CL2019002499A1 - Protodescarboxilación catalizada por metales de transición de derivados de ácido a-halo-acrílico. - Google Patents

Protodescarboxilación catalizada por metales de transición de derivados de ácido a-halo-acrílico.

Info

Publication number
CL2019002499A1
CL2019002499A1 CL2019002499A CL2019002499A CL2019002499A1 CL 2019002499 A1 CL2019002499 A1 CL 2019002499A1 CL 2019002499 A CL2019002499 A CL 2019002499A CL 2019002499 A CL2019002499 A CL 2019002499A CL 2019002499 A1 CL2019002499 A1 CL 2019002499A1
Authority
CL
Chile
Prior art keywords
halo
protodecarboxylation
acrylic acid
transition metal
acid derivatives
Prior art date
Application number
CL2019002499A
Other languages
English (en)
Inventor
Ivan N Volchkov
Jonathan Timothy Reeves
Mai Thi Quynh Dang
Thomas Armin Hampel
Sandra Koch
Fredrik Lars Nordstrom
Carsten Reichel
Marvin Schoerer
Christian Stange
Li Zhong
Uwe Johannes Zimmermann
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of CL2019002499A1 publication Critical patent/CL2019002499A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J23/00—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00
    • B01J23/70—Catalysts comprising metals or metal oxides or hydroxides, not provided for in group B01J21/00 of the iron group metals or copper
    • B01J23/72—Copper
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J27/00—Catalysts comprising the elements or compounds of halogens, sulfur, selenium, tellurium, phosphorus or nitrogen; Catalysts comprising carbon compounds
    • B01J27/20—Carbon compounds
    • B01J27/232—Carbonates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN SE REFIERE A UN MÉTODO PARA LA SÍNTESIS DE UNA HALO OLEFINA DE LA FÓRMULA (I), EN DONDE HAL, R1 , R2 , R3 , R4 , X E Y SE DEFINEN DE ACUERDO CON LA REIVINDICACIÓN 1, O UNA SAL DE AQUELLA QUE COMPRENDE LA ETAPA DE PROTODESCARBOXILACIÓN DE UN DERIVADO DE ÁCIDO Α-HALOACRÍLICO EN PRESENCIA DE UNA CANTIDAD CATALÍTICA DE COBRE Y/O PLATA.
CL2019002499A 2017-03-01 2019-08-30 Protodescarboxilación catalizada por metales de transición de derivados de ácido a-halo-acrílico. CL2019002499A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201762465398P 2017-03-01 2017-03-01
US201762512777P 2017-05-31 2017-05-31

Publications (1)

Publication Number Publication Date
CL2019002499A1 true CL2019002499A1 (es) 2020-01-31

Family

ID=61557253

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019002499A CL2019002499A1 (es) 2017-03-01 2019-08-30 Protodescarboxilación catalizada por metales de transición de derivados de ácido a-halo-acrílico.

Country Status (17)

Country Link
US (3) US10252994B2 (es)
EP (1) EP3589606B1 (es)
JP (1) JP7145872B2 (es)
KR (1) KR102550845B1 (es)
CN (1) CN110366547B (es)
AU (1) AU2018226955B2 (es)
BR (1) BR112019017309B1 (es)
CA (1) CA3053869A1 (es)
CL (1) CL2019002499A1 (es)
DK (1) DK3589606T3 (es)
ES (1) ES2965478T3 (es)
HU (1) HUE064755T2 (es)
MX (1) MX2019010311A (es)
NZ (1) NZ755847A (es)
PH (1) PH12019501980A1 (es)
PL (1) PL3589606T3 (es)
WO (1) WO2018158140A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3901143B1 (en) * 2018-12-20 2024-05-29 Shangdong Danhong Pharmaceutical Co., Ltd. Process route of compound of formula (iv), crystal form and preparation method therefor
EP4168411A1 (en) 2020-06-22 2023-04-26 PMV Pharmaceuticals, Inc. Methods and compounds for restoring mutant p53 function
CN112341373B (zh) * 2020-11-30 2022-04-08 山东嘉成医药科技有限公司 一种酞丁安的制备方法

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE259803C (es)
DD259803A1 (de) 1979-11-30 1988-09-07 Akad Wissenschaften Ddr Verfahren zur herstellung von 5-(2-fluorvinyl-)pyrimidinen
ES2399634T3 (es) * 2003-11-07 2013-04-02 Sumitomo Chemical Company, Limited Método para la producción de 3,3-dimetil-2-(1-propenil)ciclopropanocarboxilato
CN1921841A (zh) * 2004-02-25 2007-02-28 拉卓拉药物公司 用于治疗疾病的胺和酰胺类化合物
CA2556914A1 (en) * 2004-02-25 2005-09-09 La Jolla Pharmaceutical Company Amines and amides for the treatment of diseases
WO2006094201A2 (en) 2005-03-02 2006-09-08 La Jolla Pharmaceutical Company Semicarbazide-sensitive amide oxidase inhibitors
US20070293548A1 (en) * 2006-03-31 2007-12-20 Wang Eric Y Inhibitors of semicarbazide-sensitive amine oxidase (SSAO) and VAP-1 mediated adhesion useful for treatment and prevention of diseases
SG186008A1 (en) * 2007-11-21 2012-12-28 Pharmaxis Ltd Haloallylamine inhibitors of ssao/vap-1 and uses therefor
KR20120016651A (ko) * 2009-05-15 2012-02-24 사노피 Ｔａｆｉａ의 억제제로서 유용한 화합물의 제조방법
PT2844637T (pt) * 2012-05-02 2018-04-17 Boehringer Ingelheim Int Inibidores de 3-haloalilamina substituídos de ssao e as suas utilizações

Also Published As

Publication number Publication date
US20200231544A1 (en) 2020-07-23
US20190177273A1 (en) 2019-06-13
DK3589606T3 (da) 2024-01-02
EP3589606B1 (en) 2023-09-20
NZ755847A (en) 2021-12-24
US10252994B2 (en) 2019-04-09
US10654803B2 (en) 2020-05-19
MX2019010311A (es) 2020-01-20
US20180251427A1 (en) 2018-09-06
JP2020509034A (ja) 2020-03-26
AU2018226955B2 (en) 2021-02-18
WO2018158140A1 (en) 2018-09-07
BR112019017309B1 (pt) 2022-11-29
CN110366547A (zh) 2019-10-22
KR20190125394A (ko) 2019-11-06
US11046648B2 (en) 2021-06-29
JP7145872B2 (ja) 2022-10-03
CA3053869A1 (en) 2018-09-07
ES2965478T3 (es) 2024-04-15
HUE064755T2 (hu) 2024-04-28
BR112019017309A2 (pt) 2020-03-31
CN110366547B (zh) 2023-02-17
AU2018226955A1 (en) 2019-08-15
PH12019501980A1 (en) 2020-09-28
KR102550845B1 (ko) 2023-07-05
PL3589606T3 (pl) 2024-03-04
EP3589606A1 (en) 2020-01-08

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