MX2016000020A - Estructura de nanoparticula del tipo oligonucleotido mejorada que tiene alta eficiencia y metodo para preparar la misma. - Google Patents

Estructura de nanoparticula del tipo oligonucleotido mejorada que tiene alta eficiencia y metodo para preparar la misma.

Info

Publication number
MX2016000020A
MX2016000020A MX2016000020A MX2016000020A MX2016000020A MX 2016000020 A MX2016000020 A MX 2016000020A MX 2016000020 A MX2016000020 A MX 2016000020A MX 2016000020 A MX2016000020 A MX 2016000020A MX 2016000020 A MX2016000020 A MX 2016000020A
Authority
MX
Mexico
Prior art keywords
oligonucleotide
oligonucleotide structure
preparing
linked
same
Prior art date
Application number
MX2016000020A
Other languages
English (en)
Inventor
CHAE Jeiwook
Oh Park Han
Oh Yoon Pyoung
Han Boram
Eun CHOI Gi-
KO Youngho
Kwon Taewoo
Don LEE Jae
Gi KIM Sun
Original Assignee
Bioneer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioneer Corp filed Critical Bioneer Corp
Publication of MX2016000020A publication Critical patent/MX2016000020A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
    • A61K47/6929—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle
    • A61K47/6931—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer
    • A61K47/6935—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores the form being a nanoparticle, e.g. an immuno-nanoparticle the material constituting the nanoparticle being a polymer the polymer being obtained otherwise than by reactions involving carbon to carbon unsaturated bonds, e.g. polyesters, polyamides or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/111—General methods applicable to biologically active non-coding nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/35—Nature of the modification
    • C12N2310/351—Conjugate
    • C12N2310/3515—Lipophilic moiety, e.g. cholesterol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/32—Special delivery means, e.g. tissue-specific
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2330/00—Production
    • C12N2330/30—Production chemically synthesised
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Optics & Photonics (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Abstract

La presente invención se refiere a una estructura oligonucleótida y un método para la preparación de la misma, y más particularmente, a una estructura orgánica pligonucleótida en la que un compuesto polimérico se una a un oligonucleótido por medio de un enlace covalente para mejorar la estabilidad in vivo del oligonucleótido y la eficiencia de la entrega celular del oligonucleótido; y a un método para preparar el mismo. La estructura oligonucleótida es mejorada en un metal homogéneo, por lo tanto, se resuelve el problema en la verificación del material debido a las características de polidispersión que ocurre cuando el material hidrofilico unido al oligonucleótido es un polímero sintético, la estructura oligonucleótida es fácil de sintetizar comparado con el proceso existente; y el tamaño de una estructura oligo ARN bicatenario se puede ajustar de manera segura a través del control de repetición de un bloque de material hidrofilico, y de este modo, la función de regulación de la expresión del gen del oligonucleótido no se deteriora a través de la síntesis de la estructura oligonucleótida optimizada, y el oligonucleótido se puede entregar en celular incluso en una dosis dem baja concentración. Por lo tanto, la estructura oligonucléotida de la presente invención puede ser útil como un sistema de entrega del oligonucleótido del tipo novedoso, así como también una herrramienta para el tratamiento de canceres, enfermedades infecciosas y similares.
MX2016000020A 2013-07-05 2014-07-04 Estructura de nanoparticula del tipo oligonucleotido mejorada que tiene alta eficiencia y metodo para preparar la misma. MX2016000020A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20130079309 2013-07-05
PCT/KR2014/006031 WO2015002511A1 (ko) 2013-07-05 2014-07-04 개선된 고효율 나노입자형 올리고뉴클레오타이드 구조체 및 그의 제조방법

Publications (1)

Publication Number Publication Date
MX2016000020A true MX2016000020A (es) 2016-08-18

Family

ID=52144016

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016000020A MX2016000020A (es) 2013-07-05 2014-07-04 Estructura de nanoparticula del tipo oligonucleotido mejorada que tiene alta eficiencia y metodo para preparar la misma.

Country Status (13)

Country Link
US (1) US10030243B2 (es)
EP (1) EP3018208B1 (es)
JP (1) JP6422961B2 (es)
KR (1) KR101862349B1 (es)
CN (1) CN105705638B (es)
AU (1) AU2014284834B2 (es)
BR (1) BR112016000160B1 (es)
CA (1) CA2917299C (es)
ES (1) ES2809481T3 (es)
MX (1) MX2016000020A (es)
PL (1) PL3018208T3 (es)
RU (1) RU2670164C2 (es)
WO (1) WO2015002511A1 (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USD800850S1 (en) 2016-03-24 2017-10-24 Judy Janke Female doll
USD800848S1 (en) 2016-03-24 2017-10-24 Judy Janke Male doll
KR101861738B1 (ko) * 2016-08-24 2018-05-29 (주)바이오니아 마이크로 rna를 포함하는 이중나선 올리고 rna 구조체
KR102473989B1 (ko) * 2018-11-28 2022-12-07 (주)바이오니아 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물
WO2020149644A1 (ko) * 2019-01-15 2020-07-23 (주)바이오니아 Dkk1 유전자를 표적으로 하는 이중나선 올리고뉴클레오티드, 이를 포함하는 구조체 및 이를 포함하는 탈모 예방 또는 발모용 조성물
KR102376945B1 (ko) * 2019-12-19 2022-03-21 상지대학교산학협력단 파킨슨병용 약제학적 조성물 및 그 치료제
EP3896160A1 (en) * 2020-04-17 2021-10-20 Bia Separations D.O.O. A method of single-stranded rna purification
EP4225326A1 (en) * 2020-10-12 2023-08-16 The Regents of the University of California Endosomal escape domains for delivery of macromolecules into cells
CA3206861A1 (en) 2021-02-25 2022-09-01 Han-Oh Park Composition for alleviating hair graying, promoting hair growth and/or preventing or alleviating hair loss, comprising double-stranded mirna as active ingredient
CN117677402A (zh) 2021-03-08 2024-03-08 柏业公司 用于使用超声雾化器施用用于预防或治疗包括covid-19的呼吸道病毒感染、由病毒感染引起的肺纤维化或呼吸道疾病的双链寡核苷酸结构的组合物
WO2024206870A1 (en) * 2023-03-29 2024-10-03 Sir Nagen Therapeutics Incorporated Dna-rna heteroduplex targeting androgen receptor

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6005087A (en) 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US5660985A (en) 1990-06-11 1997-08-26 Nexstar Pharmaceuticals, Inc. High affinity nucleic acid ligands containing modified nucleotides
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
AU6554594A (en) 1993-04-02 1994-10-24 Anticancer, Inc. Method for delivering beneficial compositions to hair follicles
US6277967B1 (en) 1998-07-14 2001-08-21 Isis Pharmaceuticals, Inc. Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
US6175001B1 (en) 1998-10-16 2001-01-16 The Scripps Research Institute Functionalized pyrimidine nucleosides and nucleotides and DNA's incorporating same
US20030224353A1 (en) 2001-10-16 2003-12-04 Stein David A. Antisense antiviral agent and method for treating ssRNA viral infection
JP4903146B2 (ja) 2004-08-16 2012-03-28 イミューン ディズィーズ インスティテュート インコーポレイテッド Ｒｎａ干渉を送達する方法およびその使用法
AU2005292083A1 (en) 2004-09-29 2006-04-13 Alza Corporation Microparticles and nanoparticles containing a lipopolymer
TWI386225B (zh) 2004-12-23 2013-02-21 Alcon Inc 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術
CA2619533C (en) * 2005-08-17 2014-02-04 Bioneer Corporation Sirna-hydrophilic polymer conjugates for intracellular delivery of sirna and method thereof
US20090047338A1 (en) 2005-10-05 2009-02-19 Immune Disease Institute, Inc. Method to Treat Flavivirus Infection with siRNA
JP2009523823A (ja) 2006-01-23 2009-06-25 アボット・ラボラトリーズ ｓｉＲＮＡ送達のための化学的に修飾されたポリカチオンポリマー
EP2059597A2 (en) 2006-08-24 2009-05-20 Alcon Research, Ltd. Rnai-mediated inhibition of gremlin for treatment of iop-related conditions
JP2010507387A (ja) 2006-10-25 2010-03-11 クアーク・ファーマスーティカルス、インコーポレイテッド 新規のｓｉＲＮＡおよびその使用方法
JP2010515771A (ja) 2007-01-16 2010-05-13 プロテオロジクス リミテッド トポイソメラーゼインヒビターの治療効果を増強する方法
CA2702028A1 (en) * 2007-10-02 2009-04-09 Rxi Pharmaceuticals Corp. Tripartite rnai constructs
CA2708173C (en) * 2007-12-04 2016-02-02 Alnylam Pharmaceuticals, Inc. Targeting lipids
CA2740125A1 (en) 2008-10-09 2010-04-15 Northeastern University Multifunctional self-assembling polymeric nanosystems
ES2931174T3 (es) 2009-03-20 2022-12-27 Egen Inc Derivados de poliamina
KR101224828B1 (ko) * 2009-05-14 2013-01-22 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법
US8569256B2 (en) 2009-07-01 2013-10-29 Protiva Biotherapeutics, Inc. Cationic lipids and methods for the delivery of therapeutic agents
WO2011054939A2 (en) 2009-11-09 2011-05-12 F. Hoffmann-La Roche Ag Compositions and methods for inhibiting expression of kif10 genes
US20110206617A1 (en) 2010-02-22 2011-08-25 Krishnendu Roy Modified polysaccharides for drug and contrast agent delivery
RU2466188C2 (ru) * 2010-11-08 2012-11-10 Российская Федерация, от имени которой выступает Министерство образования и науки Ингибитор репродукции вируса гриппа а на основе комплекса наночастиц диоксида титана и олигонуклеотида
US9328347B2 (en) 2011-07-18 2016-05-03 Oregon Health & Science University siRNA useful in the treatment of flavivirus infection
PL2736887T3 (pl) 2011-07-29 2018-03-30 Karyopharm Therapeutics, Inc. Modulatory transportu jądrowego zawierające ugrupowanie hydrazydu i ich zastosowania
DK2751270T3 (en) * 2011-08-29 2018-10-29 Ionis Pharmaceuticals Inc OLIGOMER-CONJUGATE COMPLEXES AND THEIR USE
PL3597644T3 (pl) 2011-10-18 2022-01-17 Dicerna Pharmaceuticals, Inc. Aminowe lipidy kationowe i ich zastosowania
EP2796150B1 (en) * 2011-12-15 2021-02-24 Bioneer Corporation Novel oligonucleotide conjugates and use thereof
KR20130068032A (ko) * 2011-12-15 2013-06-25 (주)바이오니아 안정한 안티센스 올리고뉴클레오티드 접합체 및 그 제조방법
BR112014016562B1 (pt) 2012-01-05 2021-08-10 Bioneer Corporation Estrutura de oligo-rna de dupla hélice, nanopartícula e método de preparação
KR101392973B1 (ko) 2012-10-15 2014-05-09 (주)바이오니아 ｓｉＲＮＡ 접합체 및 그 제조방법

Also Published As

Publication number Publication date
PL3018208T3 (pl) 2020-09-21
RU2016103738A (ru) 2017-08-10
CA2917299A1 (en) 2015-01-08
EP3018208A4 (en) 2017-03-08
KR101862349B1 (ko) 2018-05-31
AU2014284834B2 (en) 2017-06-08
JP2016530875A (ja) 2016-10-06
EP3018208B1 (en) 2020-05-27
US20170152512A1 (en) 2017-06-01
CA2917299C (en) 2020-07-21
CN105705638B (zh) 2019-11-26
BR112016000160B1 (pt) 2021-06-08
KR20160039607A (ko) 2016-04-11
JP6422961B2 (ja) 2018-11-14
RU2670164C2 (ru) 2018-10-18
WO2015002511A1 (ko) 2015-01-08
CN105705638A (zh) 2016-06-22
EP3018208A1 (en) 2016-05-11
AU2014284834A1 (en) 2016-02-18
US10030243B2 (en) 2018-07-24
ES2809481T3 (es) 2021-03-04

Similar Documents

Publication Publication Date Title
MX2016000020A (es) Estructura de nanoparticula del tipo oligonucleotido mejorada que tiene alta eficiencia y metodo para preparar la misma.
MX2021006932A (es) Receptores de celulas t humanas con alta afinidad modificados por medio de manipulacion genetica.
MX2015013118A (es) Composiciones y métodos para la producción y administración de ácido ribonucleico.
MX354618B (es) Sistema de nanopartículas nts-poliplex para terapia génica de cáncer.
WO2014186585A3 (en) Methods and compositions for treatment of a genetic condition
MX2019006379A (es) Induccion de gen de trail de molecula pequeña en celulas normales y tumorales como una terapia anticancer.
MX364229B (es) Composiciones y metodos para tratar enfermedades cardiovasculares.
FR2981643B1 (fr) Procede de preparation d'un materiau composite silicium/carbone, materiau ainsi prepare, et electrode notamment electrode negative, comprenant ce materiau.
MX2013004353A (es) Produccion recombinante de n-propanol e isopropanol.
SG10201810928SA (en) Novel antitumoral use of cabazitaxel
EP3009454A3 (en) Antibodies specific to cadherin-17
MY150559A (en) New core shell particle multistage polymer powder, its manufacturing process and composition comprising it
WO2013120038A3 (en) Morpholino targeting dux4 for treating fshd
BR112016013845A2 (pt) Métodos de perfilagem de epítopos de células t, produção de composições de células t e tratamento de doenças
MX2015011781A (es) Medio de cultivo celular y metodos de produccion de anticuerpos.
WO2012151016A3 (en) Low pour point renewable fuel blend
SG10201806064XA (en) Anti-tumor compositions and methods
MX2018008448A (es) Reducción de especies de alto peso molecular, especies con carga ácida, y fragmentos en una composición de anticuerpo monoclonal.
WO2014203189A9 (en) Nanocarrier system for micrornas and uses thereof
MX2022007279A (es) Metodos y materiales para producir productos metanogenicos identificables.
EA201591014A1 (ru) Способ получения сополимеров пропилена
EA201590170A1 (ru) Биосинтетический ген uk-2 и способ улучшения продуктивности uk-2 с использованием такого гена
WO2012177565A3 (en) Regulation of macrophage activation using mir - 125b
MX2017014841A (es) Proceso para preparar compuestos basados en platino supramoleculares.
IN2015KN00569A (es)