MX2015013312A - Composiciones y metodos para producir cetosis elevada y sostenida. - Google Patents
Composiciones y metodos para producir cetosis elevada y sostenida.Info
- Publication number
- MX2015013312A MX2015013312A MX2015013312A MX2015013312A MX2015013312A MX 2015013312 A MX2015013312 A MX 2015013312A MX 2015013312 A MX2015013312 A MX 2015013312A MX 2015013312 A MX2015013312 A MX 2015013312A MX 2015013312 A MX2015013312 A MX 2015013312A
- Authority
- MX
- Mexico
- Prior art keywords
- ketosis
- blood
- medium chain
- dietary restriction
- initiating
- Prior art date
Links
- 208000007976 Ketosis Diseases 0.000 title abstract 4
- 230000004140 ketosis Effects 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title 1
- 230000002459 sustained effect Effects 0.000 title 1
- 239000008280 blood Substances 0.000 abstract 3
- 210000004369 blood Anatomy 0.000 abstract 3
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 2
- 235000020805 dietary restrictions Nutrition 0.000 abstract 2
- 239000008103 glucose Substances 0.000 abstract 2
- 230000000977 initiatory effect Effects 0.000 abstract 2
- 150000002576 ketones Chemical class 0.000 abstract 2
- WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 abstract 1
- 206010022489 Insulin Resistance Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000020887 ketogenic diet Nutrition 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 150000004667 medium chain fatty acids Chemical class 0.000 abstract 1
- 229940057917 medium chain triglycerides Drugs 0.000 abstract 1
- 230000002503 metabolic effect Effects 0.000 abstract 1
- 229940059579 mineral salts in combination Drugs 0.000 abstract 1
- 230000036314 physical performance Effects 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 239000013589 supplement Substances 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
- 230000004580 weight loss Effects 0.000 abstract 1
- 208000016261 weight loss Diseases 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Diabetes (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Child & Adolescent Psychology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Las sales minerales de beta-hidroxibutirato en combinación con ácidos grasos de cadena media o un éster de los mismos tales como triglicéridos de cadena media, se utilizaron para inducir cetosis, alcanzando niveles de cetona en sangre de (2-7 mmol/L), con o sin restricción alimenticia. La combinación da por resultado en mejoras sustanciales en los biomarcadores metabólicos con relación a la resistencia a insulina, diabetes, pérdida de peso y desempeño físico en un período de tiempo corto. Además, el uso de estos suplementos para alcanzar la cetosis proporciona una elevación significativa de cetonas en sangre y la reducción de niveles de glucosa en sangre. El uso de estas sustancias no afecta adversamente los perfiles lipídicos. Al iniciar una cetosis rápida y al acelerar la velocidad de ceto-adaptación, esta invención es útil para evitar los síntomas de retiro de glucosa experimentados comúnmente por individuos que inician una dieta cetogénica, y reduce al mínimo la pérdida de masa corporal magra durante una restricción alimenticia.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361803203P | 2013-03-19 | 2013-03-19 | |
| US201461926664P | 2014-01-13 | 2014-01-13 | |
| PCT/US2014/031237 WO2014153416A1 (en) | 2013-03-19 | 2014-03-19 | Compositions and methods for producing elevated and sustained ketosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015013312A true MX2015013312A (es) | 2016-06-07 |
| MX371259B MX371259B (es) | 2020-01-23 |
Family
ID=51581503
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015013312A MX371259B (es) | 2013-03-19 | 2014-03-19 | Composiciones y métodos para producir cetosis elevada y sostenida. |
| MX2019010248A MX2019010248A (es) | 2013-03-19 | 2015-09-17 | Composiciones y metodos para producir cetosis elevada y sostenida. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019010248A MX2019010248A (es) | 2013-03-19 | 2015-09-17 | Composiciones y metodos para producir cetosis elevada y sostenida. |
Country Status (21)
| Country | Link |
|---|---|
| US (4) | US9138420B2 (es) |
| EP (1) | EP2976073B1 (es) |
| JP (2) | JP6491189B2 (es) |
| KR (2) | KR20150130312A (es) |
| CN (1) | CN105050594B (es) |
| AU (2) | AU2014236004B2 (es) |
| BR (1) | BR112015024186B1 (es) |
| CA (1) | CA2902603C (es) |
| CL (2) | CL2015002802A1 (es) |
| CR (1) | CR20150579A (es) |
| HK (1) | HK1216847A1 (es) |
| IL (2) | IL241316B (es) |
| MX (2) | MX371259B (es) |
| MY (1) | MY180761A (es) |
| NZ (1) | NZ711433A (es) |
| PE (1) | PE20151949A1 (es) |
| PH (1) | PH12015501966B1 (es) |
| RU (2) | RU2659386C2 (es) |
| SG (2) | SG10201808690PA (es) |
| WO (1) | WO2014153416A1 (es) |
| ZA (1) | ZA201506387B (es) |
Families Citing this family (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2670413T3 (es) | 2003-06-03 | 2018-05-30 | The United States Government As Represented By The Department Of Health And Human Services | Suplementos nutricionales y composiciones terapéuticas que comprenden derivados de (R)-3-hidroxibutirato |
| US8642654B2 (en) | 2009-04-16 | 2014-02-04 | Isis Innovation Limited | Hydroxybutyrate ester and medical use thereof |
| JP6883384B2 (ja) | 2012-11-05 | 2021-06-09 | ザ ユナイテッド ステイツ オブ アメリカ， アズ リプレゼンテッド バイ ザ セクレタリー， デパートメント オブ ヘルス アンド ヒューマン サービシーズ | 電離放射線による傷害から組織を防護するためのケトン体 |
| GB201304467D0 (en) | 2013-03-12 | 2013-04-24 | Tdeltas Ltd | Compound for use in protecting skin |
| GB2515603B (en) | 2013-03-14 | 2015-10-14 | Isis Innovation | Process for producing (R)-3-Hydroxybutyl (R)-3-Hydroxybutyrate |
| CN105377252A (zh) | 2013-03-14 | 2016-03-02 | 佛罗里达大学研究基金会 | 利用天然化合物和/或饮食调控癌症 |
| GB201314127D0 (en) * | 2013-08-07 | 2013-09-18 | Tdeltas Ltd | Ketone body and ketone body ester for reducing muscle breakdown |
| CA2944479C (en) | 2014-04-02 | 2023-02-21 | University Of Southern California | Dietary formulation and method for treating autoimmune and inflammatory diseases |
| US11020372B2 (en) | 2015-03-24 | 2021-06-01 | University Of Florida Research Foundation, Incorporated | Dietary and natural product management of negative side effects of cancer treatment |
| KR20180014194A (ko) * | 2015-06-26 | 2018-02-07 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 천연 화합물 및/또는 식단을 사용하는 염증의 치료 방법 |
| US10987340B2 (en) | 2015-07-24 | 2021-04-27 | Jesse Alexander Galinski | Composition and method for rapidly inducing an endogenous ketosis |
| US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
| US10245242B1 (en) * | 2017-11-22 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10596130B2 (en) | 2017-12-19 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
| US10292952B2 (en) * | 2016-03-11 | 2019-05-21 | Axcess Global Sciences, Llc | Mixed salt compositions for maintaining or restoring electrolyte balance while producing elevated and sustained ketosis |
| US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
| US10245243B1 (en) * | 2017-12-19 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
| US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
| US10596129B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10596131B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
| US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
| US20170266147A1 (en) * | 2016-03-18 | 2017-09-21 | Csilla Ari D'Agostino | Methods of increasing latency of anesthetic induction using ketone supplementation |
| EP3463320A4 (en) * | 2016-03-21 | 2019-12-25 | University of South Florida | METHODS FOR IMPROVING MOTOR FUNCTION BY KETONE SUPPLEMENTATION |
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| JP6935994B2 (ja) * | 2016-08-19 | 2021-09-15 | 株式会社明治 | ケトン体生成促進用組成物 |
| US20180057846A1 (en) | 2016-08-30 | 2018-03-01 | KetoneAid Inc. | Partially buffered free acid and/or ketone blend for rapid onset ketosis and metabolic therapy |
| CA3036516A1 (en) * | 2016-09-13 | 2018-03-22 | Abbott Laboratories | Ketogenic nutritional compositions |
| AU2017347778A1 (en) * | 2016-10-24 | 2019-05-16 | University Of South Florida | Delaying latency to seizure by combinations of ketone supplements |
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| US11596616B2 (en) | 2017-12-12 | 2023-03-07 | University Of South Florida | Compositions and methods for weight loss maintenance |
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