IT201700016321A1 - Mutanti di cas9 ad alta specificita' e loro applicazioni. - Google Patents
Mutanti di cas9 ad alta specificita' e loro applicazioni.Info
- Publication number
- IT201700016321A1 IT201700016321A1 IT102017000016321A IT201700016321A IT201700016321A1 IT 201700016321 A1 IT201700016321 A1 IT 201700016321A1 IT 102017000016321 A IT102017000016321 A IT 102017000016321A IT 201700016321 A IT201700016321 A IT 201700016321A IT 201700016321 A1 IT201700016321 A1 IT 201700016321A1
- Authority
- IT
- Italy
- Prior art keywords
- cas9
- group
- seq
- modified
- modified cas9
- Prior art date
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- C12Y—ENZYMES
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/71—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/80—Fusion polypeptide containing a DNA binding domain, e.g. Lacl or Tet-repressor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102017000016321A IT201700016321A1 (it) | 2017-02-14 | 2017-02-14 | Mutanti di cas9 ad alta specificita' e loro applicazioni. |
| CN201880011895.5A CN110520528B (zh) | 2017-02-14 | 2018-02-14 | 高保真性cas9变体及其应用 |
| MX2019009651A MX2019009651A (es) | 2017-02-14 | 2018-02-14 | Variantes de cas9 de alta fidelidad y aplicaciones de las mismas. |
| KR1020197026441A KR20190116407A (ko) | 2017-02-14 | 2018-02-14 | 고-충실도 Cas9 변이체 및 그의 적용 |
| AU2018221644A AU2018221644A1 (en) | 2017-02-14 | 2018-02-14 | High-fidelity Cas9 variants and applications thereof |
| JP2019565062A JP7232531B2 (ja) | 2017-02-14 | 2018-02-14 | 高忠実度ｃａｓ９バリアントおよびそれらの利用 |
| EP18708920.6A EP3583209B8 (en) | 2017-02-14 | 2018-02-14 | High-fidelity cas9 variants and applications thereof |
| PCT/EP2018/053717 WO2018149888A1 (en) | 2017-02-14 | 2018-02-14 | High-fidelity cas9 variants and applications thereof |
| EA201991913A EA037825B1 (ru) | 2017-02-14 | 2018-02-14 | ВЫСОКОТОЧНЫЕ ВАРИАНТЫ Cas9 И ИХ ПРИМЕНЕНИЯ |
| BR112019016765-0A BR112019016765A2 (pt) | 2017-02-14 | 2018-02-14 | Molécula de cas9 modificada isolada, método para produzir uma cas9 modificada, complexos de proteína ou ribonucleoproteína ou complexos de proteína e ribonucleoproteína misturadas ou lipídeo, proteína de fusão, sequência de nucleotídeos, ácido nucleico, vetor, célula, animal ou planta, composição farmacêutica, uso in vitro de uma cas9 modificada recombinante, kit de partes, e, método in vitro para alterar o genoma de uma célula |
| US16/485,253 US11525127B2 (en) | 2017-02-14 | 2018-02-14 | High-fidelity CAS9 variants and applications thereof |
| CA3053218A CA3053218A1 (en) | 2017-02-14 | 2018-02-14 | High-fidelity cas9 variants and applications thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102017000016321A IT201700016321A1 (it) | 2017-02-14 | 2017-02-14 | Mutanti di cas9 ad alta specificita' e loro applicazioni. |
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| US9526784B2 (en) | 2013-09-06 | 2016-12-27 | President And Fellows Of Harvard College | Delivery system for functional nucleases |
| US9340799B2 (en) | 2013-09-06 | 2016-05-17 | President And Fellows Of Harvard College | MRNA-sensing switchable gRNAs |
| US20150165054A1 (en) | 2013-12-12 | 2015-06-18 | President And Fellows Of Harvard College | Methods for correcting caspase-9 point mutations |
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| AU2018221644A1 (en) | 2019-08-29 |
| CA3053218A1 (en) | 2018-08-23 |
| US20200149020A1 (en) | 2020-05-14 |
| EP3583209A1 (en) | 2019-12-25 |
| EA037825B1 (ru) | 2021-05-25 |
| JP2020507347A (ja) | 2020-03-12 |
| US11525127B2 (en) | 2022-12-13 |
| CN110520528B (zh) | 2024-08-13 |
| BR112019016765A2 (pt) | 2020-05-26 |
| MX2019009651A (es) | 2019-12-18 |
| EP3583209B1 (en) | 2024-12-04 |
| EA201991913A1 (ru) | 2020-01-22 |
| WO2018149888A1 (en) | 2018-08-23 |
| CN110520528A (zh) | 2019-11-29 |
| EP3583209C0 (en) | 2024-12-04 |
| JP7232531B2 (ja) | 2023-03-03 |
| KR20190116407A (ko) | 2019-10-14 |
| EP3583209B8 (en) | 2025-02-26 |
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