MX2015007714A - Agente terapeutico de direccionamiento a glipicano 3 (gpc3) que es administrado a pacientes para quienes la terapia con agentes terapeuticos de direccionamiento a gpc3 es eficaz. - Google Patents
Agente terapeutico de direccionamiento a glipicano 3 (gpc3) que es administrado a pacientes para quienes la terapia con agentes terapeuticos de direccionamiento a gpc3 es eficaz.Info
- Publication number
- MX2015007714A MX2015007714A MX2015007714A MX2015007714A MX2015007714A MX 2015007714 A MX2015007714 A MX 2015007714A MX 2015007714 A MX2015007714 A MX 2015007714A MX 2015007714 A MX2015007714 A MX 2015007714A MX 2015007714 A MX2015007714 A MX 2015007714A
- Authority
- MX
- Mexico
- Prior art keywords
- gpc3
- therapeutic agent
- targeted therapeutic
- agent therapy
- patient
- Prior art date
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57438—Specifically defined cancers of liver, pancreas or kidney
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4722—Proteoglycans, e.g. aggreccan
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Abstract
La presente invención describe un método para determinar la eficacia de la terapia con fármacos de direccionamiento a GPC3 contra el cáncer en un paciente antes del comienzo de la terapia con fármacos de direccionamiento a GPC3 para un paciente o para determinar la continuación de la terapia con fármacos de direccionamiento a GPC3 para un paciente, que incluye el monitoreo de una concentración de GPC3 libre en una muestra biológica aislada del paciente antes del comienzo de la terapia con fármacos de direccionamiento a GPC3 y/o en el paciente tratado con la terapia con fármacos de direccionamiento a GPC3, en donde cuando la concentración de GPC3 libre es un valor predeterminado, se determina la eficacia de la terapia con fármacos de direccionamiento a GPC3 o se determina la continuación de la terapia con fármacos de direccionamiento a GPC3. La presente invención describe además un fármaco de direccionamiento a GPC3 o una preparación que será administrada a su vez a un paciente para quien se ha determinado la eficacia de la terapia con fármacos de direccionamiento a GPC3 o se ha determinado la continuación de la terapia con fármacos de direccionamiento a GPC3.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012280304 | 2012-12-21 | ||
PCT/JP2013/007529 WO2014097648A1 (ja) | 2012-12-21 | 2013-12-24 | Gpc3標的治療剤療法が有効である患者に投与されるgpc3標的治療剤 |
Publications (1)
Publication Number | Publication Date |
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MX2015007714A true MX2015007714A (es) | 2015-09-07 |
Family
ID=50978006
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2015007714A MX2015007714A (es) | 2012-12-21 | 2013-12-24 | Agente terapeutico de direccionamiento a glipicano 3 (gpc3) que es administrado a pacientes para quienes la terapia con agentes terapeuticos de direccionamiento a gpc3 es eficaz. |
Country Status (15)
Country | Link |
---|---|
US (2) | US10782300B2 (es) |
EP (1) | EP2937697B1 (es) |
JP (2) | JP6359461B2 (es) |
KR (1) | KR102216345B1 (es) |
CN (2) | CN104871003B (es) |
AR (1) | AR094269A1 (es) |
AU (1) | AU2013365430B2 (es) |
CA (1) | CA2895333A1 (es) |
HK (1) | HK1208910A1 (es) |
IL (1) | IL239488B (es) |
MX (1) | MX2015007714A (es) |
RU (1) | RU2707882C2 (es) |
SG (2) | SG11201504604WA (es) |
TW (1) | TWI693073B (es) |
WO (1) | WO2014097648A1 (es) |
Families Citing this family (27)
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US20070087005A1 (en) | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
TWI693073B (zh) | 2012-12-21 | 2020-05-11 | 日商中外製藥股份有限公司 | 對gpc3標的治療劑療法為有效之患者投與的gpc3標的治療劑 |
SG11201609014TA (en) | 2014-05-08 | 2016-12-29 | Chugai Pharmaceutical Co Ltd | Gpc3 -targeting drug which is administered to patient responsive to gpc3-targeting drug therapy |
MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
TWI687434B (zh) | 2014-10-07 | 2020-03-11 | 日商賽多利克公司 | 使用來自hsp70之胜肽之用於治療或預防癌之醫藥組成物、免疫誘導劑、及抗原呈現細胞之製造方法 |
TW201636358A (zh) * | 2014-12-09 | 2016-10-16 | 腫瘤療法 科學股份有限公司 | 對於th1細胞之gpc3抗原決定位胜肽及含此之疫苗 |
RU2714117C2 (ru) * | 2015-03-09 | 2020-02-11 | Ситлимик Инк. | Пептид, полученный из gpc3, фармацевтическая композиция для лечения или предотвращения рака с его использованием, индуктор иммунитета и способ получения антиген-презентирующих клеток |
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WO2017002934A1 (ja) * | 2015-07-01 | 2017-01-05 | 中外製薬株式会社 | Gpc3標的治療剤が有効である患者に投与されるgpc3標的治療剤 |
CN106397593B (zh) * | 2015-08-03 | 2019-09-10 | 科济生物医药(上海)有限公司 | 抗磷脂酰肌醇蛋白多糖-3的抗体及其应用 |
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CA2720124C (en) | 2008-05-13 | 2015-07-21 | Genentech, Inc. | Analysis of antibody drug conjugates by bead-based affinity capture and mass spectrometry |
EP2420515A4 (en) * | 2009-04-16 | 2013-08-28 | Univ Tokyo | DIAGNOSIS AND TREATMENT OF CANCER USING ANTI-TMPRSS11E ANTIBODY |
JP2013509882A (ja) * | 2009-11-05 | 2013-03-21 | スローン − ケッタリング インスティチュート フォー キャンサー リサーチ | カテナ:漿液性癌幹細胞 |
CN102276721B (zh) | 2010-06-12 | 2013-12-25 | 上海市肿瘤研究所 | 一种用于肝癌血清学诊断的单克隆抗体及其用途 |
AU2011337704B2 (en) | 2010-11-30 | 2017-06-15 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
CN103596985B (zh) * | 2011-04-19 | 2016-06-08 | 美国政府(由卫生和人类服务部的部长所代表) | 对磷脂酰肌醇蛋白聚糖3特异的人单克隆抗体及其用途 |
WO2013070468A1 (en) | 2011-11-08 | 2013-05-16 | The Trustees Of The University Of Pennsylvania | Glypican-3-specific antibody and uses thereof |
EP2813568A4 (en) | 2012-02-09 | 2016-04-06 | Chugai Pharmaceutical Co Ltd | MODIFIED FC REGION OF ANTIBODY |
JP2015511702A (ja) | 2012-03-02 | 2015-04-20 | ロシュ グリクアート アーゲー | Adcc増強抗体を用いた癌治療のための予測バイオマーカー |
JP6494507B2 (ja) | 2012-06-01 | 2019-04-03 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | グリピカン−3に対する高親和性モノクローナル抗体およびその使用 |
CA2876916A1 (en) | 2012-06-18 | 2013-12-27 | National Cancer Center | Kit for diagnosing malignant melanoma |
TWI693073B (zh) | 2012-12-21 | 2020-05-11 | 日商中外製藥股份有限公司 | 對gpc3標的治療劑療法為有效之患者投與的gpc3標的治療劑 |
JP5876012B2 (ja) * | 2013-07-25 | 2016-03-02 | 株式会社スギノマシン | 継手 |
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2013
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- 2013-12-20 AR ARP130105015A patent/AR094269A1/es unknown
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- 2013-12-24 EP EP13864465.3A patent/EP2937697B1/en active Active
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US10782300B2 (en) | 2020-09-22 |
SG10201704963TA (en) | 2017-07-28 |
EP2937697A4 (en) | 2016-07-13 |
RU2015129697A (ru) | 2017-01-26 |
HK1208910A1 (en) | 2016-03-18 |
KR102216345B1 (ko) | 2021-02-17 |
US20150285806A1 (en) | 2015-10-08 |
KR20150096384A (ko) | 2015-08-24 |
SG11201504604WA (en) | 2015-07-30 |
AR094269A1 (es) | 2015-07-22 |
IL239488B (en) | 2020-08-31 |
NZ707774A (en) | 2020-10-30 |
EP2937697A1 (en) | 2015-10-28 |
CN111060687A (zh) | 2020-04-24 |
JPWO2014097648A1 (ja) | 2017-01-12 |
JP6359461B2 (ja) | 2018-07-18 |
CA2895333A1 (en) | 2014-06-26 |
EP2937697B1 (en) | 2019-07-03 |
US10451627B2 (en) | 2019-10-22 |
WO2014097648A1 (ja) | 2014-06-26 |
JP6484562B2 (ja) | 2019-03-13 |
TW201436805A (zh) | 2014-10-01 |
IL239488A0 (en) | 2015-08-31 |
RU2707882C2 (ru) | 2019-12-02 |
CN104871003A (zh) | 2015-08-26 |
AU2013365430B2 (en) | 2019-10-31 |
TWI693073B (zh) | 2020-05-11 |
US20170010270A1 (en) | 2017-01-12 |
AU2013365430A1 (en) | 2015-05-21 |
CN104871003B (zh) | 2019-12-20 |
JPWO2015097928A1 (ja) | 2017-03-23 |
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