CA3024295C - IMPROVEMENTS TO OR RELATING TO NUCLEIC ACID AMPLIFICATION PROCESSES - Google Patents
IMPROVEMENTS TO OR RELATING TO NUCLEIC ACID AMPLIFICATION PROCESSESInfo
- Publication number
- CA3024295C CA3024295C CA3024295A CA3024295A CA3024295C CA 3024295 C CA3024295 C CA 3024295C CA 3024295 A CA3024295 A CA 3024295A CA 3024295 A CA3024295 A CA 3024295A CA 3024295 C CA3024295 C CA 3024295C
- Authority
- CA
- Canada
- Prior art keywords
- temperature
- amplification
- target
- reaction
- polymerase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L7/00—Heating or cooling apparatus; Heat insulating devices
- B01L7/52—Heating or cooling apparatus; Heat insulating devices with provision for submitting samples to a predetermined sequence of different temperatures, e.g. for treating nucleic acid samples
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6848—Nucleic acid amplification reactions characterised by the means for preventing contamination or increasing the specificity or sensitivity of an amplification reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6853—Nucleic acid amplification reactions using modified primers or templates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/101—DNA polymerase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/10—Nucleotidyl transfering
- C12Q2521/107—RNA dependent DNA polymerase,(i.e. reverse transcriptase)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/30—Phosphoric diester hydrolysing, i.e. nuclease
- C12Q2521/307—Single strand endonuclease
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2521/00—Reaction characterised by the enzymatic activity
- C12Q2521/50—Other enzymatic activities
- C12Q2521/531—Glycosylase
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/113—Modifications characterised by incorporating modified backbone
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/131—Modifications characterised by incorporating a restriction site
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/30—Oligonucleotides characterised by their secondary structure
- C12Q2525/301—Hairpin oligonucleotides
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2527/00—Reactions demanding special reaction conditions
- C12Q2527/101—Temperature
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/137—Reactions characterised by the reaction format or use of a specific feature the purpose or use of a displacement step
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Clinical Laboratory Science (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1611469.6 | 2016-06-30 | ||
| GBGB1611469.6A GB201611469D0 (en) | 2016-06-30 | 2016-06-30 | Improvements in or relating to nucleic acid amplification processes |
| PCT/GB2017/051927 WO2018002649A1 (en) | 2016-06-30 | 2017-06-30 | Improvements in or relating to nucleic acid amplification processes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3024295A1 CA3024295A1 (en) | 2018-01-04 |
| CA3024295C true CA3024295C (en) | 2024-09-24 |
Family
ID=56891177
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3024295A Active CA3024295C (en) | 2016-06-30 | 2017-06-30 | IMPROVEMENTS TO OR RELATING TO NUCLEIC ACID AMPLIFICATION PROCESSES |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11591643B2 (enExample) |
| EP (1) | EP3478853B2 (enExample) |
| JP (2) | JP6957527B2 (enExample) |
| KR (1) | KR102392010B1 (enExample) |
| CN (1) | CN109642251B (enExample) |
| AU (1) | AU2017287852B2 (enExample) |
| CA (1) | CA3024295C (enExample) |
| ES (1) | ES2841624T5 (enExample) |
| GB (1) | GB201611469D0 (enExample) |
| IL (1) | IL263870A (enExample) |
| MX (1) | MX2018015421A (enExample) |
| RU (1) | RU2760915C2 (enExample) |
| SG (1) | SG11201809927XA (enExample) |
| WO (1) | WO2018002649A1 (enExample) |
| ZA (1) | ZA201807460B (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114481656B (zh) | 2015-06-11 | 2024-03-22 | 思科有限责任公司 | 用于从植物基和再生材料生产纸浆、能源和生物衍生物的方法和系统 |
| GB201611469D0 (en) | 2016-06-30 | 2016-08-17 | Lumiradx Tech Ltd | Improvements in or relating to nucleic acid amplification processes |
| GB2569965A (en) * | 2018-01-04 | 2019-07-10 | Lumiradx Uk Ltd | Improvements in or relating to amplification of nucleic acids |
| GB201812149D0 (en) | 2018-07-25 | 2018-09-05 | Sense Biodetection Ltd | Nucleic acid detection method |
| GB201915346D0 (en) | 2019-06-21 | 2019-12-04 | Lumiradx Tech Ltd | Improvements in or relating to nicking enzymes |
| CN115003828A (zh) | 2020-01-25 | 2022-09-02 | 圣斯生物检测有限公司 | 病毒检测 |
| US20220316003A1 (en) * | 2020-03-09 | 2022-10-06 | Illumina, Inc. | Methods for sequencing polynucleotides |
| US20240218438A1 (en) * | 2021-05-27 | 2024-07-04 | Lumiradx Uk Ltd. | Improvements in or relating to digestion of reaction products |
| TW202330758A (zh) | 2021-09-16 | 2023-08-01 | 美商賽克股份有限公司 | 從由廢棄材料解聚合所形成再生二酸形成聚酯之方法 |
| EP4402119A4 (en) * | 2021-09-16 | 2025-10-15 | Circ Llc | AGING PROCESS FOR REGENERATED DIACID CRYSTALS |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2017821C1 (ru) * | 1990-10-10 | 1994-08-15 | Анатолий Михайлович Онищенко | Способ амплификации днк и устройство для его осуществления |
| US5432065A (en) | 1993-03-30 | 1995-07-11 | United States Biochemical Corporation | Cycle sequencing with non-thermostable DNA polymerases |
| US20020025555A1 (en) * | 1997-03-06 | 2002-02-28 | Janice Au-Young | GPCR diagnostic for brain cancer |
| DE1049806T1 (de) | 1998-01-27 | 2001-04-19 | Cytocell Ltd., Banbury | Verfahren zum nachweis von nukleinsäure-zielsequenzen mittels in vitro transkription von einem rna-promoter |
| ATE286981T1 (de) | 1999-09-28 | 2005-01-15 | Roche Diagnostics Gmbh | Thermostabiles enzym welches die genauigkeit thermostabiler dna polymerasen erhöht - zur verbesserung der nucleinsäuresynthese und in vitro amplifikation |
| US20010047200A1 (en) | 1999-10-13 | 2001-11-29 | Raymond Sun | Non-foreshortening intraluminal prosthesis |
| NO314091B1 (no) * | 2000-01-12 | 2003-01-27 | Biotec Pharmacon Asa | Varmelabil uracil-DNA-glykosylase, DNA-sekvens som koder for enzymet, mikroorganisme som inneholder DNA-sekvensen, samt anvendelse av enzymet |
| US6191267B1 (en) | 2000-06-02 | 2001-02-20 | New England Biolabs, Inc. | Cloning and producing the N.BstNBI nicking endonuclease |
| ATE312942T1 (de) | 2000-10-25 | 2005-12-15 | Hoffmann La Roche | Amplifizierung unter verwendung von modifizierten primern |
| GB0101397D0 (en) | 2001-01-19 | 2001-03-07 | Amersham Pharm Biotech Uk Ltd | Suppression of non-specific nucleic acid amplication |
| US20030211506A1 (en) | 2001-06-01 | 2003-11-13 | Huimin Kong | N. bstnbi nicking endonuclease and methods for using endonucleases in single-stranded displacement amplification |
| EP1470250A2 (en) * | 2001-07-15 | 2004-10-27 | Keck Graduate Institute | Gene expression analysis using nicking agents |
| WO2003048393A1 (en) | 2001-12-04 | 2003-06-12 | Bio3 Research Srl | Mixture of two partially denaturating agents for the preparation of pcr buffer solutions |
| WO2005118853A2 (en) | 2004-06-01 | 2005-12-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| US7399590B2 (en) | 2002-02-21 | 2008-07-15 | Asm Scientific, Inc. | Recombinase polymerase amplification |
| WO2004055193A1 (en) | 2002-12-18 | 2004-07-01 | Dingbang Xu | Pcr method and application by transnormal low thermo-denaturation temperature |
| WO2004090153A2 (en) | 2003-04-01 | 2004-10-21 | Eragen Biosciences,Inc. | Polymerase inhibitor and method of using same |
| EP1771250B1 (en) * | 2004-06-04 | 2011-01-26 | Abacus Diagnostica OY | Temperature control of reaction vessel, system with reaction vessel and use of system |
| FR2878254B1 (fr) | 2004-11-22 | 2010-08-20 | Bio Rad Pasteur | Composition pour l'amplification d'acides nucleiques |
| EP1762627A1 (de) | 2005-09-09 | 2007-03-14 | Qiagen GmbH | Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion |
| US7537917B2 (en) | 2006-03-31 | 2009-05-26 | Collins Michael J | Microwave assisted PCR amplification of DNA |
| US20090092967A1 (en) | 2006-06-26 | 2009-04-09 | Epoch Biosciences, Inc. | Method for generating target nucleic acid sequences |
| EP2140033B1 (en) | 2007-03-28 | 2012-10-10 | Signal Diagnostics | System and method for high resolution analysis of nucleic acids to detect sequence variations |
| US9689031B2 (en) * | 2007-07-14 | 2017-06-27 | Ionian Technologies, Inc. | Nicking and extension amplification reaction for the exponential amplification of nucleic acids |
| US8143006B2 (en) * | 2007-08-03 | 2012-03-27 | Igor Kutyavin | Accelerated cascade amplification (ACA) of nucleic acids comprising strand and sequence specific DNA nicking |
| FI20085450A0 (fi) | 2008-05-14 | 2008-05-14 | Arto Orpana | Menetelmä DNA-juosteen syntetisoimiseksi |
| US20120156728A1 (en) | 2010-12-17 | 2012-06-21 | Life Technologies Corporation | Clonal amplification of nucleic acid on solid surface with template walking |
| GB0915664D0 (en) * | 2009-09-08 | 2009-10-07 | Enigma Diagnostics Ltd | Reaction method |
| WO2011038197A1 (en) | 2009-09-25 | 2011-03-31 | Alere San Diego, Inc. | Detection of nucleic acids in crude matrices |
| EP2560759B1 (en) * | 2010-04-20 | 2020-02-12 | QIAGEN GmbH | Temperature control method and apparatus |
| US9845495B2 (en) | 2010-12-10 | 2017-12-19 | Abbott Laboratories | Method and kit for detecting target nucleic acid |
| CN103649333B (zh) | 2011-04-20 | 2017-02-15 | 梅撒生物科技公司 | 用于核酸检测和鉴定的集成装置 |
| US8343752B2 (en) * | 2011-05-03 | 2013-01-01 | Verdezyne, Inc. | Biological methods for preparing adipic acid |
| NZ723570A (en) | 2012-04-09 | 2018-06-29 | Envirologix Inc | Compositions and methods for quantifying a nucleic acid sequence in a sample |
| CA3096342C (en) | 2012-06-08 | 2023-04-04 | Ionian Technologies, Llc | Nucleic acid amplifications |
| CA2936157C (en) | 2014-01-15 | 2021-08-24 | Tokyo Institute Of Technology | Covered sequence conversion dna and detection methods |
| CN107075585B (zh) | 2014-10-14 | 2021-07-20 | 雅培实验室 | 具有锁核酸的序列转换和信号扩增dna以及使用其的检测方法 |
| ES2791280T3 (es) | 2014-12-24 | 2020-11-03 | Abbott Lab | Método de detección, composición y kit basados en reacciones en cascada de ADN amplificador de señal con extensión de la diana |
| GB201513128D0 (en) | 2015-07-24 | 2015-09-09 | Sense Biodetection Ltd | Nucleic acid detection method |
| CA2995468A1 (en) | 2015-08-12 | 2017-02-16 | Circulogene Theranostics, Llc | Method of preparing cell free nucleic acid molecules by in situ amplification |
| US10329601B2 (en) | 2015-12-28 | 2019-06-25 | Ionian Technologies, Inc. | Nicking and extension amplification reaction (NEAR) of Streptococcus species |
| GB201611469D0 (en) | 2016-06-30 | 2016-08-17 | Lumiradx Tech Ltd | Improvements in or relating to nucleic acid amplification processes |
| GB201701262D0 (en) | 2017-01-25 | 2017-03-08 | Sense Biodetection Ltd | Nucleic acid detection method |
| EP3676394A4 (en) | 2017-08-31 | 2021-06-02 | Ionian Technologies, LLC | SYNCYTIAL SYNCHRONIZATION AND EXTENSION AMPLIFICATION REACTION (NEAR) OF RESPIRATORY VIRUS SPECIES |
| GB2569965A (en) | 2018-01-04 | 2019-07-10 | Lumiradx Uk Ltd | Improvements in or relating to amplification of nucleic acids |
| GB201812149D0 (en) | 2018-07-25 | 2018-09-05 | Sense Biodetection Ltd | Nucleic acid detection method |
-
2016
- 2016-06-30 GB GBGB1611469.6A patent/GB201611469D0/en not_active Ceased
-
2017
- 2017-06-30 CN CN201780040770.0A patent/CN109642251B/zh active Active
- 2017-06-30 US US16/313,750 patent/US11591643B2/en active Active
- 2017-06-30 RU RU2019101504A patent/RU2760915C2/ru active
- 2017-06-30 SG SG11201809927XA patent/SG11201809927XA/en unknown
- 2017-06-30 MX MX2018015421A patent/MX2018015421A/es unknown
- 2017-06-30 EP EP17736737.2A patent/EP3478853B2/en active Active
- 2017-06-30 ES ES17736737T patent/ES2841624T5/es active Active
- 2017-06-30 JP JP2018565020A patent/JP6957527B2/ja active Active
- 2017-06-30 WO PCT/GB2017/051927 patent/WO2018002649A1/en not_active Ceased
- 2017-06-30 CA CA3024295A patent/CA3024295C/en active Active
- 2017-06-30 AU AU2017287852A patent/AU2017287852B2/en active Active
- 2017-06-30 KR KR1020187035782A patent/KR102392010B1/ko active Active
-
2018
- 2018-11-07 ZA ZA2018/07460A patent/ZA201807460B/en unknown
- 2018-12-20 IL IL263870A patent/IL263870A/en unknown
-
2021
- 2021-10-06 JP JP2021164854A patent/JP2022017268A/ja active Pending
-
2023
- 2023-01-26 US US18/102,031 patent/US20230340579A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| KR20190024890A (ko) | 2019-03-08 |
| ES2841624T5 (en) | 2026-03-19 |
| CA3024295A1 (en) | 2018-01-04 |
| RU2019101504A3 (enExample) | 2020-11-30 |
| SG11201809927XA (en) | 2019-01-30 |
| JP2022017268A (ja) | 2022-01-25 |
| AU2017287852A1 (en) | 2018-11-22 |
| US20190226015A1 (en) | 2019-07-25 |
| ES2841624T3 (es) | 2021-07-08 |
| RU2019101504A (ru) | 2020-07-30 |
| JP6957527B2 (ja) | 2021-11-02 |
| RU2760915C2 (ru) | 2021-12-01 |
| KR102392010B1 (ko) | 2022-04-27 |
| BR112018075801A2 (pt) | 2019-03-26 |
| US11591643B2 (en) | 2023-02-28 |
| CN109642251B (zh) | 2022-08-19 |
| WO2018002649A1 (en) | 2018-01-04 |
| ZA201807460B (en) | 2021-06-30 |
| MX2018015421A (es) | 2019-11-28 |
| EP3478853B1 (en) | 2020-10-07 |
| IL263870A (en) | 2019-01-31 |
| EP3478853B2 (en) | 2025-11-26 |
| GB201611469D0 (en) | 2016-08-17 |
| AU2017287852B2 (en) | 2022-11-24 |
| JP2019519231A (ja) | 2019-07-11 |
| US20230340579A1 (en) | 2023-10-26 |
| EP3478853A1 (en) | 2019-05-08 |
| CN109642251A (zh) | 2019-04-16 |
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