MX2018000071A - Musculo cardiaco humanizado. - Google Patents
Musculo cardiaco humanizado.Info
- Publication number
- MX2018000071A MX2018000071A MX2018000071A MX2018000071A MX2018000071A MX 2018000071 A MX2018000071 A MX 2018000071A MX 2018000071 A MX2018000071 A MX 2018000071A MX 2018000071 A MX2018000071 A MX 2018000071A MX 2018000071 A MX2018000071 A MX 2018000071A
- Authority
- MX
- Mexico
- Prior art keywords
- human
- handii
- nkx2
- tbx5
- combination
- Prior art date
Links
- 210000004165 myocardium Anatomy 0.000 title 1
- -1 HANDII Proteins 0.000 abstract 9
- 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 abstract 9
- 108010014480 T-box transcription factor 5 Proteins 0.000 abstract 7
- 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 abstract 6
- 102100024755 T-box transcription factor TBX5 Human genes 0.000 abstract 6
- 210000002459 blastocyst Anatomy 0.000 abstract 4
- 102000043416 human NKX2-5 Human genes 0.000 abstract 3
- 210000004102 animal cell Anatomy 0.000 abstract 2
- 238000004519 manufacturing process Methods 0.000 abstract 2
- 210000000287 oocyte Anatomy 0.000 abstract 2
- 101150115978 tbx5 gene Proteins 0.000 abstract 2
- 230000003213 activating effect Effects 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 238000010374 somatic cell nuclear transfer Methods 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187040P | 2015-06-30 | 2015-06-30 | |
| PCT/US2016/040431 WO2017004388A1 (en) | 2015-06-30 | 2016-06-30 | Humanized heart muscle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2018000071A true MX2018000071A (es) | 2018-03-16 |
Family
ID=57609529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018000071A MX2018000071A (es) | 2015-06-30 | 2016-06-30 | Musculo cardiaco humanizado. |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10897880B2 (https=) |
| EP (1) | EP3316899A4 (https=) |
| JP (1) | JP2018523999A (https=) |
| KR (1) | KR20180021135A (https=) |
| CN (1) | CN108472318A (https=) |
| AU (1) | AU2016288671A1 (https=) |
| BR (1) | BR112017028608A2 (https=) |
| CA (1) | CA2991056A1 (https=) |
| CO (1) | CO2018000859A2 (https=) |
| IL (1) | IL256544A (https=) |
| MX (1) | MX2018000071A (https=) |
| RU (1) | RU2018103234A (https=) |
| WO (1) | WO2017004388A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102684690B1 (ko) | 2015-03-03 | 2024-07-15 | 리젠츠 오브 더 유니버시티 오브 미네소타 | Etv2 및 그의 용도 |
| WO2017004388A1 (en) | 2015-06-30 | 2017-01-05 | Regents Of The University Of Minnesota | Humanized heart muscle |
| RU2018103093A (ru) | 2015-06-30 | 2019-07-31 | Реджентс Оф Зэ Юниверсити Оф Миннесота | Гуманизированная скелетная мышца |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1997025412A1 (en) * | 1996-01-09 | 1997-07-17 | The Regents Of The University Of California | Ungulate embryonic stem-like cells, methods of making and using the cells to produce transgenic ungulates |
| US5994619A (en) * | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) * | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
| US20050039222A1 (en) | 2001-10-24 | 2005-02-17 | Kiyoshi Habu | Sgrf gene-modified non-human animals |
| US20040133931A1 (en) | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| US20050125853A1 (en) | 2002-03-22 | 2005-06-09 | St. Jude Children's Resarch Hospital | Method for generating genetically modified animals |
| CA2488725A1 (en) * | 2002-07-03 | 2004-01-15 | Su Qian | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| GB2398784B (en) * | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| US20060008451A1 (en) | 2004-07-06 | 2006-01-12 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| JP5425641B2 (ja) | 2007-01-11 | 2014-02-26 | ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション | 尿路病状の処置のための筋由来細胞ならびにその作製および使用の方法 |
| US20100107263A1 (en) | 2007-01-20 | 2010-04-29 | Boehringer Ingelheim International Gmbh & Co., Kg | C-reactive protein (crp) knockout mouse |
| JPWO2008102602A1 (ja) * | 2007-02-22 | 2010-05-27 | 国立大学法人 東京大学 | Ｂｌａｓｔｏｃｙｓｔｃｏｍｐｌｅｍｅｎｔａｔｉｏｎを利用した臓器再生法 |
| JP5688788B2 (ja) | 2008-02-22 | 2015-03-25 | 国立大学法人 東京大学 | 遺伝子改変による致死性表現型を持つ動物の繁殖用ファウンダー動物作製法 |
| GB2490443B8 (en) | 2008-08-22 | 2014-08-13 | Univ Tokyo | Organ regeneration method utilizing iPS cell and blastocyst complementation |
| WO2010108126A2 (en) | 2009-03-19 | 2010-09-23 | Fate Therapeutics, Inc. | Reprogramming compositions and methods of using the same |
| CA2762584A1 (en) * | 2009-05-20 | 2010-11-25 | Cardio3 Biosciences S.A. | Pharmaceutical composition for the treatment of heart diseases |
| AU2012249390B2 (en) | 2011-04-27 | 2017-03-30 | Amyris, Inc. | Methods for genomic modification |
| AU2012262139B2 (en) * | 2011-06-02 | 2017-02-23 | Children's Medical Center Corporation | Methods and uses for ex vivo tissue culture systems |
| US9862929B2 (en) | 2011-11-18 | 2018-01-09 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| BR112016024945A2 (pt) | 2014-04-28 | 2017-10-24 | Recombinetics Inc | edição de gene multiplex em suínos |
| KR102684690B1 (ko) | 2015-03-03 | 2024-07-15 | 리젠츠 오브 더 유니버시티 오브 미네소타 | Etv2 및 그의 용도 |
| RU2018103093A (ru) | 2015-06-30 | 2019-07-31 | Реджентс Оф Зэ Юниверсити Оф Миннесота | Гуманизированная скелетная мышца |
| WO2017004388A1 (en) | 2015-06-30 | 2017-01-05 | Regents Of The University Of Minnesota | Humanized heart muscle |
| EP3367785A4 (en) | 2015-10-27 | 2019-08-14 | Regents of the University of Minnesota | COMPOSITIONS AND METHODS FOR CHIMERIC EMBRYO-ASSISTED ORGAN PRODUCTION |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
-
2016
- 2016-06-30 WO PCT/US2016/040431 patent/WO2017004388A1/en not_active Ceased
- 2016-06-30 KR KR1020187002387A patent/KR20180021135A/ko not_active Ceased
- 2016-06-30 CN CN201680050242.9A patent/CN108472318A/zh active Pending
- 2016-06-30 BR BR112017028608A patent/BR112017028608A2/pt not_active Application Discontinuation
- 2016-06-30 RU RU2018103234A patent/RU2018103234A/ru not_active Application Discontinuation
- 2016-06-30 MX MX2018000071A patent/MX2018000071A/es unknown
- 2016-06-30 EP EP16818799.5A patent/EP3316899A4/en not_active Withdrawn
- 2016-06-30 AU AU2016288671A patent/AU2016288671A1/en not_active Abandoned
- 2016-06-30 US US15/739,066 patent/US10897880B2/en active Active
- 2016-06-30 CA CA2991056A patent/CA2991056A1/en not_active Abandoned
- 2016-06-30 JP JP2017568252A patent/JP2018523999A/ja active Pending
-
2017
- 2017-12-25 IL IL256544A patent/IL256544A/en unknown
-
2018
- 2018-01-29 CO CONC2018/0000859A patent/CO2018000859A2/es unknown
-
2020
- 2020-12-11 US US17/118,981 patent/US20210169054A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| IL256544A (en) | 2018-02-28 |
| KR20180021135A (ko) | 2018-02-28 |
| JP2018523999A (ja) | 2018-08-30 |
| CA2991056A1 (en) | 2017-01-05 |
| AU2016288671A1 (en) | 2018-02-01 |
| BR112017028608A2 (pt) | 2018-09-04 |
| US10897880B2 (en) | 2021-01-26 |
| US20180177165A1 (en) | 2018-06-28 |
| RU2018103234A (ru) | 2019-07-31 |
| CN108472318A (zh) | 2018-08-31 |
| EP3316899A1 (en) | 2018-05-09 |
| WO2017004388A1 (en) | 2017-01-05 |
| CO2018000859A2 (es) | 2018-07-10 |
| US20210169054A1 (en) | 2021-06-10 |
| EP3316899A4 (en) | 2019-04-03 |
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