MX2019007594A - Composiciones y metodos para tratar la deficiencia de alfa-1 antitripsina. - Google Patents

Composiciones y metodos para tratar la deficiencia de alfa-1 antitripsina.

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Publication number
MX2019007594A
MX2019007594A MX2019007594A MX2019007594A MX2019007594A MX 2019007594 A MX2019007594 A MX 2019007594A MX 2019007594 A MX2019007594 A MX 2019007594A MX 2019007594 A MX2019007594 A MX 2019007594A MX 2019007594 A MX2019007594 A MX 2019007594A
Authority
MX
Mexico
Prior art keywords
compositions
methods
antitrypsin deficiency
treating alpha
antitrypsin
Prior art date
Application number
MX2019007594A
Other languages
English (en)
Inventor
Strapps Walter
Odate Shobu
Michael Lescarbeau Reynald
Original Assignee
Intellia Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intellia Therapeutics Inc filed Critical Intellia Therapeutics Inc
Publication of MX2019007594A publication Critical patent/MX2019007594A/es

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
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Abstract

Se proporcionan composiciones y métodos para introducir rupturas de doble cadena dentro del gen de SERPINA 1. Se proporcionan composiciones y métodos para reducir y eliminar las formas mutantes de a1-antitripsina (AAT), tal como se observa en los sujetos que tienen deficiencia de a1-antitripsina (AATD).
MX2019007594A 2016-12-22 2017-12-21 Composiciones y metodos para tratar la deficiencia de alfa-1 antitripsina. MX2019007594A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201662438219P 2016-12-22 2016-12-22
PCT/US2017/067800 WO2018119182A1 (en) 2016-12-22 2017-12-21 Compositions and methods for treating alpha-1 antitrypsin deficiency

Publications (1)

Publication Number Publication Date
MX2019007594A true MX2019007594A (es) 2019-12-16

Family

ID=61054487

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2019007594A MX2019007594A (es) 2016-12-22 2017-12-21 Composiciones y metodos para tratar la deficiencia de alfa-1 antitripsina.

Country Status (18)

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US (2) US11549107B2 (es)
EP (1) EP3559232A1 (es)
JP (2) JP7383478B2 (es)
KR (1) KR102551664B1 (es)
CN (2) CN110382697B (es)
AU (2) AU2017379073B2 (es)
BR (1) BR112019012825A2 (es)
CA (1) CA3047415A1 (es)
CO (1) CO2019007776A2 (es)
EA (1) EA201991455A1 (es)
IL (1) IL267448A (es)
MX (1) MX2019007594A (es)
NZ (1) NZ754739A (es)
PH (1) PH12019501457A1 (es)
SG (1) SG10202106412RA (es)
TW (1) TW201833331A (es)
WO (1) WO2018119182A1 (es)
ZA (1) ZA202007632B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ754739A (en) * 2016-12-22 2024-01-26 Intellia Therapeutics Inc Compositions and methods for treating alpha-1 antitrypsin deficiency
CA3077413A1 (en) * 2017-09-29 2019-04-04 Intellia Therapeutics, Inc. Formulations
WO2020006708A1 (en) * 2018-07-04 2020-01-09 Yale University Compositions and methods for enhancement of homology-directed repair mediated precise gene editing by programming dna repair with a single rna-guided endonuclease
WO2020082047A1 (en) 2018-10-18 2020-04-23 Intellia Therapeutics, Inc. Compositions and methods for treating alpha-1 antitrypsin deficiencey
JP7472121B2 (ja) * 2018-10-18 2024-04-22 インテリア セラピューティクス，インコーポレーテッド アルブミン遺伝子座からの導入遺伝子発現のための組成物及び方法
US20220160847A1 (en) * 2020-11-20 2022-05-26 Mark Egly Method of preventing and/or treating a plurality of diseases
EP4259792A1 (en) 2020-12-11 2023-10-18 Intellia Therapeutics, Inc. Polynucleotides, compositions, and methods for genome editing involving deamination

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JP6932698B2 (ja) * 2015-12-01 2021-09-08 クリスパー・セラピューティクス・アクチェンゲゼルシャフトＣＲＩＳＰＲ Ｔｈｅｒａｐｅｕｔｉｃｓ ＡＧ アルファ１アンチトリプシン欠乏症の治療のための材料および方法
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NZ754739A (en) * 2016-12-22 2024-01-26 Intellia Therapeutics Inc Compositions and methods for treating alpha-1 antitrypsin deficiency
WO2020082047A1 (en) * 2018-10-18 2020-04-23 Intellia Therapeutics, Inc. Compositions and methods for treating alpha-1 antitrypsin deficiencey

Also Published As

Publication number Publication date
NZ754739A (en) 2024-01-26
ZA202007632B (en) 2023-03-29
IL267448A (en) 2019-08-29
SG10202106412RA (en) 2021-07-29
JP2020501582A (ja) 2020-01-23
PH12019501457A1 (en) 2020-03-09
US11549107B2 (en) 2023-01-10
JP7383478B2 (ja) 2023-11-20
WO2018119182A1 (en) 2018-06-28
TW201833331A (zh) 2018-09-16
KR102551664B1 (ko) 2023-07-05
EA201991455A1 (ru) 2020-01-15
EP3559232A1 (en) 2019-10-30
CN117737062A (zh) 2024-03-22
CA3047415A1 (en) 2018-06-28
AU2024201464A1 (en) 2024-03-28
US20230212575A1 (en) 2023-07-06
KR20190100943A (ko) 2019-08-29
BR112019012825A2 (pt) 2019-11-26
AU2017379073B2 (en) 2023-12-14
US20190316129A1 (en) 2019-10-17
CO2019007776A2 (es) 2019-10-09
JP2023075164A (ja) 2023-05-30
AU2017379073A1 (en) 2019-07-11
CN110382697A (zh) 2019-10-25
CN110382697B (zh) 2023-12-29

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