MX2020012771A - Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida. - Google Patents

Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida.

Info

Publication number
MX2020012771A
MX2020012771A MX2020012771A MX2020012771A MX2020012771A MX 2020012771 A MX2020012771 A MX 2020012771A MX 2020012771 A MX2020012771 A MX 2020012771A MX 2020012771 A MX2020012771 A MX 2020012771A MX 2020012771 A MX2020012771 A MX 2020012771A
Authority
MX
Mexico
Prior art keywords
methods
phenylbenzo
dihydro
amine
preparing substituted
Prior art date
Application number
MX2020012771A
Other languages
English (en)
Inventor
David P Reed
Craig Bates
Jianmin Mao
Original Assignee
Arqule Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arqule Inc filed Critical Arqule Inc
Publication of MX2020012771A publication Critical patent/MX2020012771A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

La presente invención se refiere a métodos para preparar el Compuesto A: o una sal del mismo, y una sal diclorhidrato del Compuesto A polimórfica.
MX2020012771A 2015-12-17 2016-12-16 Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida. MX2020012771A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201562268758P 2015-12-17 2015-12-17
PCT/US2016/067161 WO2017106639A1 (en) 2015-12-17 2016-12-16 Methods for preparing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine

Publications (1)

Publication Number Publication Date
MX2020012771A true MX2020012771A (es) 2022-10-04

Family

ID=59057623

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2018007415A MX2018007415A (es) 2015-12-17 2016-12-16 Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida.
MX2020012771A MX2020012771A (es) 2015-12-17 2016-12-16 Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2018007415A MX2018007415A (es) 2015-12-17 2016-12-16 Metodos para preparar 5,6-dihidro-6-fenilbenzo[f]isoquinolin-2-ami na sustituida.

Country Status (16)

Country Link
US (4) US9834519B2 (es)
EP (2) EP3390368A4 (es)
JP (2) JP6940504B2 (es)
KR (1) KR20180085814A (es)
CN (2) CN108602779A (es)
AU (2) AU2016369520B2 (es)
BR (1) BR112018012325A2 (es)
CA (1) CA3006077A1 (es)
EA (1) EA201891431A1 (es)
HK (1) HK1255014A1 (es)
IL (1) IL259557A (es)
MX (2) MX2018007415A (es)
NZ (1) NZ742785A (es)
SG (1) SG11201804601TA (es)
TW (1) TWI748972B (es)
WO (1) WO2017106639A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201804670PA (en) * 2015-12-17 2018-07-30 Arqule Inc Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
EP3390368A4 (en) * 2015-12-17 2019-07-03 ArQule, Inc. PROCESS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYL BENZO [F] ISOCHINOLINE-2-AMINE
CN110669015A (zh) * 2018-07-03 2020-01-10 上海喀露蓝科技有限公司 一种fgfr抑制剂的制备方法
WO2022053708A1 (en) 2020-09-14 2022-03-17 Basilea Pharmaceutica International AG Pharmaceutical combinations for use in the treatment of gastric adenocarcinoma

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
JP2001507349A (ja) * 1996-12-23 2001-06-05 セルテック セラピューティックス リミテッド 縮合多環式２−アミノピリミジン誘導体、それらの製造およびたんぱく質チロシンキナーゼ抑制因子としてのそれらの使用
GB9713087D0 (en) * 1997-06-20 1997-08-27 Celltech Therapeutics Ltd Chemical compounds
WO2006066172A1 (en) 2004-12-17 2006-06-22 Amgen, Inc. Aminopyrimidine compounds and methods of use
JP2010514810A (ja) 2006-12-29 2010-05-06 ライジェル ファーマシューティカルズ， インコーポレイテッド Ａｘｌインヒビターとして有用な置換トリアゾール
GB2449293A (en) * 2007-05-17 2008-11-19 Evotec Compounds having Hsp90 inhibitory activity
BRPI0923786C8 (pt) * 2008-12-30 2021-05-25 Arqule Inc compostos 5,6-dihidro-6-fenilbenzo(f) isoquinolina-2- amina substituidos e composições farmacêuticas compreendendo ditos compostos
CN103476770B (zh) 2010-11-25 2017-02-15 拉蒂欧制药有限责任公司 阿法替尼盐和多晶型物
WO2012177852A1 (en) * 2011-06-24 2012-12-27 Arqule, Inc Substituted imidazopyridinyl compounds
SG11201607772WA (en) * 2014-03-31 2016-10-28 Debiopharm Int Sa Fgfr fusions
SG11201804670PA (en) 2015-12-17 2018-07-30 Arqule Inc Solid forms of substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds
EP3390368A4 (en) 2015-12-17 2019-07-03 ArQule, Inc. PROCESS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYL BENZO [F] ISOCHINOLINE-2-AMINE

Also Published As

Publication number Publication date
TWI748972B (zh) 2021-12-11
US20200102276A1 (en) 2020-04-02
JP2021191782A (ja) 2021-12-16
EA201891431A1 (ru) 2018-11-30
KR20180085814A (ko) 2018-07-27
AU2016369520A1 (en) 2018-06-07
US20190241527A1 (en) 2019-08-08
MX2018007415A (es) 2018-11-09
CA3006077A1 (en) 2017-06-22
CN108602779A (zh) 2018-09-28
AU2021202610A1 (en) 2021-05-27
US11279679B2 (en) 2022-03-22
EP4015508A1 (en) 2022-06-22
AU2021202610B2 (en) 2022-06-02
WO2017106639A1 (en) 2017-06-22
AU2016369520B2 (en) 2021-02-18
CN114874149A (zh) 2022-08-09
US10093632B2 (en) 2018-10-09
US9834519B2 (en) 2017-12-05
US10766868B2 (en) 2020-09-08
JP6940504B2 (ja) 2021-09-29
HK1255014A1 (zh) 2019-08-02
EP3390368A1 (en) 2018-10-24
NZ742785A (en) 2023-06-30
TW201733992A (zh) 2017-10-01
IL259557A (en) 2018-07-31
BR112018012325A2 (pt) 2018-12-04
EP3390368A4 (en) 2019-07-03
US20180065937A1 (en) 2018-03-08
SG11201804601TA (en) 2018-07-30
US20170174637A1 (en) 2017-06-22
JP2018537495A (ja) 2018-12-20

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