MX2015004618A - Proceso de preparacion de vitamina k2 del tipo mk-7. - Google Patents

Proceso de preparacion de vitamina k2 del tipo mk-7.

Info

Publication number
MX2015004618A
MX2015004618A MX2015004618A MX2015004618A MX2015004618A MX 2015004618 A MX2015004618 A MX 2015004618A MX 2015004618 A MX2015004618 A MX 2015004618A MX 2015004618 A MX2015004618 A MX 2015004618A MX 2015004618 A MX2015004618 A MX 2015004618A
Authority
MX
Mexico
Prior art keywords
formula
hexaprenyl
vitamin
preparation
vii
Prior art date
Application number
MX2015004618A
Other languages
English (en)
Inventor
Krysztof Krajewski
Andrzej Kutner
Jadwiga Gutowska
Marek Napiórkowski
Jerzy Winiarski
Marek Kubiszewski
Lukasz Jedynak
Jadwiga Dzikowksa
Jacek Morzycki
Stanislao Witkowski
Aneta Baj
Piotr Walejko
Original Assignee
Nattopharma R&D Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50442211&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2015004618(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Nattopharma R&D Ltd filed Critical Nattopharma R&D Ltd
Publication of MX2015004618A publication Critical patent/MX2015004618A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
    • C07C49/553—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C315/00—Preparation of sulfones; Preparation of sulfoxides
    • C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Proceso para la preparación de la vitamina K2 del tipo MK-7 que se caracteriza porque al unir la cadena de hexaprenil de configuración´+on 2all trans" al derivado de monoprenil de menadiol siguiendo la estrategia sintética de "1 + 6". De acuerdo a la invención, el carbanion a-sufonil generado in sintu a partir del monoprenil menadiol protegido de la formula (II), caracterizada porque R1 representa el grupo C1-3, es reaccionada con hexaprenil haluro de la formula (VII), caracterizada porque X representa átomo de halógeno, p´referentemente bromuro, tanto Z´ Y ZZ´´ representan H o una de Z´y Z´´ representa H y la otra representa el grupo de fenilsulfonil - SO,PH en la reacción de alquilación. El haluro de hexaprenil de la formula (VII) es obtenido mediante el acoplamiento de dos unidades de triprenil en reacción de alquilación, con o sin separación de los intermedios.
MX2015004618A 2012-10-12 2013-10-11 Proceso de preparacion de vitamina k2 del tipo mk-7. MX2015004618A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PL401195A PL401195A1 (pl) 2012-10-12 2012-10-12 Sposób wytwarzania witaminy K2 w formie MK-7
US201361771741P 2013-03-01 2013-03-01
PCT/PL2013/000132 WO2014058330A2 (en) 2012-10-12 2013-10-11 Process for preparation of mk-7 type of vitamin k2

Publications (1)

Publication Number Publication Date
MX2015004618A true MX2015004618A (es) 2016-06-10

Family

ID=50442211

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015004618A MX2015004618A (es) 2012-10-12 2013-10-11 Proceso de preparacion de vitamina k2 del tipo mk-7.

Country Status (19)

Country Link
US (1) US9828323B2 (es)
EP (1) EP2917171B1 (es)
JP (1) JP2015531404A (es)
KR (1) KR102229841B1 (es)
CN (1) CN104903282B (es)
AU (1) AU2013330517B2 (es)
BR (1) BR112015008021A2 (es)
CA (1) CA2888010C (es)
CY (1) CY1121117T1 (es)
DK (1) DK2917171T3 (es)
ES (1) ES2701808T3 (es)
IL (1) IL238199A (es)
LT (1) LT2917171T (es)
MX (1) MX2015004618A (es)
PL (2) PL401195A1 (es)
RU (1) RU2015117398A (es)
TN (1) TN2015000137A1 (es)
TR (1) TR201818397T4 (es)
WO (1) WO2014058330A2 (es)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0817528D0 (en) 2008-09-24 2008-10-29 Syntavit As Process
PL424875A1 (pl) * 2018-03-12 2019-09-23 Vitasynth Spółka Z Ograniczoną Odpowiedzialnością Sposób syntezy witaminy K2
WO2019194690A1 (en) 2018-04-06 2019-10-10 Instytut Farmaceutyczny Process of vitamin k2 derivatives preparation
WO2021071372A1 (en) 2019-10-07 2021-04-15 Sieć Badawcza Łukasiewicz - Instytut Farmaceutyczny Process of vitamin k2 derivatives preparation
PL243187B1 (pl) 2020-07-16 2023-07-10 Vitasynth Spolka Z Ograniczona Odpowiedzialnoscia Sposób i związki pośrednie do otrzymywania menachinonu MK-7
CN113403348B (zh) * 2021-06-18 2022-03-22 山东润德生物科技有限公司 一种维生素k2的制备方法
WO2023031841A1 (en) * 2021-09-03 2023-03-09 Synergia Life Sciences Pvt. Ltd. A process for the stereospecific synthesis of vitamin k2 and its intermediates
CN114149314B (zh) * 2021-11-26 2024-05-28 安徽先和医药研究有限公司 Vk2的合成方法
WO2024013633A1 (en) * 2022-07-11 2024-01-18 Synergia Life Sciences Pvt. Ltd. Process for the synthesis of vitamin k2
CN117867044A (zh) * 2023-12-27 2024-04-12 杭州微远生物科技有限公司 一种维生素mk-4的生物酶法制备工艺

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1091680A (en) 1976-10-19 1980-12-16 Shinji Terao Method for production of quinones
FR2435466A1 (fr) * 1978-08-02 1980-04-04 Kuraray Co Derives de l'hydroquinone et leur procede de preparation
WO2004058113A1 (en) * 2002-12-16 2004-07-15 The Ohio State University Parametric model based ablative surgical systems and methods
FR2925908A1 (fr) * 2007-12-27 2009-07-03 Bmuestar Silicones France Sas Composition reticulable/polymerisable par voie cationique comprenant un borate de iodonium et degageant une odeur acceptable
DE202008008134U1 (de) 2008-06-17 2009-06-25 Bischof + Klein Gmbh & Co. Kg Seitenfaltenbeutel
GB0817528D0 (en) * 2008-09-24 2008-10-29 Syntavit As Process
GB201004876D0 (en) 2010-03-23 2010-05-05 Syntavit As Process for the preparation of vitamin K2

Also Published As

Publication number Publication date
TR201818397T4 (tr) 2019-01-21
KR102229841B1 (ko) 2021-03-22
US20150291498A1 (en) 2015-10-15
ES2701808T3 (es) 2019-02-26
JP2015531404A (ja) 2015-11-02
DK2917171T3 (en) 2019-01-07
CY1121117T1 (el) 2019-12-11
CA2888010C (en) 2021-05-25
CN104903282A (zh) 2015-09-09
IL238199A (en) 2017-04-30
TN2015000137A1 (en) 2016-10-03
US9828323B2 (en) 2017-11-28
WO2014058330A2 (en) 2014-04-17
BR112015008021A2 (pt) 2017-07-04
AU2013330517B2 (en) 2017-07-20
CA2888010A1 (en) 2014-04-17
EP2917171B1 (en) 2018-11-07
PL2917171T3 (pl) 2019-04-30
RU2015117398A (ru) 2016-11-27
PL401195A1 (pl) 2014-04-14
CN104903282B (zh) 2018-10-23
KR20150091469A (ko) 2015-08-11
AU2013330517A1 (en) 2015-05-28
WO2014058330A3 (en) 2014-06-19
LT2917171T (lt) 2019-01-25
EP2917171A2 (en) 2015-09-16

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