MX2019010311A - Protodescarboxilación catalizada por metales de transición de derivados de ácido a-halo-acrílico. - Google Patents

Protodescarboxilación catalizada por metales de transición de derivados de ácido a-halo-acrílico.

Info

Publication number
MX2019010311A
MX2019010311A MX2019010311A MX2019010311A MX2019010311A MX 2019010311 A MX2019010311 A MX 2019010311A MX 2019010311 A MX2019010311 A MX 2019010311A MX 2019010311 A MX2019010311 A MX 2019010311A MX 2019010311 A MX2019010311 A MX 2019010311A
Authority
MX
Mexico
Prior art keywords
halo
protodecarboxylation
acrylic acid
catalyzed
transition metal
Prior art date
Application number
MX2019010311A
Other languages
English (en)
Inventor
Stange Christian
Reichel Carsten
Timothy Reeves Jonathan
Zhong Li
N Volchkov Ivan
Thi Quynh Dang Mai
Armin Hampel Thomas
Koch Sandra
Lars Nordstrom Fredrik
SCHOERER Marvin
Johannes Zimmermann Uwe
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MX2019010311A publication Critical patent/MX2019010311A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/72—Copper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
    • B01J27/20—Carbon compounds
    • B01J27/232—Carbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)

Abstract

La presente invención se refiere a un método para la síntesis de una halo olefina de la Fórmula (I)en donde Hal, R1, R2, R3, R4, X e Y se definen de conformidad con la reivindicación 1, o una sal de aquella que comprende la etapa de protodescarboxilación de un derivado de ácido a-halo-acrílico en presencia de una cantidad catalítica de cobre y/o plata.
MX2019010311A 2017-03-01 2018-02-22 Protodescarboxilación catalizada por metales de transición de derivados de ácido a-halo-acrílico. MX2019010311A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762465398P 2017-03-01 2017-03-01
US201762512777P 2017-05-31 2017-05-31
PCT/EP2018/054428 WO2018158140A1 (en) 2017-03-01 2018-02-22 TRANSITION METAL-CATALYZED PROTODECARBOXYLATION OF α-HALO-ACRYLIC ACID DERIVATIVES

Publications (1)

Publication Number Publication Date
MX2019010311A true MX2019010311A (es) 2020-01-20

Family

ID=61557253

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019010311A MX2019010311A (es) 2017-03-01 2018-02-22 Protodescarboxilación catalizada por metales de transición de derivados de ácido a-halo-acrílico.

Country Status (17)

Country Link
US (3) US10252994B2 (es)
EP (1) EP3589606B1 (es)
JP (1) JP7145872B2 (es)
KR (1) KR102550845B1 (es)
CN (1) CN110366547B (es)
AU (1) AU2018226955B2 (es)
BR (1) BR112019017309B1 (es)
CA (1) CA3053869A1 (es)
CL (1) CL2019002499A1 (es)
DK (1) DK3589606T3 (es)
ES (1) ES2965478T3 (es)
HU (1) HUE064755T2 (es)
MX (1) MX2019010311A (es)
NZ (1) NZ755847A (es)
PH (1) PH12019501980A1 (es)
PL (1) PL3589606T3 (es)
WO (1) WO2018158140A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7245911B2 (ja) * 2018-12-20 2023-03-24 シャンドン ダンホン ファーマスーティカル カンパニー リミテッド 式（ｉｖ）で表される化合物の製造工程経路、結晶形及びその製造方法
US11731953B2 (en) 2020-06-22 2023-08-22 Pmv Pharmaceuticals, Inc. Methods and compounds for restoring mutant p53 function
CN112341373B (zh) * 2020-11-30 2022-04-08 山东嘉成医药科技有限公司 一种酞丁安的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE259803C (es)
DD259803A1 (de) 1979-11-30 1988-09-07 Akad Wissenschaften Ddr Verfahren zur herstellung von 5-(2-fluorvinyl-)pyrimidinen
ES2399634T3 (es) * 2003-11-07 2013-04-02 Sumitomo Chemical Company, Limited Método para la producción de 3,3-dimetil-2-(1-propenil)ciclopropanocarboxilato
CN1921841A (zh) * 2004-02-25 2007-02-28 拉卓拉药物公司 用于治疗疾病的胺和酰胺类化合物
AU2005216955A1 (en) * 2004-02-25 2005-09-09 La Jolla Pharmaceutical Company Amines and amides for the treatment of diseases
WO2006094201A2 (en) 2005-03-02 2006-09-08 La Jolla Pharmaceutical Company Semicarbazide-sensitive amide oxidase inhibitors
WO2007120528A2 (en) 2006-03-31 2007-10-25 La Jolla Pharmaceutical Company Inhibitors of semicarbazide-sensitive amine oxidase (ssao) and vap-1 mediated adhesion useful for treatment and prevention of diseases
WO2009066152A2 (en) * 2007-11-21 2009-05-28 Pharmaxis Ltd. Haloallylamine inhibitors of ssao/vap-1 and uses therefor
SG176558A1 (en) * 2009-05-15 2012-01-30 Sanofi Sa Process for the preparation of a compound useful as an inhibitor of tafia
PL2844637T3 (pl) * 2012-05-02 2018-09-28 Boehringer Ingelheim International Gmbh Podstawione 3-haloalliloaminowe inhibitory ssao i ich zastosowania

Also Published As

Publication number Publication date
CL2019002499A1 (es) 2020-01-31
PH12019501980A1 (en) 2020-09-28
EP3589606B1 (en) 2023-09-20
BR112019017309A2 (pt) 2020-03-31
US11046648B2 (en) 2021-06-29
US20190177273A1 (en) 2019-06-13
KR102550845B1 (ko) 2023-07-05
ES2965478T3 (es) 2024-04-15
KR20190125394A (ko) 2019-11-06
BR112019017309B1 (pt) 2022-11-29
PL3589606T3 (pl) 2024-03-04
DK3589606T3 (da) 2024-01-02
EP3589606A1 (en) 2020-01-08
JP7145872B2 (ja) 2022-10-03
US10252994B2 (en) 2019-04-09
AU2018226955B2 (en) 2021-02-18
CN110366547A (zh) 2019-10-22
HUE064755T2 (hu) 2024-04-28
WO2018158140A1 (en) 2018-09-07
JP2020509034A (ja) 2020-03-26
US20180251427A1 (en) 2018-09-06
AU2018226955A1 (en) 2019-08-15
CN110366547B (zh) 2023-02-17
CA3053869A1 (en) 2018-09-07
NZ755847A (en) 2021-12-24
US20200231544A1 (en) 2020-07-23
US10654803B2 (en) 2020-05-19

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