BRPI0811052A2 - Composições de proteção de isquemia/reperfusão e métodos de uso. - Google Patents
Composições de proteção de isquemia/reperfusão e métodos de uso.Info
- Publication number
- BRPI0811052A2 BRPI0811052A2 BRPI0811052-2A2A BRPI0811052A BRPI0811052A2 BR PI0811052 A2 BRPI0811052 A2 BR PI0811052A2 BR PI0811052 A BRPI0811052 A BR PI0811052A BR PI0811052 A2 BRPI0811052 A2 BR PI0811052A2
- Authority
- BR
- Brazil
- Prior art keywords
- ischemia
- methods
- protection compositions
- reperfusion protection
- reperfusion
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A61K31/4045—Indole-alkylamines; Amides thereof, e.g. serotonin, melatonin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US91146007P | 2007-04-12 | 2007-04-12 | |
US2632108P | 2008-02-05 | 2008-02-05 | |
PCT/US2008/060100 WO2008128095A1 (en) | 2007-04-12 | 2008-04-11 | Ischemia/reperfusion protection compositions and methods of using |
Publications (1)
Publication Number | Publication Date |
---|---|
BRPI0811052A2 true BRPI0811052A2 (pt) | 2015-01-27 |
Family
ID=42269849
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0811052-2A2A BRPI0811052A2 (pt) | 2007-04-12 | 2008-04-11 | Composições de proteção de isquemia/reperfusão e métodos de uso. |
Country Status (12)
Country | Link |
---|---|
US (4) | US9186340B2 (pt) |
EP (1) | EP2146711A4 (pt) |
JP (1) | JP2010523714A (pt) |
KR (1) | KR20100016456A (pt) |
CN (1) | CN101677996A (pt) |
AU (1) | AU2008240211A1 (pt) |
BR (1) | BRPI0811052A2 (pt) |
CA (1) | CA2684213A1 (pt) |
IL (1) | IL201406A0 (pt) |
MX (1) | MX2009011002A (pt) |
RU (1) | RU2459624C2 (pt) |
WO (1) | WO2008128095A1 (pt) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2146711A4 (en) | 2007-04-12 | 2011-10-26 | Univ Minnesota | PROTECTIVE COMPOSITIONS AGAINST ISCHEMIA / REPERFUSION AND METHODS OF USE |
SG10201502029RA (en) * | 2010-04-08 | 2015-05-28 | Hospital For Sick Children | Use of remote ischemic conditioning for traumatic injury |
NL2004569C2 (en) * | 2010-04-16 | 2011-10-18 | Angteq B V | Compounds for prevention of cell injury. |
US9532952B2 (en) | 2011-01-28 | 2017-01-03 | Physician's Seal, LLC | Controlled-release compositions of melatonin combined with sedative and/or analgesic ingredients |
WO2012103411A2 (en) | 2011-01-28 | 2012-08-02 | Zx Pharma, Llc | Controlled-release melatonin composition and related methods |
US10531655B2 (en) | 2011-12-02 | 2020-01-14 | The Regents Of The University Of California | Reperfusion protection solution and uses thereof |
RU2488388C1 (ru) | 2012-05-24 | 2013-07-27 | Ооо "Валента Интеллект" | Фармацевтическая композиция для профилактики и лечения психических, поведенческих, когнитивных расстройств |
ITMI20120913A1 (it) * | 2012-05-28 | 2013-11-29 | Nicoletta Maxia | Uso della n-acetil-5-metossitriptamina o suoi analoghi per favorire il meccanismo di impianto dell' embrione, e relative composizioni e mezzi di coltura |
UA107653U (uk) | 2012-10-01 | 2016-06-24 | Общєство С Огранічєнной Отвєтствєнностью "Валєнта-Інтєллєкт" | Композиція лікарських засобів для лікування та профілактики поведінкових, психічних та когнітивних розладів |
WO2014153416A1 (en) | 2013-03-19 | 2014-09-25 | University Of South Florida | Compositions and methods for producing elevated and sustained ketosis |
CN104208059A (zh) * | 2014-09-05 | 2014-12-17 | 中国医学科学院北京协和医院 | 褪黑素在制备保护吸烟引起血管损伤药物中的应用 |
US10596129B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
US10596131B2 (en) | 2017-11-22 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
US10736861B2 (en) | 2016-03-11 | 2020-08-11 | Axcess Global Sciences, Llc | Mixed salt compositions for producing elevated and sustained ketosis |
US10973792B2 (en) | 2019-02-13 | 2021-04-13 | Axcess Global Sciences, Llc | Racemic beta-hydroxybutyrate mixed salt-acid compositions and methods of use |
US10292952B2 (en) | 2016-03-11 | 2019-05-21 | Axcess Global Sciences, Llc | Mixed salt compositions for maintaining or restoring electrolyte balance while producing elevated and sustained ketosis |
US11241403B2 (en) | 2016-03-11 | 2022-02-08 | Axcess Global Sciences, Llc | Beta-hydroxybutyrate mixed salt compositions and methods of use |
US10973786B2 (en) | 2016-03-11 | 2021-04-13 | Axcess Global Sciences, Llc | R-beta-hydroxybutyrate, S-beta-hydroxybutyrate, and RS-beta-hydroxybutyrate mixed salt compositions |
US10245243B1 (en) | 2017-12-19 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
US10245242B1 (en) | 2017-11-22 | 2019-04-02 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
US10596130B2 (en) | 2017-12-19 | 2020-03-24 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the S-enantiomer and methods of use |
US11103470B2 (en) | 2017-11-22 | 2021-08-31 | Axcess Global Sciences, Llc | Non-racemic beta-hydroxybutyrate compounds and compositions enriched with the R-enantiomer and methods of use |
US11185518B2 (en) | 2017-12-19 | 2021-11-30 | Axcess Global Sciences, Llc | S-beta-hydroxybutyrate compounds and compositions enriched with S-enantiomer |
US20170266147A1 (en) * | 2016-03-18 | 2017-09-21 | Csilla Ari D'Agostino | Methods of increasing latency of anesthetic induction using ketone supplementation |
AU2017238103A1 (en) * | 2016-03-21 | 2018-11-22 | University Of South Florida | Methods of improving motor function using ketone supplementation |
AU2017322708A1 (en) * | 2016-09-12 | 2019-03-21 | University Of South Florida | Neuroregeneration improved by ketone |
US10307398B2 (en) | 2016-09-20 | 2019-06-04 | Regents Of The University Of Minnesota | Resuscitation composition and methods of making and using |
US9925164B1 (en) | 2017-01-12 | 2018-03-27 | Neuroenergy Ventures, Inc. | Glyceryl 3-hydroxybutyrates for traumatic brain injury |
EP3595628B1 (en) * | 2017-03-16 | 2021-12-01 | RepoCeuticals A/S | Compositions for retarding the decomposition of melatonin in solution |
EP3609484A4 (en) * | 2017-04-12 | 2020-12-16 | Cavaleri, Franco | BUTYRATE AND BETA HYDROXYBUTYRATE COMPOSITIONS AND METHODS FOR THEIR USE |
CN110891982B (zh) | 2017-04-17 | 2023-12-22 | 芝加哥大学 | 向肠道递送短链脂肪酸以用于人体保健和疾病治疗的聚合物材料 |
US10179095B2 (en) * | 2017-06-07 | 2019-01-15 | Dr. Raymond Laboratories | Autophage activating resveratrol topical composition for skin improvement and treatment |
US11202769B2 (en) | 2017-11-22 | 2021-12-21 | Axcess Global Sciences, Llc | Ketone body esters of s-beta-hydroxybutyrate and/or s-1,3-butanediol for modifying metabolic function |
US10925843B2 (en) | 2018-04-18 | 2021-02-23 | Axcess Global Sciences, Llc | Compositions and methods for keto stacking with beta-hydroxybutyrate and acetoacetate |
US11944598B2 (en) | 2017-12-19 | 2024-04-02 | Axcess Global Sciences, Llc | Compositions containing s-beta-hydroxybutyrate or non-racemic mixtures enriched with the s-enatiomer |
US11806324B2 (en) | 2018-04-18 | 2023-11-07 | Axcess Global Sciences, Llc | Beta-hydroxybutyric acid compositions and methods for oral delivery of ketone bodies |
US10512615B1 (en) | 2018-08-27 | 2019-12-24 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
US11241401B2 (en) | 2020-02-06 | 2022-02-08 | Axcess Global Sciences, Llc | Enantiomerically pure r-beta-hydroxybutyrate mixed salt-acid compositions |
US11419836B2 (en) | 2019-02-13 | 2022-08-23 | Axcess Global Sciences, Llc | Racemic and near racemic beta-hydroxybutyrate mixed salt-acid compositions |
US10980772B2 (en) | 2018-08-27 | 2021-04-20 | Axcess Global Sciences, Llc | Compositions and methods for delivering tetrahydrocannabinol and ketone bodies |
US11129802B2 (en) | 2018-08-27 | 2021-09-28 | Axcess Global Sciences, Llc | Compositions and methods for delivering cannabidiol and ketone bodies |
AU2018260927B1 (en) * | 2018-05-25 | 2019-02-21 | Graham Sherard Baldwin | Methods and compositions for inhibiting a noxious insult |
JP2020125254A (ja) * | 2019-02-04 | 2020-08-20 | 株式会社協和 | 化粧料、紫外線に対する細胞保護剤、光老化防止剤 |
US20220288006A1 (en) | 2019-05-30 | 2022-09-15 | Neuroenergy Ventures, Inc. | Glyceryl tris (beta-hydroxybutyrate) and neuronal transient ischemic attacks |
US11033553B2 (en) | 2019-06-21 | 2021-06-15 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
US11950616B2 (en) | 2019-06-21 | 2024-04-09 | Axcess Global Sciences, Llc | Non-vasoconstricting energy-promoting compositions containing ketone bodies |
US20230277484A1 (en) * | 2022-03-04 | 2023-09-07 | Guardian Biosciences, LLC | Compositions and methods to promote brain health |
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GB0427145D0 (en) * | 2004-12-10 | 2005-01-12 | Ketocytonyx Inc | Compositions for use in surgery |
EP2146711A4 (en) | 2007-04-12 | 2011-10-26 | Univ Minnesota | PROTECTIVE COMPOSITIONS AGAINST ISCHEMIA / REPERFUSION AND METHODS OF USE |
-
2008
- 2008-04-11 EP EP08745661A patent/EP2146711A4/en not_active Withdrawn
- 2008-04-11 US US12/595,586 patent/US9186340B2/en active Active
- 2008-04-11 AU AU2008240211A patent/AU2008240211A1/en not_active Abandoned
- 2008-04-11 KR KR1020097023554A patent/KR20100016456A/ko not_active Application Discontinuation
- 2008-04-11 BR BRPI0811052-2A2A patent/BRPI0811052A2/pt not_active IP Right Cessation
- 2008-04-11 WO PCT/US2008/060100 patent/WO2008128095A1/en active Application Filing
- 2008-04-11 US US12/082,526 patent/US8728532B2/en active Active
- 2008-04-11 JP JP2010503249A patent/JP2010523714A/ja active Pending
- 2008-04-11 CA CA002684213A patent/CA2684213A1/en not_active Abandoned
- 2008-04-11 RU RU2009141713/15A patent/RU2459624C2/ru not_active IP Right Cessation
- 2008-04-11 MX MX2009011002A patent/MX2009011002A/es not_active Application Discontinuation
- 2008-04-11 CN CN200880016109A patent/CN101677996A/zh active Pending
-
2009
- 2009-10-11 IL IL201406A patent/IL201406A0/en unknown
-
2014
- 2014-04-24 US US14/260,377 patent/US9149450B2/en active Active
-
2015
- 2015-09-23 US US14/862,416 patent/US20160008325A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20110111049A1 (en) | 2011-05-12 |
JP2010523714A (ja) | 2010-07-15 |
US20140235690A1 (en) | 2014-08-21 |
US20100197758A1 (en) | 2010-08-05 |
US8728532B2 (en) | 2014-05-20 |
CA2684213A1 (en) | 2008-10-23 |
US9149450B2 (en) | 2015-10-06 |
MX2009011002A (es) | 2010-03-15 |
CN101677996A (zh) | 2010-03-24 |
IL201406A0 (en) | 2010-05-31 |
EP2146711A4 (en) | 2011-10-26 |
WO2008128095A1 (en) | 2008-10-23 |
US20160008325A1 (en) | 2016-01-14 |
RU2009141713A (ru) | 2011-05-20 |
KR20100016456A (ko) | 2010-02-12 |
RU2459624C2 (ru) | 2012-08-27 |
EP2146711A1 (en) | 2010-01-27 |
AU2008240211A1 (en) | 2008-10-23 |
US9186340B2 (en) | 2015-11-17 |
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