MX2019009651A - Variantes de cas9 de alta fidelidad y aplicaciones de las mismas. - Google Patents

Variantes de cas9 de alta fidelidad y aplicaciones de las mismas.

Info

Publication number
MX2019009651A
MX2019009651A MX2019009651A MX2019009651A MX2019009651A MX 2019009651 A MX2019009651 A MX 2019009651A MX 2019009651 A MX2019009651 A MX 2019009651A MX 2019009651 A MX2019009651 A MX 2019009651A MX 2019009651 A MX2019009651 A MX 2019009651A
Authority
MX
Mexico
Prior art keywords
variants
fidelity
evocas9
spcas9
present
Prior art date
Application number
MX2019009651A
Other languages
English (en)
Spanish (es)
Inventor
Cereseto Anna
Casini Antonio
Petris Gianluca
Inga Alberto
Olivieri Michele
Original Assignee
Univ Degli Studi Di Trento
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Degli Studi Di Trento filed Critical Univ Degli Studi Di Trento
Publication of MX2019009651A publication Critical patent/MX2019009651A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y301/00—Hydrolases acting on ester bonds (3.1)

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
MX2019009651A 2017-02-14 2018-02-14 Variantes de cas9 de alta fidelidad y aplicaciones de las mismas. MX2019009651A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT102017000016321A IT201700016321A1 (it) 2017-02-14 2017-02-14 Mutanti di cas9 ad alta specificita' e loro applicazioni.
PCT/EP2018/053717 WO2018149888A1 (en) 2017-02-14 2018-02-14 High-fidelity cas9 variants and applications thereof

Publications (1)

Publication Number Publication Date
MX2019009651A true MX2019009651A (es) 2019-12-18

Family

ID=59067822

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019009651A MX2019009651A (es) 2017-02-14 2018-02-14 Variantes de cas9 de alta fidelidad y aplicaciones de las mismas.

Country Status (12)

Country Link
US (1) US11525127B2 (https=)
EP (1) EP3583209B8 (https=)
JP (1) JP7232531B2 (https=)
KR (1) KR20190116407A (https=)
CN (1) CN110520528B (https=)
AU (1) AU2018221644A1 (https=)
BR (1) BR112019016765A2 (https=)
CA (1) CA3053218A1 (https=)
EA (1) EA037825B1 (https=)
IT (1) IT201700016321A1 (https=)
MX (1) MX2019009651A (https=)
WO (1) WO2018149888A1 (https=)

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Also Published As

Publication number Publication date
IT201700016321A1 (it) 2018-08-14
AU2018221644A1 (en) 2019-08-29
CA3053218A1 (en) 2018-08-23
US20200149020A1 (en) 2020-05-14
EP3583209A1 (en) 2019-12-25
EA037825B1 (ru) 2021-05-25
JP2020507347A (ja) 2020-03-12
US11525127B2 (en) 2022-12-13
CN110520528B (zh) 2024-08-13
BR112019016765A2 (pt) 2020-05-26
EP3583209B1 (en) 2024-12-04
EA201991913A1 (ru) 2020-01-22
WO2018149888A1 (en) 2018-08-23
CN110520528A (zh) 2019-11-29
EP3583209C0 (en) 2024-12-04
JP7232531B2 (ja) 2023-03-03
KR20190116407A (ko) 2019-10-14
EP3583209B8 (en) 2025-02-26

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