MX2018015421A - Mejoras en o relacionadas con los procesos de amplificacion de acidos nucleicos. - Google Patents

Mejoras en o relacionadas con los procesos de amplificacion de acidos nucleicos.

Info

Publication number
MX2018015421A
MX2018015421A MX2018015421A MX2018015421A MX2018015421A MX 2018015421 A MX2018015421 A MX 2018015421A MX 2018015421 A MX2018015421 A MX 2018015421A MX 2018015421 A MX2018015421 A MX 2018015421A MX 2018015421 A MX2018015421 A MX 2018015421A
Authority
MX
Mexico
Prior art keywords
nucleic acid
cut
duplex
steps
polymerase
Prior art date
Application number
MX2018015421A
Other languages
English (en)
Spanish (es)
Inventor
Provins Jarrod
Shen Daiwei
Kraynack Bryan
Original Assignee
Lumiradx Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=56891177&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2018015421(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lumiradx Uk Ltd filed Critical Lumiradx Uk Ltd
Publication of MX2018015421A publication Critical patent/MX2018015421A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L7/00—Heating or cooling apparatus; Heat insulating devices
    • B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/101—DNA polymerase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/10—Nucleotidyl transfering
    • C12Q2521/107—RNA dependent DNA polymerase,(i.e. reverse transcriptase)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
    • C12Q2521/307—Single strand endonuclease
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2521/00—Reaction characterised by the enzymatic activity
    • C12Q2521/50—Other enzymatic activities
    • C12Q2521/531—Glycosylase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/113—Modifications characterised by incorporating modified backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/10—Modifications characterised by
    • C12Q2525/131—Modifications characterised by incorporating a restriction site
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
    • C12Q2525/30—Oligonucleotides characterised by their secondary structure
    • C12Q2525/301—Hairpin oligonucleotides
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2527/00—Reactions demanding special reaction conditions
    • C12Q2527/101—Temperature
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/137—Reactions characterised by the reaction format or use of a specific feature the purpose or use of a displacement step

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Clinical Laboratory Science (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
MX2018015421A 2016-06-30 2017-06-30 Mejoras en o relacionadas con los procesos de amplificacion de acidos nucleicos. MX2018015421A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1611469.6A GB201611469D0 (en) 2016-06-30 2016-06-30 Improvements in or relating to nucleic acid amplification processes
PCT/GB2017/051927 WO2018002649A1 (en) 2016-06-30 2017-06-30 Improvements in or relating to nucleic acid amplification processes

Publications (1)

Publication Number Publication Date
MX2018015421A true MX2018015421A (es) 2019-11-28

Family

ID=56891177

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2018015421A MX2018015421A (es) 2016-06-30 2017-06-30 Mejoras en o relacionadas con los procesos de amplificacion de acidos nucleicos.

Country Status (15)

Country Link
US (2) US11591643B2 (enExample)
EP (1) EP3478853B2 (enExample)
JP (2) JP6957527B2 (enExample)
KR (1) KR102392010B1 (enExample)
CN (1) CN109642251B (enExample)
AU (1) AU2017287852B2 (enExample)
CA (1) CA3024295C (enExample)
ES (1) ES2841624T5 (enExample)
GB (1) GB201611469D0 (enExample)
IL (1) IL263870A (enExample)
MX (1) MX2018015421A (enExample)
RU (1) RU2760915C2 (enExample)
SG (1) SG11201809927XA (enExample)
WO (1) WO2018002649A1 (enExample)
ZA (1) ZA201807460B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114481656B (zh) 2015-06-11 2024-03-22 思科有限责任公司 用于从植物基和再生材料生产纸浆、能源和生物衍生物的方法和系统
GB201611469D0 (en) 2016-06-30 2016-08-17 Lumiradx Tech Ltd Improvements in or relating to nucleic acid amplification processes
GB2569965A (en) * 2018-01-04 2019-07-10 Lumiradx Uk Ltd Improvements in or relating to amplification of nucleic acids
GB201812149D0 (en) 2018-07-25 2018-09-05 Sense Biodetection Ltd Nucleic acid detection method
GB201915346D0 (en) 2019-06-21 2019-12-04 Lumiradx Tech Ltd Improvements in or relating to nicking enzymes
CN115003828A (zh) 2020-01-25 2022-09-02 圣斯生物检测有限公司 病毒检测
US20220316003A1 (en) * 2020-03-09 2022-10-06 Illumina, Inc. Methods for sequencing polynucleotides
US20240218438A1 (en) * 2021-05-27 2024-07-04 Lumiradx Uk Ltd. Improvements in or relating to digestion of reaction products
TW202330758A (zh) 2021-09-16 2023-08-01 美商賽克股份有限公司 從由廢棄材料解聚合所形成再生二酸形成聚酯之方法
EP4402119A4 (en) * 2021-09-16 2025-10-15 Circ Llc AGING PROCESS FOR REGENERATED DIACID CRYSTALS

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2017821C1 (ru) * 1990-10-10 1994-08-15 Анатолий Михайлович Онищенко Способ амплификации днк и устройство для его осуществления
US5432065A (en) 1993-03-30 1995-07-11 United States Biochemical Corporation Cycle sequencing with non-thermostable DNA polymerases
US20020025555A1 (en) * 1997-03-06 2002-02-28 Janice Au-Young GPCR diagnostic for brain cancer
DE1049806T1 (de) 1998-01-27 2001-04-19 Cytocell Ltd., Banbury Verfahren zum nachweis von nukleinsäure-zielsequenzen mittels in vitro transkription von einem rna-promoter
ATE286981T1 (de) 1999-09-28 2005-01-15 Roche Diagnostics Gmbh Thermostabiles enzym welches die genauigkeit thermostabiler dna polymerasen erhöht - zur verbesserung der nucleinsäuresynthese und in vitro amplifikation
US20010047200A1 (en) 1999-10-13 2001-11-29 Raymond Sun Non-foreshortening intraluminal prosthesis
NO314091B1 (no) * 2000-01-12 2003-01-27 Biotec Pharmacon Asa Varmelabil uracil-DNA-glykosylase, DNA-sekvens som koder for enzymet, mikroorganisme som inneholder DNA-sekvensen, samt anvendelse av enzymet
US6191267B1 (en) 2000-06-02 2001-02-20 New England Biolabs, Inc. Cloning and producing the N.BstNBI nicking endonuclease
ATE312942T1 (de) 2000-10-25 2005-12-15 Hoffmann La Roche Amplifizierung unter verwendung von modifizierten primern
GB0101397D0 (en) 2001-01-19 2001-03-07 Amersham Pharm Biotech Uk Ltd Suppression of non-specific nucleic acid amplication
US20030211506A1 (en) 2001-06-01 2003-11-13 Huimin Kong N. bstnbi nicking endonuclease and methods for using endonucleases in single-stranded displacement amplification
EP1470250A2 (en) * 2001-07-15 2004-10-27 Keck Graduate Institute Gene expression analysis using nicking agents
WO2003048393A1 (en) 2001-12-04 2003-06-12 Bio3 Research Srl Mixture of two partially denaturating agents for the preparation of pcr buffer solutions
WO2005118853A2 (en) 2004-06-01 2005-12-15 Asm Scientific, Inc. Recombinase polymerase amplification
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
WO2004055193A1 (en) 2002-12-18 2004-07-01 Dingbang Xu Pcr method and application by transnormal low thermo-denaturation temperature
WO2004090153A2 (en) 2003-04-01 2004-10-21 Eragen Biosciences,Inc. Polymerase inhibitor and method of using same
EP1771250B1 (en) * 2004-06-04 2011-01-26 Abacus Diagnostica OY Temperature control of reaction vessel, system with reaction vessel and use of system
FR2878254B1 (fr) 2004-11-22 2010-08-20 Bio Rad Pasteur Composition pour l'amplification d'acides nucleiques
EP1762627A1 (de) 2005-09-09 2007-03-14 Qiagen GmbH Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
US7537917B2 (en) 2006-03-31 2009-05-26 Collins Michael J Microwave assisted PCR amplification of DNA
US20090092967A1 (en) 2006-06-26 2009-04-09 Epoch Biosciences, Inc. Method for generating target nucleic acid sequences
EP2140033B1 (en) 2007-03-28 2012-10-10 Signal Diagnostics System and method for high resolution analysis of nucleic acids to detect sequence variations
US9689031B2 (en) * 2007-07-14 2017-06-27 Ionian Technologies, Inc. Nicking and extension amplification reaction for the exponential amplification of nucleic acids
US8143006B2 (en) * 2007-08-03 2012-03-27 Igor Kutyavin Accelerated cascade amplification (ACA) of nucleic acids comprising strand and sequence specific DNA nicking
FI20085450A0 (fi) 2008-05-14 2008-05-14 Arto Orpana Menetelmä DNA-juosteen syntetisoimiseksi
US20120156728A1 (en) 2010-12-17 2012-06-21 Life Technologies Corporation Clonal amplification of nucleic acid on solid surface with template walking
GB0915664D0 (en) * 2009-09-08 2009-10-07 Enigma Diagnostics Ltd Reaction method
WO2011038197A1 (en) 2009-09-25 2011-03-31 Alere San Diego, Inc. Detection of nucleic acids in crude matrices
EP2560759B1 (en) * 2010-04-20 2020-02-12 QIAGEN GmbH Temperature control method and apparatus
US9845495B2 (en) 2010-12-10 2017-12-19 Abbott Laboratories Method and kit for detecting target nucleic acid
CN103649333B (zh) 2011-04-20 2017-02-15 梅撒生物科技公司 用于核酸检测和鉴定的集成装置
US8343752B2 (en) * 2011-05-03 2013-01-01 Verdezyne, Inc. Biological methods for preparing adipic acid
NZ723570A (en) 2012-04-09 2018-06-29 Envirologix Inc Compositions and methods for quantifying a nucleic acid sequence in a sample
CA3096342C (en) 2012-06-08 2023-04-04 Ionian Technologies, Llc Nucleic acid amplifications
CA2936157C (en) 2014-01-15 2021-08-24 Tokyo Institute Of Technology Covered sequence conversion dna and detection methods
CN107075585B (zh) 2014-10-14 2021-07-20 雅培实验室 具有锁核酸的序列转换和信号扩增dna以及使用其的检测方法
ES2791280T3 (es) 2014-12-24 2020-11-03 Abbott Lab Método de detección, composición y kit basados en reacciones en cascada de ADN amplificador de señal con extensión de la diana
GB201513128D0 (en) 2015-07-24 2015-09-09 Sense Biodetection Ltd Nucleic acid detection method
CA2995468A1 (en) 2015-08-12 2017-02-16 Circulogene Theranostics, Llc Method of preparing cell free nucleic acid molecules by in situ amplification
US10329601B2 (en) 2015-12-28 2019-06-25 Ionian Technologies, Inc. Nicking and extension amplification reaction (NEAR) of Streptococcus species
GB201611469D0 (en) 2016-06-30 2016-08-17 Lumiradx Tech Ltd Improvements in or relating to nucleic acid amplification processes
GB201701262D0 (en) 2017-01-25 2017-03-08 Sense Biodetection Ltd Nucleic acid detection method
EP3676394A4 (en) 2017-08-31 2021-06-02 Ionian Technologies, LLC SYNCYTIAL SYNCHRONIZATION AND EXTENSION AMPLIFICATION REACTION (NEAR) OF RESPIRATORY VIRUS SPECIES
GB2569965A (en) 2018-01-04 2019-07-10 Lumiradx Uk Ltd Improvements in or relating to amplification of nucleic acids
GB201812149D0 (en) 2018-07-25 2018-09-05 Sense Biodetection Ltd Nucleic acid detection method

Also Published As

Publication number Publication date
KR20190024890A (ko) 2019-03-08
ES2841624T5 (en) 2026-03-19
CA3024295A1 (en) 2018-01-04
RU2019101504A3 (enExample) 2020-11-30
SG11201809927XA (en) 2019-01-30
JP2022017268A (ja) 2022-01-25
AU2017287852A1 (en) 2018-11-22
US20190226015A1 (en) 2019-07-25
ES2841624T3 (es) 2021-07-08
RU2019101504A (ru) 2020-07-30
JP6957527B2 (ja) 2021-11-02
RU2760915C2 (ru) 2021-12-01
KR102392010B1 (ko) 2022-04-27
CA3024295C (en) 2024-09-24
BR112018075801A2 (pt) 2019-03-26
US11591643B2 (en) 2023-02-28
CN109642251B (zh) 2022-08-19
WO2018002649A1 (en) 2018-01-04
ZA201807460B (en) 2021-06-30
EP3478853B1 (en) 2020-10-07
IL263870A (en) 2019-01-31
EP3478853B2 (en) 2025-11-26
GB201611469D0 (en) 2016-08-17
AU2017287852B2 (en) 2022-11-24
JP2019519231A (ja) 2019-07-11
US20230340579A1 (en) 2023-10-26
EP3478853A1 (en) 2019-05-08
CN109642251A (zh) 2019-04-16

Similar Documents

Publication Publication Date Title
JP2015156872A5 (enExample)
PE20191351A1 (es) Tratamiento aav de la enfermedad de huntington
EP4389888A3 (en) Methods for adding adapters to nucleic acids and compositions for practicing the same
EP4310196A3 (en) Methods and compositions for manipulating nucleic acids
EP4269582A3 (en) Target enrichment by unidirectional dual probe primer extension
AU2017287852A1 (en) Improvements in or relating to Nucleic Acid amplification processes
MX2018000729A (es) Métodos para amplificar las secuencias de ácido nucleico.
EA201890012A1 (ru) Способы и композиции для рнк-направляемого лечения инфекции, вызываемой вич
ES2531055T3 (es) Cebadores de polinucleótidos para detectar mutaciones de PIK3CA
WO2014004852A3 (en) Kit for isothermal dna amplification starting from an rna template
BR112017009754A2 (pt) processo para produção de hexanotriol a partir de 5-hidroximetfilfurfural
BR112016018282A8 (pt) mistura de catalisador para pirólise rápida catalítica e método para produzir produtos monoaromáticos
BR112016029548A2 (pt) método de sequenciamento de um ácido nucleico e sistema de sonda biológico multicomponente
JP2017532044A5 (enExample)
MY184632A (en) A method of identifying parentage in freshwater prawn macrobrachium rosenbergii
AR100946A1 (es) Composiciones y métodos para regular la expresión génica por medio de la interferencia de arn
AR090558A1 (es) Evento de maiz dp-004114-3 y metodos para su deteccion
EA201792538A1 (ru) Способ биологического получения метакриловой кислоты
AR114192A1 (es) Mejoras en, o relacionadas con, la amplificación de ácidos nucleicos
RU2015150098A (ru) Способ амплификации днк на основе внедрения в цепь
BR112018007709A2 (pt) processo de produção de 5-hidroximetilfurfural na presença de um catalisador tipo ácido de lewis e/ou de um catalisador tipo base heterogêneo e de um catalisador orgânico homogêneo tipo ácido de brønsted na presença de pelo menos um solvente polar aprótico
MX2018011052A (es) Compuestos y metodos para la sintesis de fosforamidato de 5-(n-triptamina carboxamida protegida)-2'-desoxiuridina para ser incorporados en una secuencia nucleica.
MX2021006293A (es) Metodo para detectar la incorporación de polimerasa de nucleótidos.
BR112017013025A2 (pt) recuperação de óleo da lama de palma
ATE497022T1 (de) Verfahren zur amplifikation von nukleinsäure