MX2019006165A - Proceso para la preparacion de derivados del acido biliar de las sulfonilureas. - Google Patents
Proceso para la preparacion de derivados del acido biliar de las sulfonilureas.Info
- Publication number
- MX2019006165A MX2019006165A MX2019006165A MX2019006165A MX2019006165A MX 2019006165 A MX2019006165 A MX 2019006165A MX 2019006165 A MX2019006165 A MX 2019006165A MX 2019006165 A MX2019006165 A MX 2019006165A MX 2019006165 A MX2019006165 A MX 2019006165A
- Authority
- MX
- Mexico
- Prior art keywords
- preparation
- relates
- present
- bile acid
- acid derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
- C07J9/005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane containing a carboxylic function directly attached or attached by a chain containing only carbon atoms to the cyclopenta[a]hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente invención se relaciona con a proceso para la preparación de un compuesto de la Fórmula(I): (ver fórmula) o un solvato o sal aceptable farmacéuticamente del mismo. Estos compuestos y composiciones farmacéuticas son útiles como moduladores de FXR o TGR5. Específicamente, la presente invención se refiere a derivados de ácido biliar y métodos para su preparación y uso. La presente invención se refiere a un proceso para la preparación de un compuesto (II) y sus sales y derivados que son intermediarios útiles en la síntesis de moléculas biológicamente activas, especialmente en la síntesis de moduladores de FXR y TGR5 (ver fórmula). La presente invención también se refiere a un proceso para la preparación de un compuesto (III) y su sal de dietilamina (ver fórmula).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662427354P | 2016-11-29 | 2016-11-29 | |
PCT/US2017/063720 WO2018102418A1 (en) | 2016-11-29 | 2017-11-29 | Process for preparation of sulfonylurea bile acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2019006165A true MX2019006165A (es) | 2019-10-14 |
Family
ID=62188840
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2019006165A MX2019006165A (es) | 2016-11-29 | 2017-11-29 | Proceso para la preparacion de derivados del acido biliar de las sulfonilureas. |
Country Status (11)
Country | Link |
---|---|
US (2) | US10584145B2 (es) |
EP (1) | EP3548038B1 (es) |
JP (1) | JP7057783B2 (es) |
KR (1) | KR102499441B1 (es) |
CN (1) | CN110121347A (es) |
AU (1) | AU2017368069B2 (es) |
BR (1) | BR112019010798A2 (es) |
CA (1) | CA3045023A1 (es) |
ES (1) | ES2918698T3 (es) |
MX (1) | MX2019006165A (es) |
WO (1) | WO2018102418A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2017118569A (ru) | 2014-11-06 | 2018-12-06 | Энанта Фармасьютикалс, Инк. | Аналоги желчных кислот как агонисты fxr/tgr5 и способы их применения |
US10208081B2 (en) | 2014-11-26 | 2019-02-19 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR/TGR5 agonists and methods of use thereof |
US11578097B2 (en) | 2014-11-26 | 2023-02-14 | Enanta Pharmaceuticals, Inc. | Tetrazole derivatives of bile acids as FXR/TGR5 agonists and methods of use thereof |
WO2016086169A1 (en) | 2014-11-26 | 2016-06-02 | Enanta Pharmaceuticals, Inc. | Bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
CN107427527B (zh) | 2015-03-31 | 2021-01-26 | 英安塔制药有限公司 | 作为fxr/tgr5激动剂的胆汁酸衍生物及其使用方法 |
US10323060B2 (en) | 2016-02-23 | 2019-06-18 | Enanta Pharmaceuticals, Inc. | Benzoic acid derivatives of bile acid as FXR/TGR5 agonists and methods of use thereof |
WO2017147174A1 (en) | 2016-02-23 | 2017-08-31 | Enanta Pharmaceuticals, Inc. | Heteroaryl containing bile acid analogs as fxr/tgr5 agonists and methods of use thereof |
WO2018102418A1 (en) * | 2016-11-29 | 2018-06-07 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonylurea bile acid derivatives |
US10472386B2 (en) | 2017-02-14 | 2019-11-12 | Enanta Pharmaceuticals, Inc. | Bile acid derivatives as FXR agonists and methods of use thereof |
EP3606533B1 (en) | 2017-04-07 | 2023-11-15 | Enanta Pharmaceuticals, Inc. | Process for preparation of sulfonyl carbamate bile acid derivatives |
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-
2017
- 2017-11-29 WO PCT/US2017/063720 patent/WO2018102418A1/en unknown
- 2017-11-29 KR KR1020197018568A patent/KR102499441B1/ko active IP Right Grant
- 2017-11-29 CA CA3045023A patent/CA3045023A1/en active Pending
- 2017-11-29 BR BR112019010798A patent/BR112019010798A2/pt unknown
- 2017-11-29 AU AU2017368069A patent/AU2017368069B2/en active Active
- 2017-11-29 ES ES17877352T patent/ES2918698T3/es active Active
- 2017-11-29 MX MX2019006165A patent/MX2019006165A/es unknown
- 2017-11-29 JP JP2019528041A patent/JP7057783B2/ja active Active
- 2017-11-29 CN CN201780081494.2A patent/CN110121347A/zh active Pending
- 2017-11-29 US US15/826,233 patent/US10584145B2/en active Active
- 2017-11-29 EP EP17877352.9A patent/EP3548038B1/en active Active
-
2020
- 2020-02-07 US US16/784,296 patent/US10947264B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
BR112019010798A2 (pt) | 2019-10-01 |
WO2018102418A1 (en) | 2018-06-07 |
AU2017368069B2 (en) | 2021-07-08 |
ES2918698T3 (es) | 2022-07-19 |
AU2017368069A1 (en) | 2019-06-13 |
CA3045023A1 (en) | 2018-06-07 |
US10947264B2 (en) | 2021-03-16 |
US10584145B2 (en) | 2020-03-10 |
KR102499441B1 (ko) | 2023-02-13 |
KR20190114960A (ko) | 2019-10-10 |
EP3548038B1 (en) | 2022-04-13 |
EP3548038A4 (en) | 2020-07-01 |
US20180148469A1 (en) | 2018-05-31 |
JP2019535777A (ja) | 2019-12-12 |
CN110121347A (zh) | 2019-08-13 |
JP7057783B2 (ja) | 2022-04-20 |
US20200247839A1 (en) | 2020-08-06 |
EP3548038A1 (en) | 2019-10-09 |
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