MX2020000955A - Método para la producción de cannabinoides a partir de tipos de cáñamo industrial. - Google Patents

Método para la producción de cannabinoides a partir de tipos de cáñamo industrial.

Info

Publication number
MX2020000955A
MX2020000955A MX2020000955A MX2020000955A MX2020000955A MX 2020000955 A MX2020000955 A MX 2020000955A MX 2020000955 A MX2020000955 A MX 2020000955A MX 2020000955 A MX2020000955 A MX 2020000955A MX 2020000955 A MX2020000955 A MX 2020000955A
Authority
MX
Mexico
Prior art keywords
production
cbd
industrial hemp
cannabinoids
types
Prior art date
Application number
MX2020000955A
Other languages
English (en)
Inventor
Giovanni Cipolletti
Luana Vagnoli
Marina Matulli
Barbara Febbruari
Jacopo Chini
Original Assignee
Inalco S R L
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inalco S R L filed Critical Inalco S R L
Publication of MX2020000955A publication Critical patent/MX2020000955A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/004—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by obtaining phenols from plant material or from animal material
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/04—Solvent extraction of solutions which are liquid
    • B01D11/0492—Applications, solvents used
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/0004—Crystallisation cooling by heat exchange
    • B01D9/0013—Crystallisation cooling by heat exchange by indirect heat exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D9/00—Crystallisation
    • B01D9/004—Fractional crystallisation; Fractionating or rectifying columns
    • B01D9/0045—Washing of crystals, e.g. in wash columns
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/50—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring by reactions decreasing the number of carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C37/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring
    • C07C37/68—Purification; separation; Use of additives, e.g. for stabilisation
    • C07C37/70—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment
    • C07C37/84—Purification; separation; Use of additives, e.g. for stabilisation by physical treatment by crystallisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/16—Systems containing only non-condensed rings with a six-membered ring the ring being unsaturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Botany (AREA)
  • Physics & Mathematics (AREA)
  • Thermal Sciences (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención describe un proceso para la producción de (-)-cannabidiol (CBD) a partir de cáñamo industrial por medio de una extracción seguida de dos procesos de trabajo alternativos: un proceso A que proporciona extracción con disolventes primero hasta un pH alcalino y a continuación hasta un pH ácido para aislar la forma carboxilo del CBD que a continuación se somete a descarboxilación y un proceso B que proporciona la eliminación de ceras y brea y a continuación purificación mediante cromatografía; al final de ambos procesos de trabajo alternativos, el CBD se cristaliza y se obtiene en una forma cristalina de alta pureza.
MX2020000955A 2017-07-26 2018-07-26 Método para la producción de cannabinoides a partir de tipos de cáñamo industrial. MX2020000955A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102017000085508A IT201700085508A1 (it) 2017-07-26 2017-07-26 Metodo per la produzione di cannabinoidi da varietà di canapa industriale
PCT/EP2018/070275 WO2019020738A1 (en) 2017-07-26 2018-07-26 PROCESS FOR PRODUCING CANNABINOIDS FROM TYPES OF INDUSTRIAL HEMP

Publications (1)

Publication Number Publication Date
MX2020000955A true MX2020000955A (es) 2020-07-22

Family

ID=60451089

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2020000955A MX2020000955A (es) 2017-07-26 2018-07-26 Método para la producción de cannabinoides a partir de tipos de cáñamo industrial.

Country Status (15)

Country Link
US (1) US11505518B2 (es)
EP (1) EP3658524B1 (es)
JP (1) JP7196153B2 (es)
CN (1) CN110997607B (es)
AU (1) AU2018308925B2 (es)
BR (1) BR112020001704A2 (es)
CA (1) CA3071053A1 (es)
ES (1) ES2901132T3 (es)
IT (1) IT201700085508A1 (es)
MA (1) MA49689A (es)
MX (1) MX2020000955A (es)
PL (1) PL3658524T3 (es)
PT (1) PT3658524T (es)
UA (1) UA126811C2 (es)
WO (1) WO2019020738A1 (es)

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GB2531281A (en) 2014-10-14 2016-04-20 Gw Pharma Ltd Use of cannabidiol in the treatment of intractable epilepsy
US10239808B1 (en) 2016-12-07 2019-03-26 Canopy Holdings, LLC Cannabis extracts
WO2019152736A1 (en) 2018-01-31 2019-08-08 Canopy Holdings, LLC Hemp powder
US10843102B2 (en) * 2018-06-29 2020-11-24 Senti Solutions Inc. Resinous compound crystallization using non-polar solvent sequence
WO2020028198A1 (en) 2018-08-03 2020-02-06 Biomass Oil Separation Solutions, Llc Processes and apparatus for extraction of substances and enriched extracts from plant material
CA3119729A1 (en) 2018-10-10 2020-04-16 Treehouse Biotech, Inc. Synthesis of cannabigerol
CA3130256A1 (en) * 2019-02-15 2020-08-20 Ebers Tech Inc. L-pipecolic acid cocrystal of cannabidiol
CN111848364B (zh) * 2019-04-30 2021-04-02 云南汉盟制药有限公司 从大麻中提取大麻二酚的方法
WO2021012044A1 (en) 2019-07-22 2021-01-28 Canopy Growth Corporation Continuous crystallization of cannabinoids in a stirred-tank reactor
US10799546B1 (en) 2019-07-26 2020-10-13 Biomass Oil Separation Solutions, Llc Modular, integrated process and apparatus for extracting, refining and remediating active substances from plant material
BR112022003258A2 (pt) * 2019-08-22 2022-05-17 Medpharm Iowa Llc Processos de extração e purificação à base de água para ácidos canabinoides
US10858303B1 (en) * 2019-10-30 2020-12-08 Heinkel Filtering Systems, Inc. Cannabidiol isolate production systems and methods
US10751640B1 (en) * 2019-10-30 2020-08-25 Heinkel Filtering Systems, Inc. Cannabidiol isolate production systems and methods
EP4069215A4 (en) 2019-12-06 2024-01-17 JLABS Beauty LLC TOPICAL COMPOSITIONS CONTAINING ROSE OIL AND CANNABIDIOL AND METHODS OF PREPARING AND USING THE SAME
US11291699B1 (en) 2019-12-13 2022-04-05 Delmarva Hemp, LLC Method for solvent-free extraction and concentration of full spectrum of cannabinoids in a carrier oil
US11351476B2 (en) * 2020-01-07 2022-06-07 Agrify Corporation Method for chemical separation of cannabinoids
GB202002754D0 (en) 2020-02-27 2020-04-15 Gw Res Ltd Methods of treating tuberous sclerosis complex with cannabidiol and everolimus
US11813549B1 (en) 2020-03-04 2023-11-14 Eco-Logic Environmental Engineering Inc. Devices and methods for essential oils, terpenes, flavonoids, and hydrosols extraction
AU2021276680A1 (en) 2020-05-22 2023-01-19 Ilera Derm LLC Compositions for treating acne and dermatological conditions
US20210370198A1 (en) * 2020-05-29 2021-12-02 Chemtor, Lp Purification and extraction of cannabinoids
CN111792981B (zh) * 2020-06-24 2023-05-02 深圳市云麻生物科技有限公司 一种大麻二酚的提纯方法
GB202013765D0 (en) * 2020-09-02 2020-10-14 Gw Res Ltd Method of preparing cannabinoids
WO2022047574A1 (en) * 2020-09-02 2022-03-10 Purcann Pharma Inc. Method for producing a purified cannabinoid extract, and a purified cannabinoid extract obtained therefrom
CN112057894A (zh) * 2020-09-08 2020-12-11 云南工麻生物科技有限公司 一种提取大麻二酚的方法
WO2022140197A1 (en) * 2020-12-23 2022-06-30 M-For, LLC Extraction and purification of cannabinoids
PE20231737A1 (es) * 2021-03-23 2023-10-31 Pobeltsch Gle Ad Metodos y sistemas para el extraccion de cannabinoides
WO2023209046A1 (en) 2022-04-27 2023-11-02 GW Research Limited Treatment of spasticity and pain in renally-impaired patients
EP4374864A1 (en) 2022-11-23 2024-05-29 Bioactive Botanicals Swiss AG Method for preparing thc-reduced cannabis plant extract
WO2024115774A1 (en) 2022-12-02 2024-06-06 GW Research Limited Cannabinoids for treating essential tremor in patients
KR102585373B1 (ko) 2023-04-03 2023-10-06 한국콜마주식회사 헴프로부터 칸나비디올을 정제하는 방법 및 이에 의해 정제되는 칸나비디올
KR102641482B1 (ko) * 2023-05-18 2024-02-28 재단법인춘천바이오산업진흥원 고순도의 칸나비디올 정제 및 결정 제조방법

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NZ552547A (en) 2002-02-01 2008-03-28 Resolution Chemicals Ltd Production of Delta 9 tetrahydrocannabinol from plant material
GB2393182B (en) * 2002-09-23 2007-03-14 Gw Pharma Ltd Method of preparing cannabidiol from plant material
GB0222077D0 (en) * 2002-09-23 2002-10-30 Gw Pharma Ltd Methods of preparing cannabinoids from plant material
ES2806034T3 (es) * 2011-09-29 2021-02-16 Thc Pharm Gmbh The Health Concept Acidos carboxílicos de cannabinoide, sales de ácidos carboxílicos de cannabinoide, su preparación y aplicaciones
US9340475B2 (en) * 2014-07-02 2016-05-17 Cv Sciences, Inc. Process for generating hemp oil with a high cannabidiol (CBD) content
UY36530A (es) * 2015-01-22 2016-08-31 Phytoplant Res S L Métodos para purificar cannabinoides, composiciones y kits de estos
PT3274321T (pt) 2015-03-23 2019-10-28 Echo Pharmaceuticals Bv Isolado de canabidiol em câmara industrial e sua utilização em preparações farmacêuticas e/ou cosméticas
BG112018A (bg) * 2015-05-22 2016-11-30 "Побелч-Гле" Оод Метод за получаване на канабиноиден извлек от коноп
CN106278828A (zh) * 2016-08-16 2017-01-04 云南汉素生物科技有限公司 一种从工业大麻花叶中提取大麻二酚的方法
US10189762B1 (en) * 2017-07-07 2019-01-29 Orochem Technologies, Inc. Process for purification and separation of cannabinoids, from dried hemp and cannabis leaves

Also Published As

Publication number Publication date
PL3658524T3 (pl) 2022-05-02
EP3658524A1 (en) 2020-06-03
CN110997607B (zh) 2023-05-09
ES2901132T3 (es) 2022-03-21
WO2019020738A1 (en) 2019-01-31
CA3071053A1 (en) 2019-01-31
UA126811C2 (uk) 2023-02-08
RU2020108066A3 (es) 2021-10-22
IT201700085508A1 (it) 2019-01-26
RU2020108066A (ru) 2021-08-26
JP7196153B2 (ja) 2022-12-26
JP2020528066A (ja) 2020-09-17
AU2018308925A1 (en) 2020-03-12
BR112020001704A2 (pt) 2020-07-21
US11505518B2 (en) 2022-11-22
MA49689A (fr) 2020-06-03
US20200181050A1 (en) 2020-06-11
EP3658524B1 (en) 2021-09-08
CN110997607A (zh) 2020-04-10
AU2018308925B2 (en) 2022-02-17
PT3658524T (pt) 2021-12-03

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