229960000653 valrubicin Drugs 0.000 description 2
• ZOCKGBMQLCSHFP-KQRAQHLDSA-N valrubicin Chemical compound O([C@H]1C[C@](CC2=C(O)C=3C(=O)C4=CC=CC(OC)=C4C(=O)C=3C(O)=C21)(O)C(=O)COC(=O)CCCC)[C@H]1C[C@H](NC(=O)C(F)(F)F)[C@H](O)[C@H](C)O1 ZOCKGBMQLCSHFP-KQRAQHLDSA-N 0.000 description 2
• 229960000241 vandetanib Drugs 0.000 description 2
• UHTHHESEBZOYNR-UHFFFAOYSA-N vandetanib Chemical compound COC1=CC(C(/N=CN2)=N/C=3C(=CC(Br)=CC=3)F)=C2C=C1OCC1CCN(C)CC1 UHTHHESEBZOYNR-UHFFFAOYSA-N 0.000 description 2
• 229960003048 vinblastine Drugs 0.000 description 2
• 230000003442 weekly effect Effects 0.000 description 2
• DNXHEGUUPJUMQT-UHFFFAOYSA-N (+)-estrone Natural products OC1=CC=C2C3CCC(C)(C(CC4)=O)C4C3CCC2=C1 DNXHEGUUPJUMQT-UHFFFAOYSA-N 0.000 description 1
• HBUBKKRHXORPQB-FJFJXFQQSA-N (2R,3S,4S,5R)-2-(6-amino-2-fluoro-9-purinyl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC(F)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1O HBUBKKRHXORPQB-FJFJXFQQSA-N 0.000 description 1
• XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 description 1
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
• MMHDBUJXLOFTLC-WOYTXXSLSA-N (2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2s)-1-acetylpyrrolidine-2-carbonyl]amino]-3-(1h-imidazol-5-yl)propanoyl]amino]-3-hydroxypropanoyl]amino]-3-sulfanylpropanoyl]amino]butanediamide Chemical compound CC(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(N)=O)CC1=CN=CN1 MMHDBUJXLOFTLC-WOYTXXSLSA-N 0.000 description 1
• NECZZOFFLFZNHL-XVGZVFJZSA-N (2s)-2-amino-5-[[(2r)-3-[2-[bis[bis(2-chloroethyl)amino]-oxidophosphaniumyl]oxyethylsulfonyl]-1-[[(r)-carboxy(phenyl)methyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid;hydron;chloride Chemical compound Cl.ClCCN(CCCl)P(=O)(N(CCCl)CCCl)OCCS(=O)(=O)C[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)N[C@@H](C(O)=O)C1=CC=CC=C1 NECZZOFFLFZNHL-XVGZVFJZSA-N 0.000 description 1
• MHFUWOIXNMZFIW-WNQIDUERSA-N (2s)-2-hydroxypropanoic acid;n-[4-[4-(4-methylpiperazin-1-yl)-6-[(5-methyl-1h-pyrazol-3-yl)amino]pyrimidin-2-yl]sulfanylphenyl]cyclopropanecarboxamide Chemical compound C[C@H](O)C(O)=O.C1CN(C)CCN1C1=CC(NC2=NNC(C)=C2)=NC(SC=2C=CC(NC(=O)C3CC3)=CC=2)=N1 MHFUWOIXNMZFIW-WNQIDUERSA-N 0.000 description 1
• PSVUJBVBCOISSP-SPFKKGSWSA-N (2s,3r,4s,5s,6r)-2-bis(2-chloroethylamino)phosphoryloxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound OC[C@H]1O[C@@H](OP(=O)(NCCCl)NCCCl)[C@H](O)[C@@H](O)[C@@H]1O PSVUJBVBCOISSP-SPFKKGSWSA-N 0.000 description 1
• DEQANNDTNATYII-OULOTJBUSA-N (4r,7s,10s,13r,16s,19r)-10-(4-aminobutyl)-19-[[(2r)-2-amino-3-phenylpropanoyl]amino]-16-benzyl-n-[(2r,3r)-1,3-dihydroxybutan-2-yl]-7-[(1r)-1-hydroxyethyl]-13-(1h-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carboxa Chemical compound C([C@@H](N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC=2C3=CC=CC=C3NC=2)NC(=O)[C@H](CC=2C=CC=CC=2)NC1=O)C(=O)N[C@H](CO)[C@H](O)C)C1=CC=CC=C1 DEQANNDTNATYII-OULOTJBUSA-N 0.000 description 1
• ZGNLFUXWZJGETL-YUSKDDKASA-N (Z)-[(2S)-2-amino-2-carboxyethyl]-hydroxyimino-oxidoazanium Chemical compound N[C@@H](C\[N+]([O-])=N\O)C(O)=O ZGNLFUXWZJGETL-YUSKDDKASA-N 0.000 description 1
• GSQOBTOAOGXIFL-LFIBNONCSA-N (e)-2-cyano-3-(3,4-dihydroxyphenyl)-n-(3-phenylpropyl)prop-2-enamide Chemical compound C1=C(O)C(O)=CC=C1\C=C(/C#N)C(=O)NCCCC1=CC=CC=C1 GSQOBTOAOGXIFL-LFIBNONCSA-N 0.000 description 1
• GWCNJMUSWLTSCW-SFQUDFHCSA-N (e)-2-cyano-3-(3,4-dihydroxyphenyl)-n-(4-phenylbutyl)prop-2-enamide Chemical compound C1=C(O)C(O)=CC=C1\C=C(/C#N)C(=O)NCCCCC1=CC=CC=C1 GWCNJMUSWLTSCW-SFQUDFHCSA-N 0.000 description 1
• 101150084750 1 gene Proteins 0.000 description 1
• PVCULFYROUOVGJ-UHFFFAOYSA-N 1-[2-chloroethyl(methylsulfonyl)amino]-3-methyl-1-methylsulfonylurea Chemical compound CNC(=O)N(S(C)(=O)=O)N(S(C)(=O)=O)CCCl PVCULFYROUOVGJ-UHFFFAOYSA-N 0.000 description 1
• BJHCYTJNPVGSBZ-YXSASFKJSA-N 1-[4-[6-amino-5-[(Z)-methoxyiminomethyl]pyrimidin-4-yl]oxy-2-chlorophenyl]-3-ethylurea Chemical compound CCNC(=O)Nc1ccc(Oc2ncnc(N)c2\C=N/OC)cc1Cl BJHCYTJNPVGSBZ-YXSASFKJSA-N 0.000 description 1
• 102100025573 1-alkyl-2-acetylglycerophosphocholine esterase Human genes 0.000 description 1
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
• BNZPFJBUHRBLNB-UHFFFAOYSA-N 1-oxido-1,2,4-benzotriazin-1-ium Chemical class C1=CC=C2[N+]([O-])=NC=NC2=C1 BNZPFJBUHRBLNB-UHFFFAOYSA-N 0.000 description 1
• 102100024341 10 kDa heat shock protein, mitochondrial Human genes 0.000 description 1
• SDWMVMBAKVYNMX-UHFFFAOYSA-N 11-(4-bromophenyl)-9-piperidin-1-ylnaphtho[2,1-b][1,10]phenanthroline-8-carbonitrile Chemical compound BrC1=CC=C(C=C1)C1=C2C=CC3=NC=4C=5N=CC=CC=5C=CC=4C=C3C2=C(C(=C1)N1CCCCC1)C#N SDWMVMBAKVYNMX-UHFFFAOYSA-N 0.000 description 1
• ZESRJSPZRDMNHY-YFWFAHHUSA-N 11-deoxycorticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 ZESRJSPZRDMNHY-YFWFAHHUSA-N 0.000 description 1
• WHBHBVVOGNECLV-OBQKJFGGSA-N 11-deoxycortisol Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 WHBHBVVOGNECLV-OBQKJFGGSA-N 0.000 description 1
• 102100030489 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Human genes 0.000 description 1
• 101710141733 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Proteins 0.000 description 1
• BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
• DBPWSSGDRRHUNT-CEGNMAFCSA-N 17α-hydroxyprogesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2 DBPWSSGDRRHUNT-CEGNMAFCSA-N 0.000 description 1
• PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical class NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 description 1
• VTJXFTPMFYAJJU-UHFFFAOYSA-N 2-[(3,4-dihydroxyphenyl)methylidene]propanedinitrile Chemical compound OC1=CC=C(C=C(C#N)C#N)C=C1O VTJXFTPMFYAJJU-UHFFFAOYSA-N 0.000 description 1
• KRQUFUKTQHISJB-YYADALCUSA-N 2-[(E)-N-[2-(4-chlorophenoxy)propoxy]-C-propylcarbonimidoyl]-3-hydroxy-5-(thian-3-yl)cyclohex-2-en-1-one Chemical compound CCC\C(=N/OCC(C)OC1=CC=C(Cl)C=C1)C1=C(O)CC(CC1=O)C1CCCSC1 KRQUFUKTQHISJB-YYADALCUSA-N 0.000 description 1
• LKBXWNYXDMSFQU-ONNFQVAWSA-N 2-[2-[4-[[(e)-3-(4-bromophenyl)prop-2-enoyl]amino]-3-fluorophenyl]-1,3-benzoxazol-5-yl]acetic acid Chemical compound N=1C2=CC(CC(=O)O)=CC=C2OC=1C(C=C1F)=CC=C1NC(=O)\C=C\C1=CC=C(Br)C=C1 LKBXWNYXDMSFQU-ONNFQVAWSA-N 0.000 description 1
• OXURYBANZVUSFY-UHFFFAOYSA-N 2-[3-(diaminomethylideneamino)propyl]butanedioic acid Chemical compound NC(N)=NCCCC(C(O)=O)CC(O)=O OXURYBANZVUSFY-UHFFFAOYSA-N 0.000 description 1
• RTQWWZBSTRGEAV-PKHIMPSTSA-N 2-[[(2s)-2-[bis(carboxymethyl)amino]-3-[4-(methylcarbamoylamino)phenyl]propyl]-[2-[bis(carboxymethyl)amino]propyl]amino]acetic acid Chemical compound CNC(=O)NC1=CC=C(C[C@@H](CN(CC(C)N(CC(O)=O)CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O)C=C1 RTQWWZBSTRGEAV-PKHIMPSTSA-N 0.000 description 1
• FSPQCTGGIANIJZ-UHFFFAOYSA-N 2-[[(3,4-dimethoxyphenyl)-oxomethyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide Chemical compound C1=C(OC)C(OC)=CC=C1C(=O)NC1=C(C(N)=O)C(CCCC2)=C2S1 FSPQCTGGIANIJZ-UHFFFAOYSA-N 0.000 description 1
• 125000005999 2-bromoethyl group Chemical group 0.000 description 1
• HZLCGUXUOFWCCN-UHFFFAOYSA-N 2-hydroxynonadecane-1,2,3-tricarboxylic acid Chemical compound CCCCCCCCCCCCCCCCC(C(O)=O)C(O)(C(O)=O)CC(O)=O HZLCGUXUOFWCCN-UHFFFAOYSA-N 0.000 description 1
• CTRPRMNBTVRDFH-UHFFFAOYSA-N 2-n-methyl-1,3,5-triazine-2,4,6-triamine Chemical class CNC1=NC(N)=NC(N)=N1 CTRPRMNBTVRDFH-UHFFFAOYSA-N 0.000 description 1
• FTBBGQKRYUTLMP-UHFFFAOYSA-N 2-nitro-1h-pyrrole Chemical class [O-][N+](=O)C1=CC=CN1 FTBBGQKRYUTLMP-UHFFFAOYSA-N 0.000 description 1
• YZEUHQHUFTYLPH-UHFFFAOYSA-N 2-nitroimidazole Chemical compound [O-][N+](=O)C1=NC=CN1 YZEUHQHUFTYLPH-UHFFFAOYSA-N 0.000 description 1
• 150000004959 2-nitroimidazoles Chemical class 0.000 description 1
• NDMPLJNOPCLANR-UHFFFAOYSA-N 3,4-dihydroxy-15-(4-hydroxy-18-methoxycarbonyl-5,18-seco-ibogamin-18-yl)-16-methoxy-1-methyl-6,7-didehydro-aspidospermidine-3-carboxylic acid methyl ester Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 NDMPLJNOPCLANR-UHFFFAOYSA-N 0.000 description 1
• AXRCEOKUDYDWLF-UHFFFAOYSA-N 3-(1-methyl-3-indolyl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-3-indolyl]pyrrole-2,5-dione Chemical compound C12=CC=CC=C2N(C)C=C1C(C(NC1=O)=O)=C1C(C1=CC=CC=C11)=CN1C(CC1)CCN1CC1=CC=CC=N1 AXRCEOKUDYDWLF-UHFFFAOYSA-N 0.000 description 1
• TVZRAEYQIKYCPH-UHFFFAOYSA-N 3-(trimethylsilyl)propane-1-sulfonic acid Chemical compound C[Si](C)(C)CCCS(O)(=O)=O TVZRAEYQIKYCPH-UHFFFAOYSA-N 0.000 description 1
• UZFPOOOQHWICKY-UHFFFAOYSA-N 3-[13-[1-[1-[8,12-bis(2-carboxyethyl)-17-(1-hydroxyethyl)-3,7,13,18-tetramethyl-21,24-dihydroporphyrin-2-yl]ethoxy]ethyl]-18-(2-carboxyethyl)-8-(1-hydroxyethyl)-3,7,12,17-tetramethyl-22,23-dihydroporphyrin-2-yl]propanoic acid Chemical compound N1C(C=C2C(=C(CCC(O)=O)C(C=C3C(=C(C)C(C=C4N5)=N3)CCC(O)=O)=N2)C)=C(C)C(C(C)O)=C1C=C5C(C)=C4C(C)OC(C)C1=C(N2)C=C(N3)C(C)=C(C(O)C)C3=CC(C(C)=C3CCC(O)=O)=NC3=CC(C(CCC(O)=O)=C3C)=NC3=CC2=C1C UZFPOOOQHWICKY-UHFFFAOYSA-N 0.000 description 1
• CCRNCEKMSVYFLU-UHFFFAOYSA-N 4,5-dinitro-1h-imidazole Chemical class [O-][N+](=O)C=1N=CNC=1[N+]([O-])=O CCRNCEKMSVYFLU-UHFFFAOYSA-N 0.000 description 1
• CLPFFLWZZBQMAO-UHFFFAOYSA-N 4-(5,6,7,8-tetrahydroimidazo[1,5-a]pyridin-5-yl)benzonitrile Chemical compound C1=CC(C#N)=CC=C1C1N2C=NC=C2CCC1 CLPFFLWZZBQMAO-UHFFFAOYSA-N 0.000 description 1
• AKJHMTWEGVYYSE-AIRMAKDCSA-N 4-HPR Chemical compound C=1C=C(O)C=CC=1NC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C AKJHMTWEGVYYSE-AIRMAKDCSA-N 0.000 description 1
• QSFREBZMBNRGOK-UHFFFAOYSA-N 4-[(2,5-dihydroxyphenyl)methylamino]benzoic acid methyl ester Chemical compound C1=CC(C(=O)OC)=CC=C1NCC1=CC(O)=CC=C1O QSFREBZMBNRGOK-UHFFFAOYSA-N 0.000 description 1
• BKTRENAPTCBBFA-UHFFFAOYSA-N 4-[2-(4-hydroxy-3-phenylphenyl)propan-2-yl]-2-phenylphenol Chemical compound C=1C=C(O)C(C=2C=CC=CC=2)=CC=1C(C)(C)C(C=1)=CC=C(O)C=1C1=CC=CC=C1 BKTRENAPTCBBFA-UHFFFAOYSA-N 0.000 description 1
• ROMPPAWVATWIKR-UHFFFAOYSA-N 4-[3-(4-chlorophenyl)-1,2,4-oxadiazol-5-yl]butanoic acid Chemical compound O1C(CCCC(=O)O)=NC(C=2C=CC(Cl)=CC=2)=N1 ROMPPAWVATWIKR-UHFFFAOYSA-N 0.000 description 1
• LTZZZXXIKHHTMO-UHFFFAOYSA-N 4-[[4-fluoro-3-[4-(4-fluorobenzoyl)piperazine-1-carbonyl]phenyl]methyl]-2H-phthalazin-1-one Chemical compound FC1=C(C=C(CC2=NNC(C3=CC=CC=C23)=O)C=C1)C(=O)N1CCN(CC1)C(C1=CC=C(C=C1)F)=O LTZZZXXIKHHTMO-UHFFFAOYSA-N 0.000 description 1
• NMUSYJAQQFHJEW-UHFFFAOYSA-N 5-Azacytidine Natural products O=C1N=C(N)N=CN1C1C(O)C(O)C(CO)O1 NMUSYJAQQFHJEW-UHFFFAOYSA-N 0.000 description 1
• DQOGWKZQQBYYMW-LQGIGNHCSA-N 5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline-2,4-diamine;(2s,3s,4s,5r,6s)-3,4,5,6-tetrahydroxyoxane-2-carboxylic acid Chemical compound O[C@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O.COC1=C(OC)C(OC)=CC(NCC=2C(=C3C(N)=NC(N)=NC3=CC=2)C)=C1 DQOGWKZQQBYYMW-LQGIGNHCSA-N 0.000 description 1
• KUEFXPHXHHANKS-UHFFFAOYSA-N 5-nitro-1h-1,2,4-triazole Chemical compound [O-][N+](=O)C1=NC=NN1 KUEFXPHXHHANKS-UHFFFAOYSA-N 0.000 description 1
• PBCZSGKMGDDXIJ-HQCWYSJUSA-N 7-hydroxystaurosporine Chemical compound N([C@H](O)C1=C2C3=CC=CC=C3N3C2=C24)C(=O)C1=C2C1=CC=CC=C1N4[C@H]1C[C@@H](NC)[C@@H](OC)[C@]3(C)O1 PBCZSGKMGDDXIJ-HQCWYSJUSA-N 0.000 description 1
• HFDKKNHCYWNNNQ-YOGANYHLSA-N 75976-10-2 Chemical compound C([C@@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@@H](NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C1=CC=C(O)C=C1 HFDKKNHCYWNNNQ-YOGANYHLSA-N 0.000 description 1
• PBCZSGKMGDDXIJ-UHFFFAOYSA-N 7beta-hydroxystaurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3C(O)NC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 PBCZSGKMGDDXIJ-UHFFFAOYSA-N 0.000 description 1
• JJTNLWSCFYERCK-UHFFFAOYSA-N 7h-pyrrolo[2,3-d]pyrimidine Chemical class N1=CN=C2NC=CC2=C1 JJTNLWSCFYERCK-UHFFFAOYSA-N 0.000 description 1
• 101710100366 A disintegrin and metalloproteinase with thrombospondin motifs 2 Proteins 0.000 description 1
• 101710100373 A disintegrin and metalloproteinase with thrombospondin motifs 4 Proteins 0.000 description 1
• 101710100374 A disintegrin and metalloproteinase with thrombospondin motifs 5 Proteins 0.000 description 1
• 101710100385 A disintegrin and metalloproteinase with thrombospondin motifs 8 Proteins 0.000 description 1
• 102100033824 A-kinase anchor protein 12 Human genes 0.000 description 1
• 108091005660 ADAMTS1 Proteins 0.000 description 1
• 108091005661 ADAMTS3 Proteins 0.000 description 1
• 108091005664 ADAMTS4 Proteins 0.000 description 1
• 108091005663 ADAMTS5 Proteins 0.000 description 1
• 102000009062 ADP Ribose Transferases Human genes 0.000 description 1
• 108010049290 ADP Ribose Transferases Proteins 0.000 description 1
• 102100031585 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Human genes 0.000 description 1
• 208000030507 AIDS Diseases 0.000 description 1
• 101710168331 ALK tyrosine kinase receptor Proteins 0.000 description 1
• 108010038861 ARG tyrosine kinase Proteins 0.000 description 1
• 244000215068 Acacia senegal Species 0.000 description 1
• 208000007876 Acrospiroma Diseases 0.000 description 1
• 101710111216 Activated RNA polymerase II transcriptional coactivator p15 Proteins 0.000 description 1
• 102100027647 Activin receptor type-2B Human genes 0.000 description 1
• 206010000830 Acute leukaemia Diseases 0.000 description 1
• 208000024893 Acute lymphoblastic leukemia Diseases 0.000 description 1
• 208000014697 Acute lymphocytic leukaemia Diseases 0.000 description 1
• 208000031261 Acute myeloid leukaemia Diseases 0.000 description 1
• 208000036762 Acute promyelocytic leukaemia Diseases 0.000 description 1
• 102000010650 Adaptor Protein Complex 2 Human genes 0.000 description 1
• 108010077852 Adaptor Protein Complex 2 Proteins 0.000 description 1
• 102100035886 Adenine DNA glycosylase Human genes 0.000 description 1
• 206010001197 Adenocarcinoma of the cervix Diseases 0.000 description 1
• 241000321096 Adenoides Species 0.000 description 1
• 208000003200 Adenoma Diseases 0.000 description 1
• 206010001233 Adenoma benign Diseases 0.000 description 1
• 102100032605 Adhesion G protein-coupled receptor B1 Human genes 0.000 description 1
• 102400001318 Adrenomedullin Human genes 0.000 description 1
• 101800004616 Adrenomedullin Proteins 0.000 description 1
• 241000349731 Afzelia bipindensis Species 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• 101001015038 Albizia kalkora Kunitz-type trypsin inhibitor alpha chain Proteins 0.000 description 1
• 102100027211 Albumin Human genes 0.000 description 1
• 108010012934 Albumin-Bound Paclitaxel Proteins 0.000 description 1
• 108010053754 Aldehyde reductase Proteins 0.000 description 1
• 102000005602 Aldo-Keto Reductases Human genes 0.000 description 1
• 108010084469 Aldo-Keto Reductases Proteins 0.000 description 1
• OGSPWJRAVKPPFI-UHFFFAOYSA-N Alendronic Acid Chemical compound NCCCC(O)(P(O)(O)=O)P(O)(O)=O OGSPWJRAVKPPFI-UHFFFAOYSA-N 0.000 description 1
• 102000002260 Alkaline Phosphatase Human genes 0.000 description 1
• 108020004774 Alkaline Phosphatase Proteins 0.000 description 1
• 102100024321 Alkaline phosphatase, placental type Human genes 0.000 description 1
• 101710161969 Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 description 1
• 102100022463 Alpha-1-acid glycoprotein 1 Human genes 0.000 description 1
• 102100024402 Alpha-1B adrenergic receptor Human genes 0.000 description 1
• 102100028042 Alpha-2-HS-glycoprotein Human genes 0.000 description 1
• 102100031317 Alpha-N-acetylgalactosaminidase Human genes 0.000 description 1
• 102100034668 Alpha-lactalbumin Human genes 0.000 description 1
• WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 1
• 229940097396 Aminopeptidase inhibitor Drugs 0.000 description 1
• 108010033760 Amphiregulin Proteins 0.000 description 1
• 108010079054 Amyloid beta-Protein Precursor Proteins 0.000 description 1
• 102000014303 Amyloid beta-Protein Precursor Human genes 0.000 description 1
• 108700004603 Anaphase-Promoting Complex-Cyclosome Apc6 Subunit Proteins 0.000 description 1
• 102100026468 Androgen-induced gene 1 protein Human genes 0.000 description 1
• YUWPMEXLKGOSBF-GACAOOTBSA-N Anecortave acetate Chemical compound O=C1CC[C@]2(C)C3=CC[C@]4(C)[C@](C(=O)COC(=O)C)(O)CC[C@H]4[C@@H]3CCC2=C1 YUWPMEXLKGOSBF-GACAOOTBSA-N 0.000 description 1
• 102100022987 Angiogenin Human genes 0.000 description 1
• 206010051810 Angiomyolipoma Diseases 0.000 description 1
• 102100034608 Angiopoietin-2 Human genes 0.000 description 1
• 201000003076 Angiosarcoma Diseases 0.000 description 1
• 102400000068 Angiostatin Human genes 0.000 description 1
• 108010079709 Angiostatins Proteins 0.000 description 1
• 108010049777 Ankyrins Proteins 0.000 description 1
• 102000008102 Ankyrins Human genes 0.000 description 1
• 108090000663 Annexin A1 Proteins 0.000 description 1
• 102100028118 Annexin A11 Human genes 0.000 description 1
• 102100034612 Annexin A4 Human genes 0.000 description 1
• 102100034273 Annexin A7 Human genes 0.000 description 1
• MXPOCMVWFLDDLZ-NSCUHMNNSA-N Apaziquone Chemical compound CN1C(\C=C\CO)=C(CO)C(C2=O)=C1C(=O)C=C2N1CC1 MXPOCMVWFLDDLZ-NSCUHMNNSA-N 0.000 description 1
• 102000005666 Apolipoprotein A-I Human genes 0.000 description 1
• 108010059886 Apolipoprotein A-I Proteins 0.000 description 1
• 102100030942 Apolipoprotein A-II Human genes 0.000 description 1
• 108010087614 Apolipoprotein A-II Proteins 0.000 description 1
• 102000011772 Apolipoprotein C-I Human genes 0.000 description 1
• 108010076807 Apolipoprotein C-I Proteins 0.000 description 1
• 102100022954 Apolipoprotein D Human genes 0.000 description 1
• 102100029470 Apolipoprotein E Human genes 0.000 description 1
• 102100027308 Apoptosis regulator BAX Human genes 0.000 description 1
• 101100385295 Arabidopsis thaliana CRSP gene Proteins 0.000 description 1
• 101000995014 Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16) Iron-sulfur flavoprotein AF_1436 Proteins 0.000 description 1
• 102100030356 Arginase-2, mitochondrial Human genes 0.000 description 1
• 108010014223 Armadillo Domain Proteins Proteins 0.000 description 1
• BFYIZQONLCFLEV-DAELLWKTSA-N Aromasine Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CC(=C)C2=C1 BFYIZQONLCFLEV-DAELLWKTSA-N 0.000 description 1
• 229940122815 Aromatase inhibitor Drugs 0.000 description 1
• 108090000448 Aryl Hydrocarbon Receptors Proteins 0.000 description 1
• 102100030907 Aryl hydrocarbon receptor nuclear translocator Human genes 0.000 description 1
• 102100038110 Arylamine N-acetyltransferase 2 Human genes 0.000 description 1
• 108010024976 Asparaginase Proteins 0.000 description 1
• 241000416162 Astragalus gummifer Species 0.000 description 1
• 206010003571 Astrocytoma Diseases 0.000 description 1
• 208000036075 Autosomal dominant tubulointerstitial kidney disease Diseases 0.000 description 1
• NOWKCMXCCJGMRR-UHFFFAOYSA-N Aziridine Chemical class C1CN1 NOWKCMXCCJGMRR-UHFFFAOYSA-N 0.000 description 1
• 208000036170 B-Cell Marginal Zone Lymphoma Diseases 0.000 description 1
• 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 description 1
• 208000003950 B-cell lymphoma Diseases 0.000 description 1
• 108010074708 B7-H1 Antigen Proteins 0.000 description 1
• 102100037152 BAG family molecular chaperone regulator 1 Human genes 0.000 description 1
• 102100035656 BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 Human genes 0.000 description 1
• 102100035080 BDNF/NT-3 growth factors receptor Human genes 0.000 description 1
• 102000008836 BTB/POZ domains Human genes 0.000 description 1
• 108050000749 BTB/POZ domains Proteins 0.000 description 1
• 101000798402 Bacillus licheniformis Ornithine racemase Proteins 0.000 description 1
• 101000963440 Bacillus subtilis (strain 168) Biotin carboxylase 1 Proteins 0.000 description 1
• 101000782621 Bacillus subtilis (strain 168) Biotin carboxylase 2 Proteins 0.000 description 1
• 102100021676 Baculoviral IAP repeat-containing protein 1 Human genes 0.000 description 1
• 102100027515 Baculoviral IAP repeat-containing protein 6 Human genes 0.000 description 1
• 208000023514 Barrett esophagus Diseases 0.000 description 1
• 208000023665 Barrett oesophagus Diseases 0.000 description 1
• 206010004146 Basal cell carcinoma Diseases 0.000 description 1
• 102000018720 Basic Helix-Loop-Helix Transcription Factors Human genes 0.000 description 1
• 108010027344 Basic Helix-Loop-Helix Transcription Factors Proteins 0.000 description 1
• 101000804670 Beet necrotic yellow vein virus (isolate Japan/S) Probable suppressor of RNA silencing Proteins 0.000 description 1
• 206010004453 Benign salivary gland neoplasm Diseases 0.000 description 1
• 102100027314 Beta-2-microglobulin Human genes 0.000 description 1
• 102000015735 Beta-catenin Human genes 0.000 description 1
• 108060000903 Beta-catenin Proteins 0.000 description 1
• 101710164563 Beta-catenin-like protein 1 Proteins 0.000 description 1
• 102100023995 Beta-nerve growth factor Human genes 0.000 description 1
• 102100040904 Beta-parvin Human genes 0.000 description 1
• 206010005003 Bladder cancer Diseases 0.000 description 1
• 108010025544 Bleomycin hydrolase Proteins 0.000 description 1
• 102000015081 Blood Coagulation Factors Human genes 0.000 description 1
• 108010039209 Blood Coagulation Factors Proteins 0.000 description 1
• 102000004506 Blood Proteins Human genes 0.000 description 1
• 108010017384 Blood Proteins Proteins 0.000 description 1
• 206010005949 Bone cancer Diseases 0.000 description 1
• 102100024506 Bone morphogenetic protein 2 Human genes 0.000 description 1
• 102100024505 Bone morphogenetic protein 4 Human genes 0.000 description 1
• 208000018084 Bone neoplasm Diseases 0.000 description 1
• 101710100402 Bone sialoprotein 2 Proteins 0.000 description 1
• 241000283690 Bos taurus Species 0.000 description 1
• 101100120045 Bos taurus FGF1 gene Proteins 0.000 description 1
• 208000003174 Brain Neoplasms Diseases 0.000 description 1
• 102000004219 Brain-derived neurotrophic factor Human genes 0.000 description 1
• 108090000715 Brain-derived neurotrophic factor Proteins 0.000 description 1
• 102100024794 Breast cancer metastasis-suppressor 1 Human genes 0.000 description 1
• 102100025401 Breast cancer type 1 susceptibility protein Human genes 0.000 description 1
• 208000007690 Brenner tumor Diseases 0.000 description 1
• 206010073258 Brenner tumour Diseases 0.000 description 1
• 206010070487 Brown tumour Diseases 0.000 description 1
• 208000029402 Bulbospinal muscular atrophy Diseases 0.000 description 1
• 208000011691 Burkitt lymphomas Diseases 0.000 description 1
• 108010037003 Buserelin Proteins 0.000 description 1
• COVZYZSDYWQREU-UHFFFAOYSA-N Busulfan Chemical compound CS(=O)(=O)OCCCCOS(C)(=O)=O COVZYZSDYWQREU-UHFFFAOYSA-N 0.000 description 1
• 102100031174 C-C chemokine receptor type 10 Human genes 0.000 description 1
• 101710112613 C-C motif chemokine 13 Proteins 0.000 description 1
• 101710112622 C-C motif chemokine 19 Proteins 0.000 description 1
• 101710155856 C-C motif chemokine 3 Proteins 0.000 description 1
• 101710155855 C-C motif chemokine 4 Proteins 0.000 description 1
• 101710155834 C-C motif chemokine 7 Proteins 0.000 description 1
• 101710155833 C-C motif chemokine 8 Proteins 0.000 description 1
• 108090000342 C-Type Lectins Proteins 0.000 description 1
• 102000003930 C-Type Lectins Human genes 0.000 description 1
• 101710082513 C-X-C chemokine receptor type 4 Proteins 0.000 description 1
• 101710085500 C-X-C motif chemokine 9 Proteins 0.000 description 1
• 102100032752 C-reactive protein Human genes 0.000 description 1
• 208000010482 CADASIL Diseases 0.000 description 1
• 102100024217 CAMPATH-1 antigen Human genes 0.000 description 1
• 108091005932 CCKBR Proteins 0.000 description 1
• 108700012434 CCL3 Proteins 0.000 description 1
• 101150013553 CD40 gene Proteins 0.000 description 1
• 210000001266 CD8-positive T-lymphocyte Anatomy 0.000 description 1
• 101710139831 CD82 antigen Proteins 0.000 description 1
• 101150017278 CDC16 gene Proteins 0.000 description 1
• 101150047144 CDC28 gene Proteins 0.000 description 1
• 229940126074 CDK kinase inhibitor Drugs 0.000 description 1
• 108091008038 CHOP Proteins 0.000 description 1
• 108091058556 CTAG1B Proteins 0.000 description 1
• 108010061299 CXCR4 Receptors Proteins 0.000 description 1
• 101710196881 Cadherin-17 Proteins 0.000 description 1
• 101100450705 Caenorhabditis elegans hif-1 gene Proteins 0.000 description 1
• 102100031272 Calcineurin B homologous protein 2 Human genes 0.000 description 1
• 102100025588 Calcitonin gene-related peptide 1 Human genes 0.000 description 1
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
• 102100032220 Calcium and integrin-binding family member 2 Human genes 0.000 description 1
• 101710164735 Calmodulin-1 Proteins 0.000 description 1
• 101710164734 Calmodulin-2 Proteins 0.000 description 1
• 102100025926 Calmodulin-3 Human genes 0.000 description 1
• 102100033620 Calponin-1 Human genes 0.000 description 1
• 108090000549 Calreticulin Proteins 0.000 description 1
• 241000282836 Camelus dromedarius Species 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• GAGWJHPBXLXJQN-UHFFFAOYSA-N Capecitabine Natural products C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1C1C(O)C(O)C(C)O1 GAGWJHPBXLXJQN-UHFFFAOYSA-N 0.000 description 1
• GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 description 1
• 101710086403 Carbonic anhydrase-related protein Proteins 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 208000009458 Carcinoma in Situ Diseases 0.000 description 1
• 201000000274 Carcinosarcoma Diseases 0.000 description 1
• 102100027992 Casein kinase II subunit beta Human genes 0.000 description 1
• 108010076119 Caseins Proteins 0.000 description 1
• 102000011632 Caseins Human genes 0.000 description 1
• 108090000567 Caspase 7 Proteins 0.000 description 1
• 102100035904 Caspase-1 Human genes 0.000 description 1
• 108090000426 Caspase-1 Proteins 0.000 description 1
• 102100026549 Caspase-10 Human genes 0.000 description 1
• 108090000552 Caspase-2 Proteins 0.000 description 1
• 101710090338 Caspase-4 Proteins 0.000 description 1
• 102100038916 Caspase-5 Human genes 0.000 description 1
• 101710090333 Caspase-5 Proteins 0.000 description 1
• 102100038918 Caspase-6 Human genes 0.000 description 1
• 102000004039 Caspase-9 Human genes 0.000 description 1
• 102100035882 Catalase Human genes 0.000 description 1
• 108010053835 Catalase Proteins 0.000 description 1
• 102000053642 Catalytic RNA Human genes 0.000 description 1
• 108090000994 Catalytic RNA Proteins 0.000 description 1
• 102100028003 Catenin alpha-1 Human genes 0.000 description 1
• 101710106619 Catenin alpha-3 Proteins 0.000 description 1
• 102000016362 Catenins Human genes 0.000 description 1
• 108010067316 Catenins Proteins 0.000 description 1
• 102100021633 Cathepsin B Human genes 0.000 description 1
• 102100035888 Caveolin-1 Human genes 0.000 description 1
• 101000850966 Cavia porcellus Eosinophil granule major basic protein 1 Proteins 0.000 description 1
• 102100027047 Cell division control protein 6 homolog Human genes 0.000 description 1
• 208000007389 Cementoma Diseases 0.000 description 1
• 102100023344 Centromere protein F Human genes 0.000 description 1
• 208000033221 Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy Diseases 0.000 description 1
• 208000033935 Cerebral autosomal dominant arteriopathy-subcortical infarcts-leukoencephalopathy Diseases 0.000 description 1
• 102100023321 Ceruloplasmin Human genes 0.000 description 1
• 206010008342 Cervix carcinoma Diseases 0.000 description 1
• 101710181333 Chaperone protein dnaK1 Proteins 0.000 description 1
• 108010058432 Chaperonin 60 Proteins 0.000 description 1
• 108050001186 Chaperonin Cpn60 Proteins 0.000 description 1
• 102000052603 Chaperonins Human genes 0.000 description 1
• 102000004003 Chemokine CCL11 Human genes 0.000 description 1
• 108010082548 Chemokine CCL11 Proteins 0.000 description 1
• 102000003805 Chemokine CCL19 Human genes 0.000 description 1
• 108010082161 Chemokine CCL19 Proteins 0.000 description 1
• 108010083702 Chemokine CCL21 Proteins 0.000 description 1
• 102000000013 Chemokine CCL3 Human genes 0.000 description 1
• 102000001326 Chemokine CCL4 Human genes 0.000 description 1
• 108010055165 Chemokine CCL4 Proteins 0.000 description 1
• 108010008978 Chemokine CXCL10 Proteins 0.000 description 1
• 108010008955 Chemokine CXCL13 Proteins 0.000 description 1
• 102000006574 Chemokine CXCL13 Human genes 0.000 description 1
• 108010014414 Chemokine CXCL2 Proteins 0.000 description 1
• 102000016951 Chemokine CXCL2 Human genes 0.000 description 1
• 102000016937 Chemokine CXCL9 Human genes 0.000 description 1
• 108010014231 Chemokine CXCL9 Proteins 0.000 description 1
• JWBOIMRXGHLCPP-UHFFFAOYSA-N Chloditan Chemical compound C=1C=CC=C(Cl)C=1C(C(Cl)Cl)C1=CC=C(Cl)C=C1 JWBOIMRXGHLCPP-UHFFFAOYSA-N 0.000 description 1
• 206010008583 Chloroma Diseases 0.000 description 1
• 201000005262 Chondroma Diseases 0.000 description 1
• 201000009047 Chordoma Diseases 0.000 description 1
• 102100031199 Choriogonadotropin subunit beta 7 Human genes 0.000 description 1
• 102000017589 Chromo domains Human genes 0.000 description 1
• 108050005811 Chromo domains Proteins 0.000 description 1
• 206010008909 Chronic Hepatitis Diseases 0.000 description 1
• 108010005939 Ciliary Neurotrophic Factor Proteins 0.000 description 1
• 102100031614 Ciliary neurotrophic factor Human genes 0.000 description 1
• PTOAARAWEBMLNO-KVQBGUIXSA-N Cladribine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@H]1C[C@H](O)[C@@H](CO)O1 PTOAARAWEBMLNO-KVQBGUIXSA-N 0.000 description 1
• 108090000601 Claudin-4 Proteins 0.000 description 1
• 206010073140 Clear cell sarcoma of soft tissue Diseases 0.000 description 1
• 102000003780 Clusterin Human genes 0.000 description 1
• 102100029058 Coagulation factor XIII B chain Human genes 0.000 description 1
• 102000008186 Collagen Human genes 0.000 description 1
• 108010035532 Collagen Proteins 0.000 description 1
• 108010048623 Collagen Receptors Proteins 0.000 description 1
• 102100031519 Collagen alpha-1(VI) chain Human genes 0.000 description 1
• 102100033781 Collagen alpha-2(IV) chain Human genes 0.000 description 1
• 102100033780 Collagen alpha-3(IV) chain Human genes 0.000 description 1
• 102100033779 Collagen alpha-4(IV) chain Human genes 0.000 description 1
• 206010048832 Colon adenoma Diseases 0.000 description 1
• 102000016917 Complement C1 Human genes 0.000 description 1
• 108010028774 Complement C1 Proteins 0.000 description 1
• 108010028771 Complement C6 Proteins 0.000 description 1
• 108010028776 Complement C7 Proteins 0.000 description 1
• 102100024339 Complement component C6 Human genes 0.000 description 1
• 102100024336 Complement component C7 Human genes 0.000 description 1
• 102100027591 Copper-transporting ATPase 2 Human genes 0.000 description 1
• 229920002261 Corn starch Polymers 0.000 description 1
• OMFXVFTZEKFJBZ-UHFFFAOYSA-N Corticosterone Natural products O=C1CCC2(C)C3C(O)CC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 OMFXVFTZEKFJBZ-UHFFFAOYSA-N 0.000 description 1
• 239000000055 Corticotropin-Releasing Hormone Substances 0.000 description 1
• 101000817067 Corynebacterium glutamicum (strain ATCC 13032 / DSM 20300 / BCRC 11384 / JCM 1318 / LMG 3730 / NCIMB 10025) Uncharacterized protein Cgl2226/cg2444 Proteins 0.000 description 1
• 208000009798 Craniopharyngioma Diseases 0.000 description 1
• 102100022785 Creatine kinase B-type Human genes 0.000 description 1
• 102100039193 Cullin-2 Human genes 0.000 description 1
• 102100025525 Cullin-5 Human genes 0.000 description 1
• 101710094483 Cullin-5 Proteins 0.000 description 1
• 108050006400 Cyclin Proteins 0.000 description 1
• 108010024986 Cyclin-Dependent Kinase 2 Proteins 0.000 description 1
• 108010025464 Cyclin-Dependent Kinase 4 Proteins 0.000 description 1
• 108010025468 Cyclin-Dependent Kinase 6 Proteins 0.000 description 1
• 108010009392 Cyclin-Dependent Kinase Inhibitor p16 Proteins 0.000 description 1
• 108010016788 Cyclin-Dependent Kinase Inhibitor p21 Proteins 0.000 description 1
• 108010017222 Cyclin-Dependent Kinase Inhibitor p57 Proteins 0.000 description 1
• 102100038250 Cyclin-G2 Human genes 0.000 description 1
• 102100036239 Cyclin-dependent kinase 2 Human genes 0.000 description 1
• 102100036252 Cyclin-dependent kinase 4 Human genes 0.000 description 1
• 102100026804 Cyclin-dependent kinase 6 Human genes 0.000 description 1
• 101710154003 Cyclin-dependent kinase inhibitor 2A Proteins 0.000 description 1
• 102100034770 Cyclin-dependent kinase inhibitor 3 Human genes 0.000 description 1
• 102000003903 Cyclin-dependent kinases Human genes 0.000 description 1
• 108090000266 Cyclin-dependent kinases Proteins 0.000 description 1
• 102100034501 Cyclin-dependent kinases regulatory subunit 1 Human genes 0.000 description 1
• 102100032522 Cyclin-dependent kinases regulatory subunit 2 Human genes 0.000 description 1
• 229940122204 Cyclooxygenase inhibitor Drugs 0.000 description 1
• 102100026897 Cystatin-C Human genes 0.000 description 1
• 102100038381 Cystatin-M Human genes 0.000 description 1
• 201000003883 Cystic fibrosis Diseases 0.000 description 1
• 108091000069 Cystinyl Aminopeptidase Proteins 0.000 description 1
• 102100024889 Cytochrome P450 2E1 Human genes 0.000 description 1
• 102100036035 Cytochrome c oxidase copper chaperone Human genes 0.000 description 1
• 102000004127 Cytokines Human genes 0.000 description 1
• 108090000695 Cytokines Proteins 0.000 description 1
• 102000013816 Cytotoxic T-lymphocyte antigen 4 Human genes 0.000 description 1
• 101710197960 D-aminoacyl-tRNA deacylase Proteins 0.000 description 1
• 101710109959 D-aminoacyl-tRNA deacylase 1 Proteins 0.000 description 1
• 101710109969 D-aminoacyl-tRNA deacylase 2 Proteins 0.000 description 1
• 101150051043 DLC1 gene Proteins 0.000 description 1
• 102100035186 DNA excision repair protein ERCC-1 Human genes 0.000 description 1
• 102100033195 DNA ligase 4 Human genes 0.000 description 1
• 102100021147 DNA mismatch repair protein Msh6 Human genes 0.000 description 1
• 102100039606 DNA replication licensing factor MCM3 Human genes 0.000 description 1
• 102100034001 DNA replication licensing factor MCM5 Human genes 0.000 description 1
• 102000005768 DNA-Activated Protein Kinase Human genes 0.000 description 1
• 108010006124 DNA-Activated Protein Kinase Proteins 0.000 description 1
• 230000004568 DNA-binding Effects 0.000 description 1
• 101710096438 DNA-binding protein Proteins 0.000 description 1
• 101710152088 DNA-binding protein inhibitor ID-1 Proteins 0.000 description 1
• 101710152064 DNA-binding protein inhibitor ID-3 Proteins 0.000 description 1
• 101710157074 DNA-dependent protein kinase catalytic subunit Proteins 0.000 description 1
• ZBNZXTGUTAYRHI-UHFFFAOYSA-N Dasatinib Chemical compound C=1C(N2CCN(CCO)CC2)=NC(C)=NC=1NC(S1)=NC=C1C(=O)NC1=C(C)C=CC=C1Cl ZBNZXTGUTAYRHI-UHFFFAOYSA-N 0.000 description 1
• 241000289632 Dasypodidae Species 0.000 description 1
• WEAHRLBPCANXCN-UHFFFAOYSA-N Daunomycin Natural products CCC1(O)CC(OC2CC(N)C(O)C(C)O2)c3cc4C(=O)c5c(OC)cccc5C(=O)c4c(O)c3C1 WEAHRLBPCANXCN-UHFFFAOYSA-N 0.000 description 1
• 102100038713 Death domain-containing protein CRADD Human genes 0.000 description 1
• 102000010170 Death domains Human genes 0.000 description 1
• 108050001718 Death domains Proteins 0.000 description 1
• 102100038587 Death-associated protein kinase 1 Human genes 0.000 description 1
• 102000000541 Defensins Human genes 0.000 description 1
• 108010002069 Defensins Proteins 0.000 description 1
• 102100036912 Desmin Human genes 0.000 description 1
• 229920002307 Dextran Polymers 0.000 description 1
• 101000573165 Dickeya dadantii (strain 3937) Pectinesterase A Proteins 0.000 description 1
• 101001098814 Dictyostelium discoideum 3',5'-cyclic-nucleotide phosphodiesterase regA Proteins 0.000 description 1
• 101000836720 Dictyostelium discoideum Aldose reductase A Proteins 0.000 description 1
• 101000884308 Dictyostelium discoideum Anaphase-promoting complex subunit 6 Proteins 0.000 description 1
• 101000785279 Dictyostelium discoideum Calcium-transporting ATPase PAT1 Proteins 0.000 description 1
• 101000876610 Dictyostelium discoideum Extracellular signal-regulated kinase 2 Proteins 0.000 description 1
• 101000595765 Dictyostelium discoideum Protein kinase 3 Proteins 0.000 description 1
• 101100327311 Dictyostelium discoideum anapc6 gene Proteins 0.000 description 1
• 102100024746 Dihydrofolate reductase Human genes 0.000 description 1
• 102100029721 DnaJ homolog subfamily B member 1 Human genes 0.000 description 1
• 102100039104 Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Human genes 0.000 description 1
• 101710120363 Double-strand break repair protein MRE11 Proteins 0.000 description 1
• 102100037069 Doublecortin domain-containing protein 1 Human genes 0.000 description 1
• 241000255581 Drosophila <fruit fly, genus> Species 0.000 description 1
• 101000652725 Drosophila melanogaster Transcription initiation factor TFIID subunit 5 Proteins 0.000 description 1
• 101710132784 Dual specificity protein phosphatase 1 Proteins 0.000 description 1
• 101710132801 Dual specificity protein phosphatase 4 Proteins 0.000 description 1
• 102100023115 Dual specificity tyrosine-phosphorylation-regulated kinase 2 Human genes 0.000 description 1
• 101710096197 Dynein light chain 1, cytoplasmic Proteins 0.000 description 1
• 208000007033 Dysgerminoma Diseases 0.000 description 1
• 206010058314 Dysplasia Diseases 0.000 description 1
• 108010013976 Dystonin Proteins 0.000 description 1
• 108050002772 E3 ubiquitin-protein ligase Mdm2 Proteins 0.000 description 1
• 101150084967 EPCAM gene Proteins 0.000 description 1
• 206010063045 Effusion Diseases 0.000 description 1
• LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 1
• 201000009051 Embryonal Carcinoma Diseases 0.000 description 1
• 206010014733 Endometrial cancer Diseases 0.000 description 1
• 206010014759 Endometrial neoplasm Diseases 0.000 description 1
• 108010079505 Endostatins Proteins 0.000 description 1
• 108010041308 Endothelial Growth Factors Proteins 0.000 description 1
• 101710128765 Enhancer of filamentation 1 Proteins 0.000 description 1
• 101000619174 Enterobacteria phage HK97 Prohead protease Proteins 0.000 description 1
• 101710126496 Envelope glycoprotein I Proteins 0.000 description 1
• 101710139422 Eotaxin Proteins 0.000 description 1
• 102100030340 Ephrin type-A receptor 2 Human genes 0.000 description 1
• 108010043945 Ephrin-A1 Proteins 0.000 description 1
• 108010043939 Ephrin-A5 Proteins 0.000 description 1
• 108010044085 Ephrin-B3 Proteins 0.000 description 1
• 101800003838 Epidermal growth factor Proteins 0.000 description 1
• 102100025403 Epoxide hydrolase 1 Human genes 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 102000003951 Erythropoietin Human genes 0.000 description 1
• 108090000394 Erythropoietin Proteins 0.000 description 1
• 108010075944 Erythropoietin Receptors Proteins 0.000 description 1
• 102100036509 Erythropoietin receptor Human genes 0.000 description 1
• 101001039702 Escherichia coli (strain K12) Methyl-accepting chemotaxis protein I Proteins 0.000 description 1
• 101000759376 Escherichia phage Mu Tail sheath protein Proteins 0.000 description 1
• 208000000461 Esophageal Neoplasms Diseases 0.000 description 1
• DNXHEGUUPJUMQT-CBZIJGRNSA-N Estrone Chemical compound OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1 DNXHEGUUPJUMQT-CBZIJGRNSA-N 0.000 description 1
• BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
• 108010089790 Eukaryotic Initiation Factor-3 Proteins 0.000 description 1
• 102000012858 Eukaryotic Initiation Factor-4G Human genes 0.000 description 1
• 108010057192 Eukaryotic Initiation Factor-4G Proteins 0.000 description 1
• 101710109050 Eukaryotic translation initiation factor 3 subunit H Proteins 0.000 description 1
• 108050000946 Eukaryotic translation initiation factor 4E-binding protein 1 Proteins 0.000 description 1
• 206010061850 Extranodal marginal zone B-cell lymphoma (MALT type) Diseases 0.000 description 1
• 102100020903 Ezrin Human genes 0.000 description 1
• 101710202081 FAD-linked sulfhydryl oxidase Proteins 0.000 description 1
• 108010071289 Factor XIII Proteins 0.000 description 1
• 229940124226 Farnesyltransferase inhibitor Drugs 0.000 description 1
• 108010039471 Fas Ligand Protein Proteins 0.000 description 1
• 102100026748 Fatty acid-binding protein, intestinal Human genes 0.000 description 1
• 102100026745 Fatty acid-binding protein, liver Human genes 0.000 description 1
• 241000282324 Felis Species 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 102100031752 Fibrinogen alpha chain Human genes 0.000 description 1
• 102100028313 Fibrinogen beta chain Human genes 0.000 description 1
• 101710170765 Fibrinogen beta chain Proteins 0.000 description 1
• 102100024783 Fibrinogen gamma chain Human genes 0.000 description 1
• 108090000386 Fibroblast Growth Factor 1 Proteins 0.000 description 1
• 102100035308 Fibroblast growth factor 17 Human genes 0.000 description 1
• 102100031734 Fibroblast growth factor 19 Human genes 0.000 description 1
• 102100024785 Fibroblast growth factor 2 Human genes 0.000 description 1
• 102100024802 Fibroblast growth factor 23 Human genes 0.000 description 1
• 102100028075 Fibroblast growth factor 6 Human genes 0.000 description 1
• 102100028071 Fibroblast growth factor 7 Human genes 0.000 description 1
• 108090000368 Fibroblast growth factor 8 Proteins 0.000 description 1
• 102100037680 Fibroblast growth factor 8 Human genes 0.000 description 1
• 102100037665 Fibroblast growth factor 9 Human genes 0.000 description 1
• 101710182386 Fibroblast growth factor receptor 1 Proteins 0.000 description 1
• 101710182389 Fibroblast growth factor receptor 2 Proteins 0.000 description 1
• 201000008808 Fibrosarcoma Diseases 0.000 description 1
• 206010053717 Fibrous histiocytoma Diseases 0.000 description 1
• 101710088570 Flagellar hook-associated protein 1 Proteins 0.000 description 1
• 108090000652 Flap endonucleases Proteins 0.000 description 1
• 102100035047 Flavin-containing monooxygenase 5 Human genes 0.000 description 1
• 101710164820 Flotillin-2 Proteins 0.000 description 1
• YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
• 101000742140 Foeniculum vulgare Pathogenesis-related protein Proteins 0.000 description 1
• 108010079345 Follicle Stimulating Hormone Proteins 0.000 description 1
• 102000012673 Follicle Stimulating Hormone Human genes 0.000 description 1
• 108010014612 Follistatin Proteins 0.000 description 1
• 102000016970 Follistatin Human genes 0.000 description 1
• 102100020921 Follistatin Human genes 0.000 description 1
• 102100040977 Follitropin subunit beta Human genes 0.000 description 1
• 101710088165 Forkhead box protein J1 Proteins 0.000 description 1
• 101710088110 Forkhead box protein Q1 Proteins 0.000 description 1
• 102000003817 Fos-related antigen 1 Human genes 0.000 description 1
• 108090000123 Fos-related antigen 1 Proteins 0.000 description 1
• 102100021259 Frizzled-1 Human genes 0.000 description 1
• 102100021265 Frizzled-2 Human genes 0.000 description 1
• 102100022277 Fructose-bisphosphate aldolase A Human genes 0.000 description 1
• 102100022272 Fructose-bisphosphate aldolase B Human genes 0.000 description 1
• 102100027269 Fructose-bisphosphate aldolase C Human genes 0.000 description 1
• VWUXBMIQPBEWFH-WCCTWKNTSA-N Fulvestrant Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3[C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)CC2=C1 VWUXBMIQPBEWFH-WCCTWKNTSA-N 0.000 description 1
• 230000037057 G1 phase arrest Effects 0.000 description 1
• 102100032340 G2/mitotic-specific cyclin-B1 Human genes 0.000 description 1
• 102100033201 G2/mitotic-specific cyclin-B2 Human genes 0.000 description 1
• 102000054184 GADD45 Human genes 0.000 description 1
• 108010082772 GFB 111 Proteins 0.000 description 1
• 108050007570 GTP-binding protein Rad Proteins 0.000 description 1
• 102100029974 GTPase HRas Human genes 0.000 description 1
• 102100030708 GTPase KRas Human genes 0.000 description 1
• 108010001496 Galectin 2 Proteins 0.000 description 1
• 108010001515 Galectin 4 Proteins 0.000 description 1
• 102000000805 Galectin 4 Human genes 0.000 description 1
• 101710197901 Galectin-3-binding protein Proteins 0.000 description 1
• 208000022072 Gallbladder Neoplasms Diseases 0.000 description 1
• 101100226596 Gallus gallus FABP gene Proteins 0.000 description 1
• 102100028652 Gamma-enolase Human genes 0.000 description 1
• 102100039417 Gap junction beta-5 protein Human genes 0.000 description 1
• 102100030875 Gastricsin Human genes 0.000 description 1
• 102400000921 Gastrin Human genes 0.000 description 1
• 102100021022 Gastrin Human genes 0.000 description 1
• 102100036016 Gastrin/cholecystokinin type B receptor Human genes 0.000 description 1
• 108010052343 Gastrins Proteins 0.000 description 1
• 206010017993 Gastrointestinal neoplasms Diseases 0.000 description 1
• JRZJKWGQFNTSRN-UHFFFAOYSA-N Geldanamycin Natural products C1C(C)CC(OC)C(O)C(C)C=C(C)C(OC(N)=O)C(OC)CCC=C(C)C(=O)NC2=CC(=O)C(OC)=C1C2=O JRZJKWGQFNTSRN-UHFFFAOYSA-N 0.000 description 1
• 102100039956 Geminin Human genes 0.000 description 1
• 208000021309 Germ cell tumor Diseases 0.000 description 1
• 208000007569 Giant Cell Tumors Diseases 0.000 description 1
• 101710199302 Girdin Proteins 0.000 description 1
• 201000005409 Gliomatosis cerebri Diseases 0.000 description 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
• 102100035172 Glucose-6-phosphate 1-dehydrogenase Human genes 0.000 description 1
• 101710183768 Glutamate carboxypeptidase 2 Proteins 0.000 description 1
• 102000004263 Glutamate-Cysteine Ligase Human genes 0.000 description 1
• 108010081687 Glutamate-cysteine ligase Proteins 0.000 description 1
• 102100033398 Glutamate-cysteine ligase regulatory subunit Human genes 0.000 description 1
• 101710153770 Glutathione S-transferase Mu 1 Proteins 0.000 description 1
• 102100036528 Glutathione S-transferase Mu 3 Human genes 0.000 description 1
• 102100033039 Glutathione peroxidase 1 Human genes 0.000 description 1
• 102100033044 Glutathione peroxidase 2 Human genes 0.000 description 1
• 102000003886 Glycoproteins Human genes 0.000 description 1
• 108090000288 Glycoproteins Proteins 0.000 description 1
• BLCLNMBMMGCOAS-URPVMXJPSA-N Goserelin Chemical compound C([C@@H](C(=O)N[C@H](COC(C)(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1[C@@H](CCC1)C(=O)NNC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 BLCLNMBMMGCOAS-URPVMXJPSA-N 0.000 description 1
• 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 1
• 208000005234 Granulosa Cell Tumor Diseases 0.000 description 1
• 102100038395 Granzyme K Human genes 0.000 description 1
• 102100031150 Growth arrest and DNA damage-inducible protein GADD45 alpha Human genes 0.000 description 1
• 102100036683 Growth arrest-specific protein 1 Human genes 0.000 description 1
• 101710191157 Growth hormone variant Proteins 0.000 description 1
• 101710194460 Growth/differentiation factor 15 Proteins 0.000 description 1
• 108020004202 Guanylate Kinase Proteins 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 208000035773 Gynandroblastoma Diseases 0.000 description 1
• 102100028967 HLA class I histocompatibility antigen, alpha chain G Human genes 0.000 description 1
• 102100030595 HLA class II histocompatibility antigen gamma chain Human genes 0.000 description 1
• 108010024164 HLA-G Antigens Proteins 0.000 description 1
• 108010036652 HSC70 Heat-Shock Proteins Proteins 0.000 description 1
• 108010045100 HSP27 Heat-Shock Proteins Proteins 0.000 description 1
• 102000004447 HSP40 Heat-Shock Proteins Human genes 0.000 description 1
• 108010027992 HSP70 Heat-Shock Proteins Proteins 0.000 description 1
• 102000018932 HSP70 Heat-Shock Proteins Human genes 0.000 description 1
• 102000014702 Haptoglobin Human genes 0.000 description 1
• 108050005077 Haptoglobin Proteins 0.000 description 1
• 102000000039 Heat Shock Transcription Factor Human genes 0.000 description 1
• 108050008339 Heat Shock Transcription Factor Proteins 0.000 description 1
• 102100040408 Heat shock 70 kDa protein 1-like Human genes 0.000 description 1
• 102100040352 Heat shock 70 kDa protein 1A Human genes 0.000 description 1
• 102100040407 Heat shock 70 kDa protein 1B Human genes 0.000 description 1
• 102100032606 Heat shock factor protein 1 Human genes 0.000 description 1
• 101710100504 Heat shock protein beta-1 Proteins 0.000 description 1
• 102100028515 Heat shock-related 70 kDa protein 2 Human genes 0.000 description 1
• 208000006050 Hemangiopericytoma Diseases 0.000 description 1
• 208000001258 Hemangiosarcoma Diseases 0.000 description 1
• 102100028006 Heme oxygenase 1 Human genes 0.000 description 1
• 229920002971 Heparan sulfate Polymers 0.000 description 1
• 102100024025 Heparanase Human genes 0.000 description 1
• 229940122588 Heparanase inhibitor Drugs 0.000 description 1
• HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
• 102000003745 Hepatocyte Growth Factor Human genes 0.000 description 1
• 101710086591 Hepatocyte growth factor-like protein Proteins 0.000 description 1
• 208000017095 Hereditary nonpolyposis colon cancer Diseases 0.000 description 1
• 102100030338 Hexokinase-1 Human genes 0.000 description 1
• 102100029242 Hexokinase-2 Human genes 0.000 description 1
• 101710121996 Hexon protein p72 Proteins 0.000 description 1
• 102100029009 High mobility group protein HMG-I/HMG-Y Human genes 0.000 description 1
• 102000008157 Histone Demethylases Human genes 0.000 description 1
• 108010074870 Histone Demethylases Proteins 0.000 description 1
• 102100039265 Histone H2A type 1-C Human genes 0.000 description 1
• 101710083341 Histone acetyltransferase KAT2B Proteins 0.000 description 1
• 102000003893 Histone acetyltransferases Human genes 0.000 description 1
• 108090000246 Histone acetyltransferases Proteins 0.000 description 1
• 102000003964 Histone deacetylase Human genes 0.000 description 1
• 108090000353 Histone deacetylase Proteins 0.000 description 1
• 108050004676 Histone deacetylase 5 Proteins 0.000 description 1
• 108010016918 Histone-Lysine N-Methyltransferase Proteins 0.000 description 1
• 102000000581 Histone-lysine N-methyltransferase Human genes 0.000 description 1
• 101710196274 Histone-lysine N-methyltransferase EZH2 Proteins 0.000 description 1
• 108010033040 Histones Proteins 0.000 description 1
• 208000021519 Hodgkin lymphoma Diseases 0.000 description 1
• 208000010747 Hodgkins lymphoma Diseases 0.000 description 1
• 101000980303 Homo sapiens 10 kDa heat shock protein, mitochondrial Proteins 0.000 description 1
• 101000600756 Homo sapiens 3-phosphoinositide-dependent protein kinase 1 Proteins 0.000 description 1
• 101000936395 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 3 Proteins 0.000 description 1
• 101000936397 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 4 Proteins 0.000 description 1
• 101000730038 Homo sapiens A disintegrin and metalloproteinase with thrombospondin motifs 8 Proteins 0.000 description 1
• 101000777636 Homo sapiens ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 Proteins 0.000 description 1
• 101001029059 Homo sapiens ATP-binding cassette sub-family C member 10 Proteins 0.000 description 1
• 101001000351 Homo sapiens Adenine DNA glycosylase Proteins 0.000 description 1
• 101000924577 Homo sapiens Adenomatous polyposis coli protein Proteins 0.000 description 1
• 101000775498 Homo sapiens Adenylate cyclase type 10 Proteins 0.000 description 1
• 101000796780 Homo sapiens Adhesion G protein-coupled receptor B1 Proteins 0.000 description 1
• 101000836540 Homo sapiens Aldo-keto reductase family 1 member B1 Proteins 0.000 description 1
• 101000574445 Homo sapiens Alkaline phosphatase, tissue-nonspecific isozyme Proteins 0.000 description 1
• 101000678195 Homo sapiens Alpha-1-acid glycoprotein 1 Proteins 0.000 description 1
• 101000689698 Homo sapiens Alpha-1B adrenergic receptor Proteins 0.000 description 1
• 101000946384 Homo sapiens Alpha-lactalbumin Proteins 0.000 description 1
• 101000924727 Homo sapiens Alternative prion protein Proteins 0.000 description 1
• 101000809450 Homo sapiens Amphiregulin Proteins 0.000 description 1
• 101000775732 Homo sapiens Androgen receptor Proteins 0.000 description 1
• 101000718108 Homo sapiens Androgen-induced gene 1 protein Proteins 0.000 description 1
• 101000757236 Homo sapiens Angiogenin Proteins 0.000 description 1
• 101000924533 Homo sapiens Angiopoietin-2 Proteins 0.000 description 1
• 101000768066 Homo sapiens Annexin A11 Proteins 0.000 description 1
• 101000924461 Homo sapiens Annexin A4 Proteins 0.000 description 1
• 101000780144 Homo sapiens Annexin A7 Proteins 0.000 description 1
• 101000793223 Homo sapiens Apolipoprotein C-III Proteins 0.000 description 1
• 101000971171 Homo sapiens Apoptosis regulator Bcl-2 Proteins 0.000 description 1
• 101000752722 Homo sapiens Apoptosis-stimulating of p53 protein 1 Proteins 0.000 description 1
• 101000792835 Homo sapiens Arginase-2, mitochondrial Proteins 0.000 description 1
• 101000690540 Homo sapiens Aryl hydrocarbon receptor Proteins 0.000 description 1
• 101000793115 Homo sapiens Aryl hydrocarbon receptor nuclear translocator Proteins 0.000 description 1
• 101000884399 Homo sapiens Arylamine N-acetyltransferase 2 Proteins 0.000 description 1
• 101000740062 Homo sapiens BAG family molecular chaperone regulator 1 Proteins 0.000 description 1
• 101000803294 Homo sapiens BCL2/adenovirus E1B 19 kDa protein-interacting protein 3 Proteins 0.000 description 1
• 101000596896 Homo sapiens BDNF/NT-3 growth factors receptor Proteins 0.000 description 1
• 101000984516 Homo sapiens BH3-like motif-containing cell death inducer Proteins 0.000 description 1
• 101000896156 Homo sapiens Baculoviral IAP repeat-containing protein 1 Proteins 0.000 description 1
• 101000936081 Homo sapiens Baculoviral IAP repeat-containing protein 6 Proteins 0.000 description 1
• 101001111439 Homo sapiens Beta-nerve growth factor Proteins 0.000 description 1
• 101000613557 Homo sapiens Beta-parvin Proteins 0.000 description 1
• 101001027506 Homo sapiens Bis(5'-adenosyl)-triphosphatase Proteins 0.000 description 1
• 101000984541 Homo sapiens Bleomycin hydrolase Proteins 0.000 description 1
• 101000762366 Homo sapiens Bone morphogenetic protein 2 Proteins 0.000 description 1
• 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 description 1
• 101000761839 Homo sapiens Breast cancer metastasis-suppressor 1 Proteins 0.000 description 1
• 101000934870 Homo sapiens Breast cancer type 1 susceptibility protein Proteins 0.000 description 1
• 101000984925 Homo sapiens Butyrophilin subfamily 2 member A2 Proteins 0.000 description 1
• 101000777564 Homo sapiens C-C chemokine receptor type 1 Proteins 0.000 description 1
• 101000777558 Homo sapiens C-C chemokine receptor type 10 Proteins 0.000 description 1
• 101000947172 Homo sapiens C-X-C motif chemokine 9 Proteins 0.000 description 1
• 101000740685 Homo sapiens C4b-binding protein alpha chain Proteins 0.000 description 1
• 101000980814 Homo sapiens CAMPATH-1 antigen Proteins 0.000 description 1
• 101000980840 Homo sapiens CD166 antigen Proteins 0.000 description 1
• 101000940485 Homo sapiens COP9 signalosome complex subunit 1 Proteins 0.000 description 1
• 101000762247 Homo sapiens Cadherin-17 Proteins 0.000 description 1
• 101000777239 Homo sapiens Calcineurin B homologous protein 2 Proteins 0.000 description 1
• 101000898052 Homo sapiens Calnexin Proteins 0.000 description 1
• 101000914321 Homo sapiens Carcinoembryonic antigen-related cell adhesion molecule 7 Proteins 0.000 description 1
• 101000892015 Homo sapiens Casein kinase II subunit alpha' Proteins 0.000 description 1
• 101000858625 Homo sapiens Casein kinase II subunit beta Proteins 0.000 description 1
• 101000715398 Homo sapiens Caspase-1 Proteins 0.000 description 1
• 101000983518 Homo sapiens Caspase-10 Proteins 0.000 description 1
• 101000741072 Homo sapiens Caspase-5 Proteins 0.000 description 1
• 101000983523 Homo sapiens Caspase-9 Proteins 0.000 description 1
• 101000898449 Homo sapiens Cathepsin B Proteins 0.000 description 1
• 101000715467 Homo sapiens Caveolin-1 Proteins 0.000 description 1
• 101000914465 Homo sapiens Cell division control protein 6 homolog Proteins 0.000 description 1
• 101000884307 Homo sapiens Cell division cycle protein 16 homolog Proteins 0.000 description 1
• 101000907941 Homo sapiens Centromere protein F Proteins 0.000 description 1
• 101000737602 Homo sapiens Ceramide synthase 1 Proteins 0.000 description 1
• 101000908019 Homo sapiens Ceruloplasmin Proteins 0.000 description 1
• 101000776616 Homo sapiens Choriogonadotropin subunit beta 7 Proteins 0.000 description 1
• 101000902167 Homo sapiens Clustered mitochondria protein homolog Proteins 0.000 description 1
• 101000918350 Homo sapiens Coagulation factor XIII B chain Proteins 0.000 description 1
• 101000945357 Homo sapiens Collagen alpha-1(I) chain Proteins 0.000 description 1
• 101000941581 Homo sapiens Collagen alpha-1(VI) chain Proteins 0.000 description 1
• 101000710873 Homo sapiens Collagen alpha-3(IV) chain Proteins 0.000 description 1
• 101000710870 Homo sapiens Collagen alpha-4(IV) chain Proteins 0.000 description 1
• 101000710886 Homo sapiens Collagen alpha-5(IV) chain Proteins 0.000 description 1
• 101000577887 Homo sapiens Collagenase 3 Proteins 0.000 description 1
• 101000936280 Homo sapiens Copper-transporting ATPase 2 Proteins 0.000 description 1
• 101000746072 Homo sapiens Cullin-2 Proteins 0.000 description 1
• 101000856395 Homo sapiens Cullin-9 Proteins 0.000 description 1
• 101000974934 Homo sapiens Cyclic AMP-dependent transcription factor ATF-2 Proteins 0.000 description 1
• 101000934314 Homo sapiens Cyclin-A1 Proteins 0.000 description 1
• 101000934320 Homo sapiens Cyclin-A2 Proteins 0.000 description 1
• 101000884216 Homo sapiens Cyclin-G2 Proteins 0.000 description 1
• 101000713120 Homo sapiens Cyclin-H Proteins 0.000 description 1
• 101000716088 Homo sapiens Cyclin-L1 Proteins 0.000 description 1
• 101000980920 Homo sapiens Cyclin-dependent kinase 4 inhibitor D Proteins 0.000 description 1
• 101000945639 Homo sapiens Cyclin-dependent kinase inhibitor 3 Proteins 0.000 description 1
• 101000710200 Homo sapiens Cyclin-dependent kinases regulatory subunit 1 Proteins 0.000 description 1
• 101000942317 Homo sapiens Cyclin-dependent kinases regulatory subunit 2 Proteins 0.000 description 1
• 101000912205 Homo sapiens Cystatin-C Proteins 0.000 description 1
• 101000884770 Homo sapiens Cystatin-M Proteins 0.000 description 1
• 101000919361 Homo sapiens Cytochrome P450 2C19 Proteins 0.000 description 1
• 101000909131 Homo sapiens Cytochrome P450 2E1 Proteins 0.000 description 1
• 101000745711 Homo sapiens Cytochrome P450 3A4 Proteins 0.000 description 1
• 101000875933 Homo sapiens Cytochrome c oxidase copper chaperone Proteins 0.000 description 1
• 101000935548 Homo sapiens Cytoplasmic tyrosine-protein kinase BMX Proteins 0.000 description 1
• 101001107795 Homo sapiens Cytosolic Fe-S cluster assembly factor NUBP2 Proteins 0.000 description 1
• 101000968229 Homo sapiens DDIT3 upstream open reading frame protein Proteins 0.000 description 1
• 101000918631 Homo sapiens DNA damage-inducible transcript 3 protein Proteins 0.000 description 1
• 101000876529 Homo sapiens DNA excision repair protein ERCC-1 Proteins 0.000 description 1
• 101000927810 Homo sapiens DNA ligase 4 Proteins 0.000 description 1
• 101000968658 Homo sapiens DNA mismatch repair protein Msh6 Proteins 0.000 description 1
• 101000915428 Homo sapiens Death domain-associated protein 6 Proteins 0.000 description 1
• 101000957914 Homo sapiens Death domain-containing protein CRADD Proteins 0.000 description 1
• 101000956145 Homo sapiens Death-associated protein kinase 1 Proteins 0.000 description 1
• 101001053992 Homo sapiens Deleted in lung and esophageal cancer protein 1 Proteins 0.000 description 1
• 101000928044 Homo sapiens Desmin Proteins 0.000 description 1
• 101000838507 Homo sapiens Developmentally-regulated GTP-binding protein 1 Proteins 0.000 description 1
• 101000845887 Homo sapiens DnaJ homolog subfamily C member 2 Proteins 0.000 description 1
• 101000884921 Homo sapiens Dolichyl-diphosphooligosaccharide-protein glycosyltransferase subunit DAD1 Proteins 0.000 description 1
• 101000954712 Homo sapiens Doublecortin domain-containing protein 1 Proteins 0.000 description 1
• 101001115402 Homo sapiens Dual specificity mitogen-activated protein kinase kinase 2 Proteins 0.000 description 1
• 101001049990 Homo sapiens Dual specificity tyrosine-phosphorylation-regulated kinase 2 Proteins 0.000 description 1
• 101000715390 Homo sapiens E3 ubiquitin-protein ligase CBL Proteins 0.000 description 1
• 101001048720 Homo sapiens ETS domain-containing protein Elk-3 Proteins 0.000 description 1
• 101000866749 Homo sapiens Elongation factor 2 Proteins 0.000 description 1
• 101000925493 Homo sapiens Endothelin-1 Proteins 0.000 description 1
• 101000978392 Homo sapiens Eotaxin Proteins 0.000 description 1
• 101000898647 Homo sapiens Ephrin type-A receptor 4 Proteins 0.000 description 1
• 101001049377 Homo sapiens Ephrin-B3 Proteins 0.000 description 1
• 101000851181 Homo sapiens Epidermal growth factor receptor Proteins 0.000 description 1
• 101001077852 Homo sapiens Epoxide hydrolase 1 Proteins 0.000 description 1
• 101001034825 Homo sapiens Eukaryotic translation initiation factor 4 gamma 1 Proteins 0.000 description 1
• 101000678280 Homo sapiens Eukaryotic translation initiation factor 4E-binding protein 1 Proteins 0.000 description 1
• 101001055992 Homo sapiens Exosome complex component RRP42 Proteins 0.000 description 1
• 101000854648 Homo sapiens Ezrin Proteins 0.000 description 1
• 101000893764 Homo sapiens FUN14 domain-containing protein 2 Proteins 0.000 description 1
• 101000911337 Homo sapiens Fatty acid-binding protein, intestinal Proteins 0.000 description 1
• 101000878128 Homo sapiens Fibroblast growth factor 18 Proteins 0.000 description 1
• 101000846394 Homo sapiens Fibroblast growth factor 19 Proteins 0.000 description 1
• 101001052035 Homo sapiens Fibroblast growth factor 2 Proteins 0.000 description 1
• 101001051973 Homo sapiens Fibroblast growth factor 23 Proteins 0.000 description 1
• 101001060280 Homo sapiens Fibroblast growth factor 3 Proteins 0.000 description 1
• 101001060265 Homo sapiens Fibroblast growth factor 6 Proteins 0.000 description 1
• 101001060261 Homo sapiens Fibroblast growth factor 7 Proteins 0.000 description 1
• 101001027382 Homo sapiens Fibroblast growth factor 8 Proteins 0.000 description 1
• 101001027380 Homo sapiens Fibroblast growth factor 9 Proteins 0.000 description 1
• 101000893054 Homo sapiens Follitropin subunit beta Proteins 0.000 description 1
• 101000818310 Homo sapiens Forkhead box protein C1 Proteins 0.000 description 1
• 101000861406 Homo sapiens Forkhead box protein Q1 Proteins 0.000 description 1
• 101000819438 Homo sapiens Frizzled-1 Proteins 0.000 description 1
• 101000819477 Homo sapiens Frizzled-2 Proteins 0.000 description 1
• 101000755879 Homo sapiens Fructose-bisphosphate aldolase A Proteins 0.000 description 1
• 101000755933 Homo sapiens Fructose-bisphosphate aldolase B Proteins 0.000 description 1
• 101000836545 Homo sapiens Fructose-bisphosphate aldolase C Proteins 0.000 description 1
• 101000980756 Homo sapiens G1/S-specific cyclin-D1 Proteins 0.000 description 1
• 101000738575 Homo sapiens G1/S-specific cyclin-E2 Proteins 0.000 description 1
• 101000868643 Homo sapiens G2/mitotic-specific cyclin-B1 Proteins 0.000 description 1
• 101000713023 Homo sapiens G2/mitotic-specific cyclin-B2 Proteins 0.000 description 1
• 101000584633 Homo sapiens GTPase HRas Proteins 0.000 description 1
• 101001058231 Homo sapiens Gamma-enolase Proteins 0.000 description 1
• 101001058904 Homo sapiens Gamma-tubulin complex component 2 Proteins 0.000 description 1
• 101000941284 Homo sapiens Gastric triacylglycerol lipase Proteins 0.000 description 1
• 101000886596 Homo sapiens Geminin Proteins 0.000 description 1
• 101000870644 Homo sapiens Glutamate-cysteine ligase regulatory subunit Proteins 0.000 description 1
• 101001071716 Homo sapiens Glutathione S-transferase Mu 3 Proteins 0.000 description 1
• 101000871129 Homo sapiens Glutathione peroxidase 2 Proteins 0.000 description 1
• 101001014636 Homo sapiens Golgin subfamily A member 4 Proteins 0.000 description 1
• 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 description 1
• 101001033007 Homo sapiens Granzyme K Proteins 0.000 description 1
• 101001072723 Homo sapiens Growth arrest-specific protein 1 Proteins 0.000 description 1
• 101001082627 Homo sapiens HLA class II histocompatibility antigen gamma chain Proteins 0.000 description 1
• 101001037977 Homo sapiens Heat shock 70 kDa protein 1-like Proteins 0.000 description 1
• 101001037968 Homo sapiens Heat shock 70 kDa protein 1B Proteins 0.000 description 1
• 101000867525 Homo sapiens Heat shock factor protein 1 Proteins 0.000 description 1
• 101001078626 Homo sapiens Heat shock protein HSP 90-alpha A2 Proteins 0.000 description 1
• 101000985806 Homo sapiens Heat shock-related 70 kDa protein 2 Proteins 0.000 description 1
• 101001079623 Homo sapiens Heme oxygenase 1 Proteins 0.000 description 1
• 101001066338 Homo sapiens Hepatocyte growth factor activator Proteins 0.000 description 1
• 101000986380 Homo sapiens High mobility group protein HMG-I/HMG-Y Proteins 0.000 description 1
• 101001036109 Homo sapiens Histone H2A type 1-C Proteins 0.000 description 1
• 101001046967 Homo sapiens Histone acetyltransferase KAT2A Proteins 0.000 description 1
• 101001028782 Homo sapiens Histone-lysine N-methyltransferase EZH1 Proteins 0.000 description 1
• 101000843809 Homo sapiens Hydroxycarboxylic acid receptor 2 Proteins 0.000 description 1
• 101001054725 Homo sapiens Inhibin beta B chain Proteins 0.000 description 1
• 101000994880 Homo sapiens Inorganic pyrophosphatase 2, mitochondrial Proteins 0.000 description 1
• 101000976075 Homo sapiens Insulin Proteins 0.000 description 1
• 101001044940 Homo sapiens Insulin-like growth factor-binding protein 2 Proteins 0.000 description 1
• 101000994365 Homo sapiens Integrin alpha-6 Proteins 0.000 description 1
• 101001015006 Homo sapiens Integrin beta-4 Proteins 0.000 description 1
• 101001015059 Homo sapiens Integrin beta-5 Proteins 0.000 description 1
• 101001015064 Homo sapiens Integrin beta-6 Proteins 0.000 description 1
• 101000997670 Homo sapiens Integrin beta-8 Proteins 0.000 description 1
• 101000852865 Homo sapiens Interferon alpha/beta receptor 2 Proteins 0.000 description 1
• 101000599940 Homo sapiens Interferon gamma Proteins 0.000 description 1
• 101001001496 Homo sapiens Interferon gamma receptor 2 Proteins 0.000 description 1
• 101001033233 Homo sapiens Interleukin-10 Proteins 0.000 description 1
• 101001010568 Homo sapiens Interleukin-11 Proteins 0.000 description 1
• 101000852992 Homo sapiens Interleukin-12 subunit beta Proteins 0.000 description 1
• 101001003135 Homo sapiens Interleukin-13 receptor subunit alpha-1 Proteins 0.000 description 1
• 101000998146 Homo sapiens Interleukin-17A Proteins 0.000 description 1
• 101001033312 Homo sapiens Interleukin-4 receptor subunit alpha Proteins 0.000 description 1
• 101000960969 Homo sapiens Interleukin-5 Proteins 0.000 description 1
• 101000599048 Homo sapiens Interleukin-6 receptor subunit alpha Proteins 0.000 description 1
• 101001055216 Homo sapiens Interleukin-9 Proteins 0.000 description 1
• 101000605514 Homo sapiens Kallikrein-13 Proteins 0.000 description 1
• 101000605520 Homo sapiens Kallikrein-14 Proteins 0.000 description 1
• 101000605528 Homo sapiens Kallikrein-2 Proteins 0.000 description 1
• 101001091388 Homo sapiens Kallikrein-7 Proteins 0.000 description 1
• 101000614439 Homo sapiens Keratin, type I cytoskeletal 15 Proteins 0.000 description 1
• 101000998027 Homo sapiens Keratin, type I cytoskeletal 17 Proteins 0.000 description 1
• 101000998020 Homo sapiens Keratin, type I cytoskeletal 18 Proteins 0.000 description 1
• 101001005128 Homo sapiens LIM domain kinase 1 Proteins 0.000 description 1
• 101001047511 Homo sapiens LLGL scribble cell polarity complex component 2 Proteins 0.000 description 1
• 101000798114 Homo sapiens Lactotransferrin Proteins 0.000 description 1
• 101001004946 Homo sapiens Lactoylglutathione lyase Proteins 0.000 description 1
• 101000619898 Homo sapiens Leukotriene A-4 hydrolase Proteins 0.000 description 1
• 101000984620 Homo sapiens Low-density lipoprotein receptor-related protein 1B Proteins 0.000 description 1
• 101000965689 Homo sapiens Lutropin subunit beta Proteins 0.000 description 1
• 101000624625 Homo sapiens M-phase inducer phosphatase 1 Proteins 0.000 description 1
• 101000590691 Homo sapiens MAGUK p55 subfamily member 2 Proteins 0.000 description 1
• 101001115423 Homo sapiens MAGUK p55 subfamily member 4 Proteins 0.000 description 1
• 101001014572 Homo sapiens MARCKS-related protein Proteins 0.000 description 1
• 101000916628 Homo sapiens Macrophage colony-stimulating factor 1 Proteins 0.000 description 1
• 101000577881 Homo sapiens Macrophage metalloelastase Proteins 0.000 description 1
• 101001056308 Homo sapiens Malate dehydrogenase, cytoplasmic Proteins 0.000 description 1
• 101001011906 Homo sapiens Matrix metalloproteinase-14 Proteins 0.000 description 1
• 101001057193 Homo sapiens Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Proteins 0.000 description 1
• 101001027925 Homo sapiens Metastasis-associated protein MTA1 Proteins 0.000 description 1
• 101001091223 Homo sapiens Metastasis-suppressor KiSS-1 Proteins 0.000 description 1
• 101000581507 Homo sapiens Methyl-CpG-binding domain protein 1 Proteins 0.000 description 1
• 101000615488 Homo sapiens Methyl-CpG-binding domain protein 2 Proteins 0.000 description 1
• 101001052490 Homo sapiens Mitogen-activated protein kinase 3 Proteins 0.000 description 1
• 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 description 1
• 101000969812 Homo sapiens Multidrug resistance-associated protein 1 Proteins 0.000 description 1
• 101000593405 Homo sapiens Myb-related protein B Proteins 0.000 description 1
• 101000616778 Homo sapiens Myelin-associated glycoprotein Proteins 0.000 description 1
• 101000586000 Homo sapiens Myocardin Proteins 0.000 description 1
• 101000982032 Homo sapiens Myosin-binding protein C, cardiac-type Proteins 0.000 description 1
• 101000654298 Homo sapiens N-terminal kinase-like protein Proteins 0.000 description 1
• 101000998194 Homo sapiens NF-kappa-B inhibitor epsilon Proteins 0.000 description 1
• 101001124571 Homo sapiens NT-3 growth factor receptor Proteins 0.000 description 1
• 101001125417 Homo sapiens Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Proteins 0.000 description 1
• 101001123834 Homo sapiens Neprilysin Proteins 0.000 description 1
• 101001041015 Homo sapiens Netrin receptor DCC Proteins 0.000 description 1
• 101000581981 Homo sapiens Neural cell adhesion molecule 1 Proteins 0.000 description 1
• 101000577202 Homo sapiens Neurogenic locus notch homolog protein 3 Proteins 0.000 description 1
• 101000596404 Homo sapiens Neuronal vesicle trafficking-associated protein 1 Proteins 0.000 description 1
• 101000603386 Homo sapiens Neuropeptide Y receptor type 1 Proteins 0.000 description 1
• 101000634196 Homo sapiens Neurotrophin-3 Proteins 0.000 description 1
• 101000990908 Homo sapiens Neutrophil collagenase Proteins 0.000 description 1
• 101000998855 Homo sapiens Nicotinamide phosphoribosyltransferase Proteins 0.000 description 1
• 101000974009 Homo sapiens Nitric oxide synthase, brain Proteins 0.000 description 1
• 101000979342 Homo sapiens Nuclear factor NF-kappa-B p105 subunit Proteins 0.000 description 1
• 101000633503 Homo sapiens Nuclear receptor subfamily 2 group E member 1 Proteins 0.000 description 1
• 101000973960 Homo sapiens Nucleolar protein 3 Proteins 0.000 description 1
• 101000721757 Homo sapiens Olfactory receptor 51E2 Proteins 0.000 description 1
• 101000744394 Homo sapiens Oxidized purine nucleoside triphosphate hydrolase Proteins 0.000 description 1
• 101000736088 Homo sapiens PC4 and SFRS1-interacting protein Proteins 0.000 description 1
• 101001000773 Homo sapiens POU domain, class 2, transcription factor 2 Proteins 0.000 description 1
• 101001123300 Homo sapiens PR domain zinc finger protein 13 Proteins 0.000 description 1
• 101000601724 Homo sapiens Paired box protein Pax-5 Proteins 0.000 description 1
• 101001135770 Homo sapiens Parathyroid hormone Proteins 0.000 description 1
• 101000589873 Homo sapiens Parathyroid hormone/parathyroid hormone-related peptide receptor Proteins 0.000 description 1
• 101000932178 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP4 Proteins 0.000 description 1
• 101000878221 Homo sapiens Peptidyl-prolyl cis-trans isomerase FKBP8 Proteins 0.000 description 1
• 101000691852 Homo sapiens Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Proteins 0.000 description 1
• 101001090047 Homo sapiens Peroxiredoxin-4 Proteins 0.000 description 1
• 101001098116 Homo sapiens Phosphatidylinositol 3-kinase regulatory subunit gamma Proteins 0.000 description 1
• 101000689394 Homo sapiens Phospholipid scramblase 4 Proteins 0.000 description 1
• 101001091365 Homo sapiens Plasma kallikrein Proteins 0.000 description 1
• 101001126417 Homo sapiens Platelet-derived growth factor receptor alpha Proteins 0.000 description 1
• 101001113483 Homo sapiens Poly [ADP-ribose] polymerase 1 Proteins 0.000 description 1
• 101001035694 Homo sapiens Polyamine deacetylase HDAC10 Proteins 0.000 description 1
• 101000617725 Homo sapiens Pregnancy-specific beta-1-glycoprotein 2 Proteins 0.000 description 1
• 101000617536 Homo sapiens Presenilin-1 Proteins 0.000 description 1
• 101001109800 Homo sapiens Pro-neuregulin-1, membrane-bound isoform Proteins 0.000 description 1
• 101000599816 Homo sapiens Probable E3 ubiquitin-protein ligase IRF2BPL Proteins 0.000 description 1
• 101001135995 Homo sapiens Probable peptidyl-tRNA hydrolase Proteins 0.000 description 1
• 101001092930 Homo sapiens Prosaposin Proteins 0.000 description 1
• 101000605122 Homo sapiens Prostaglandin G/H synthase 1 Proteins 0.000 description 1
• 101000605127 Homo sapiens Prostaglandin G/H synthase 2 Proteins 0.000 description 1
• 101001136592 Homo sapiens Prostate stem cell antigen Proteins 0.000 description 1
• 101000605534 Homo sapiens Prostate-specific antigen Proteins 0.000 description 1
• 101001001272 Homo sapiens Prostatic acid phosphatase Proteins 0.000 description 1
• 101000892360 Homo sapiens Protein AF-17 Proteins 0.000 description 1
• 101000892338 Homo sapiens Protein AF1q Proteins 0.000 description 1
• 101001116549 Homo sapiens Protein CBFA2T2 Proteins 0.000 description 1
• 101001028689 Homo sapiens Protein JTB Proteins 0.000 description 1
• 101000653784 Homo sapiens Protein S100-A12 Proteins 0.000 description 1
• 101000620365 Homo sapiens Protein TMEPAI Proteins 0.000 description 1
• 101000757232 Homo sapiens Protein arginine N-methyltransferase 2 Proteins 0.000 description 1
• 101001051777 Homo sapiens Protein kinase C alpha type Proteins 0.000 description 1
• 101001026852 Homo sapiens Protein kinase C epsilon type Proteins 0.000 description 1
• 101000971404 Homo sapiens Protein kinase C iota type Proteins 0.000 description 1
• 101001000998 Homo sapiens Protein phosphatase 1 regulatory subunit 12C Proteins 0.000 description 1
• 101000611643 Homo sapiens Protein phosphatase 1 regulatory subunit 15A Proteins 0.000 description 1
• 101000651439 Homo sapiens Prothrombin Proteins 0.000 description 1
• 101000579425 Homo sapiens Proto-oncogene tyrosine-protein kinase receptor Ret Proteins 0.000 description 1
• 101000713296 Homo sapiens Proton-coupled amino acid transporter 1 Proteins 0.000 description 1
• 101000795018 Homo sapiens Putative trypsin-6 Proteins 0.000 description 1
• 101000779418 Homo sapiens RAC-alpha serine/threonine-protein kinase Proteins 0.000 description 1
• 101000798015 Homo sapiens RAC-beta serine/threonine-protein kinase Proteins 0.000 description 1
• 101000668165 Homo sapiens RNA-binding motif, single-stranded-interacting protein 1 Proteins 0.000 description 1
• 101001096541 Homo sapiens Rac GTPase-activating protein 1 Proteins 0.000 description 1
• 101000580039 Homo sapiens Ras-specific guanine nucleotide-releasing factor 1 Proteins 0.000 description 1
• 101001010819 Homo sapiens Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 description 1
• 101001010823 Homo sapiens Receptor tyrosine-protein kinase erbB-4 Proteins 0.000 description 1
• 101001109145 Homo sapiens Receptor-interacting serine/threonine-protein kinase 1 Proteins 0.000 description 1
• 101001096332 Homo sapiens Retinol-binding protein 5 Proteins 0.000 description 1
• 101000927796 Homo sapiens Rho guanine nucleotide exchange factor 7 Proteins 0.000 description 1
• 101000686685 Homo sapiens Ribonuclease P protein subunit p14 Proteins 0.000 description 1
• 101000650588 Homo sapiens Roundabout homolog 3 Proteins 0.000 description 1
• 101000687715 Homo sapiens SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 Proteins 0.000 description 1
• 101000867469 Homo sapiens Segment polarity protein dishevelled homolog DVL-3 Proteins 0.000 description 1
• 101000705949 Homo sapiens Serine protease 57 Proteins 0.000 description 1
• 101000872580 Homo sapiens Serine protease hepsin Proteins 0.000 description 1
• 101000701401 Homo sapiens Serine/threonine-protein kinase 38 Proteins 0.000 description 1
• 101000777293 Homo sapiens Serine/threonine-protein kinase Chk1 Proteins 0.000 description 1
• 101001059454 Homo sapiens Serine/threonine-protein kinase MARK2 Proteins 0.000 description 1
• 101000595531 Homo sapiens Serine/threonine-protein kinase pim-1 Proteins 0.000 description 1
• 101001001648 Homo sapiens Serine/threonine-protein kinase pim-2 Proteins 0.000 description 1
• 101001001645 Homo sapiens Serine/threonine-protein kinase pim-3 Proteins 0.000 description 1
• 101000868152 Homo sapiens Son of sevenless homolog 1 Proteins 0.000 description 1
• 101000616188 Homo sapiens Splicing factor 3B subunit 6 Proteins 0.000 description 1
• 101000577874 Homo sapiens Stromelysin-2 Proteins 0.000 description 1
• 101000577877 Homo sapiens Stromelysin-3 Proteins 0.000 description 1
• 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 description 1
• 101000712674 Homo sapiens TGF-beta receptor type-1 Proteins 0.000 description 1
• 101000635804 Homo sapiens Tissue factor Proteins 0.000 description 1
• 101000819111 Homo sapiens Trans-acting T-cell-specific transcription factor GATA-3 Proteins 0.000 description 1
• 101000904150 Homo sapiens Transcription factor E2F3 Proteins 0.000 description 1
• 101000866336 Homo sapiens Transcription factor E2F5 Proteins 0.000 description 1
• 101001050288 Homo sapiens Transcription factor Jun Proteins 0.000 description 1
• 101001050297 Homo sapiens Transcription factor JunD Proteins 0.000 description 1
• 101001074042 Homo sapiens Transcriptional activator GLI3 Proteins 0.000 description 1
• 101000796673 Homo sapiens Transformation/transcription domain-associated protein Proteins 0.000 description 1
• 101000634975 Homo sapiens Tripartite motif-containing protein 29 Proteins 0.000 description 1
• 101000850794 Homo sapiens Tropomyosin alpha-3 chain Proteins 0.000 description 1
• 101000610605 Homo sapiens Tumor necrosis factor receptor superfamily member 10A Proteins 0.000 description 1
• 101000610604 Homo sapiens Tumor necrosis factor receptor superfamily member 10B Proteins 0.000 description 1
• 101000611185 Homo sapiens Tumor necrosis factor receptor superfamily member 5 Proteins 0.000 description 1
• 101000823271 Homo sapiens Tyrosine-protein kinase ABL2 Proteins 0.000 description 1
• 101000984551 Homo sapiens Tyrosine-protein kinase Blk Proteins 0.000 description 1
• 101001026790 Homo sapiens Tyrosine-protein kinase Fes/Fps Proteins 0.000 description 1
• 101000638886 Homo sapiens Urokinase-type plasminogen activator Proteins 0.000 description 1
• 101000742599 Homo sapiens Vascular endothelial growth factor D Proteins 0.000 description 1
• 101000851030 Homo sapiens Vascular endothelial growth factor receptor 3 Proteins 0.000 description 1
• 101000723920 Homo sapiens Zinc finger protein 40 Proteins 0.000 description 1
• 101001117146 Homo sapiens [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Proteins 0.000 description 1
• 102100031568 Hsp90 co-chaperone Cdc37 Human genes 0.000 description 1
• 101150065069 Hsp90b1 gene Proteins 0.000 description 1
• 208000029966 Hutchinson Melanotic Freckle Diseases 0.000 description 1
• DOMWKUIIPQCAJU-LJHIYBGHSA-N Hydroxyprogesterone caproate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)CCCCC)[C@@]1(C)CC2 DOMWKUIIPQCAJU-LJHIYBGHSA-N 0.000 description 1
• VSNHCAURESNICA-UHFFFAOYSA-N Hydroxyurea Chemical compound NC(=O)NO VSNHCAURESNICA-UHFFFAOYSA-N 0.000 description 1
• 206010021143 Hypoxia Diseases 0.000 description 1
• 108010028501 Hypoxia-Inducible Factor 1 Proteins 0.000 description 1
• 102000016878 Hypoxia-Inducible Factor 1 Human genes 0.000 description 1
• XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
• 108091058560 IL8 Proteins 0.000 description 1
• 102000043138 IRF family Human genes 0.000 description 1
• 108091054729 IRF family Proteins 0.000 description 1
• MPBVHIBUJCELCL-UHFFFAOYSA-N Ibandronate Chemical compound CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)(O)=O MPBVHIBUJCELCL-UHFFFAOYSA-N 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 102000037978 Immune checkpoint receptors Human genes 0.000 description 1
• 108091008028 Immune checkpoint receptors Proteins 0.000 description 1
• 108060003951 Immunoglobulin Proteins 0.000 description 1
• 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 description 1
• 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 description 1
• 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
• 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
• 206010062016 Immunosuppression Diseases 0.000 description 1
• 102100040061 Indoleamine 2,3-dioxygenase 1 Human genes 0.000 description 1
• 101710120843 Indoleamine 2,3-dioxygenase 1 Proteins 0.000 description 1
• 102100027004 Inhibin beta A chain Human genes 0.000 description 1
• 102100027003 Inhibin beta B chain Human genes 0.000 description 1
• 102000055031 Inhibitor of Apoptosis Proteins Human genes 0.000 description 1
• 108010055912 Inhibitor of Differentiation Protein 2 Proteins 0.000 description 1
• 102100034415 Inorganic pyrophosphatase 2, mitochondrial Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 1
• 102100022710 Insulin-like growth factor-binding protein 2 Human genes 0.000 description 1
• 102100032818 Integrin alpha-4 Human genes 0.000 description 1
• 102000000507 Integrin alpha2 Human genes 0.000 description 1
• 108010008212 Integrin alpha4beta1 Proteins 0.000 description 1
• 108010041014 Integrin alpha5 Proteins 0.000 description 1
• 102100033010 Integrin beta-5 Human genes 0.000 description 1
• 102100033011 Integrin beta-6 Human genes 0.000 description 1
• 102100033336 Integrin beta-8 Human genes 0.000 description 1
• 108010022222 Integrin beta1 Proteins 0.000 description 1
• 102000012355 Integrin beta1 Human genes 0.000 description 1
• 102000008607 Integrin beta3 Human genes 0.000 description 1
• 102100020944 Integrin-linked protein kinase Human genes 0.000 description 1
• 101710083924 Inter-alpha-trypsin inhibitor heavy chain H4 Proteins 0.000 description 1
• 102100036718 Interferon alpha/beta receptor 2 Human genes 0.000 description 1
• 102100036981 Interferon regulatory factor 1 Human genes 0.000 description 1
• 101710166698 Interferon-induced protein with tetratricopeptide repeats 2 Proteins 0.000 description 1
• 229940119178 Interleukin 1 receptor antagonist Drugs 0.000 description 1
• 102000051628 Interleukin-1 receptor antagonist Human genes 0.000 description 1
• 101710144554 Interleukin-1 receptor antagonist protein Proteins 0.000 description 1
• 102000003814 Interleukin-10 Human genes 0.000 description 1
• 108090000177 Interleukin-11 Proteins 0.000 description 1
• 102000013462 Interleukin-12 Human genes 0.000 description 1
• 108010065805 Interleukin-12 Proteins 0.000 description 1
• 101710194995 Interleukin-12 subunit alpha Proteins 0.000 description 1
• 102000003816 Interleukin-13 Human genes 0.000 description 1
• 102100033461 Interleukin-17A Human genes 0.000 description 1
• 102000003810 Interleukin-18 Human genes 0.000 description 1
• 102100039078 Interleukin-4 receptor subunit alpha Human genes 0.000 description 1
• 102000004889 Interleukin-6 Human genes 0.000 description 1
• 102100037792 Interleukin-6 receptor subunit alpha Human genes 0.000 description 1
• 102100021592 Interleukin-7 Human genes 0.000 description 1
• 108010002586 Interleukin-7 Proteins 0.000 description 1
• 208000005016 Intestinal Neoplasms Diseases 0.000 description 1
• 241000764238 Isis Species 0.000 description 1
• 102000042838 JAK family Human genes 0.000 description 1
• 108091082332 JAK family Proteins 0.000 description 1
• 101710176060 JNK1/MAPK8-associated membrane protein Proteins 0.000 description 1
• 102100038315 Kallikrein-13 Human genes 0.000 description 1
• 102100038298 Kallikrein-14 Human genes 0.000 description 1
• 102100038356 Kallikrein-2 Human genes 0.000 description 1
• 101710176225 Kallikrein-8 Proteins 0.000 description 1
• 101710183403 Keratin, type I cytoskeletal 13 Proteins 0.000 description 1
• 101710183392 Keratin, type I cytoskeletal 15 Proteins 0.000 description 1
• 102100033511 Keratin, type I cytoskeletal 17 Human genes 0.000 description 1
• 102100033421 Keratin, type I cytoskeletal 18 Human genes 0.000 description 1
• 101710183399 Keratin, type I cytoskeletal 19 Proteins 0.000 description 1
• 108010066330 Keratin-15 Proteins 0.000 description 1
• 108010070921 Keratin-4 Proteins 0.000 description 1
• 208000008839 Kidney Neoplasms Diseases 0.000 description 1
• 102000010638 Kinesin Human genes 0.000 description 1
• 108010063296 Kinesin Proteins 0.000 description 1
• 102100023426 Kinesin-like protein KIF2A Human genes 0.000 description 1
• 101710177504 Kit ligand Proteins 0.000 description 1
• MLFKVJCWGUZWNV-UHFFFAOYSA-N L-alanosine Natural products OC(=O)C(N)CN(O)N=O MLFKVJCWGUZWNV-UHFFFAOYSA-N 0.000 description 1
• 102100034671 L-lactate dehydrogenase A chain Human genes 0.000 description 1
• ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
• 239000002067 L01XE06 - Dasatinib Substances 0.000 description 1
• 239000002136 L01XE07 - Lapatinib Substances 0.000 description 1
• 239000005536 L01XE08 - Nilotinib Substances 0.000 description 1
• 102000007330 LDL Lipoproteins Human genes 0.000 description 1
• 108010007622 LDL Lipoproteins Proteins 0.000 description 1
• 102100026023 LIM domain kinase 1 Human genes 0.000 description 1
• UIARLYUEJFELEN-LROUJFHJSA-N LSM-1231 Chemical compound C12=C3N4C5=CC=CC=C5C3=C3C(=O)NCC3=C2C2=CC=CC=C2N1[C@]1(C)[C@](CO)(O)C[C@H]4O1 UIARLYUEJFELEN-LROUJFHJSA-N 0.000 description 1
• 101710191666 Lactadherin Proteins 0.000 description 1
• 102100032241 Lactotransferrin Human genes 0.000 description 1
• 102100026004 Lactoylglutathione lyase Human genes 0.000 description 1
• 108010085895 Laminin Proteins 0.000 description 1
• 102100034710 Laminin subunit gamma-1 Human genes 0.000 description 1
• 206010023825 Laryngeal cancer Diseases 0.000 description 1
• 206010024218 Lentigo maligna Diseases 0.000 description 1
• 102100030874 Leptin Human genes 0.000 description 1
• 208000035036 Lethal congenital contracture syndrome type 2 Diseases 0.000 description 1
• ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
• 102100022118 Leukotriene A-4 hydrolase Human genes 0.000 description 1
• 201000004462 Leydig Cell Tumor Diseases 0.000 description 1
• 108010057281 Lipocalin 1 Proteins 0.000 description 1
• 102000001774 Low Density Lipoprotein Receptor-Related Protein-6 Human genes 0.000 description 1
• 108010015179 Low Density Lipoprotein Receptor-Related Protein-6 Proteins 0.000 description 1
• 101710136784 Low-density lipoprotein receptor-related protein 1B Proteins 0.000 description 1
• 101710183224 Lutropin subunit beta Proteins 0.000 description 1
• 206010025219 Lymphangioma Diseases 0.000 description 1
• 102100020862 Lymphocyte activation gene 3 protein Human genes 0.000 description 1
• 208000028018 Lymphocytic leukaemia Diseases 0.000 description 1
• 102000003959 Lymphotoxin-beta Human genes 0.000 description 1
• 108090000362 Lymphotoxin-beta Proteins 0.000 description 1
• 201000003791 MALT lymphoma Diseases 0.000 description 1
• 102100034069 MAP kinase-activated protein kinase 2 Human genes 0.000 description 1
• 101710141394 MAP kinase-activated protein kinase 2 Proteins 0.000 description 1
• 229940124647 MEK inhibitor Drugs 0.000 description 1
• 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 description 1
• 101710127797 Macrophage colony-stimulating factor 1 Proteins 0.000 description 1
• 108030001712 Macrophage elastases Proteins 0.000 description 1
• 235000019759 Maize starch Nutrition 0.000 description 1
• 101710125418 Major capsid protein Proteins 0.000 description 1
• 101710094960 Major vault protein Proteins 0.000 description 1
• 101001059732 Malassezia furfur Putative peroxiredoxin Proteins 0.000 description 1
• 102100026475 Malate dehydrogenase, cytoplasmic Human genes 0.000 description 1
• 206010064281 Malignant atrophic papulosis Diseases 0.000 description 1
• 101710202646 Malonyl-CoA decarboxylase, mitochondrial Proteins 0.000 description 1
• 241000124008 Mammalia Species 0.000 description 1
• 108090000855 Matrilysin Proteins 0.000 description 1
• 108010076497 Matrix Metalloproteinase 10 Proteins 0.000 description 1
• 108010076502 Matrix Metalloproteinase 11 Proteins 0.000 description 1
• 108010076503 Matrix Metalloproteinase 13 Proteins 0.000 description 1
• 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 description 1
• 102100030216 Matrix metalloproteinase-14 Human genes 0.000 description 1
• 102000004043 Matrix metalloproteinase-15 Human genes 0.000 description 1
• 102000001776 Matrix metalloproteinase-9 Human genes 0.000 description 1
• 108010015302 Matrix metalloproteinase-9 Proteins 0.000 description 1
• 102000000490 Mediator Complex Human genes 0.000 description 1
• 108010080991 Mediator Complex Proteins 0.000 description 1
• 102000010904 Mediator Complex Subunit 1 Human genes 0.000 description 1
• 108010062495 Mediator Complex Subunit 1 Proteins 0.000 description 1
• 208000007054 Medullary Carcinoma Diseases 0.000 description 1
• 208000000172 Medulloblastoma Diseases 0.000 description 1
• 102100022185 Melanoma-derived growth regulatory protein Human genes 0.000 description 1
• ZRVUJXDFFKFLMG-UHFFFAOYSA-N Meloxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=NC=C(C)S1 ZRVUJXDFFKFLMG-UHFFFAOYSA-N 0.000 description 1
• 108010047230 Member 1 Subfamily B ATP Binding Cassette Transporter Proteins 0.000 description 1
• 101710132836 Membrane primary amine oxidase Proteins 0.000 description 1
• 101710137278 Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1 Proteins 0.000 description 1
• 208000002030 Merkel cell carcinoma Diseases 0.000 description 1
• 102000003735 Mesothelin Human genes 0.000 description 1
• 108090000015 Mesothelin Proteins 0.000 description 1
• 206010027406 Mesothelioma Diseases 0.000 description 1
• 101710140999 Metallocarboxypeptidase inhibitor Proteins 0.000 description 1
• 102000005741 Metalloproteases Human genes 0.000 description 1
• 108010006035 Metalloproteases Proteins 0.000 description 1
• 102100039364 Metalloproteinase inhibitor 1 Human genes 0.000 description 1
• 101710196500 Metallothionein-1A Proteins 0.000 description 1
• 102100037512 Metallothionein-1G Human genes 0.000 description 1
• 101710196491 Metallothionein-1G Proteins 0.000 description 1
• 206010054949 Metaplasia Diseases 0.000 description 1
• 102100037517 Metastasis-associated protein MTA1 Human genes 0.000 description 1
• 101710111887 Methyl-CpG-binding domain protein 1 Proteins 0.000 description 1
• 102100021299 Methyl-CpG-binding domain protein 2 Human genes 0.000 description 1
• 102100025825 Methylated-DNA-protein-cysteine methyltransferase Human genes 0.000 description 1
• 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
• 108010092801 Midkine Proteins 0.000 description 1
• 108010079788 Minichromosome Maintenance Complex Component 3 Proteins 0.000 description 1
• 108010079756 Minichromosome Maintenance Complex Component 5 Proteins 0.000 description 1
• 102000044589 Mitogen-Activated Protein Kinase 1 Human genes 0.000 description 1
• 102000046795 Mitogen-Activated Protein Kinase 3 Human genes 0.000 description 1
• 108700027649 Mitogen-Activated Protein Kinase 3 Proteins 0.000 description 1
• 108700027648 Mitogen-Activated Protein Kinase 8 Proteins 0.000 description 1
• 102000004232 Mitogen-Activated Protein Kinase Kinases Human genes 0.000 description 1
• 108090000744 Mitogen-Activated Protein Kinase Kinases Proteins 0.000 description 1
• 108700015928 Mitogen-activated protein kinase 13 Proteins 0.000 description 1
• 102000054819 Mitogen-activated protein kinase 14 Human genes 0.000 description 1
• 102100024192 Mitogen-activated protein kinase 3 Human genes 0.000 description 1
• 102100038792 Mitotic spindle assembly checkpoint protein MAD2A Human genes 0.000 description 1
• 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 description 1
• 208000003445 Mouth Neoplasms Diseases 0.000 description 1
• 108010063954 Mucins Proteins 0.000 description 1
• 102000015728 Mucins Human genes 0.000 description 1
• 108010066419 Multidrug Resistance-Associated Protein 2 Proteins 0.000 description 1
• 102100021339 Multidrug resistance-associated protein 1 Human genes 0.000 description 1
• 101000957364 Mus musculus Cytochrome P450 2B10 Proteins 0.000 description 1
• 101001002507 Mus musculus Immunoglobulin-binding protein 1 Proteins 0.000 description 1
• 101100460138 Mus musculus Nedd8 gene Proteins 0.000 description 1
• 101001067395 Mus musculus Phospholipid scramblase 1 Proteins 0.000 description 1
• 101000612136 Mus musculus Procollagen C-endopeptidase enhancer 1 Proteins 0.000 description 1
• 101000686934 Mus musculus Prolactin-7D1 Proteins 0.000 description 1
• 101710135898 Myc proto-oncogene protein Proteins 0.000 description 1
• 101000983859 Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) Lipoprotein LpqH Proteins 0.000 description 1
• 102100038610 Myeloperoxidase Human genes 0.000 description 1
• 108090000235 Myeloperoxidases Proteins 0.000 description 1
• 102100030217 Myocardin Human genes 0.000 description 1
• 101001055320 Myxine glutinosa Insulin-like growth factor Proteins 0.000 description 1
• 206010073137 Myxoid liposarcoma Diseases 0.000 description 1
• WNYADZVDBIBLJJ-UHFFFAOYSA-N N-Nitrosopyrrolidine Chemical compound O=NN1CCCC1 WNYADZVDBIBLJJ-UHFFFAOYSA-N 0.000 description 1
• 102100031911 NEDD8 Human genes 0.000 description 1
• 108010057466 NF-kappa B Proteins 0.000 description 1
• 101710083073 NF-kappa-B inhibitor alpha Proteins 0.000 description 1
• 108020001364 NR0 subfamily Proteins 0.000 description 1
• KTDZCOWXCWUPEO-UHFFFAOYSA-N NS-398 Chemical compound CS(=O)(=O)NC1=CC=C([N+]([O-])=O)C=C1OC1CCCCC1 KTDZCOWXCWUPEO-UHFFFAOYSA-N 0.000 description 1
• GPVKLYONJSSZFL-UHFFFAOYSA-N NSC 750259 Natural products CCC(C)C=CC(O)C(O)C(O)C(OC)C(=O)NC1CCCCNC1=O GPVKLYONJSSZFL-UHFFFAOYSA-N 0.000 description 1
• 102100029166 NT-3 growth factor receptor Human genes 0.000 description 1
• 102100029467 Na(+)/H(+) exchange regulatory cofactor NHE-RF3 Human genes 0.000 description 1
• 208000034176 Neoplasms, Germ Cell and Embryonal Diseases 0.000 description 1
• 102100028782 Neprilysin Human genes 0.000 description 1
• 108010032605 Nerve Growth Factor Receptors Proteins 0.000 description 1
• 102100021153 Netrin receptor DCC Human genes 0.000 description 1
• 108010074223 Netrin-1 Proteins 0.000 description 1
• 102000009065 Netrin-1 Human genes 0.000 description 1
• 102400000058 Neuregulin-1 Human genes 0.000 description 1
• 101800000675 Neuregulin-2 Proteins 0.000 description 1
• 206010029260 Neuroblastoma Diseases 0.000 description 1
• 101710126796 Neuroendocrine secretory protein 55 Proteins 0.000 description 1
• 201000004404 Neurofibroma Diseases 0.000 description 1
• 208000005890 Neuroma Diseases 0.000 description 1
• 108090000772 Neuropilin-1 Proteins 0.000 description 1
• 102100028492 Neuropilin-2 Human genes 0.000 description 1
• 108090000770 Neuropilin-2 Proteins 0.000 description 1
• 101001122350 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial Proteins 0.000 description 1
• 102100029268 Neurotrophin-3 Human genes 0.000 description 1
• 108030001564 Neutrophil collagenases Proteins 0.000 description 1
• 108010064862 Nicotinamide phosphoribosyltransferase Proteins 0.000 description 1
• 101710111444 Nitric oxide synthase, brain Proteins 0.000 description 1
• 101710090055 Nitric oxide synthase, endothelial Proteins 0.000 description 1
• 101710089543 Nitric oxide synthase, inducible Proteins 0.000 description 1
• 206010029488 Nodular melanoma Diseases 0.000 description 1
• 108010029756 Notch3 Receptor Proteins 0.000 description 1
• MSHZHSPISPJWHW-UHFFFAOYSA-N O-(chloroacetylcarbamoyl)fumagillol Chemical compound O1C(CC=C(C)C)C1(C)C1C(OC)C(OC(=O)NC(=O)CCl)CCC21CO2 MSHZHSPISPJWHW-UHFFFAOYSA-N 0.000 description 1
• MBJMCOJMDMARNB-UHFFFAOYSA-N O.O.O.O.[Na].[Na].OP(O)(=O)C(Cl)(Cl)P(O)(O)=O Chemical compound O.O.O.O.[Na].[Na].OP(O)(=O)C(Cl)(Cl)P(O)(O)=O MBJMCOJMDMARNB-UHFFFAOYSA-N 0.000 description 1
• 108010016076 Octreotide Proteins 0.000 description 1
• 208000007871 Odontogenic Tumors Diseases 0.000 description 1
• 206010030155 Oesophageal carcinoma Diseases 0.000 description 1
• 102100025128 Olfactory receptor 51E2 Human genes 0.000 description 1
• 201000010133 Oligodendroglioma Diseases 0.000 description 1
• 206010048757 Oncocytoma Diseases 0.000 description 1
• 108090000630 Oncostatin M Proteins 0.000 description 1
• 102100031942 Oncostatin-M Human genes 0.000 description 1
• 101710131039 Opsin-5 Proteins 0.000 description 1
• 206010033128 Ovarian cancer Diseases 0.000 description 1
• 206010061535 Ovarian neoplasm Diseases 0.000 description 1
• 206010073261 Ovarian theca cell tumour Diseases 0.000 description 1
• 102100039792 Oxidized purine nucleoside triphosphate hydrolase Human genes 0.000 description 1
• 102000004020 Oxygenases Human genes 0.000 description 1
• 108090000417 Oxygenases Proteins 0.000 description 1
• 208000002063 Oxyphilic Adenoma Diseases 0.000 description 1
• 108010091640 PAX8 Transcription Factor Proteins 0.000 description 1
• 102000018549 PAX8 Transcription Factor Human genes 0.000 description 1
• SUDAHWBOROXANE-VIFPVBQESA-N PD 0325901-Cl Chemical compound OC[C@H](O)CONC(=O)C1=CC=C(F)C(F)=C1NC1=CC=C(I)C=C1F SUDAHWBOROXANE-VIFPVBQESA-N 0.000 description 1
• 101150062285 PGF gene Proteins 0.000 description 1
• 239000009820 PHY 906 Substances 0.000 description 1
• 101150038998 PLAUR gene Proteins 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 108010016731 PPAR gamma Proteins 0.000 description 1
• 102100028973 PR domain zinc finger protein 13 Human genes 0.000 description 1
• 101150071808 PTHLH gene Proteins 0.000 description 1
• 102100037504 Paired box protein Pax-5 Human genes 0.000 description 1
• 201000010630 Pancoast tumor Diseases 0.000 description 1
• 208000015330 Pancoast tumour Diseases 0.000 description 1
• 206010061902 Pancreatic neoplasm Diseases 0.000 description 1
• 108030001694 Pappalysin-1 Proteins 0.000 description 1
• 206010061332 Paraganglion neoplasm Diseases 0.000 description 1
• 108090000445 Parathyroid hormone Proteins 0.000 description 1
• 102000007497 Patched-2 Receptor Human genes 0.000 description 1
• 108010071083 Patched-2 Receptor Proteins 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 206010059631 Penile squamous cell carcinoma Diseases 0.000 description 1
• 108010068204 Peptide Elongation Factors Proteins 0.000 description 1
• 102000002508 Peptide Elongation Factors Human genes 0.000 description 1
• 102100026114 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Human genes 0.000 description 1
• 241001442654 Percnon planissimum Species 0.000 description 1
• 101710199268 Periostin Proteins 0.000 description 1
• 102000007456 Peroxiredoxin Human genes 0.000 description 1
• 101710185562 Peroxiredoxin 2 Proteins 0.000 description 1
• 102100034768 Peroxiredoxin-4 Human genes 0.000 description 1
• 208000009565 Pharyngeal Neoplasms Diseases 0.000 description 1
• 206010034811 Pharyngeal cancer Diseases 0.000 description 1
• 102100026177 Phosphatidylinositol 3-kinase regulatory subunit beta Human genes 0.000 description 1
• 102100037553 Phosphatidylinositol 3-kinase regulatory subunit gamma Human genes 0.000 description 1
• 102000045595 Phosphoprotein Phosphatases Human genes 0.000 description 1
• 108700019535 Phosphoprotein Phosphatases Proteins 0.000 description 1
• 101710201137 Photosystem II manganese-stabilizing polypeptide Proteins 0.000 description 1
• 206010050487 Pinealoblastoma Diseases 0.000 description 1
• 208000007641 Pinealoma Diseases 0.000 description 1
• 208000021308 Pituicytoma Diseases 0.000 description 1
• 201000005746 Pituitary adenoma Diseases 0.000 description 1
• 206010061538 Pituitary tumour benign Diseases 0.000 description 1
• 208000007452 Plasmacytoma Diseases 0.000 description 1
• 102100038124 Plasminogen Human genes 0.000 description 1
• 101710202087 Platelet glycoprotein 4 Proteins 0.000 description 1
• 108010068588 Platelet-Derived Growth Factor alpha Receptor Proteins 0.000 description 1
• 108010051742 Platelet-Derived Growth Factor beta Receptor Proteins 0.000 description 1
• 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 description 1
• 102100040990 Platelet-derived growth factor subunit B Human genes 0.000 description 1
• 101710179684 Poly [ADP-ribose] polymerase Proteins 0.000 description 1
• 102100023712 Poly [ADP-ribose] polymerase 1 Human genes 0.000 description 1
• 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 1
• 102100039388 Polyamine deacetylase HDAC10 Human genes 0.000 description 1
• 229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
• 102100035187 Polymeric immunoglobulin receptor Human genes 0.000 description 1
• 101710163348 Potassium voltage-gated channel subfamily H member 8 Proteins 0.000 description 1
• 101150104557 Ppargc1a gene Proteins 0.000 description 1
• 208000006664 Precursor Cell Lymphoblastic Leukemia-Lymphoma Diseases 0.000 description 1
• 102100026651 Pro-adrenomedullin Human genes 0.000 description 1
• 102100022661 Pro-neuregulin-1, membrane-bound isoform Human genes 0.000 description 1
• 102100022659 Pro-neuregulin-3, membrane-bound isoform Human genes 0.000 description 1
• 101710189650 Probable AP endonuclease Proteins 0.000 description 1
• 108700030875 Programmed Cell Death 1 Ligand 2 Proteins 0.000 description 1
• 102000003946 Prolactin Human genes 0.000 description 1
• 108010057464 Prolactin Proteins 0.000 description 1
• 102100036691 Proliferating cell nuclear antigen Human genes 0.000 description 1
• 102100023832 Prolyl endopeptidase FAP Human genes 0.000 description 1
• 108050003243 Prostaglandin G/H synthase 1 Proteins 0.000 description 1
• 102100036735 Prostate stem cell antigen Human genes 0.000 description 1
• 108010072866 Prostate-Specific Antigen Proteins 0.000 description 1
• 102100040638 Protein AF-17 Human genes 0.000 description 1
• 102100040665 Protein AF1q Human genes 0.000 description 1
• 102000017975 Protein C Human genes 0.000 description 1
• 101800004937 Protein C Proteins 0.000 description 1
• 102100037171 Protein JTB Human genes 0.000 description 1
• 108010015499 Protein Kinase C-theta Proteins 0.000 description 1
• 102000001892 Protein Kinase C-theta Human genes 0.000 description 1
• 101710156990 Protein S100-A9 Proteins 0.000 description 1
• 102100022429 Protein TMEPAI Human genes 0.000 description 1
• 102000002727 Protein Tyrosine Phosphatase Human genes 0.000 description 1
• 102100027584 Protein c-Fos Human genes 0.000 description 1
• 101710158946 Protein diaphanous homolog 3 Proteins 0.000 description 1
• 102100024924 Protein kinase C alpha type Human genes 0.000 description 1
• 102100037339 Protein kinase C epsilon type Human genes 0.000 description 1
• 102100040714 Protein phosphatase 1 regulatory subunit 15A Human genes 0.000 description 1
• 102100038675 Protein phosphatase 1D Human genes 0.000 description 1
• 102100027378 Prothrombin Human genes 0.000 description 1
• 108010071563 Proto-Oncogene Proteins c-fos Proteins 0.000 description 1
• 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 description 1
• 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 description 1
• 102100028286 Proto-oncogene tyrosine-protein kinase receptor Ret Human genes 0.000 description 1
• 201000004681 Psoriasis Diseases 0.000 description 1
• 101710113369 Putative acyl-CoA-binding protein Proteins 0.000 description 1
• 102100031269 Putative peripheral benzodiazepine receptor-related protein Human genes 0.000 description 1
• 102100029629 Putative trypsin-6 Human genes 0.000 description 1
• CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 description 1
• 108010009413 Pyrophosphatases Proteins 0.000 description 1
• 102000009609 Pyrophosphatases Human genes 0.000 description 1
• 101710152724 Pyruvate kinase PKM Proteins 0.000 description 1
• 102100032315 RAC-beta serine/threonine-protein kinase Human genes 0.000 description 1
• 101710107530 Ral GTPase-activating protein subunit alpha-2 Proteins 0.000 description 1
• 208000034541 Rare lymphatic malformation Diseases 0.000 description 1
• 101000832669 Rattus norvegicus Probable alcohol sulfotransferase Proteins 0.000 description 1
• 101710100969 Receptor tyrosine-protein kinase erbB-3 Proteins 0.000 description 1
• 102100029981 Receptor tyrosine-protein kinase erbB-4 Human genes 0.000 description 1
• 102100022501 Receptor-interacting serine/threonine-protein kinase 1 Human genes 0.000 description 1
• 101710151245 Receptor-type tyrosine-protein kinase FLT3 Proteins 0.000 description 1
• 208000015634 Rectal Neoplasms Diseases 0.000 description 1
• 206010038389 Renal cancer Diseases 0.000 description 1
• 208000006265 Renal cell carcinoma Diseases 0.000 description 1
• 102220514190 Ret finger protein-like 1_S287E_mutation Human genes 0.000 description 1
• 201000000582 Retinoblastoma Diseases 0.000 description 1
• 208000008938 Rhabdoid tumor Diseases 0.000 description 1
• 206010073334 Rhabdoid tumour Diseases 0.000 description 1
• 208000005678 Rhabdomyoma Diseases 0.000 description 1
• 101710116900 Rho GTPase-activating protein 7 Proteins 0.000 description 1
• 101000937826 Rhodococcus erythropolis Barbiturase Proteins 0.000 description 1
• 101000584469 Rice tungro bacilliform virus (isolate Philippines) Protein P1 Proteins 0.000 description 1
• IIDJRNMFWXDHID-UHFFFAOYSA-N Risedronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CC1=CC=CN=C1 IIDJRNMFWXDHID-UHFFFAOYSA-N 0.000 description 1
• 244000117054 Rungia klossii Species 0.000 description 1
• 235000002492 Rungia klossii Nutrition 0.000 description 1
• YJDYDFNKCBANTM-QCWCSKBGSA-N SDZ PSC 833 Chemical compound C\C=C\C[C@@H](C)C(=O)[C@@H]1N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C(=O)[C@H](C(C)C)NC1=O YJDYDFNKCBANTM-QCWCSKBGSA-N 0.000 description 1
• 102000001332 SRC Human genes 0.000 description 1
• 108060006706 SRC Proteins 0.000 description 1
• 101000633277 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Peroxiredoxin TSA1 Proteins 0.000 description 1
• 101000654577 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) Protein transport protein SFT1 Proteins 0.000 description 1
• 101800001700 Saposin-D Proteins 0.000 description 1
• 208000006938 Schwannomatosis Diseases 0.000 description 1
• 102100033004 Securin Human genes 0.000 description 1
• 108010061477 Securin Proteins 0.000 description 1
• 102000012152 Securin Human genes 0.000 description 1
• 102100032754 Segment polarity protein dishevelled homolog DVL-3 Human genes 0.000 description 1
• 201000010208 Seminoma Diseases 0.000 description 1
• MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 1
• 102100034801 Serine protease hepsin Human genes 0.000 description 1
• 102100028904 Serine/threonine-protein kinase MARK2 Human genes 0.000 description 1
• 102100036077 Serine/threonine-protein kinase pim-1 Human genes 0.000 description 1
• 102100036120 Serine/threonine-protein kinase pim-2 Human genes 0.000 description 1
• 102100036119 Serine/threonine-protein kinase pim-3 Human genes 0.000 description 1
• 208000003274 Sertoli cell tumor Diseases 0.000 description 1
• 102100035476 Serum paraoxonase/arylesterase 1 Human genes 0.000 description 1
• 208000002669 Sex Cord-Gonadal Stromal Tumors Diseases 0.000 description 1
• 208000009359 Sezary Syndrome Diseases 0.000 description 1
• 208000021388 Sezary disease Diseases 0.000 description 1
• 201000002946 Simpson-Golabi-Behmel syndrome type 1 Diseases 0.000 description 1
• 208000000453 Skin Neoplasms Diseases 0.000 description 1
• 206010041067 Small cell lung cancer Diseases 0.000 description 1
• 108091027967 Small hairpin RNA Proteins 0.000 description 1
• 208000021712 Soft tissue sarcoma Diseases 0.000 description 1
• 101000611441 Solanum lycopersicum Pathogenesis-related leaf protein 6 Proteins 0.000 description 1
• 101000777063 Solanum tuberosum Ubiquinol-cytochrome c reductase complex 6.7 kDa protein Proteins 0.000 description 1
• 108010017622 Somatomedin Receptors Proteins 0.000 description 1
• 102000004584 Somatomedin Receptors Human genes 0.000 description 1
• 102000013275 Somatomedins Human genes 0.000 description 1
• 206010041329 Somatostatinoma Diseases 0.000 description 1
• 108050007673 Somatotropin Proteins 0.000 description 1
• 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 description 1
• 206010041848 Squamous cell carcinoma of the cervix Diseases 0.000 description 1
• 208000036765 Squamous cell carcinoma of the esophagus Diseases 0.000 description 1
• 208000032249 Squamous cell carcinoma of the penis Diseases 0.000 description 1
• 235000021355 Stearic acid Nutrition 0.000 description 1
• 101000879638 Streptomyces mobaraensis Transglutaminase-activating metalloprotease inhibitor Proteins 0.000 description 1
• ZSJLQEPLLKMAKR-UHFFFAOYSA-N Streptozotocin Natural products O=NN(C)C(=O)NC1C(O)OC(CO)C(O)C1O ZSJLQEPLLKMAKR-UHFFFAOYSA-N 0.000 description 1
• 238000000692 Student's t-test Methods 0.000 description 1
• 229930006000 Sucrose Natural products 0.000 description 1
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• 101100007768 Sus scrofa CRSP1 gene Proteins 0.000 description 1
• 101000983124 Sus scrofa Pancreatic prohormone precursor Proteins 0.000 description 1
• 108091008874 T cell receptors Proteins 0.000 description 1
• 230000005867 T cell response Effects 0.000 description 1
• 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
• 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 description 1
• 101150057140 TACSTD1 gene Proteins 0.000 description 1
• 108700011582 TER 286 Proteins 0.000 description 1
• 108700012411 TNFSF10 Proteins 0.000 description 1
• JACAAXNEHGBPOQ-LLVKDONJSA-N Talampanel Chemical compound C([C@H](N(N=1)C(C)=O)C)C2=CC=3OCOC=3C=C2C=1C1=CC=C(N)C=C1 JACAAXNEHGBPOQ-LLVKDONJSA-N 0.000 description 1
• JXAGDPXECXQWBC-LJQANCHMSA-N Tanomastat Chemical compound C([C@H](C(=O)O)CC(=O)C=1C=CC(=CC=1)C=1C=CC(Cl)=CC=1)SC1=CC=CC=C1 JXAGDPXECXQWBC-LJQANCHMSA-N 0.000 description 1
• LGGHDPFKSSRQNS-UHFFFAOYSA-N Tariquidar Chemical compound C1=CC=CC2=CC(C(=O)NC3=CC(OC)=C(OC)C=C3C(=O)NC3=CC=C(C=C3)CCN3CCC=4C=C(C(=CC=4C3)OC)OC)=CN=C21 LGGHDPFKSSRQNS-UHFFFAOYSA-N 0.000 description 1
• 229940123237 Taxane Drugs 0.000 description 1
• 229940123582 Telomerase inhibitor Drugs 0.000 description 1
• 108091033399 Telomestatin Proteins 0.000 description 1
• 208000024313 Testicular Neoplasms Diseases 0.000 description 1
• 201000000331 Testicular germ cell cancer Diseases 0.000 description 1
• 206010057644 Testis cancer Diseases 0.000 description 1
• PDMMFKSKQVNJMI-BLQWBTBKSA-N Testosterone propionate Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](OC(=O)CC)[C@@]1(C)CC2 PDMMFKSKQVNJMI-BLQWBTBKSA-N 0.000 description 1
• 239000004098 Tetracycline Substances 0.000 description 1
• 101000652566 Tetrahymena thermophila (strain SB210) Telomerase-associated protein of 19 kDa Proteins 0.000 description 1
• QHOPXUFELLHKAS-UHFFFAOYSA-N Thespesin Natural products CC(C)c1c(O)c(O)c2C(O)Oc3c(c(C)cc1c23)-c1c2OC(O)c3c(O)c(O)c(C(C)C)c(cc1C)c23 QHOPXUFELLHKAS-UHFFFAOYSA-N 0.000 description 1
• FOCVUCIESVLUNU-UHFFFAOYSA-N Thiotepa Chemical compound C1CN1P(N1CC1)(=S)N1CC1 FOCVUCIESVLUNU-UHFFFAOYSA-N 0.000 description 1
• 206010043515 Throat cancer Diseases 0.000 description 1
• 108010078233 Thymalfasin Proteins 0.000 description 1
• 208000024770 Thyroid neoplasm Diseases 0.000 description 1
• DKJJVAGXPKPDRL-UHFFFAOYSA-N Tiludronic acid Chemical compound OP(O)(=O)C(P(O)(O)=O)SC1=CC=C(Cl)C=C1 DKJJVAGXPKPDRL-UHFFFAOYSA-N 0.000 description 1
• 102100030859 Tissue factor Human genes 0.000 description 1
• 229920001615 Tragacanth Polymers 0.000 description 1
• 102100021386 Trans-acting T-cell-specific transcription factor GATA-3 Human genes 0.000 description 1
• 108010057666 Transcription Factor CHOP Proteins 0.000 description 1
• 102100024027 Transcription factor E2F3 Human genes 0.000 description 1
• 102100031632 Transcription factor E2F5 Human genes 0.000 description 1
• 102100023118 Transcription factor JunD Human genes 0.000 description 1
• 102100035559 Transcriptional activator GLI3 Human genes 0.000 description 1
• 101710150448 Transcriptional regulator Myc Proteins 0.000 description 1
• 101000878575 Trypanosoma cruzi Flagellar calcium-binding protein Proteins 0.000 description 1
• 101710098580 Tubulin gamma-1 chain Proteins 0.000 description 1
• 102100024598 Tumor necrosis factor ligand superfamily member 10 Human genes 0.000 description 1
• 108050002568 Tumor necrosis factor ligand superfamily member 6 Proteins 0.000 description 1
• 102100040113 Tumor necrosis factor receptor superfamily member 10A Human genes 0.000 description 1
• 102100040112 Tumor necrosis factor receptor superfamily member 10B Human genes 0.000 description 1
• 101710102803 Tumor suppressor ARF Proteins 0.000 description 1
• 208000035896 Twin-reversed arterial perfusion sequence Diseases 0.000 description 1
• 102100022651 Tyrosine-protein kinase ABL2 Human genes 0.000 description 1
• 102100027053 Tyrosine-protein kinase Blk Human genes 0.000 description 1
• 102100037333 Tyrosine-protein kinase Fes/Fps Human genes 0.000 description 1
• 102100037236 Tyrosine-protein kinase receptor UFO Human genes 0.000 description 1
• 108010085193 UDP-N-acetylglucosamine 1-carboxyvinyltransferase Proteins 0.000 description 1
• 102000006275 Ubiquitin-Protein Ligases Human genes 0.000 description 1
• 108010083111 Ubiquitin-Protein Ligases Proteins 0.000 description 1
• 101710135389 Unconventional myosin-Ia Proteins 0.000 description 1
• 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
• 208000008385 Urogenital Neoplasms Diseases 0.000 description 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 1
• 208000002495 Uterine Neoplasms Diseases 0.000 description 1
• 201000005969 Uveal melanoma Diseases 0.000 description 1
• 108091008605 VEGF receptors Proteins 0.000 description 1
• 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 description 1
• 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 1
• 208000014070 Vestibular schwannoma Diseases 0.000 description 1
• 206010047741 Vulval cancer Diseases 0.000 description 1
• 208000004354 Vulvar Neoplasms Diseases 0.000 description 1
• 208000033559 Waldenström macroglobulinemia Diseases 0.000 description 1
• 208000021146 Warthin tumor Diseases 0.000 description 1
• 208000000260 Warts Diseases 0.000 description 1
• 208000008383 Wilms tumor Diseases 0.000 description 1
• 101001099854 Xenopus laevis Cellular retinoic acid-binding protein 2 Proteins 0.000 description 1
• 101000707286 Xenopus laevis Protein Shroom1 Proteins 0.000 description 1
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
• 101710112814 Zuotin Proteins 0.000 description 1
• SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 description 1
• DFYPFJSPLUVPFJ-QJEDTDQSSA-N [(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[(2R,3S,5R)-2-[[[(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-2-[[[5-(2-amino-6-oxo-1H-purin-9-yl)-2-(hydroxymethyl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-3-yl]oxy-hydroxyphosphoryl]oxymethyl]oxolan-3-yl] [(2R,3S,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methyl hydrogen phosphate Chemical compound Cc1cn([C@H]2C[C@H](OP(O)(=O)OC[C@H]3O[C@H](C[C@@H]3OP(O)(=O)OC[C@H]3O[C@H](C[C@@H]3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)[C@@H](COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)O[C@H]3C[C@@H](O[C@@H]3COP(O)(=O)OC3CC(OC3CO)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)O2)c(=O)[nH]c1=O DFYPFJSPLUVPFJ-QJEDTDQSSA-N 0.000 description 1
• FKCMADOPPWWGNZ-YUMQZZPRSA-N [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid Chemical compound CC(C)[C@H](N)C(=O)N1CCC[C@H]1B(O)O FKCMADOPPWWGNZ-YUMQZZPRSA-N 0.000 description 1
• QBDVVYNLLXGUGN-XGTBZJOHSA-N [(3r,4s,5s,6r)-5-methoxy-4-[(2r,3r)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] n-[(2r)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate Chemical compound C([C@H]([C@H]([C@@H]1[C@]2(C)[C@H](O2)CC=C(C)C)OC)OC(=O)N[C@H](C(C)C)C(N)=O)C[C@@]21CO2 QBDVVYNLLXGUGN-XGTBZJOHSA-N 0.000 description 1
• DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 1
• ODEDPKNSRBCSDO-UHFFFAOYSA-N [2-(hexadecylsulfanylmethyl)-3-methoxypropyl] 2-(trimethylazaniumyl)ethyl phosphate Chemical compound CCCCCCCCCCCCCCCCSCC(COC)COP([O-])(=O)OCC[N+](C)(C)C ODEDPKNSRBCSDO-UHFFFAOYSA-N 0.000 description 1
• IBXPAFBDJCXCDW-MHFPCNPESA-A [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1cn([C@H]2C[C@H](O)[C@@H](COP([S-])(=O)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3CO)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].Cc1cn([C@H]2C[C@H](O)[C@@H](COP([S-])(=O)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3COP([O-])(=S)O[C@H]3C[C@@H](O[C@@H]3CO)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3cnc4c3nc(N)[nH]c4=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3cnc4c3nc(N)[nH]c4=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O IBXPAFBDJCXCDW-MHFPCNPESA-A 0.000 description 1
• 102100024148 [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial Human genes 0.000 description 1
• 108010023617 abarelix Proteins 0.000 description 1
• 229960002184 abarelix Drugs 0.000 description 1
• AIWRTTMUVOZGPW-HSPKUQOVSA-N abarelix Chemical compound C([C@@H](C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)N(C)C(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 AIWRTTMUVOZGPW-HSPKUQOVSA-N 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
• 108010011755 acetyl-prolyl-histidyl-seryl-cysteinyl-asparaginamide Proteins 0.000 description 1
• 229940081735 acetylcellulose Drugs 0.000 description 1
• 208000006336 acinar cell carcinoma Diseases 0.000 description 1
• 208000004064 acoustic neuroma Diseases 0.000 description 1
• 208000017733 acquired polycythemia vera Diseases 0.000 description 1
• 208000009621 actinic keratosis Diseases 0.000 description 1
• 230000009471 action Effects 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 210000002534 adenoid Anatomy 0.000 description 1
• 201000008395 adenosquamous carcinoma Diseases 0.000 description 1
• 210000001789 adipocyte Anatomy 0.000 description 1
• 239000002671 adjuvant Substances 0.000 description 1
• 201000005188 adrenal gland cancer Diseases 0.000 description 1
• 208000024447 adrenal gland neoplasm Diseases 0.000 description 1
• ULCUCJFASIJEOE-NPECTJMMSA-N adrenomedullin Chemical compound C([C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)NCC(=O)N[C@@H]1C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(N)=O)[C@@H](C)O)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](N)CC=1C=CC(O)=CC=1)C1=CC=CC=C1 ULCUCJFASIJEOE-NPECTJMMSA-N 0.000 description 1
• 229940009456 adriamycin Drugs 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 235000010419 agar Nutrition 0.000 description 1
• 229940040563 agaric acid Drugs 0.000 description 1
• 201000002440 age related macular degeneration 5 Diseases 0.000 description 1
• 229950005033 alanosine Drugs 0.000 description 1
• 229960004343 alendronic acid Drugs 0.000 description 1
• 235000010443 alginic acid Nutrition 0.000 description 1
• 239000000783 alginic acid Substances 0.000 description 1
• 229920000615 alginic acid Polymers 0.000 description 1
• 229960001126 alginic acid Drugs 0.000 description 1
• 150000004781 alginic acids Chemical class 0.000 description 1
• 239000012670 alkaline solution Substances 0.000 description 1
• 150000003797 alkaloid derivatives Chemical class 0.000 description 1
• 229940045714 alkyl sulfonate alkylating agent Drugs 0.000 description 1
• 150000008052 alkyl sulfonates Chemical class 0.000 description 1
• SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
• 108010029483 alpha 1 Chain Collagen Type I Proteins 0.000 description 1
• 229960000473 altretamine Drugs 0.000 description 1
• 229950010817 alvocidib Drugs 0.000 description 1
• BIIVYFLTOXDAOV-YVEFUNNKSA-N alvocidib Chemical compound O[C@@H]1CN(C)CC[C@@H]1C1=C(O)C=C(O)C2=C1OC(C=1C(=CC=CC=1)Cl)=CC2=O BIIVYFLTOXDAOV-YVEFUNNKSA-N 0.000 description 1
• 230000002707 ameloblastic effect Effects 0.000 description 1
• 229960001097 amifostine Drugs 0.000 description 1
• 230000001195 anabolic effect Effects 0.000 description 1
• 238000000540 analysis of variance Methods 0.000 description 1
• 238000004458 analytical method Methods 0.000 description 1
• 229960002932 anastrozole Drugs 0.000 description 1
• YBBLVLTVTVSKRW-UHFFFAOYSA-N anastrozole Chemical compound N#CC(C)(C)C1=CC(C(C)(C#N)C)=CC(CN2N=CN=C2)=C1 YBBLVLTVTVSKRW-UHFFFAOYSA-N 0.000 description 1
• 239000003098 androgen Substances 0.000 description 1
• 229940030486 androgens Drugs 0.000 description 1
• 229960001232 anecortave Drugs 0.000 description 1
• 239000004037 angiogenesis inhibitor Substances 0.000 description 1
• 229940121369 angiogenesis inhibitor Drugs 0.000 description 1
• 238000010171 animal model Methods 0.000 description 1
• 239000005557 antagonist Substances 0.000 description 1
• RGHILYZRVFRRNK-UHFFFAOYSA-N anthracene-1,2-dione Chemical class C1=CC=C2C=C(C(C(=O)C=C3)=O)C3=CC2=C1 RGHILYZRVFRRNK-UHFFFAOYSA-N 0.000 description 1
• 229940045799 anthracyclines and related substance Drugs 0.000 description 1
• 150000004056 anthraquinones Chemical class 0.000 description 1
• 230000000181 anti-adherent effect Effects 0.000 description 1
• 238000011224 anti-cancer immunotherapy Methods 0.000 description 1
• 229940124650 anti-cancer therapies Drugs 0.000 description 1
• 230000003474 anti-emetic effect Effects 0.000 description 1
• 229940124599 anti-inflammatory drug Drugs 0.000 description 1
• 239000003911 antiadherent Substances 0.000 description 1
• 238000011319 anticancer therapy Methods 0.000 description 1
• 239000002111 antiemetic agent Substances 0.000 description 1
• 210000000612 antigen-presenting cell Anatomy 0.000 description 1
• 229940045687 antimetabolites folic acid analogs Drugs 0.000 description 1
• 229940034982 antineoplastic agent Drugs 0.000 description 1
• 239000003972 antineoplastic antibiotic Substances 0.000 description 1
• 229940041181 antineoplastic drug Drugs 0.000 description 1
• 229940045985 antineoplastic platinum compound Drugs 0.000 description 1
• 239000000074 antisense oligonucleotide Substances 0.000 description 1
• 238000012230 antisense oligonucleotides Methods 0.000 description 1
• 229950002465 apaziquone Drugs 0.000 description 1
• 239000007864 aqueous solution Substances 0.000 description 1
• 229940046844 aromatase inhibitors Drugs 0.000 description 1
• FZCSTZYAHCUGEM-UHFFFAOYSA-N aspergillomarasmine B Natural products OC(=O)CNC(C(O)=O)CNC(C(O)=O)CC(O)=O FZCSTZYAHCUGEM-UHFFFAOYSA-N 0.000 description 1
• 238000003556 assay Methods 0.000 description 1
• 229950004810 atamestane Drugs 0.000 description 1
• PEPMWUSGRKINHX-TXTPUJOMSA-N atamestane Chemical compound C1C[C@@H]2[C@@]3(C)C(C)=CC(=O)C=C3CC[C@H]2[C@@H]2CCC(=O)[C@]21C PEPMWUSGRKINHX-TXTPUJOMSA-N 0.000 description 1
• 229950003462 atiprimod Drugs 0.000 description 1
• SERHTTSLBVGRBY-UHFFFAOYSA-N atiprimod Chemical compound C1CC(CCC)(CCC)CCC11CN(CCCN(CC)CC)CC1 SERHTTSLBVGRBY-UHFFFAOYSA-N 0.000 description 1
• 201000011347 autosomal recessive nonsyndromic deafness 39 Diseases 0.000 description 1
• 208000032695 autosomal recessive nonsyndromic hearing loss 39 Diseases 0.000 description 1
• 229960003005 axitinib Drugs 0.000 description 1
• RITAVMQDGBJQJZ-FMIVXFBMSA-N axitinib Chemical compound CNC(=O)C1=CC=CC=C1SC1=CC=C(C(\C=C\C=2N=CC=CC=2)=NN2)C2=C1 RITAVMQDGBJQJZ-FMIVXFBMSA-N 0.000 description 1
• 108010023337 axl receptor tyrosine kinase Proteins 0.000 description 1
• 229950001858 batimastat Drugs 0.000 description 1
• XFILPEOLDIKJHX-QYZOEREBSA-N batimastat Chemical compound C([C@@H](C(=O)NC)NC(=O)[C@H](CC(C)C)[C@H](CSC=1SC=CC=1)C(=O)NO)C1=CC=CC=C1 XFILPEOLDIKJHX-QYZOEREBSA-N 0.000 description 1
• 108700000711 bcl-X Proteins 0.000 description 1
• 239000011324 bead Substances 0.000 description 1
• 229960003094 belinostat Drugs 0.000 description 1
• NCNRHFGMJRPRSK-MDZDMXLPSA-N belinostat Chemical compound ONC(=O)\C=C\C1=CC=CC(S(=O)(=O)NC=2C=CC=CC=2)=C1 NCNRHFGMJRPRSK-MDZDMXLPSA-N 0.000 description 1
• 229930195545 bengamide Natural products 0.000 description 1
• 108010020169 beta-microseminoprotein Proteins 0.000 description 1
• 210000000013 bile duct Anatomy 0.000 description 1
• 210000003445 biliary tract Anatomy 0.000 description 1
• 201000009036 biliary tract cancer Diseases 0.000 description 1
• 208000020790 biliary tract neoplasm Diseases 0.000 description 1
• 230000004071 biological effect Effects 0.000 description 1
• 230000015572 biosynthetic process Effects 0.000 description 1
• 108010005713 bis(5'-adenosyl)triphosphatase Proteins 0.000 description 1
• 201000009076 bladder urachal carcinoma Diseases 0.000 description 1
• 201000000053 blastoma Diseases 0.000 description 1
• 239000002981 blocking agent Substances 0.000 description 1
• 210000004369 blood Anatomy 0.000 description 1
• 239000008280 blood Substances 0.000 description 1
• 210000000601 blood cell Anatomy 0.000 description 1
• 239000003114 blood coagulation factor Substances 0.000 description 1
• 201000008274 breast adenocarcinoma Diseases 0.000 description 1
• 229960002719 buserelin Drugs 0.000 description 1
• CUWODFFVMXJOKD-UVLQAERKSA-N buserelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](COC(C)(C)C)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H]1NC(=O)CC1)CC1=CC=C(O)C=C1 CUWODFFVMXJOKD-UVLQAERKSA-N 0.000 description 1
• 229960002092 busulfan Drugs 0.000 description 1
• 229960005084 calcitriol Drugs 0.000 description 1
• GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 description 1
• 235000020964 calcitriol Nutrition 0.000 description 1
• 239000011612 calcitriol Substances 0.000 description 1
• 229910052791 calcium Inorganic materials 0.000 description 1
• 239000011575 calcium Substances 0.000 description 1
• FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
• 235000011010 calcium phosphates Nutrition 0.000 description 1
• CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
• 239000008116 calcium stearate Substances 0.000 description 1
• 235000013539 calcium stearate Nutrition 0.000 description 1
• 229940088954 camptosar Drugs 0.000 description 1
• 238000002619 cancer immunotherapy Methods 0.000 description 1
• 229950000772 canfosfamide Drugs 0.000 description 1
• 229960004117 capecitabine Drugs 0.000 description 1
• 235000013877 carbamide Nutrition 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 239000005018 casein Substances 0.000 description 1
• BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 1
• 235000021240 caseins Nutrition 0.000 description 1
• 230000015556 catabolic process Effects 0.000 description 1
• 210000004323 caveolae Anatomy 0.000 description 1
• 229960002129 cefixime Drugs 0.000 description 1
• OKBVVJOGVLARMR-QSWIMTSFSA-N cefixime Chemical compound S1C(N)=NC(C(=N\OCC(O)=O)\C(=O)N[C@@H]2C(N3C(=C(C=C)CS[C@@H]32)C(O)=O)=O)=C1 OKBVVJOGVLARMR-QSWIMTSFSA-N 0.000 description 1
• 229960000590 celecoxib Drugs 0.000 description 1
• RZEKVGVHFLEQIL-UHFFFAOYSA-N celecoxib Chemical compound C1=CC(C)=CC=C1C1=CC(C(F)(F)F)=NN1C1=CC=C(S(N)(=O)=O)C=C1 RZEKVGVHFLEQIL-UHFFFAOYSA-N 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 230000024245 cell differentiation Effects 0.000 description 1
• 230000001413 cellular effect Effects 0.000 description 1
• 108010012671 cellular retinoic acid binding protein I Proteins 0.000 description 1
• 230000005754 cellular signaling Effects 0.000 description 1
• 229920002301 cellulose acetate Polymers 0.000 description 1
• 229940106189 ceramide Drugs 0.000 description 1
• 150000001783 ceramides Chemical class 0.000 description 1
• 208000016886 cerebral arteriopathy with subcortical infarcts and leukoencephalopathy Diseases 0.000 description 1
• 201000006662 cervical adenocarcinoma Diseases 0.000 description 1
• 201000010881 cervical cancer Diseases 0.000 description 1
• 201000006612 cervical squamous cell carcinoma Diseases 0.000 description 1
• HZCWPKGYTCJSEB-UHFFFAOYSA-N chembl118841 Chemical compound C12=CC(OC)=CC=C2NC2=C([N+]([O-])=O)C=CC3=C2C1=NN3CCCN(C)C HZCWPKGYTCJSEB-UHFFFAOYSA-N 0.000 description 1
• ZXFCRFYULUUSDW-OWXODZSWSA-N chembl2104970 Chemical compound C([C@H]1C2)C3=CC=CC(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2CC(O)=C(C(=O)N)C1=O ZXFCRFYULUUSDW-OWXODZSWSA-N 0.000 description 1
• AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 1
• ZGHQGWOETPXKLY-XVNBXDOJSA-N chembl77030 Chemical compound NC(=S)C(\C#N)=C\C1=CC=C(O)C(O)=C1 ZGHQGWOETPXKLY-XVNBXDOJSA-N 0.000 description 1
• 229960004630 chlorambucil Drugs 0.000 description 1
• JCKYGMPEJWAADB-UHFFFAOYSA-N chlorambucil Chemical compound OC(=O)CCCC1=CC=C(N(CCCl)CCCl)C=C1 JCKYGMPEJWAADB-UHFFFAOYSA-N 0.000 description 1
• 208000006990 cholangiocarcinoma Diseases 0.000 description 1
• 210000002987 choroid plexus Anatomy 0.000 description 1
• 230000001684 chronic effect Effects 0.000 description 1
• 208000024207 chronic leukemia Diseases 0.000 description 1
• 229950009003 cilengitide Drugs 0.000 description 1
• AMLYAMJWYAIXIA-VWNVYAMZSA-N cilengitide Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C(C)C)N(C)C(=O)[C@H]1CC1=CC=CC=C1 AMLYAMJWYAIXIA-VWNVYAMZSA-N 0.000 description 1
• 229960002436 cladribine Drugs 0.000 description 1
• 201000000292 clear cell sarcoma Diseases 0.000 description 1
• 229960002286 clodronic acid Drugs 0.000 description 1
• 229960000928 clofarabine Drugs 0.000 description 1
• WDDPHFBMKLOVOX-AYQXTPAHSA-N clofarabine Chemical compound C1=NC=2C(N)=NC(Cl)=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1F WDDPHFBMKLOVOX-AYQXTPAHSA-N 0.000 description 1
• 238000011260 co-administration Methods 0.000 description 1
• 230000003081 coactivator Effects 0.000 description 1
• 230000015271 coagulation Effects 0.000 description 1
• 238000005345 coagulation Methods 0.000 description 1
• 229940105784 coagulation factor xiii Drugs 0.000 description 1
• 108091008033 coinhibitory receptors Proteins 0.000 description 1
• 229920001436 collagen Polymers 0.000 description 1
• 210000001072 colon Anatomy 0.000 description 1
• 239000003086 colorant Substances 0.000 description 1
• WDOGQTQEKVLZIJ-WAYWQWQTSA-N combretastatin a-4 phosphate Chemical compound C1=C(OP(O)(O)=O)C(OC)=CC=C1\C=C/C1=CC(OC)=C(OC)C(OC)=C1 WDOGQTQEKVLZIJ-WAYWQWQTSA-N 0.000 description 1
• 201000000398 cone-rod dystrophy 9 Diseases 0.000 description 1
• 239000013256 coordination polymer Substances 0.000 description 1
• 239000003246 corticosteroid Substances 0.000 description 1
• 229960001334 corticosteroids Drugs 0.000 description 1
• OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 description 1
• IDLFZVILOHSSID-OVLDLUHVSA-N corticotropin Chemical compound C([C@@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(O)=O)NC(=O)[C@@H](N)CO)C1=CC=C(O)C=C1 IDLFZVILOHSSID-OVLDLUHVSA-N 0.000 description 1
• 229960000258 corticotropin Drugs 0.000 description 1
• 230000000139 costimulatory effect Effects 0.000 description 1
• 238000004132 cross linking Methods 0.000 description 1
• 238000000315 cryotherapy Methods 0.000 description 1
• 229940109262 curcumin Drugs 0.000 description 1
• 239000004148 curcumin Substances 0.000 description 1
• 235000012754 curcumin Nutrition 0.000 description 1
• 208000017763 cutaneous neuroendocrine carcinoma Diseases 0.000 description 1
• 239000002875 cyclin dependent kinase inhibitor Substances 0.000 description 1
• 229940043378 cyclin-dependent kinase inhibitor Drugs 0.000 description 1
• 108040000002 cyclin-dependent protein kinase activating kinase activity proteins Proteins 0.000 description 1
• 229960000684 cytarabine Drugs 0.000 description 1
• 108010012052 cytochrome P-450 CYP2C subfamily Proteins 0.000 description 1
• 108010038764 cytoplasmic linker protein 170 Proteins 0.000 description 1
• 108091007930 cytoplasmic receptors Proteins 0.000 description 1
• 210000005220 cytoplasmic tail Anatomy 0.000 description 1
• 231100000599 cytotoxic agent Toxicity 0.000 description 1
• 239000002619 cytotoxin Substances 0.000 description 1
• GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
• 230000000254 damaging effect Effects 0.000 description 1
• 229960002448 dasatinib Drugs 0.000 description 1
• ZESRJSPZRDMNHY-UHFFFAOYSA-N de-oxy corticosterone Natural products O=C1CCC2(C)C3CCC(C)(C(CC4)C(=O)CO)C4C3CCC2=C1 ZESRJSPZRDMNHY-UHFFFAOYSA-N 0.000 description 1
• 229940026692 decadron Drugs 0.000 description 1
• 238000006731 degradation reaction Methods 0.000 description 1
• 230000000593 degrading effect Effects 0.000 description 1
• 229940027008 deltasone Drugs 0.000 description 1
• 230000001335 demethylating effect Effects 0.000 description 1
• CFCUWKMKBJTWLW-UHFFFAOYSA-N deoliosyl-3C-alpha-L-digitoxosyl-MTM Natural products CC=1C(O)=C2C(O)=C3C(=O)C(OC4OC(C)C(O)C(OC5OC(C)C(O)C(OC6OC(C)C(O)C(C)(O)C6)C5)C4)C(C(OC)C(=O)C(O)C(C)O)CC3=CC2=CC=1OC(OC(C)C1O)CC1OC1CC(O)C(O)C(C)O1 CFCUWKMKBJTWLW-UHFFFAOYSA-N 0.000 description 1
• 230000001419 dependent effect Effects 0.000 description 1
• 230000000779 depleting effect Effects 0.000 description 1
• 229960003654 desoxycortone Drugs 0.000 description 1
• 230000000368 destabilizing effect Effects 0.000 description 1
• 238000001514 detection method Methods 0.000 description 1
• NIJJYAXOARWZEE-UHFFFAOYSA-N di-n-propyl-acetic acid Natural products CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 description 1
• 238000003745 diagnosis Methods 0.000 description 1
• 235000019700 dicalcium phosphate Nutrition 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• 229960000452 diethylstilbestrol Drugs 0.000 description 1
• VFLDPWHFBUODDF-UHFFFAOYSA-N diferuloylmethane Natural products C1=C(O)C(OC)=CC(C=CC(=O)CC(=O)C=CC=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-UHFFFAOYSA-N 0.000 description 1
• OTKJDMGTUTTYMP-UHFFFAOYSA-N dihydrosphingosine Natural products CCCCCCCCCCCCCCCC(O)C(N)CO OTKJDMGTUTTYMP-UHFFFAOYSA-N 0.000 description 1
• 239000003085 diluting agent Substances 0.000 description 1
• 108010057167 dimethylaniline monooxygenase (N-oxide forming) Proteins 0.000 description 1
• 229960003668 docetaxel Drugs 0.000 description 1
• HKXBNHCUPKIYDM-CGMHZMFXSA-N doxercalciferol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C HKXBNHCUPKIYDM-CGMHZMFXSA-N 0.000 description 1
• 229960000413 doxercalciferol Drugs 0.000 description 1
• 239000003937 drug carrier Substances 0.000 description 1
• 208000028715 ductal breast carcinoma in situ Diseases 0.000 description 1
• 239000000975 dye Substances 0.000 description 1
• 229950006700 edatrexate Drugs 0.000 description 1
• FSIRXIHZBIXHKT-MHTVFEQDSA-N edatrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CC(CC)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FSIRXIHZBIXHKT-MHTVFEQDSA-N 0.000 description 1
• BNFRJXLZYUTIII-UHFFFAOYSA-N efaproxiral Chemical compound CC1=CC(C)=CC(NC(=O)CC=2C=CC(OC(C)(C)C(O)=O)=CC=2)=C1 BNFRJXLZYUTIII-UHFFFAOYSA-N 0.000 description 1
• 229960000925 efaproxiral Drugs 0.000 description 1
• VLCYCQAOQCDTCN-UHFFFAOYSA-N eflornithine Chemical compound NCCCC(N)(C(F)F)C(O)=O VLCYCQAOQCDTCN-UHFFFAOYSA-N 0.000 description 1
• 229960002759 eflornithine Drugs 0.000 description 1
• 238000010894 electron beam technology Methods 0.000 description 1
• 201000008184 embryoma Diseases 0.000 description 1
• 210000003372 endocrine gland Anatomy 0.000 description 1
• 238000009261 endocrine therapy Methods 0.000 description 1
• 229940034984 endocrine therapy antineoplastic and immunomodulating agent Drugs 0.000 description 1
• 201000003914 endometrial carcinoma Diseases 0.000 description 1
• 108010018033 endothelial PAS domain-containing protein 1 Proteins 0.000 description 1
• 230000003511 endothelial effect Effects 0.000 description 1
• HKSZLNNOFSGOKW-UHFFFAOYSA-N ent-staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(C)O1 HKSZLNNOFSGOKW-UHFFFAOYSA-N 0.000 description 1
• 208000037902 enteropathy Diseases 0.000 description 1
• 229950002189 enzastaurin Drugs 0.000 description 1
• 230000002327 eosinophilic effect Effects 0.000 description 1
• 102000012803 ephrin Human genes 0.000 description 1
• 108060002566 ephrin Proteins 0.000 description 1
• 229940116977 epidermal growth factor Drugs 0.000 description 1
• 206010015037 epilepsy Diseases 0.000 description 1
• 229930013356 epothilone Natural products 0.000 description 1
• HESCAJZNRMSMJG-KKQRBIROSA-N epothilone A Chemical class C/C([C@@H]1C[C@@H]2O[C@@H]2CCC[C@@H]([C@@H]([C@@H](C)C(=O)C(C)(C)[C@@H](O)CC(=O)O1)O)C)=C\C1=CSC(C)=N1 HESCAJZNRMSMJG-KKQRBIROSA-N 0.000 description 1
• QTTMOCOWZLSYSV-QWAPEVOJSA-M equilin sodium sulfate Chemical compound [Na+].[O-]S(=O)(=O)OC1=CC=C2[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4C3=CCC2=C1 QTTMOCOWZLSYSV-QWAPEVOJSA-M 0.000 description 1
• UFNVPOGXISZXJD-XJPMSQCNSA-N eribulin Chemical compound C([C@H]1CC[C@@H]2O[C@@H]3[C@H]4O[C@H]5C[C@](O[C@H]4[C@H]2O1)(O[C@@H]53)CC[C@@H]1O[C@H](C(C1)=C)CC1)C(=O)C[C@@H]2[C@@H](OC)[C@@H](C[C@H](O)CN)O[C@H]2C[C@@H]2C(=C)[C@H](C)C[C@H]1O2 UFNVPOGXISZXJD-XJPMSQCNSA-N 0.000 description 1
• 229960003649 eribulin Drugs 0.000 description 1
• GTTBEUCJPZQMDZ-UHFFFAOYSA-N erlotinib hydrochloride Chemical compound [H+].[Cl-].C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 GTTBEUCJPZQMDZ-UHFFFAOYSA-N 0.000 description 1
• 230000000925 erythroid effect Effects 0.000 description 1
• 229940105423 erythropoietin Drugs 0.000 description 1
• 201000004101 esophageal cancer Diseases 0.000 description 1
• 208000007276 esophageal squamous cell carcinoma Diseases 0.000 description 1
• 229940011871 estrogen Drugs 0.000 description 1
• 239000000262 estrogen Substances 0.000 description 1
• 108010038795 estrogen receptors Proteins 0.000 description 1
• 229960003399 estrone Drugs 0.000 description 1
• 229960002568 ethinylestradiol Drugs 0.000 description 1
• MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
• LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 1
• 229940093471 ethyl oleate Drugs 0.000 description 1
• 230000003203 everyday effect Effects 0.000 description 1
• 229960000255 exemestane Drugs 0.000 description 1
• 229950000484 exisulind Drugs 0.000 description 1
• 238000011347 external beam therapy Methods 0.000 description 1
• 229950011548 fadrozole Drugs 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 229950003662 fenretinide Drugs 0.000 description 1
• 210000003754 fetus Anatomy 0.000 description 1
• 108010068256 fibroblast-derived tumor cytotoxic factor Proteins 0.000 description 1
• DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 description 1
• 229960004039 finasteride Drugs 0.000 description 1
• 229960000556 fingolimod Drugs 0.000 description 1
• KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 description 1
• 239000000796 flavoring agent Substances 0.000 description 1
• 235000019634 flavors Nutrition 0.000 description 1
• 229960000961 floxuridine Drugs 0.000 description 1
• 229960000390 fludarabine Drugs 0.000 description 1
• 229960005304 fludarabine phosphate Drugs 0.000 description 1
• 229940043075 fluocinolone Drugs 0.000 description 1
• FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 description 1
• 229910052731 fluorine Inorganic materials 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 229960001751 fluoxymesterone Drugs 0.000 description 1
• YLRFCQOZQXIBAB-RBZZARIASA-N fluoxymesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1CC[C@](C)(O)[C@@]1(C)C[C@@H]2O YLRFCQOZQXIBAB-RBZZARIASA-N 0.000 description 1
• 239000004052 folic acid antagonist Substances 0.000 description 1
• 150000002224 folic acids Chemical class 0.000 description 1
• 229940028334 follicle stimulating hormone Drugs 0.000 description 1
• 230000003325 follicular Effects 0.000 description 1
• 201000003444 follicular lymphoma Diseases 0.000 description 1
• 235000003599 food sweetener Nutrition 0.000 description 1
• 229960004421 formestane Drugs 0.000 description 1
• OSVMTWJCGUFAOD-KZQROQTASA-N formestane Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)(C(CC4)=O)[C@@H]4[C@@H]3CCC2=C1O OSVMTWJCGUFAOD-KZQROQTASA-N 0.000 description 1
• 229950011423 forodesine Drugs 0.000 description 1
• YAKWPXVTIGTRJH-UHFFFAOYSA-N fotemustine Chemical compound CCOP(=O)(OCC)C(C)NC(=O)N(CCCl)N=O YAKWPXVTIGTRJH-UHFFFAOYSA-N 0.000 description 1
• 229960004783 fotemustine Drugs 0.000 description 1
• 229960002258 fulvestrant Drugs 0.000 description 1
• 230000005714 functional activity Effects 0.000 description 1
• 108020001507 fusion proteins Proteins 0.000 description 1
• 102000037865 fusion proteins Human genes 0.000 description 1
• 229950001109 galiximab Drugs 0.000 description 1
• 201000008396 gallbladder adenocarcinoma Diseases 0.000 description 1
• 201000010175 gallbladder cancer Diseases 0.000 description 1
• 229960003692 gamma aminobutyric acid Drugs 0.000 description 1
• BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 description 1
• 201000008361 ganglioneuroma Diseases 0.000 description 1
• 239000007789 gas Substances 0.000 description 1
• 201000006585 gastric adenocarcinoma Diseases 0.000 description 1
• 229960003297 gemtuzumab ozogamicin Drugs 0.000 description 1
• 238000001415 gene therapy Methods 0.000 description 1
• 238000010353 genetic engineering Methods 0.000 description 1
• 229940045109 genistein Drugs 0.000 description 1
• TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 1
• 235000006539 genistein Nutrition 0.000 description 1
• ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 description 1
• 210000004602 germ cell Anatomy 0.000 description 1
• UIVFUQKYVFCEKJ-OPTOVBNMSA-N gimatecan Chemical compound C1=CC=C2C(\C=N\OC(C)(C)C)=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UIVFUQKYVFCEKJ-OPTOVBNMSA-N 0.000 description 1
• 229950009073 gimatecan Drugs 0.000 description 1
• 229940080856 gleevec Drugs 0.000 description 1
• 108010017007 glucose-regulated proteins Proteins 0.000 description 1
• 229950011595 glufosfamide Drugs 0.000 description 1
• 108010086596 glutathione peroxidase GPX1 Proteins 0.000 description 1
• 230000013595 glycosylation Effects 0.000 description 1
• 238000006206 glycosylation reaction Methods 0.000 description 1
• 208000003064 gonadoblastoma Diseases 0.000 description 1
• 229960002913 goserelin Drugs 0.000 description 1
• 229960003690 goserelin acetate Drugs 0.000 description 1
• 229930000755 gossypol Natural products 0.000 description 1
• 229950005277 gossypol Drugs 0.000 description 1
• 210000003714 granulocyte Anatomy 0.000 description 1
• 238000000227 grinding Methods 0.000 description 1
• 239000003102 growth factor Substances 0.000 description 1
• 102000006638 guanylate kinase Human genes 0.000 description 1
• 230000003394 haemopoietic effect Effects 0.000 description 1
• 201000009277 hairy cell leukemia Diseases 0.000 description 1
• 230000009931 harmful effect Effects 0.000 description 1
• 210000003128 head Anatomy 0.000 description 1
• 201000000459 head and neck squamous cell carcinoma Diseases 0.000 description 1
• 201000002222 hemangioblastoma Diseases 0.000 description 1
• 230000002489 hematologic effect Effects 0.000 description 1
• 108010037536 heparanase Proteins 0.000 description 1
• 208000006454 hepatitis Diseases 0.000 description 1
• 208000006359 hepatoblastoma Diseases 0.000 description 1
• 235000008216 herbs Nutrition 0.000 description 1
• 229940022353 herceptin Drugs 0.000 description 1
• UUVWYPNAQBNQJQ-UHFFFAOYSA-N hexamethylmelamine Chemical compound CN(C)C1=NC(N(C)C)=NC(N(C)C)=N1 UUVWYPNAQBNQJQ-UHFFFAOYSA-N 0.000 description 1
• 108010044853 histidine-rich proteins Proteins 0.000 description 1
• 201000000284 histiocytoma Diseases 0.000 description 1
• 229940121372 histone deacetylase inhibitor Drugs 0.000 description 1
• 229960002193 histrelin Drugs 0.000 description 1
• 108700020746 histrelin Proteins 0.000 description 1
• HHXHVIJIIXKSOE-QILQGKCVSA-N histrelin Chemical compound CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)CC(N=C1)=CN1CC1=CC=CC=C1 HHXHVIJIIXKSOE-QILQGKCVSA-N 0.000 description 1
• HYFHYPWGAURHIV-UHFFFAOYSA-N homoharringtonine Natural products C1=C2CCN3CCCC43C=C(OC)C(OC(=O)C(O)(CCCC(C)(C)O)CC(=O)OC)C4C2=CC2=C1OCO2 HYFHYPWGAURHIV-UHFFFAOYSA-N 0.000 description 1
• 230000003054 hormonal effect Effects 0.000 description 1
• 102000046485 human PRMT2 Human genes 0.000 description 1
• 229960000890 hydrocortisone Drugs 0.000 description 1
• 229960001330 hydroxycarbamide Drugs 0.000 description 1
• 229960004171 hydroxychloroquine Drugs 0.000 description 1
• 229950000801 hydroxyprogesterone caproate Drugs 0.000 description 1
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
• 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
• 238000009217 hyperthermia therapy Methods 0.000 description 1
• 230000007954 hypoxia Effects 0.000 description 1
• 229940031672 hypromellose 2910 Drugs 0.000 description 1
• 229920003125 hypromellose 2910 Polymers 0.000 description 1
• 229960005236 ibandronic acid Drugs 0.000 description 1
• 229960001001 ibritumomab tiuxetan Drugs 0.000 description 1
• 229960004716 idoxuridine Drugs 0.000 description 1
• 229950006905 ilmofosine Drugs 0.000 description 1
• 229960002240 iloprost Drugs 0.000 description 1
• HIFJCPQKFCZDDL-ACWOEMLNSA-N iloprost Chemical compound C1\C(=C/CCCC(O)=O)C[C@@H]2[C@@H](/C=C/[C@@H](O)C(C)CC#CC)[C@H](O)C[C@@H]21 HIFJCPQKFCZDDL-ACWOEMLNSA-N 0.000 description 1
• 229960003685 imatinib mesylate Drugs 0.000 description 1
• YLMAHDNUQAMNNX-UHFFFAOYSA-N imatinib methanesulfonate Chemical compound CS(O)(=O)=O.C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 YLMAHDNUQAMNNX-UHFFFAOYSA-N 0.000 description 1
• 229960002751 imiquimod Drugs 0.000 description 1
• DOUYETYNHWVLEO-UHFFFAOYSA-N imiquimod Chemical compound C1=CC=CC2=C3N(CC(C)C)C=NC3=C(N)N=C21 DOUYETYNHWVLEO-UHFFFAOYSA-N 0.000 description 1
• 230000006303 immediate early viral mRNA transcription Effects 0.000 description 1
• IWKXDMQDITUYRK-KUBHLMPHSA-N immucillin H Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)N[C@H]1C1=CNC2=C1N=CNC2=O IWKXDMQDITUYRK-KUBHLMPHSA-N 0.000 description 1
• 210000002865 immune cell Anatomy 0.000 description 1
• 230000036737 immune function Effects 0.000 description 1
• 230000028993 immune response Effects 0.000 description 1
• 230000036039 immunity Effects 0.000 description 1
• 102000018358 immunoglobulin Human genes 0.000 description 1
• 230000001506 immunosuppresive effect Effects 0.000 description 1
• 238000009169 immunotherapy Methods 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 238000002513 implantation Methods 0.000 description 1
• 201000004933 in situ carcinoma Diseases 0.000 description 1
• 238000001727 in vivo Methods 0.000 description 1
• 230000000937 inactivator Effects 0.000 description 1
• SETFNECMODOHTO-UHFFFAOYSA-N indisulam Chemical compound C1=CC(S(=O)(=O)N)=CC=C1S(=O)(=O)NC1=CC=CC2=C1NC=C2Cl SETFNECMODOHTO-UHFFFAOYSA-N 0.000 description 1
• 229960000598 infliximab Drugs 0.000 description 1
• 239000004615 ingredient Substances 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 108010093564 inter-alpha-inhibitor Proteins 0.000 description 1
• 239000000138 intercalating agent Substances 0.000 description 1
• 238000009830 intercalation Methods 0.000 description 1
• 229950000038 interferon alfa Drugs 0.000 description 1
• 229940047124 interferons Drugs 0.000 description 1
• 239000003407 interleukin 1 receptor blocking agent Substances 0.000 description 1
• 108090000681 interleukin 20 Proteins 0.000 description 1
• 229940117681 interleukin-12 Drugs 0.000 description 1
• 108040003607 interleukin-13 receptor activity proteins Proteins 0.000 description 1
• 229940028885 interleukin-4 Drugs 0.000 description 1
• 229940118526 interleukin-9 Drugs 0.000 description 1
• 229940047122 interleukins Drugs 0.000 description 1
• 238000003046 intermediate neglect of differential overlap Methods 0.000 description 1
• 201000002313 intestinal cancer Diseases 0.000 description 1
• 208000028774 intestinal disease Diseases 0.000 description 1
• 210000000936 intestine Anatomy 0.000 description 1
• 238000001361 intraarterial administration Methods 0.000 description 1
• 238000007918 intramuscular administration Methods 0.000 description 1
• 238000007912 intraperitoneal administration Methods 0.000 description 1
• 230000005865 ionizing radiation Effects 0.000 description 1
• 229950005254 irofulven Drugs 0.000 description 1
• NICJCIQSJJKZAH-AWEZNQCLSA-N irofulven Chemical compound O=C([C@@]1(O)C)C2=CC(C)=C(CO)C2=C(C)C21CC2 NICJCIQSJJKZAH-AWEZNQCLSA-N 0.000 description 1
• AWJUIBRHMBBTKR-UHFFFAOYSA-N iso-quinoline Natural products C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 description 1
• 108700025907 jun Genes Proteins 0.000 description 1
• 229960004125 ketoconazole Drugs 0.000 description 1
• 201000010982 kidney cancer Diseases 0.000 description 1
• 239000004922 lacquer Substances 0.000 description 1
• 229960001021 lactose monohydrate Drugs 0.000 description 1
• 229960004891 lapatinib Drugs 0.000 description 1
• 206010023841 laryngeal neoplasm Diseases 0.000 description 1
• 229950001845 lestaurtinib Drugs 0.000 description 1
• 231100000518 lethal Toxicity 0.000 description 1
• 201000004803 lethal congenital contracture syndrome 2 Diseases 0.000 description 1
• 230000001665 lethal effect Effects 0.000 description 1
• 229960003881 letrozole Drugs 0.000 description 1
• HPJKCIUCZWXJDR-UHFFFAOYSA-N letrozole Chemical compound C1=CC(C#N)=CC=C1C(N1N=CN=C1)C1=CC=C(C#N)C=C1 HPJKCIUCZWXJDR-UHFFFAOYSA-N 0.000 description 1
• 230000023404 leukocyte cell-cell adhesion Effects 0.000 description 1
• 208000002741 leukoplakia Diseases 0.000 description 1
• 125000005647 linker group Chemical group 0.000 description 1
• 208000012987 lip and oral cavity carcinoma Diseases 0.000 description 1
• 206010024627 liposarcoma Diseases 0.000 description 1
• 229940057995 liquid paraffin Drugs 0.000 description 1
• 239000006194 liquid suspension Substances 0.000 description 1
• 210000004185 liver Anatomy 0.000 description 1
• 201000007270 liver cancer Diseases 0.000 description 1
• 208000014018 liver neoplasm Diseases 0.000 description 1
• 229950008745 losoxantrone Drugs 0.000 description 1
• YROQEQPFUCPDCP-UHFFFAOYSA-N losoxantrone Chemical compound OCCNCCN1N=C2C3=CC=CC(O)=C3C(=O)C3=C2C1=CC=C3NCCNCCO YROQEQPFUCPDCP-UHFFFAOYSA-N 0.000 description 1
• 239000007937 lozenge Substances 0.000 description 1
• 238000009593 lumbar puncture Methods 0.000 description 1
• 201000005249 lung adenocarcinoma Diseases 0.000 description 1
• 201000005243 lung squamous cell carcinoma Diseases 0.000 description 1
• 208000012804 lymphangiosarcoma Diseases 0.000 description 1
• 210000004698 lymphocyte Anatomy 0.000 description 1
• 208000003747 lymphoid leukemia Diseases 0.000 description 1
• 210000002540 macrophage Anatomy 0.000 description 1
• 230000036210 malignancy Effects 0.000 description 1
• 208000015486 malignant pancreatic neoplasm Diseases 0.000 description 1
• 208000015179 malignant superior sulcus neoplasm Diseases 0.000 description 1
• 201000001117 malignant triton tumor Diseases 0.000 description 1
• 229960001855 mannitol Drugs 0.000 description 1
• 210000003826 marginal zone b cell Anatomy 0.000 description 1
• 229950008959 marimastat Drugs 0.000 description 1
• OCSMOTCMPXTDND-OUAUKWLOSA-N marimastat Chemical compound CNC(=O)[C@H](C(C)(C)C)NC(=O)[C@H](CC(C)C)[C@H](O)C(=O)NO OCSMOTCMPXTDND-OUAUKWLOSA-N 0.000 description 1
• 238000000681 mass spectrometry of recoiled ion Methods 0.000 description 1
• 208000000516 mast-cell leukemia Diseases 0.000 description 1
• 239000000463 material Substances 0.000 description 1
• 229940121386 matrix metalloproteinase inhibitor Drugs 0.000 description 1
• 239000003771 matrix metalloproteinase inhibitor Substances 0.000 description 1
• AEUKDPKXTPNBNY-XEYRWQBLSA-N mcp 2 Chemical compound C([C@@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@@H](N)C(C)C)C(C)C)C1=CC=CC=C1 AEUKDPKXTPNBNY-XEYRWQBLSA-N 0.000 description 1
• 230000007246 mechanism Effects 0.000 description 1
• 229960004961 mechlorethamine Drugs 0.000 description 1
• HAWPXGHAZFHHAD-UHFFFAOYSA-N mechlorethamine Chemical compound ClCCN(C)CCCl HAWPXGHAZFHHAD-UHFFFAOYSA-N 0.000 description 1
• 229960002985 medroxyprogesterone acetate Drugs 0.000 description 1
• PSGAAPLEWMOORI-PEINSRQWSA-N medroxyprogesterone acetate Chemical compound C([C@@]12C)CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2CC[C@]2(C)[C@@](OC(C)=O)(C(C)=O)CC[C@H]21 PSGAAPLEWMOORI-PEINSRQWSA-N 0.000 description 1
• 229960004296 megestrol acetate Drugs 0.000 description 1
• RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 description 1
• 229960001929 meloxicam Drugs 0.000 description 1
• 239000012528 membrane Substances 0.000 description 1
• 229960003151 mercaptamine Drugs 0.000 description 1
• 108020004999 messenger RNA Proteins 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• 230000015689 metaplastic ossification Effects 0.000 description 1
• 230000001394 metastastic effect Effects 0.000 description 1
• 206010061289 metastatic neoplasm Diseases 0.000 description 1
• SIVLENRHVVVPKJ-UHFFFAOYSA-N methyl 4-chloro-3-[(2-methoxy-7-oxo-8h-pyrido[2,3-d]pyrimidine-6-carbonyl)amino]benzoate Chemical compound COC(=O)C1=CC=C(Cl)C(NC(=O)C=2C(NC3=NC(OC)=NC=C3C=2)=O)=C1 SIVLENRHVVVPKJ-UHFFFAOYSA-N 0.000 description 1
• 229920000609 methyl cellulose Polymers 0.000 description 1
• 108040008770 methylated-DNA-[protein]-cysteine S-methyltransferase activity proteins Proteins 0.000 description 1
• 235000010981 methylcellulose Nutrition 0.000 description 1
• 239000001923 methylcellulose Substances 0.000 description 1
• 229960002900 methylcellulose Drugs 0.000 description 1
• 229960000282 metronidazole Drugs 0.000 description 1
• VAOCPAMSLUNLGC-UHFFFAOYSA-N metronidazole Chemical compound CC1=NC=C([N+]([O-])=O)N1CCO VAOCPAMSLUNLGC-UHFFFAOYSA-N 0.000 description 1
• 238000002493 microarray Methods 0.000 description 1
• 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
• 239000008108 microcrystalline cellulose Substances 0.000 description 1
• 229940016286 microcrystalline cellulose Drugs 0.000 description 1
• 210000003879 microtubule-organizing center Anatomy 0.000 description 1
• 229950010514 misonidazole Drugs 0.000 description 1
• OBBCSXFCDPPXOL-UHFFFAOYSA-N misonidazole Chemical compound COCC(O)CN1C=CN=C1[N+]([O-])=O OBBCSXFCDPPXOL-UHFFFAOYSA-N 0.000 description 1
• 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 description 1
• 229960000350 mitotane Drugs 0.000 description 1
• 238000002156 mixing Methods 0.000 description 1
• VYGYNVZNSSTDLJ-HKCOAVLJSA-N monorden Natural products CC1CC2OC2C=C/C=C/C(=O)CC3C(C(=CC(=C3Cl)O)O)C(=O)O1 VYGYNVZNSSTDLJ-HKCOAVLJSA-N 0.000 description 1
• JFOHFDSMPQIOES-UHFFFAOYSA-N motexafin Chemical compound C1=NC2=CC(OCCOCCOCCOC)=C(OCCOCCOCCOC)C=C2N=CC(C(=C2CCCO)C)=NC2=CC(C(CC)=C2CC)=NC2=CC2=C(CCCO)C(C)=C1N2 JFOHFDSMPQIOES-UHFFFAOYSA-N 0.000 description 1
• 229950011637 motexafin Drugs 0.000 description 1
• 208000022669 mucinous neoplasm Diseases 0.000 description 1
• 108010066052 multidrug resistance-associated protein 1 Proteins 0.000 description 1
• 229940124303 multikinase inhibitor Drugs 0.000 description 1
• 210000003205 muscle Anatomy 0.000 description 1
• 210000000066 myeloid cell Anatomy 0.000 description 1
• 201000005987 myeloid sarcoma Diseases 0.000 description 1
• 208000009091 myxoma Diseases 0.000 description 1
• 208000001611 myxosarcoma Diseases 0.000 description 1
• ONDPWWDPQDCQNJ-UHFFFAOYSA-N n-(3,3-dimethyl-1,2-dihydroindol-6-yl)-2-(pyridin-4-ylmethylamino)pyridine-3-carboxamide;phosphoric acid Chemical compound OP(O)(O)=O.OP(O)(O)=O.C=1C=C2C(C)(C)CNC2=CC=1NC(=O)C1=CC=CN=C1NCC1=CC=NC=C1 ONDPWWDPQDCQNJ-UHFFFAOYSA-N 0.000 description 1
• YBTGTVGEKMZEQX-UHFFFAOYSA-N n-(4-bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine Chemical compound N1=CN=C2C=C(OCCN3N=NC=C3)C(OC)=CC2=C1NC1=CC=C(Br)C=C1F YBTGTVGEKMZEQX-UHFFFAOYSA-N 0.000 description 1
• BLCLNMBMMGCOAS-UHFFFAOYSA-N n-[1-[[1-[[1-[[1-[[1-[[1-[[1-[2-[(carbamoylamino)carbamoyl]pyrrolidin-1-yl]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-[(2-methylpropan-2-yl)oxy]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amin Chemical compound C1CCC(C(=O)NNC(N)=O)N1C(=O)C(CCCN=C(N)N)NC(=O)C(CC(C)C)NC(=O)C(COC(C)(C)C)NC(=O)C(NC(=O)C(CO)NC(=O)C(CC=1C2=CC=CC=C2NC=1)NC(=O)C(CC=1NC=NC=1)NC(=O)C1NC(=O)CC1)CC1=CC=C(O)C=C1 BLCLNMBMMGCOAS-UHFFFAOYSA-N 0.000 description 1
• KWQWWUXRGIIBAS-UHFFFAOYSA-N n-[2-(4-hydroxyanilino)pyridin-3-yl]-4-methoxybenzenesulfonamide;hydrochloride Chemical compound Cl.C1=CC(OC)=CC=C1S(=O)(=O)NC1=CC=CN=C1NC1=CC=C(O)C=C1 KWQWWUXRGIIBAS-UHFFFAOYSA-N 0.000 description 1
• UMJJGDUYVQCBMC-UHFFFAOYSA-N n-ethyl-n'-[3-[3-(ethylamino)propylamino]propyl]propane-1,3-diamine Chemical compound CCNCCCNCCCNCCCNCC UMJJGDUYVQCBMC-UHFFFAOYSA-N 0.000 description 1
• VBEGHXKAFSLLGE-UHFFFAOYSA-N n-phenylnitramide Chemical class [O-][N+](=O)NC1=CC=CC=C1 VBEGHXKAFSLLGE-UHFFFAOYSA-N 0.000 description 1
• 229950009793 naptumomab estafenatox Drugs 0.000 description 1
• 208000014761 nasopharyngeal type undifferentiated carcinoma Diseases 0.000 description 1
• 210000000822 natural killer cell Anatomy 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 230000007524 negative regulation of DNA replication Effects 0.000 description 1
• CTMCWCONSULRHO-UHQPFXKFSA-N nemorubicin Chemical compound C1CO[C@H](OC)CN1[C@@H]1[C@H](O)[C@H](C)O[C@@H](O[C@@H]2C3=C(O)C=4C(=O)C5=C(OC)C=CC=C5C(=O)C=4C(O)=C3C[C@](O)(C2)C(=O)CO)C1 CTMCWCONSULRHO-UHQPFXKFSA-N 0.000 description 1
• 229950010159 nemorubicin Drugs 0.000 description 1
• 230000009826 neoplastic cell growth Effects 0.000 description 1
• 229950008835 neratinib Drugs 0.000 description 1
• ZNHPZUKZSNBOSQ-BQYQJAHWSA-N neratinib Chemical compound C=12C=C(NC\C=C\CN(C)C)C(OCC)=CC2=NC=C(C#N)C=1NC(C=C1Cl)=CC=C1OCC1=CC=CC=N1 ZNHPZUKZSNBOSQ-BQYQJAHWSA-N 0.000 description 1
• 208000023833 nerve sheath neoplasm Diseases 0.000 description 1
• 210000000653 nervous system Anatomy 0.000 description 1
• 230000001537 neural effect Effects 0.000 description 1
• 208000007538 neurilemmoma Diseases 0.000 description 1
• 201000009494 neurilemmomatosis Diseases 0.000 description 1
• 210000002241 neurite Anatomy 0.000 description 1
• 230000000508 neurotrophic effect Effects 0.000 description 1
• 229960003966 nicotinamide Drugs 0.000 description 1
• 235000005152 nicotinamide Nutrition 0.000 description 1
• 239000011570 nicotinamide Substances 0.000 description 1
• HHZIURLSWUIHRB-UHFFFAOYSA-N nilotinib Chemical compound C1=NC(C)=CN1C1=CC(NC(=O)C=2C=C(NC=3N=C(C=CN=3)C=3C=NC=CC=3)C(C)=CC=2)=CC(C(F)(F)F)=C1 HHZIURLSWUIHRB-UHFFFAOYSA-N 0.000 description 1
• 229960001346 nilotinib Drugs 0.000 description 1
• 229960002653 nilutamide Drugs 0.000 description 1
• XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 description 1
• 229910052757 nitrogen Inorganic materials 0.000 description 1
• 201000000032 nodular malignant melanoma Diseases 0.000 description 1
• 229940085033 nolvadex Drugs 0.000 description 1
• 231100000956 nontoxicity Toxicity 0.000 description 1
• 108091008584 nuclear progesterone receptors Proteins 0.000 description 1
• 239000002773 nucleotide Substances 0.000 description 1
• 125000003729 nucleotide group Chemical group 0.000 description 1
• QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
• OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
• 229960002700 octreotide Drugs 0.000 description 1
• 201000008106 ocular cancer Diseases 0.000 description 1
• 208000027825 odontogenic neoplasm Diseases 0.000 description 1
• QNDVLZJODHBUFM-WFXQOWMNSA-N okadaic acid Chemical compound C([C@H](O1)[C@H](C)/C=C/[C@H]2CC[C@@]3(CC[C@H]4O[C@@H](C([C@@H](O)[C@@H]4O3)=C)[C@@H](O)C[C@H](C)[C@@H]3[C@@H](CC[C@@]4(OCCCC4)O3)C)O2)C(C)=C[C@]21O[C@H](C[C@@](C)(O)C(O)=O)CC[C@H]2O QNDVLZJODHBUFM-WFXQOWMNSA-N 0.000 description 1
• VEFJHAYOIAAXEU-UHFFFAOYSA-N okadaic acid Natural products CC(CC(O)C1OC2CCC3(CCC(O3)C=CC(C)C4CC(=CC5(OC(CC(C)(O)C(=O)O)CCC5O)O4)C)OC2C(O)C1C)C6OC7(CCCCO7)CCC6C VEFJHAYOIAAXEU-UHFFFAOYSA-N 0.000 description 1
• 206010073131 oligoastrocytoma Diseases 0.000 description 1
• 229960002230 omacetaxine mepesuccinate Drugs 0.000 description 1
• HYFHYPWGAURHIV-JFIAXGOJSA-N omacetaxine mepesuccinate Chemical compound C1=C2CCN3CCC[C@]43C=C(OC)[C@@H](OC(=O)[C@@](O)(CCCC(C)(C)O)CC(=O)OC)[C@H]4C2=CC2=C1OCO2 HYFHYPWGAURHIV-JFIAXGOJSA-N 0.000 description 1
• 231100000590 oncogenic Toxicity 0.000 description 1
• 238000011275 oncology therapy Methods 0.000 description 1
• 210000001328 optic nerve Anatomy 0.000 description 1
• 208000027500 optic nerve neoplasm Diseases 0.000 description 1
• 208000022982 optic pathway glioma Diseases 0.000 description 1
• 229950007283 oregovomab Drugs 0.000 description 1
• 239000003960 organic solvent Substances 0.000 description 1
• 239000003791 organic solvent mixture Substances 0.000 description 1
• AICOOMRHRUFYCM-ZRRPKQBOSA-N oxazine, 1 Chemical compound C([C@@H]1[C@H](C(C[C@]2(C)[C@@H]([C@H](C)N(C)C)[C@H](O)C[C@]21C)=O)CC1=CC2)C[C@H]1[C@@]1(C)[C@H]2N=C(C(C)C)OC1 AICOOMRHRUFYCM-ZRRPKQBOSA-N 0.000 description 1
• 229960000649 oxyphenbutazone Drugs 0.000 description 1
• 108010068338 p38 Mitogen-Activated Protein Kinases Proteins 0.000 description 1
• GTUJJVSZIHQLHA-XPWFQUROSA-N pApA Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@@H]1O)O[C@H](COP(O)(O)=O)[C@H]1OP(O)(=O)OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N1C(N=CN=C2N)=C2N=C1 GTUJJVSZIHQLHA-XPWFQUROSA-N 0.000 description 1
• WRUUGTRCQOWXEG-UHFFFAOYSA-N pamidronate Chemical compound NCCC(O)(P(O)(O)=O)P(O)(O)=O WRUUGTRCQOWXEG-UHFFFAOYSA-N 0.000 description 1
• 229960003978 pamidronic acid Drugs 0.000 description 1
• 210000000496 pancreas Anatomy 0.000 description 1
• 201000002528 pancreatic cancer Diseases 0.000 description 1
• 208000008443 pancreatic carcinoma Diseases 0.000 description 1
• 229960001972 panitumumab Drugs 0.000 description 1
• 208000003154 papilloma Diseases 0.000 description 1
• 208000007312 paraganglioma Diseases 0.000 description 1
• 244000052769 pathogen Species 0.000 description 1
• 239000013610 patient sample Substances 0.000 description 1
• 229940097097 pediapred Drugs 0.000 description 1
• 239000008188 pellet Substances 0.000 description 1
• 108010072633 peptidase 7 Proteins 0.000 description 1
• 239000000816 peptidomimetic Substances 0.000 description 1
• SZFPYBIJACMNJV-UHFFFAOYSA-N perifosine Chemical compound CCCCCCCCCCCCCCCCCCOP([O-])(=O)OC1CC[N+](C)(C)CC1 SZFPYBIJACMNJV-UHFFFAOYSA-N 0.000 description 1
• 229950010632 perifosine Drugs 0.000 description 1
• 230000002093 peripheral effect Effects 0.000 description 1
• 108030002458 peroxiredoxin Proteins 0.000 description 1
• 108010060054 peroxisome-proliferator-activated receptor-gamma coactivator-1 Proteins 0.000 description 1
• 229960002087 pertuzumab Drugs 0.000 description 1
• 229960002895 phenylbutazone Drugs 0.000 description 1
• 229950006768 phenylethanolamine Drugs 0.000 description 1
• 239000010452 phosphate Substances 0.000 description 1
• XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
• XKJCHHZQLQNZHY-UHFFFAOYSA-N phthalimide Chemical class C1=CC=C2C(=O)NC(=O)C2=C1 XKJCHHZQLQNZHY-UHFFFAOYSA-N 0.000 description 1
• 239000000049 pigment Substances 0.000 description 1
• 206010035059 pineocytoma Diseases 0.000 description 1
• 229960005095 pioglitazone Drugs 0.000 description 1
• ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 description 1
• 229960003073 pirfenidone Drugs 0.000 description 1
• 208000021310 pituitary gland adenoma Diseases 0.000 description 1
• 208000010916 pituitary tumor Diseases 0.000 description 1
• 229960004403 pixantrone Drugs 0.000 description 1
• PEZPMAYDXJQYRV-UHFFFAOYSA-N pixantrone Chemical compound O=C1C2=CN=CC=C2C(=O)C2=C1C(NCCN)=CC=C2NCCN PEZPMAYDXJQYRV-UHFFFAOYSA-N 0.000 description 1
• 108010031345 placental alkaline phosphatase Proteins 0.000 description 1
• 229940072689 plaquenil Drugs 0.000 description 1
• 230000036470 plasma concentration Effects 0.000 description 1
• 239000004014 plasticizer Substances 0.000 description 1
• 108010017843 platelet-derived growth factor A Proteins 0.000 description 1
• 229910052697 platinum Inorganic materials 0.000 description 1
• 150000003058 platinum compounds Chemical class 0.000 description 1
• 102000005162 pleiotrophin Human genes 0.000 description 1
• 229920001481 poly(stearyl methacrylate) Polymers 0.000 description 1
• 208000037244 polycythemia vera Diseases 0.000 description 1
• 208000024246 polyembryoma Diseases 0.000 description 1
• 229940068918 polyethylene glycol 400 Drugs 0.000 description 1
• 238000006116 polymerization reaction Methods 0.000 description 1
• 102000040430 polynucleotide Human genes 0.000 description 1
• 108091033319 polynucleotide Proteins 0.000 description 1
• 239000002157 polynucleotide Substances 0.000 description 1
• 239000004175 ponceau 4R Substances 0.000 description 1
• 229960004293 porfimer sodium Drugs 0.000 description 1
• OXCMYAYHXIHQOA-UHFFFAOYSA-N potassium;[2-butyl-5-chloro-3-[[4-[2-(1,2,4-triaza-3-azanidacyclopenta-1,4-dien-5-yl)phenyl]phenyl]methyl]imidazol-4-yl]methanol Chemical compound [K+].CCCCC1=NC(Cl)=C(CO)N1CC1=CC=C(C=2C(=CC=CC=2)C2=N[N-]N=N2)C=C1 OXCMYAYHXIHQOA-UHFFFAOYSA-N 0.000 description 1
• 229920001592 potato starch Polymers 0.000 description 1
• 229940116317 potato starch Drugs 0.000 description 1
• 229960005205 prednisolone Drugs 0.000 description 1
• VJZLQIPZNBPASX-OJJGEMKLSA-L prednisolone sodium phosphate Chemical compound [Na+].[Na+].O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)COP([O-])([O-])=O)[C@@H]4[C@@H]3CCC2=C1 VJZLQIPZNBPASX-OJJGEMKLSA-L 0.000 description 1
• 229940096111 prelone Drugs 0.000 description 1
• 239000003755 preservative agent Substances 0.000 description 1
• 229950003608 prinomastat Drugs 0.000 description 1
• YKPYIPVDTNNYCN-INIZCTEOSA-N prinomastat Chemical compound ONC(=O)[C@H]1C(C)(C)SCCN1S(=O)(=O)C(C=C1)=CC=C1OC1=CC=NC=C1 YKPYIPVDTNNYCN-INIZCTEOSA-N 0.000 description 1
• 229960000624 procarbazine Drugs 0.000 description 1
• 230000008569 process Effects 0.000 description 1
• 239000000583 progesterone congener Substances 0.000 description 1
• 108090000468 progesterone receptors Proteins 0.000 description 1
• 229940097325 prolactin Drugs 0.000 description 1
• 230000035755 proliferation Effects 0.000 description 1
• PUIBPGHAXSCVRF-QHFGJBOXSA-N prostaglandin C1 Chemical compound CCCCC[C@H](O)\C=C\C1=CCC(=O)[C@@H]1CCCCCCC(O)=O PUIBPGHAXSCVRF-QHFGJBOXSA-N 0.000 description 1
• 239000002599 prostaglandin synthase inhibitor Substances 0.000 description 1
• 229960000856 protein c Drugs 0.000 description 1
• 108020000494 protein-tyrosine phosphatase Proteins 0.000 description 1
• 150000003212 purines Chemical class 0.000 description 1
• 150000003230 pyrimidines Chemical class 0.000 description 1
• AECPBJMOGBFQDN-YMYQVXQQSA-N radicicol Chemical compound C1CCCC(=O)C[C@H]2[C@H](Cl)C(=O)CC(=O)[C@H]2C(=O)O[C@H](C)C[C@H]2O[C@@H]21 AECPBJMOGBFQDN-YMYQVXQQSA-N 0.000 description 1
• 229930192524 radicicol Natural products 0.000 description 1
• 230000002285 radioactive effect Effects 0.000 description 1
• 238000011363 radioimmunotherapy Methods 0.000 description 1
• 229960002119 raloxifene hydrochloride Drugs 0.000 description 1
• BKXVVCILCIUCLG-UHFFFAOYSA-N raloxifene hydrochloride Chemical compound [H+].[Cl-].C1=CC(O)=CC=C1C1=C(C(=O)C=2C=CC(OCCN3CCCCC3)=CC=2)C2=CC=C(O)C=C2S1 BKXVVCILCIUCLG-UHFFFAOYSA-N 0.000 description 1
• 229950007649 ranpirnase Drugs 0.000 description 1
• 108010061338 ranpirnase Proteins 0.000 description 1
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 1
• INSACQSBHKIWNS-QZQSLCQPSA-N rebeccamycin Chemical class O[C@@H]1[C@@H](O)[C@H](OC)[C@@H](CO)O[C@H]1N1C2=C3N=C4[C](Cl)C=CC=C4C3=C3C(=O)NC(=O)C3=C2C2=CC=CC(Cl)=C21 INSACQSBHKIWNS-QZQSLCQPSA-N 0.000 description 1
• 229940075993 receptor modulator Drugs 0.000 description 1
• 206010038038 rectal cancer Diseases 0.000 description 1
• 201000001275 rectum cancer Diseases 0.000 description 1
• 230000002829 reductive effect Effects 0.000 description 1
• 230000001718 repressive effect Effects 0.000 description 1
• 238000011160 research Methods 0.000 description 1
• 230000004043 responsiveness Effects 0.000 description 1
• 230000000717 retained effect Effects 0.000 description 1
• OAKGNIRUXAZDQF-TXHRRWQRSA-N retaspimycin Chemical compound N1C(=O)\C(C)=C\C=C/[C@H](OC)[C@@H](OC(N)=O)\C(C)=C\[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)CC2=C(O)C1=CC(O)=C2NCC=C OAKGNIRUXAZDQF-TXHRRWQRSA-N 0.000 description 1
• 229930002330 retinoic acid Natural products 0.000 description 1
• 150000004492 retinoid derivatives Chemical class 0.000 description 1
• 108091092562 ribozyme Proteins 0.000 description 1
• 229940100486 rice starch Drugs 0.000 description 1
• 229960001302 ridaforolimus Drugs 0.000 description 1
• 229960000759 risedronic acid Drugs 0.000 description 1
• 229960004641 rituximab Drugs 0.000 description 1
• QXKJWHWUDVQATH-UHFFFAOYSA-N rogletimide Chemical compound C=1C=NC=CC=1C1(CC)CCC(=O)NC1=O QXKJWHWUDVQATH-UHFFFAOYSA-N 0.000 description 1
• 229960003452 romidepsin Drugs 0.000 description 1
• OHRURASPPZQGQM-GCCNXGTGSA-N romidepsin Chemical compound O1C(=O)[C@H](C(C)C)NC(=O)C(=C/C)/NC(=O)[C@H]2CSSCC\C=C\[C@@H]1CC(=O)N[C@H](C(C)C)C(=O)N2 OHRURASPPZQGQM-GCCNXGTGSA-N 0.000 description 1
• 229960004586 rosiglitazone Drugs 0.000 description 1
• 229950008902 safingol Drugs 0.000 description 1
• 229960005399 satraplatin Drugs 0.000 description 1
• 190014017285 satraplatin Chemical compound 0.000 description 1
• 206010039667 schwannoma Diseases 0.000 description 1
• 229950003647 semaxanib Drugs 0.000 description 1
• WUWDLXZGHZSWQZ-WQLSENKSSA-N semaxanib Chemical compound N1C(C)=CC(C)=C1\C=C/1C2=CC=CC=C2NC\1=O WUWDLXZGHZSWQZ-WQLSENKSSA-N 0.000 description 1
• 239000008159 sesame oil Substances 0.000 description 1
• 235000011803 sesame oil Nutrition 0.000 description 1
• 239000002453 shampoo Substances 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 239000000377 silicon dioxide Substances 0.000 description 1
• 229960002930 sirolimus Drugs 0.000 description 1
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 1
• 201000000849 skin cancer Diseases 0.000 description 1
• 201000010153 skin papilloma Diseases 0.000 description 1
• 201000010106 skin squamous cell carcinoma Diseases 0.000 description 1
• 239000004055 small Interfering RNA Substances 0.000 description 1
• 208000000649 small cell carcinoma Diseases 0.000 description 1
• 208000000587 small cell lung carcinoma Diseases 0.000 description 1
• 201000002314 small intestine cancer Diseases 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 235000015424 sodium Nutrition 0.000 description 1
• 235000010413 sodium alginate Nutrition 0.000 description 1
• 239000000661 sodium alginate Substances 0.000 description 1
• 229940005550 sodium alginate Drugs 0.000 description 1
• 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
• 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
• 239000008109 sodium starch glycolate Substances 0.000 description 1
• 229940079832 sodium starch glycolate Drugs 0.000 description 1
• 229920003109 sodium starch glycolate Polymers 0.000 description 1
• 229940045902 sodium stearyl fumarate Drugs 0.000 description 1
• 239000007901 soft capsule Substances 0.000 description 1
• 239000012439 solid excipient Substances 0.000 description 1
• 229940075620 somatostatin analogue Drugs 0.000 description 1
• 239000004071 soot Substances 0.000 description 1
• 239000002594 sorbent Substances 0.000 description 1
• 230000009870 specific binding Effects 0.000 description 1
• 238000004611 spectroscopical analysis Methods 0.000 description 1
• OTKJDMGTUTTYMP-ZWKOTPCHSA-N sphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@@H](N)CO OTKJDMGTUTTYMP-ZWKOTPCHSA-N 0.000 description 1
• 208000037959 spinal tumor Diseases 0.000 description 1
• 230000003393 splenic effect Effects 0.000 description 1
• 208000021333 squamous cell carcinoma of penis Diseases 0.000 description 1
• 230000000087 stabilizing effect Effects 0.000 description 1
• CGPUWJWCVCFERF-UHFFFAOYSA-N staurosporine Natural products C12=C3N4C5=CC=CC=C5C3=C3CNC(=O)C3=C2C2=CC=CC=C2N1C1CC(NC)C(OC)C4(OC)O1 CGPUWJWCVCFERF-UHFFFAOYSA-N 0.000 description 1
• 239000008117 stearic acid Substances 0.000 description 1
• 210000000130 stem cell Anatomy 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 210000002784 stomach Anatomy 0.000 description 1
• 108091007196 stromelysin Proteins 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 239000005720 sucrose Substances 0.000 description 1
• MVGSNCBCUWPVDA-MFOYZWKCSA-N sulindac sulfone Chemical compound CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)(=O)=O)C=C1 MVGSNCBCUWPVDA-MFOYZWKCSA-N 0.000 description 1
• 229960005314 suramin Drugs 0.000 description 1
• FIAFUQMPZJWCLV-UHFFFAOYSA-N suramin Chemical compound OS(=O)(=O)C1=CC(S(O)(=O)=O)=C2C(NC(=O)C3=CC=C(C(=C3)NC(=O)C=3C=C(NC(=O)NC=4C=C(C=CC=4)C(=O)NC=4C(=CC=C(C=4)C(=O)NC=4C5=C(C=C(C=C5C(=CC=4)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O)C)C=CC=3)C)=CC=C(S(O)(=O)=O)C2=C1 FIAFUQMPZJWCLV-UHFFFAOYSA-N 0.000 description 1
• 239000004094 surface-active agent Substances 0.000 description 1
• 238000001356 surgical procedure Methods 0.000 description 1
• 230000004083 survival effect Effects 0.000 description 1
• 239000003765 sweetening agent Substances 0.000 description 1
• 206010042863 synovial sarcoma Diseases 0.000 description 1
• 238000003786 synthesis reaction Methods 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 238000012353 t test Methods 0.000 description 1
• 229950010637 talabostat Drugs 0.000 description 1
• 108010009573 talabostat Proteins 0.000 description 1
• 229950004608 talampanel Drugs 0.000 description 1
• UXXQOJXBIDBUAC-UHFFFAOYSA-N tandutinib Chemical compound COC1=CC2=C(N3CCN(CC3)C(=O)NC=3C=CC(OC(C)C)=CC=3)N=CN=C2C=C1OCCCN1CCCCC1 UXXQOJXBIDBUAC-UHFFFAOYSA-N 0.000 description 1
• 229950005890 tariquidar Drugs 0.000 description 1
• 229940063683 taxotere Drugs 0.000 description 1
• YVSQVYZBDXIXCC-INIZCTEOSA-N telomestatin Chemical compound N=1C2=COC=1C(N=1)=COC=1C(N=1)=COC=1C(N=1)=COC=1C(N=1)=COC=1C(=C(O1)C)N=C1C(=C(O1)C)N=C1[C@@]1([H])N=C2SC1 YVSQVYZBDXIXCC-INIZCTEOSA-N 0.000 description 1
• QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 description 1
• 201000003120 testicular cancer Diseases 0.000 description 1
• 210000001550 testis Anatomy 0.000 description 1
• 229960005353 testolactone Drugs 0.000 description 1
• BPEWUONYVDABNZ-DZBHQSCQSA-N testolactone Chemical compound O=C1C=C[C@]2(C)[C@H]3CC[C@](C)(OC(=O)CC4)[C@@H]4[C@@H]3CCC2=C1 BPEWUONYVDABNZ-DZBHQSCQSA-N 0.000 description 1
• 229960003604 testosterone Drugs 0.000 description 1
• 229960001712 testosterone propionate Drugs 0.000 description 1
• 229960002180 tetracycline Drugs 0.000 description 1
• 229930101283 tetracycline Natural products 0.000 description 1
• 235000019364 tetracycline Nutrition 0.000 description 1
• 150000003522 tetracyclines Chemical class 0.000 description 1
• 208000001644 thecoma Diseases 0.000 description 1
• 238000011287 therapeutic dose Methods 0.000 description 1
• 231100001274 therapeutic index Toxicity 0.000 description 1
• 229960001196 thiotepa Drugs 0.000 description 1
• 229960004231 thymalfasin Drugs 0.000 description 1
• NZVYCXVTEHPMHE-ZSUJOUNUSA-N thymalfasin Chemical compound CC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O NZVYCXVTEHPMHE-ZSUJOUNUSA-N 0.000 description 1
• 201000002510 thyroid cancer Diseases 0.000 description 1
• 229960005324 tiludronic acid Drugs 0.000 description 1
• 229950002376 tirapazamine Drugs 0.000 description 1
• ORYDPOVDJJZGHQ-UHFFFAOYSA-N tirapazamine Chemical compound C1=CC=CC2=[N+]([O-])C(N)=N[N+]([O-])=C21 ORYDPOVDJJZGHQ-UHFFFAOYSA-N 0.000 description 1
• 239000004408 titanium dioxide Substances 0.000 description 1
• 229960001295 tocopherol Drugs 0.000 description 1
• 235000010384 tocopherol Nutrition 0.000 description 1
• 229930003799 tocopherol Natural products 0.000 description 1
• 239000011732 tocopherol Substances 0.000 description 1
• 229960000303 topotecan Drugs 0.000 description 1
• UCFGDBYHRUNTLO-QHCPKHFHSA-N topotecan Chemical compound C1=C(O)C(CN(C)C)=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 UCFGDBYHRUNTLO-QHCPKHFHSA-N 0.000 description 1
• 231100000048 toxicity data Toxicity 0.000 description 1
• 201000007363 trachea carcinoma Diseases 0.000 description 1
• 235000010487 tragacanth Nutrition 0.000 description 1
• 239000000196 tragacanth Substances 0.000 description 1
• 229940116362 tragacanth Drugs 0.000 description 1
• 230000009466 transformation Effects 0.000 description 1
• 238000013519 translation Methods 0.000 description 1
• 102000035160 transmembrane proteins Human genes 0.000 description 1
• 108091005703 transmembrane proteins Proteins 0.000 description 1
• 229960000575 trastuzumab Drugs 0.000 description 1
• 238000011269 treatment regimen Methods 0.000 description 1
• 229960005294 triamcinolone Drugs 0.000 description 1
• GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
• 150000004654 triazenes Chemical class 0.000 description 1
• 229940078499 tricalcium phosphate Drugs 0.000 description 1
• 235000019731 tricalcium phosphate Nutrition 0.000 description 1
• 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
• 229960001670 trilostane Drugs 0.000 description 1
• KVJXBPDAXMEYOA-CXANFOAXSA-N trilostane Chemical compound OC1=C(C#N)C[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CC[C@@]32O[C@@H]31 KVJXBPDAXMEYOA-CXANFOAXSA-N 0.000 description 1
• 229960000538 trimetrexate glucuronate Drugs 0.000 description 1
• 239000000107 tumor biomarker Substances 0.000 description 1
• 230000004614 tumor growth Effects 0.000 description 1
• 230000005909 tumor killing Effects 0.000 description 1
• 201000007912 type 1 diabetes mellitus 10 Diseases 0.000 description 1
• 201000007906 type 1 diabetes mellitus 2 Diseases 0.000 description 1
• 239000005483 tyrosine kinase inhibitor Substances 0.000 description 1
• TUCIOBMMDDOEMM-RIYZIHGNSA-N tyrphostin B42 Chemical compound C1=C(O)C(O)=CC=C1\C=C(/C#N)C(=O)NCC1=CC=CC=C1 TUCIOBMMDDOEMM-RIYZIHGNSA-N 0.000 description 1
• OOLLAFOLCSJHRE-ZHAKMVSLSA-N ulipristal acetate Chemical compound C1=CC(N(C)C)=CC=C1[C@@H]1C2=C3CCC(=O)C=C3CC[C@H]2[C@H](CC[C@]2(OC(C)=O)C(C)=O)[C@]2(C)C1 OOLLAFOLCSJHRE-ZHAKMVSLSA-N 0.000 description 1
• 150000003672 ureas Chemical class 0.000 description 1
• 201000005112 urinary bladder cancer Diseases 0.000 description 1
• VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 description 1
• 208000037964 urogenital cancer Diseases 0.000 description 1
• 206010046766 uterine cancer Diseases 0.000 description 1
• 229960005486 vaccine Drugs 0.000 description 1
• 206010046885 vaginal cancer Diseases 0.000 description 1
• 208000013139 vaginal neoplasm Diseases 0.000 description 1
• MSRILKIQRXUYCT-UHFFFAOYSA-M valproate semisodium Chemical compound [Na+].CCCC(C(O)=O)CCC.CCCC(C([O-])=O)CCC MSRILKIQRXUYCT-UHFFFAOYSA-M 0.000 description 1
• 229960000604 valproic acid Drugs 0.000 description 1
• 229950010938 valspodar Drugs 0.000 description 1
• 108010082372 valspodar Proteins 0.000 description 1
• 230000002792 vascular Effects 0.000 description 1
• 230000006444 vascular growth Effects 0.000 description 1
• YCOYDOIWSSHVCK-UHFFFAOYSA-N vatalanib Chemical compound C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 YCOYDOIWSSHVCK-UHFFFAOYSA-N 0.000 description 1
• LLDWLPRYLVPDTG-UHFFFAOYSA-N vatalanib succinate Chemical compound OC(=O)CCC(O)=O.C1=CC(Cl)=CC=C1NC(C1=CC=CC=C11)=NN=C1CC1=CC=NC=C1 LLDWLPRYLVPDTG-UHFFFAOYSA-N 0.000 description 1
• 239000003981 vehicle Substances 0.000 description 1
• 208000008662 verrucous carcinoma Diseases 0.000 description 1
• 108700026220 vif Genes Proteins 0.000 description 1
• KDQAABAKXDWYSZ-PNYVAJAMSA-N vinblastine sulfate Chemical compound OS(O)(=O)=O.C([C@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 KDQAABAKXDWYSZ-PNYVAJAMSA-N 0.000 description 1
• 229960004982 vinblastine sulfate Drugs 0.000 description 1
• AQTQHPDCURKLKT-JKDPCDLQSA-N vincristine sulfate Chemical compound OS(O)(=O)=O.C([C@@H](C[C@]1(C(=O)OC)C=2C(=CC3=C([C@]45[C@H]([C@@]([C@H](OC(C)=O)[C@]6(CC)C=CCN([C@H]56)CC4)(O)C(=O)OC)N3C=O)C=2)OC)C[C@@](C2)(O)CC)N2CCC2=C1NC1=CC=CC=C21 AQTQHPDCURKLKT-JKDPCDLQSA-N 0.000 description 1
• 229960002110 vincristine sulfate Drugs 0.000 description 1
• HHJUWIANJFBDHT-KOTLKJBCSA-N vindesine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(N)=O)N4C)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 HHJUWIANJFBDHT-KOTLKJBCSA-N 0.000 description 1
• 229960004355 vindesine Drugs 0.000 description 1
• NMDYYWFGPIMTKO-HBVLKOHWSA-N vinflunine Chemical compound C([C@@](C1=C(C2=CC=CC=C2N1)C1)(C2=C(OC)C=C3N(C)[C@@H]4[C@@]5(C3=C2)CCN2CC=C[C@]([C@@H]52)([C@H]([C@]4(O)C(=O)OC)OC(C)=O)CC)C(=O)OC)[C@H]2C[C@@H](C(C)(F)F)CN1C2 NMDYYWFGPIMTKO-HBVLKOHWSA-N 0.000 description 1
• 229960000922 vinflunine Drugs 0.000 description 1
• GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
• 229960002066 vinorelbine Drugs 0.000 description 1
• 229950001212 volociximab Drugs 0.000 description 1
• 229960001771 vorozole Drugs 0.000 description 1
• XLMPPFTZALNBFS-INIZCTEOSA-N vorozole Chemical compound C1([C@@H](C2=CC=C3N=NN(C3=C2)C)N2N=CN=C2)=CC=C(Cl)C=C1 XLMPPFTZALNBFS-INIZCTEOSA-N 0.000 description 1
• 201000005102 vulva cancer Diseases 0.000 description 1
• 229940100445 wheat starch Drugs 0.000 description 1
• 229960005332 zileuton Drugs 0.000 description 1
• MWLSOWXNZPKENC-SSDOTTSWSA-N zileuton Chemical compound C1=CC=C2SC([C@H](N(O)C(N)=O)C)=CC2=C1 MWLSOWXNZPKENC-SSDOTTSWSA-N 0.000 description 1
• 229910052725 zinc Inorganic materials 0.000 description 1
• 239000011701 zinc Substances 0.000 description 1
• 229960004276 zoledronic acid Drugs 0.000 description 1
• XRASPMIURGNCCH-UHFFFAOYSA-N zoledronic acid Chemical compound OP(=O)(O)C(P(O)(O)=O)(O)CN1C=CN=C1 XRASPMIURGNCCH-UHFFFAOYSA-N 0.000 description 1
• ZPFVQKPWGDRLHL-ZLYBXYBFSA-N zosuquidar trihydrochloride Chemical compound Cl.Cl.Cl.C([C@H](COC=1C2=CC=CN=C2C=CC=1)O)N(CC1)CCN1C1C2=CC=CC=C2[C@H]2C(F)(F)[C@H]2C2=CC=CC=C12 ZPFVQKPWGDRLHL-ZLYBXYBFSA-N 0.000 description 1
• 229950009819 zotarolimus Drugs 0.000 description 1
• CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 description 1
• KRJOFJHOZZPBKI-KSWODRSDSA-N α-defensin-1 Chemical compound C([C@H]1C(=O)N[C@H]2CSSC[C@H]3C(=O)N[C@H](C(N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=4C=CC(O)=CC=4)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](CC=4C=CC(O)=CC=4)NC(=O)[C@H](CSSC[C@H](NC2=O)C(O)=O)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](C)C(=O)N3)C(=O)N[C@H](C(=O)N[C@@H](CC=2C=CC(O)=CC=2)C(=O)N[C@@H](CCC(N)=O)C(=O)NCC(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](C)C(=O)N1)[C@@H](C)CC)[C@@H](C)O)=O)[C@@H](C)CC)C1=CC=CC=C1 KRJOFJHOZZPBKI-KSWODRSDSA-N 0.000 description 1
• GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1