MX2019008626A - Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). - Google Patents
Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl).Info
- Publication number
- MX2019008626A MX2019008626A MX2019008626A MX2019008626A MX2019008626A MX 2019008626 A MX2019008626 A MX 2019008626A MX 2019008626 A MX2019008626 A MX 2019008626A MX 2019008626 A MX2019008626 A MX 2019008626A MX 2019008626 A MX2019008626 A MX 2019008626A
- Authority
- MX
- Mexico
- Prior art keywords
- hydroxypropan
- trifluoro
- carbamate derivatives
- magl inhibitors
- compounds
- Prior art date
Links
- UYRJDRLVWSFELK-UHFFFAOYSA-N (1,1,1-trifluoro-3-hydroxypropan-2-yl) carbamate Chemical class C(N)(OC(C(F)(F)F)CO)=O UYRJDRLVWSFELK-UHFFFAOYSA-N 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 102100029814 Monoglyceride lipase Human genes 0.000 abstract 1
- 101710116393 Monoglyceride lipase Proteins 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000006011 Stroke Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
Classifications
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- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/10—Spiro-condensed systems
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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| US201762448498P | 2017-01-20 | 2017-01-20 | |
| PCT/IB2018/050103 WO2018134695A1 (en) | 2017-01-20 | 2018-01-08 | 1,1,1-trifluoro-3-hydroxypropan-2-yl carbamate derivatives as magl inhibitors |
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| MX375424B (es) * | 2015-07-31 | 2025-03-06 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-il carbamato y derivados de 1,1,1-trifluoro-4- hidroxibutan-2-il carbamato como inhibidores de magl |
| MX2019008626A (es) | 2017-01-20 | 2019-09-19 | Pfizer | Derivados de 1,1,1-trifluoro-3-hidroxipropan-2-ilcarbamato como inhibidores de monoacilglicerol lipasa (magl). |
| US10662159B2 (en) * | 2017-11-22 | 2020-05-26 | Makscientific, Llc | ABHD6 and dual ABHD6/MGL inhibitors and their uses |
| US20220098159A1 (en) * | 2019-01-25 | 2022-03-31 | NodThera Limited | Carbamate derivatives and uses thereof |
| WO2021191390A1 (en) * | 2020-03-26 | 2021-09-30 | Janssen Pharmaceutica Nv | Azaspirocycles as monoacylglycerol lipase modulators |
| HRP20241177T1 (hr) * | 2020-06-09 | 2024-11-22 | Pfizer Inc. | Spiro-spojevi kao antagonisti melanokortinskog receptora 4 i njihova upotreba |
| CA3192236A1 (en) | 2020-09-10 | 2022-03-17 | Tony Lahoutte | Antibody fragment against fap |
| WO2022063784A1 (en) * | 2020-09-22 | 2022-03-31 | Janssen Pharmaceutica Nv | Cyclobutyl amide monoacylglycerol lipase modulators |
| WO2022135462A1 (zh) * | 2020-12-22 | 2022-06-30 | 鲁南制药集团股份有限公司 | Magl抑制剂的医药用途 |
| KR20240128870A (ko) | 2021-12-29 | 2024-08-27 | 싸이 테라퓨틱스, 인크. | 모노아실글리세롤 리파아제(magl) 억제 |
| WO2023203135A1 (en) | 2022-04-22 | 2023-10-26 | Precirix N.V. | Improved radiolabelled antibody |
| JP2025517625A (ja) | 2022-05-02 | 2025-06-10 | プレシリックス・ナームローゼ・ベンノートシヤープ | プレターゲティング |
| WO2024168426A1 (en) | 2023-02-13 | 2024-08-22 | Apogee Pharmaceuticals, Inc. | Small molecules as monoacylglycerol lipase (magl) inhibitors, compositions and use thereof |
| CN116621792B (zh) * | 2023-05-16 | 2025-02-25 | 常州大学 | 一种制备n-正丁基-1,2-苯并异噻唑啉-3-酮-1-氧化物的方法 |
| CN118191332B (zh) * | 2024-03-19 | 2024-10-29 | 暨南大学 | 一种用于诊断术后认知功能障碍的血浆生物标志物及其应用 |
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| IL267899A (en) | 2019-09-26 |
| TWI660946B (zh) | 2019-06-01 |
| JP2020506899A (ja) | 2020-03-05 |
| AU2018208846A1 (en) | 2019-07-25 |
| US10329308B2 (en) | 2019-06-25 |
| CN110382479A (zh) | 2019-10-25 |
| TW201838975A (zh) | 2018-11-01 |
| SG11201906417RA (en) | 2019-08-27 |
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