ATE501436T1 - Verfahren zur untersuchung der reaktion auf eine behandlung mit einem monoklonalen antikörper - Google Patents
Verfahren zur untersuchung der reaktion auf eine behandlung mit einem monoklonalen antikörperInfo
- Publication number
- ATE501436T1 ATE501436T1 AT07825673T AT07825673T ATE501436T1 AT E501436 T1 ATE501436 T1 AT E501436T1 AT 07825673 T AT07825673 T AT 07825673T AT 07825673 T AT07825673 T AT 07825673T AT E501436 T1 ATE501436 T1 AT E501436T1
- Authority
- AT
- Austria
- Prior art keywords
- monoclonal antibody
- cells
- response
- treatment
- steps
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 210000000822 natural killer cell Anatomy 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 2
- 230000003834 intracellular effect Effects 0.000 abstract 2
- 102000004127 Cytokines Human genes 0.000 abstract 1
- 108090000695 Cytokines Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 238000002474 experimental method Methods 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000011534 incubation Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000013641 positive control Substances 0.000 abstract 1
- 238000003908 quality control method Methods 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0607990 | 2006-09-13 | ||
| EP06291942A EP1933137A1 (de) | 2006-12-15 | 2006-12-15 | Verfahren zur Untersuchung der Reaktion auf eine Behandlung mit einem monoklonalen Antikörper |
| FR0700456 | 2007-01-23 | ||
| PCT/IB2007/003498 WO2008032217A2 (fr) | 2006-09-13 | 2007-09-12 | Methode d'investigation de la reponse a un traitement par un anticorps monoclonal |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE501436T1 true ATE501436T1 (de) | 2011-03-15 |
Family
ID=39144376
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT07825673T ATE501436T1 (de) | 2006-09-13 | 2007-09-12 | Verfahren zur untersuchung der reaktion auf eine behandlung mit einem monoklonalen antikörper |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100167315A1 (de) |
| EP (1) | EP2062047B1 (de) |
| AT (1) | ATE501436T1 (de) |
| DE (1) | DE602007013068D1 (de) |
| WO (1) | WO2008032217A2 (de) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070087005A1 (en) | 2005-10-14 | 2007-04-19 | Lazar Gregory A | Anti-glypican-3 antibody |
| BR112014018374A8 (pt) * | 2012-03-02 | 2017-07-11 | Roche Glycart Ag | Método para predizer a resposta d eum paciente com câncer, kit, anticorpo, método para o tratamento do câncer e composição farmacêutica |
| TWI693073B (zh) | 2012-12-21 | 2020-05-11 | 日商中外製藥股份有限公司 | 對gpc3標的治療劑療法為有效之患者投與的gpc3標的治療劑 |
| WO2014114595A1 (en) * | 2013-01-23 | 2014-07-31 | Roche Glycart Ag | Predictive biomarker for cancer treatment with adcc-enhanced antibodies |
| US11760807B2 (en) | 2014-05-08 | 2023-09-19 | Chugai Seiyaku Kabushiki Kaisha | GPC3-targeting drug which is administered to patient responsive to GPC3-targeting drug therapy |
| EP3318879B1 (de) | 2015-07-01 | 2020-10-21 | Chugai Seiyaku Kabushiki Kaisha | Verabreichung eines gegen gpc3 gerichteten therapeutikums an einen patienten mit bestätigter wirksamkeit des gegen gpc3 gerichteten therapeutikums |
| PT3916392T (pt) * | 2016-05-30 | 2024-06-04 | Incyte Corp | Métodos para prever o benefício terapêutico da terapia anti-cd19 nos pacientes |
| CN111316098B (zh) | 2017-09-15 | 2024-05-14 | 拜克门寇尔特公司 | 用于治疗的基于流动的测定 |
| CN108663510B (zh) * | 2018-04-28 | 2021-06-04 | 璞晞(广州)生物免疫技术有限公司 | 肝病nk细胞功能的检测评估方法及试剂盒 |
| CN113421627B (zh) * | 2021-05-11 | 2023-04-07 | 深圳市罗湖区人民医院 | 体外评估药物对nk细胞抗衰作用的系统 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2807767B1 (fr) * | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| AU2001267922A1 (en) * | 2000-07-04 | 2002-01-14 | Chugai Seiyaku Kabushiki Kaisha | Method of assaying the function of fc fragment of antibody |
| FR2844521B1 (fr) * | 2002-09-13 | 2004-12-24 | Lab Francais Du Fractionnement | Mesure de la production de cytokines comme marqueur d'activation de cellules effectrices |
| AU2003282161B2 (en) * | 2002-09-13 | 2010-06-24 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Cytokine production-inducing antibody |
| FR2844513B1 (fr) * | 2002-09-13 | 2007-08-03 | Lab Francais Du Fractionnement | Anticorps pour adcc et induisant la production de cytokines. |
| US20080003225A1 (en) * | 2006-06-29 | 2008-01-03 | Henri Vie | Method for enhancing the antibody-dependent cellular cytotoxicity (ADCC) and uses of T cells expressing CD16 receptors |
-
2007
- 2007-09-12 AT AT07825673T patent/ATE501436T1/de not_active IP Right Cessation
- 2007-09-12 DE DE602007013068T patent/DE602007013068D1/de active Active
- 2007-09-12 WO PCT/IB2007/003498 patent/WO2008032217A2/fr not_active Ceased
- 2007-09-12 US US12/441,237 patent/US20100167315A1/en not_active Abandoned
- 2007-09-12 EP EP07825673A patent/EP2062047B1/de not_active Not-in-force
Also Published As
| Publication number | Publication date |
|---|---|
| WO2008032217A3 (fr) | 2008-06-05 |
| US20100167315A1 (en) | 2010-07-01 |
| EP2062047A2 (de) | 2009-05-27 |
| WO2008032217A2 (fr) | 2008-03-20 |
| DE602007013068D1 (de) | 2011-04-21 |
| EP2062047B1 (de) | 2011-03-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |