MX2015005633A - Terapia adyuvante con inhibidores de quinasa de la familia tec. - Google Patents
Terapia adyuvante con inhibidores de quinasa de la familia tec.Info
- Publication number
- MX2015005633A MX2015005633A MX2015005633A MX2015005633A MX2015005633A MX 2015005633 A MX2015005633 A MX 2015005633A MX 2015005633 A MX2015005633 A MX 2015005633A MX 2015005633 A MX2015005633 A MX 2015005633A MX 2015005633 A MX2015005633 A MX 2015005633A
- Authority
- MX
- Mexico
- Prior art keywords
- kinase inhibitor
- family kinase
- tec family
- adjuvant therapy
- inhibitor adjuvant
- Prior art date
Links
- 238000009098 adjuvant therapy Methods 0.000 title abstract 2
- 229940043355 kinase inhibitor Drugs 0.000 title abstract 2
- 239000003757 phosphotransferase inhibitor Substances 0.000 title abstract 2
- 102000042834 TEC family Human genes 0.000 abstract 1
- 108091082333 TEC family Proteins 0.000 abstract 1
- 239000002671 adjuvant Substances 0.000 abstract 1
- 208000026278 immune system disease Diseases 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000011275 oncology therapy Methods 0.000 abstract 1
- 230000001717 pathogenic effect Effects 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 238000002255 vaccination Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Radiology & Medical Imaging (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261722107P | 2012-11-02 | 2012-11-02 | |
| US201361785868P | 2013-03-14 | 2013-03-14 | |
| PCT/US2013/068132 WO2014071231A1 (en) | 2012-11-02 | 2013-11-01 | Tec family kinase inhibitor adjuvant therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015005633A true MX2015005633A (es) | 2016-02-03 |
Family
ID=50628113
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015005633A MX2015005633A (es) | 2012-11-02 | 2013-11-01 | Terapia adyuvante con inhibidores de quinasa de la familia tec. |
| MX2021003018A MX2021003018A (es) | 2012-11-02 | 2015-05-04 | Terapia adyuvante con inhibidores de quinasa de la familia tec. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2021003018A MX2021003018A (es) | 2012-11-02 | 2015-05-04 | Terapia adyuvante con inhibidores de quinasa de la familia tec. |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US9717731B2 (OSRAM) |
| EP (1) | EP2914263A4 (OSRAM) |
| JP (3) | JP2015536950A (OSRAM) |
| KR (1) | KR20150080592A (OSRAM) |
| CN (2) | CN104994858A (OSRAM) |
| AU (3) | AU2013337663A1 (OSRAM) |
| BR (1) | BR112015010059A2 (OSRAM) |
| CA (1) | CA2890111A1 (OSRAM) |
| CL (1) | CL2015001147A1 (OSRAM) |
| CR (1) | CR20150242A (OSRAM) |
| DO (1) | DOP2015000098A (OSRAM) |
| EA (1) | EA201590822A1 (OSRAM) |
| HK (1) | HK1214508A1 (OSRAM) |
| IL (1) | IL238548A0 (OSRAM) |
| MX (2) | MX2015005633A (OSRAM) |
| NI (1) | NI201500062A (OSRAM) |
| PE (1) | PE20151604A1 (OSRAM) |
| PH (1) | PH12015500985A1 (OSRAM) |
| SG (1) | SG11201503459SA (OSRAM) |
| TN (1) | TN2015000170A1 (OSRAM) |
| TW (1) | TW201427664A (OSRAM) |
| WO (1) | WO2014071231A1 (OSRAM) |
Families Citing this family (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI458721B (zh) | 2008-06-27 | 2014-11-01 | Celgene Avilomics Res Inc | 雜芳基化合物及其用途 |
| US11351168B1 (en) | 2008-06-27 | 2022-06-07 | Celgene Car Llc | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| US8338439B2 (en) | 2008-06-27 | 2012-12-25 | Celgene Avilomics Research, Inc. | 2,4-disubstituted pyrimidines useful as kinase inhibitors |
| KR101705158B1 (ko) | 2009-05-05 | 2017-02-09 | 다나-파버 캔서 인스티튜트 인크. | Egfr 억제제 및 질환 치료방법 |
| EA201890869A3 (ru) | 2010-06-03 | 2019-03-29 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) |
| RU2013109393A (ru) | 2010-08-10 | 2014-09-20 | Сэлджин Авиаломикс Ресеарч, Инк. | Безилатная соль ингибитора втк |
| ES2794006T3 (es) | 2010-10-26 | 2020-11-17 | Mars Inc | Inhibidores de arginasa como agentes terapéuticos |
| EP2635285B1 (en) | 2010-11-01 | 2017-05-03 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| CA2815858C (en) | 2010-11-01 | 2018-10-16 | Celgene Avilomics Research, Inc. | Heterocyclic compounds and uses thereof |
| EP2637502B1 (en) | 2010-11-10 | 2018-01-10 | Celgene CAR LLC | Mutant-selective egfr inhibitors and uses thereof |
| CA2853498A1 (en) | 2011-10-28 | 2013-05-02 | Celgene Avilomics Research, Inc. | Methods of treating a bruton's tyrosine kinase disease or disorder |
| BR112014022789B1 (pt) | 2012-03-15 | 2022-04-19 | Celgene Car Llc | Formas sólidas de um inibidor de quinase de receptor do fator de crescimento epidérmico, composição farmacêutica e usos do mesmo |
| RU2711077C9 (ru) | 2012-03-15 | 2020-08-11 | Селджен Кар Ллс | Соли ингибитора киназы рецептора эпидермального фактора роста |
| WO2014018567A1 (en) | 2012-07-24 | 2014-01-30 | Pharmacyclics, Inc. | Mutations associated with resistance to inhibitors of bruton's tyrosine kinase (btk) |
| CA2890111A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
| WO2014100748A1 (en) | 2012-12-21 | 2014-06-26 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| EP2953457B1 (en) | 2013-02-08 | 2020-04-08 | Celgene CAR LLC | Erk inhibitors and uses thereof |
| KR20160099081A (ko) | 2013-07-26 | 2016-08-19 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조합 방법 |
| AR097204A1 (es) * | 2013-08-02 | 2016-02-24 | Pharmacyclics Inc | Métodos de tratamiento de tumores sólidos |
| US9492471B2 (en) | 2013-08-27 | 2016-11-15 | Celgene Avilomics Research, Inc. | Methods of treating a disease or disorder associated with Bruton'S Tyrosine Kinase |
| TWI660739B (zh) * | 2013-10-25 | 2019-06-01 | 製藥公司 | 使用布魯頓氏酪胺酸激酶抑制劑之治療及免疫療法 |
| US10314842B2 (en) * | 2013-12-02 | 2019-06-11 | Cornell University | Methods for treating B cell proliferative disorders |
| US9415049B2 (en) | 2013-12-20 | 2016-08-16 | Celgene Avilomics Research, Inc. | Heteroaryl compounds and uses thereof |
| CA2974651A1 (en) | 2014-01-24 | 2015-07-30 | Children's Hospital Of Eastern Ontario Research Institute Inc. | Smc combination therapy for the treatment of cancer |
| CA2942528A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| US10076512B2 (en) | 2014-05-01 | 2018-09-18 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| US11311519B2 (en) | 2014-05-01 | 2022-04-26 | Eiger Biopharmaceuticals, Inc. | Treatment of hepatitis delta virus infection |
| WO2015187848A1 (en) * | 2014-06-04 | 2015-12-10 | Sampath Deepa | Hdac inhibitor and btk inhibitor combinations |
| US20150361504A1 (en) * | 2014-06-13 | 2015-12-17 | Pharmacyclics Llc | Biomarker for predicting response of cll to treatment with a btk inhibitor |
| WO2016010961A1 (en) * | 2014-07-15 | 2016-01-21 | Abbvie Inc. | Enzyme occupancy assay |
| CA2954725A1 (en) * | 2014-07-25 | 2016-01-28 | Northeastern University | Biopolymer-nanoparticle composite implant for tumor cell tracking |
| EP3179858B1 (en) | 2014-08-13 | 2019-05-15 | Celgene Car Llc | Forms and compositions of an erk inhibitor |
| WO2016044774A1 (en) * | 2014-09-18 | 2016-03-24 | Pharmacyclics Llc | Dendritic cell based vaccine with bruton's tyrosine kinase inhibitor |
| JP2017536403A (ja) * | 2014-12-04 | 2017-12-07 | アイガー・バイオファーマシューティカルズ・インコーポレイテッドEiger Biopharmaceuticals, Inc. | デルタ肝炎ウイルス感染の治療 |
| US20180098972A1 (en) | 2015-01-26 | 2018-04-12 | Children's Medical Center Corporation | Treatment of infectious diseases |
| US11318163B2 (en) | 2015-02-18 | 2022-05-03 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11596652B2 (en) | 2015-02-18 | 2023-03-07 | Enlivex Therapeutics R&D Ltd | Early apoptotic cells for use in treating sepsis |
| US11304976B2 (en) | 2015-02-18 | 2022-04-19 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11497767B2 (en) | 2015-02-18 | 2022-11-15 | Enlivex Therapeutics R&D Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11512289B2 (en) | 2015-02-18 | 2022-11-29 | Enlivex Therapeutics Rdo Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| US11000548B2 (en) | 2015-02-18 | 2021-05-11 | Enlivex Therapeutics Ltd | Combination immune therapy and cytokine control therapy for cancer treatment |
| WO2016138542A1 (en) * | 2015-02-28 | 2016-09-01 | Cyprus Therapeutics, Inc. | Methods for inhibiting tumors and drug resistance |
| JP6823587B2 (ja) | 2015-04-13 | 2021-02-03 | 第一三共株式会社 | Mdm2阻害剤とbtk阻害剤との併用治療法 |
| DK3285768T3 (da) | 2015-04-21 | 2021-01-25 | Eiger Biopharmaceuticals Inc | Farmaceutiske sammensætninger omfattende lonafarnib og ritonavir |
| US10857181B2 (en) | 2015-04-21 | 2020-12-08 | Enlivex Therapeutics Ltd | Therapeutic pooled blood apoptotic cell preparations and uses thereof |
| EP3302485B1 (en) | 2015-05-29 | 2023-07-12 | Alexion Pharmaceuticals, Inc. | Cerdulatinib for the treatment of b-cell malignancies |
| US11554138B2 (en) | 2015-07-16 | 2023-01-17 | The University Of Hong Kong | Bismuth(III) complexes as adjuvants in the treatment of cancer using platinum-based chemotherapy |
| US20170027941A1 (en) * | 2015-07-31 | 2017-02-02 | Pharmacyclics Llc | Bruton's Tyrosine Kinase Inhibitor Combinations and Uses Thereof |
| US20170042896A1 (en) * | 2015-08-12 | 2017-02-16 | Portola Pharmaceuticals, Inc. | Cerdulatinib for treating myeloma |
| PL3368541T3 (pl) * | 2015-10-30 | 2020-11-02 | Calithera Biosciences, Inc. | Kompozycje i sposoby hamowania aktywności arginazy |
| CN108367006B (zh) | 2015-12-04 | 2021-12-31 | 博尔托拉制药公司 | 用于治疗血液癌症的赛度替尼 |
| CA3014885A1 (en) | 2016-02-18 | 2017-08-24 | Enlivex Therapeutics Ltd. | Combination immune therapy and cytokine control therapy for cancer treatment |
| ES2874592T3 (es) * | 2016-02-19 | 2021-11-05 | Eiger Biopharmaceuticals Inc | Tratamiento de la infección por el virus de la hepatitis delta con interferón lambda |
| WO2018005849A1 (en) | 2016-06-29 | 2018-01-04 | Principia Biopharma Inc. | Modified release formulations of 2-[3-[4-amino-3-(2-fluoro-4-phenoxy-phenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pent-2-enenitrile |
| EP3318276A1 (en) * | 2016-11-04 | 2018-05-09 | Janssen Biotech, Inc. | Combinations of a telomerase inhibitor and a bcl-2 inhibitor for the treatment of hematological cancers |
| CN106405086A (zh) * | 2016-09-21 | 2017-02-15 | 四川大学华西医院 | 一种肺癌筛查试剂盒 |
| WO2018085731A2 (en) | 2016-11-03 | 2018-05-11 | Juno Therapeutics, Inc. | Combination therapy of a t cell therapy and a btk inhibitor |
| MA46995A (fr) | 2016-12-03 | 2019-10-09 | Acerta Pharma Bv | Méthodes et compositions pour l'utilisation de lymphocytes t thérapeutiques en association avec des inhibiteurs de kinase |
| PL3559009T3 (pl) | 2016-12-22 | 2021-10-25 | Calithera Biosciences, Inc. | Kompozycje i sposoby hamowania aktywności arginazy |
| CN108732280B (zh) * | 2017-04-18 | 2022-07-08 | 广东东阳光药业有限公司 | 一种分离检测盐酸达卡他韦及其光学异构体的方法 |
| WO2019014684A1 (en) * | 2017-07-14 | 2019-01-17 | Ohio State Innovation Foundation | EXPANSION OF IMMUNE CELLS WITH INTERLEUKIN-INDUCIBLE T CELL KINASE-INHIBITING COMPOUNDS |
| EP3688007B1 (en) | 2017-09-27 | 2024-07-31 | The University of York | Bioconjugation of polypeptides |
| CZ2017787A3 (cs) | 2017-12-08 | 2019-06-19 | Zentiva, K.S. | Farmaceutické kompozice obsahující ibrutinib |
| EP3787751A1 (en) | 2018-05-03 | 2021-03-10 | Juno Therapeutics, Inc. | Combination therapy of a chimeric antigen receptor (car) t cell therapy and a kinase inhibitor |
| JP7324778B2 (ja) | 2018-05-04 | 2023-08-10 | ポートラ ファーマシューティカルズ, エルエルシー | セルデュラチニブ(cerdulatinib)の固体形態 |
| CN111110685A (zh) * | 2018-10-31 | 2020-05-08 | 正大天晴药业集团股份有限公司 | 一种含伊布替尼的药物组合物及其应用 |
| KR20220061149A (ko) * | 2019-09-09 | 2022-05-12 | 더 칠드런스 호스피탈 오브 필라델피아 | Clec16A 기능장애 또는 손실과 관련된 장애의 치료를 위한 조성물 및 방법 |
| TWI877239B (zh) | 2019-10-14 | 2025-03-21 | 美商普林斯匹亞生物製藥公司 | 藉由投予(R)-2-[3-[4-胺基-3-(2-氟-4-苯氧基-苯基)吡唑并[3,4-d]嘧啶-1-基]哌啶-1-羰基]-4-甲基-4-[4-(氧呾-3-基)哌-1-基]戊-2-烯腈來治療免疫血小板減少症之方法 |
| US20220378025A1 (en) * | 2019-11-11 | 2022-12-01 | Biocytogen Pharmaceuticals (Beijing) Co., Ltd. | Genetically modified non-human animal with human or chimeric genes |
| BR112022014149A2 (pt) | 2020-01-22 | 2022-09-27 | Principia Biopharma Inc | Formas cristalinas de 2-[3-[4-amino-3-(2-fluoro-4-fenóxi-fenil)-1h-pirazolo[3,4-d]pirimidina-1-il]piperidina-1-carbonil]-4-metil-4-[4-(oxetan-3-il)piperazin-1-il]pent-2-enenitrila |
| WO2021207716A2 (en) * | 2020-04-10 | 2021-10-14 | Ohio State Innovation Foundation | Methods and composition for treatment of covid-19 illness requiring hospitalization |
| WO2021252494A1 (en) * | 2020-06-08 | 2021-12-16 | Icahn School Of Medicine At Mount Sinai | Use of multi-kinase inhibitors to treat rna virus infections |
| KR20240169633A (ko) * | 2022-04-05 | 2024-12-03 | 코버스 파마슈티칼스, 인크. | Th1 세포 활성을 증가시키기 위한 itk 저해제 |
| WO2023220655A1 (en) | 2022-05-11 | 2023-11-16 | Celgene Corporation | Methods to overcome drug resistance by re-sensitizing cancer cells to treatment with a prior therapy via treatment with a t cell therapy |
| WO2025071560A1 (en) * | 2023-09-28 | 2025-04-03 | Rutgers, The State University Of New Jersey | Methods of diagnosing b cell malignancies, detecting b cell malignancy relapse, and treating thereof |
| WO2024206869A2 (en) * | 2023-03-30 | 2024-10-03 | Board Of Regents, The University Of Texas System | Combination of hpk1 inhibitor and axl inhibitor in cancer therapy |
| WO2025085889A1 (en) * | 2023-10-20 | 2025-04-24 | Corvus Pharmaceuticals, Inc. | Interleukin-2-inducible t-cell kinase inhibitors to produce enhanced immune responses |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| EP1240899A3 (en) | 1996-01-23 | 2004-05-19 | Ribapharm, Inc. | Modulation of Th1/Th2 Cytokine expression by Ribavirin and Ribavirin analogs in actived T-Lymphocytes for treating HCV infections |
| EP1302474A1 (en) | 1996-10-16 | 2003-04-16 | Ribapharm, Inc. | Monocyclic L-nucleosides, analogs and uses thereof |
| US7390619B1 (en) | 1998-02-11 | 2008-06-24 | Maxygen, Inc. | Optimization of immunomodulatory properties of genetic vaccines |
| US7087236B1 (en) | 1998-09-01 | 2006-08-08 | Merrion Research I Limited | Method for inducing a cell-mediated immune response and improved parenteral vaccine formulations thereof |
| CA2345722A1 (en) | 1998-09-28 | 2000-04-06 | Albert Edge | Determining resistance to treatment for hepatitis c virus |
| US6824768B2 (en) | 1998-12-18 | 2004-11-30 | Schering Corporation | Ribavirin-pegylated interferon alfa induction HCV combination therapy |
| AU4463300A (en) | 1999-04-19 | 2000-11-02 | Schering Corporation | Hcv combination therapy, containing ribavirin in association with antioxidants |
| WO2001032210A2 (en) | 1999-10-29 | 2001-05-10 | Pharmacyclics, Inc. | Compositions for treating atheroma and neoplastic tissue |
| JP2003525907A (ja) | 2000-03-09 | 2003-09-02 | シェーリング コーポレイション | Hiv免疫アジュバント治療 |
| WO2001088199A2 (en) | 2000-05-18 | 2001-11-22 | Genetics Institute, Llc | Identification and modulationof of a t helper-1 and t helper-2 cells |
| CN1516599A (zh) | 2000-10-18 | 2004-07-28 | ���鹫˾ | 病毒唑-聚乙二醇化干扰素α联合治疗慢性传染性丙型肝炎的方法 |
| US20030103938A1 (en) | 2001-05-09 | 2003-06-05 | Alk-Abello A/S | Pharmaceutical compositions for preventing or treating Th1 and Th2 cell related diseases by modulating the Th1/Th2 ratio |
| GB0116249D0 (en) | 2001-07-05 | 2001-08-29 | Imp College Innovations Ltd | Methods |
| EP1553982A4 (en) | 2002-07-15 | 2008-03-26 | Wyeth Corp | METHOD AND COMPOSITIONS FOR MODULATING THE DEVELOPMENT AND FUNCTION OF T-HELPER CELLS (T sb H / sb) |
| EP2572714A1 (en) | 2002-12-30 | 2013-03-27 | 3M Innovative Properties Company | Immunostimulatory Combinations |
| WO2004110245A2 (en) | 2003-05-16 | 2004-12-23 | Intermune, Inc. | Combination therapy for cancer treatment |
| CA2539702A1 (en) | 2003-09-30 | 2005-04-07 | Telethon Institute For Child Health Research | Immunotherapy method |
| PT1951300E (pt) | 2005-11-04 | 2011-09-05 | Novartis Vaccines & Diagnostic | Modificação do equilíbrio de th1/th2 em vacinas da influenza fragmentadas com adjuvantes |
| WO2007059329A2 (en) | 2005-11-16 | 2007-05-24 | Pharmacyclics, Inc. | Methods and compositions for treating cancer |
| GB0605521D0 (en) | 2006-03-18 | 2006-04-26 | Isis Innovation | Adjuvant |
| CA2666814A1 (en) | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| PT2201840E (pt) | 2006-09-22 | 2012-02-14 | Pharmacyclics Inc | Inibidores da tirosina quinase de bruton |
| US20120065201A1 (en) | 2007-03-28 | 2012-03-15 | Pharmacyclics, Inc. | Inhibitors of bruton's tyrosine kinase |
| AU2008321016B2 (en) | 2007-11-12 | 2013-03-28 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| GB0805356D0 (en) | 2008-03-25 | 2008-04-30 | Isis Innovation | Vaccine adjuvant composition |
| CN105363034A (zh) | 2008-05-23 | 2016-03-02 | 香港大学 | 治疗流感的联合疗法 |
| EP2318031A4 (en) | 2008-06-03 | 2012-09-12 | Aethlon Medical Inc | IMPROVED METHODS AND DEVICES FOR ANTIVIRAL THERAPY |
| WO2010034670A2 (en) | 2008-09-26 | 2010-04-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Host cell kinases as targets for antiviral therapies against hcv infection |
| EP2379745A1 (en) | 2008-12-18 | 2011-10-26 | F. Hoffmann-La Roche AG | Biomarkers for hcv treatment response |
| WO2010093843A2 (en) | 2009-02-12 | 2010-08-19 | Vertex Pharmaceuticals Incorporated | Hcv combination therapies |
| SG175289A1 (en) | 2009-04-20 | 2011-11-28 | Genentech Inc | Adjuvant cancer therapy |
| US8299070B2 (en) * | 2009-11-25 | 2012-10-30 | Japan Tobacco Inc. | Indole compounds and pharmaceutical use thereof |
| EA201890869A3 (ru) * | 2010-06-03 | 2019-03-29 | Фармасайкликс, Инк. | Применение ингибиторов тирозинкиназы брутона (btk) |
| GB2481611A (en) | 2010-06-30 | 2012-01-04 | Statoil Asa | Test cell for well fluid assessment |
| JP2014505666A (ja) * | 2010-11-18 | 2014-03-06 | ザ ジェネラル ホスピタル コーポレイション | 癌治療のための降圧剤の組成物および使用 |
| WO2013003112A1 (en) | 2011-06-27 | 2013-01-03 | The Jackson Laboratory | Methods and compositions for treatment of cancer and autoimmune disease |
| WO2013036994A1 (en) | 2011-09-16 | 2013-03-21 | Biota Scientific Management Pty Ltd | Compounds for the treatment of hcv |
| EP2788020A4 (en) | 2011-12-05 | 2015-04-29 | Immunomedics Inc | THERAPEUTIC USE OF ANTI-CD22 ANTIBODIES FOR THE INDUCTION OF TROGO CYTOSIS |
| CA3218491A1 (en) * | 2012-06-04 | 2013-12-12 | Pharmacyclics Llc | Crystalline forms of a bruton's tyrosine kinase inhibitor |
| CA2890111A1 (en) | 2012-11-02 | 2014-05-08 | Pharmacyclics, Inc. | Tec family kinase inhibitor adjuvant therapy |
-
2013
- 2013-11-01 CA CA2890111A patent/CA2890111A1/en not_active Abandoned
- 2013-11-01 SG SG11201503459SA patent/SG11201503459SA/en unknown
- 2013-11-01 MX MX2015005633A patent/MX2015005633A/es unknown
- 2013-11-01 KR KR1020157014129A patent/KR20150080592A/ko not_active Withdrawn
- 2013-11-01 BR BR112015010059A patent/BR112015010059A2/pt not_active Application Discontinuation
- 2013-11-01 EA EA201590822A patent/EA201590822A1/ru unknown
- 2013-11-01 TW TW102139881A patent/TW201427664A/zh unknown
- 2013-11-01 AU AU2013337663A patent/AU2013337663A1/en not_active Abandoned
- 2013-11-01 CN CN201380065469.7A patent/CN104994858A/zh active Pending
- 2013-11-01 US US14/070,420 patent/US9717731B2/en active Active
- 2013-11-01 CN CN202010271248.7A patent/CN111329989A/zh active Pending
- 2013-11-01 WO PCT/US2013/068132 patent/WO2014071231A1/en not_active Ceased
- 2013-11-01 JP JP2015540834A patent/JP2015536950A/ja active Pending
- 2013-11-01 EP EP13850097.0A patent/EP2914263A4/en not_active Withdrawn
- 2013-11-01 HK HK16102454.7A patent/HK1214508A1/zh unknown
- 2013-11-01 PE PE2015000592A patent/PE20151604A1/es not_active Application Discontinuation
-
2014
- 2014-03-05 US US14/198,559 patent/US20140371241A1/en not_active Abandoned
-
2015
- 2015-04-30 DO DO2015000098A patent/DOP2015000098A/es unknown
- 2015-04-30 NI NI201500062A patent/NI201500062A/es unknown
- 2015-04-30 IL IL238548A patent/IL238548A0/en unknown
- 2015-04-30 CL CL2015001147A patent/CL2015001147A1/es unknown
- 2015-05-04 PH PH12015500985A patent/PH12015500985A1/en unknown
- 2015-05-04 TN TNP2015000170A patent/TN2015000170A1/fr unknown
- 2015-05-04 MX MX2021003018A patent/MX2021003018A/es unknown
- 2015-05-08 CR CR20150242A patent/CR20150242A/es unknown
-
2017
- 2017-07-14 US US15/650,830 patent/US20180071293A1/en not_active Abandoned
-
2018
- 2018-09-21 AU AU2018233032A patent/AU2018233032B2/en not_active Ceased
- 2018-09-25 JP JP2018179447A patent/JP2019031506A/ja not_active Ceased
-
2019
- 2019-05-21 US US16/418,590 patent/US20200147084A1/en not_active Abandoned
-
2020
- 2020-07-13 JP JP2020120047A patent/JP2020183413A/ja active Pending
- 2020-08-21 AU AU2020220205A patent/AU2020220205A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12015500985A1 (en) | Tec family kinase inhibitor adjuvant therapy | |
| PH12016501139A1 (en) | Bicyclic heterocycle compounds and their uses in therapy | |
| PH12015502161A1 (en) | Therapeutic compounds and compositions | |
| NZ707086A (en) | Anti-cd40 antibodies and methods of use | |
| PH12015500274B1 (en) | Alkylpyrimidine derivatives for the treatment of viral infections and further diseases | |
| MX366899B (es) | Nuevos compuestos. | |
| NZ707778A (en) | Therapeutic compounds and compositions and their use as pkm2 modulators | |
| MX356525B (es) | Vectores de virus asociados con adeno (aav) para uso en terapia de genes de coroideremia. | |
| MX342274B (es) | Actividades de la piruvato quinasa m2 (pkm2). | |
| MX349004B (es) | Nuevos compuestos. | |
| EA201490194A1 (ru) | Комбинированная терапия, включающая ингибитор cdk4/6 и ингибитор pi3k для применения в лечении рака | |
| MY158992A (en) | Forms of rifaximin and uses thereof | |
| MX2017005325A (es) | Enfoque de inmunoterapias de combinación para el tratamiento del cancer. | |
| WO2015009726A3 (en) | Medical uses of cd38 agonists | |
| MX2014012477A (es) | Inhibidores pirrolopirazona de tanquirasa. | |
| PH12016502291A1 (en) | Indolizine derivatives as phosphoinositide 3-kinases inhibitors | |
| HK1248588A1 (zh) | 用於癌症治疗中的天花疫苗 | |
| MY181602A (en) | Isochromene derivatives as phosphoinositide 3-kinases inhibitors | |
| PH12015500664A1 (en) | Pharmaceutical combinations comprising dual angiopoietin-2/dll4 binders and anti-vegf-r agents | |
| CO7151543A2 (es) | Combinaciones terapéuticas y métodos para tratar el melanoma | |
| AU2018253600A1 (en) | Dosage forms and therapeutic uses of l-4-chlorokynurenine | |
| MX365192B (es) | Derivados de bendamustina y compuestos relacionados, y uso medico de los mismos para la terapia de cancer. | |
| EA201590615A1 (ru) | Стимулирующие лактацию композиции на основе фосфатидилсерина | |
| NZ629475A (en) | Pharmaceutical composition comprising benzyl alcohol for the treatment of migraines | |
| TN2014000484A1 (en) | Dronedarone for use in leishmaniasis, formulations and associations for use in leishmaniasis. |