MA34578B1 - Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1 - Google Patents

Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1

Info

Publication number
MA34578B1
MA34578B1 MA35624A MA35624A MA34578B1 MA 34578 B1 MA34578 B1 MA 34578B1 MA 35624 A MA35624 A MA 35624A MA 35624 A MA35624 A MA 35624A MA 34578 B1 MA34578 B1 MA 34578B1
Authority
MA
Morocco
Prior art keywords
tetrahydrofuranyl
bradykinin
receptor antagonists
disubstituted compounds
disubstituted
Prior art date
Application number
MA35624A
Other languages
English (en)
Inventor
Norbert Hauel
Angelo Ceci
Henri Doods
Birgit Jung
Raimund Kuelzer
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of MA34578B1 publication Critical patent/MA34578B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/443—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Abstract

L'invention concerne des composés de tétrahydrofuranyl disubstitués de formule générale I dans laquelle les variables R
MA35624A 2010-08-20 2011-08-19 Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1 MA34578B1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP10173489 2010-08-20
PCT/EP2011/064260 WO2012022795A1 (fr) 2010-08-20 2011-08-19 Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1

Publications (1)

Publication Number Publication Date
MA34578B1 true MA34578B1 (fr) 2013-10-02

Family

ID=44510978

Family Applications (1)

Application Number Title Priority Date Filing Date
MA35624A MA34578B1 (fr) 2010-08-20 2011-08-19 Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1

Country Status (36)

Country Link
US (1) US8937073B2 (fr)
EP (1) EP2606042B1 (fr)
JP (1) JP5727011B2 (fr)
KR (1) KR101822371B1 (fr)
CN (1) CN103068817B (fr)
AP (1) AP2012006630A0 (fr)
AR (1) AR082507A1 (fr)
AU (1) AU2011290727B2 (fr)
BR (1) BR112013003752A2 (fr)
CA (1) CA2807086A1 (fr)
CL (1) CL2013000310A1 (fr)
CO (1) CO6680689A2 (fr)
CY (1) CY1115933T1 (fr)
DK (1) DK2606042T3 (fr)
EA (1) EA022787B1 (fr)
EC (1) ECSP13012495A (fr)
ES (1) ES2525296T3 (fr)
GE (1) GEP20146196B (fr)
HK (1) HK1178902A1 (fr)
HR (1) HRP20141172T1 (fr)
IL (1) IL224039A (fr)
MA (1) MA34578B1 (fr)
ME (1) ME01899B (fr)
MX (1) MX352548B (fr)
MY (1) MY156233A (fr)
NZ (1) NZ607435A (fr)
PE (1) PE20130810A1 (fr)
PL (1) PL2606042T3 (fr)
PT (1) PT2606042E (fr)
RS (1) RS53622B1 (fr)
SG (1) SG187835A1 (fr)
SI (1) SI2606042T1 (fr)
TW (1) TWI548632B (fr)
UA (1) UA108765C2 (fr)
UY (1) UY33565A (fr)
WO (1) WO2012022795A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102007034620A1 (de) * 2007-07-25 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue B1-Antagonisten
CA2697946C (fr) 2007-08-29 2016-06-28 Boehringer Ingelheim International Gmbh Antagonistes b1 de bradykinine
US8937073B2 (en) 2010-08-20 2015-01-20 Boehringer Ingelheim International Gmbh Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists
US10544117B2 (en) 2014-09-10 2020-01-28 Temple University—Of the Commonwealth System of Higher Education 5-hydroxytryptamine receptor 7 activity modulators and their method of use
WO2016183150A1 (fr) * 2015-05-12 2016-11-17 Temple University-Of The Commonwealth System Of Higher Education Nouveaux liants des récepteurs sigma 2 et leur procédé d'utilisation
WO2021198534A1 (fr) 2020-04-04 2021-10-07 Oxurion NV Inhibiteurs de la kallicréine plasmique destinés à être utilisés dans le traitement d'une maladie à coronavirus
US11401303B2 (en) * 2020-06-15 2022-08-02 Taian City Qihang Biotechnology Co. Synthetic peptide BRAP and application in preparation of anti-inflammatory drug for COVID-19 thereof
WO2023148016A1 (fr) 2022-02-04 2023-08-10 Oxurion NV Biomarqueur pour la réponse à une thérapie par inhibiteur de la kallicréine plasmatique

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR038377A1 (es) * 2002-02-08 2005-01-12 Merck & Co Inc Derivados de n-bifenil-aminocicloalcancarboxamida (con sustitucion con metilo)
ATE316954T1 (de) * 2002-02-08 2006-02-15 Merck & Co Inc N-biphenylmethylaminocycloalkancarboxamid- derivative
AU2003265674B2 (en) 2002-08-29 2008-12-11 Merck & Co., Inc. N-biarylmethyl aminocycloalkanecarboxamide derivatives
CN1832922A (zh) * 2003-08-07 2006-09-13 默克公司 磺酰基取代的n－(联芳基甲基)氨基环丙烷甲酰胺类
EP1654232A4 (fr) * 2003-08-07 2008-11-12 Merck & Co Inc N-(biarylmethyle) aminocyclopropanecarboxamides a substitution sulfonyle
ATE423114T1 (de) * 2004-03-02 2009-03-15 Merck & Co Inc Aminocyclopropancarbonsäureamidderivate als bradykininantagonisten
US20060173023A1 (en) 2005-02-01 2006-08-03 Wood Michael R 2-(Bicyclo)alkylamino-derivatives as mediators of chronic pain and inflammation
US7998980B2 (en) * 2006-09-15 2011-08-16 Hydra Biosciences, Inc. Compounds for modulating TRPV3 function
HUP0600809A3 (en) * 2006-10-27 2008-09-29 Richter Gedeon Nyrt New phenylsulfamoyl-benzamide derivatives as bradykinin antagonists, process and intermediates for their preparation and pharmaceutical compositions containing them
DE102007034620A1 (de) 2007-07-25 2009-01-29 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue B1-Antagonisten
EP2025675A1 (fr) 2007-08-14 2009-02-18 Boehringer Ingelheim International GmbH Arylsulfonamides ayant activité analgésique
CA2697946C (fr) 2007-08-29 2016-06-28 Boehringer Ingelheim International Gmbh Antagonistes b1 de bradykinine
AR068509A1 (es) * 2007-09-19 2009-11-18 Jerini Ag Antagosnistas del receptor de bradiquinina b1
WO2010057899A1 (fr) 2008-11-20 2010-05-27 Boehringer Ingelheim International Gmbh Dérivés de cycloalkylaminocarbonyle employés comme antagonistes du récepteur b1 de la bradykinine
WO2010097374A1 (fr) 2009-02-26 2010-09-02 Boehringer Ingelheim International Gmbh Composés servant d'antagonistes de bradykinine b1
MA33238B1 (fr) 2009-02-26 2012-05-02 Boehringer Ingelheim Int Composés utilisés comme antagonistes de la bradykinine b1
CN103980258B (zh) 2010-02-23 2016-09-07 贝林格尔.英格海姆国际有限公司 作为缓激肽b1拮抗剂的化合物
US8759537B2 (en) 2010-08-20 2014-06-24 Boehringer Ingelheim International Gmbh 3H-imidazo [4, 5-C] pyridine-6-carboxamides as anti-inflammatory agents
US8937073B2 (en) 2010-08-20 2015-01-20 Boehringer Ingelheim International Gmbh Disubstituted tetrahydrofuranyl compounds and their use as B1-receptor antagonists
US8586604B2 (en) 2010-08-20 2013-11-19 Boehringer Ingelheim International Gmbh Inhibitors of the microsomal prostaglandin E2 synthase-1
PL2606044T3 (pl) 2010-08-20 2014-09-30 Allergan Inc Związki, które działają na wiele receptorów prostaglandyn, wywołujące ogólną odpowiedź przeciwzapalną
WO2012022794A1 (fr) 2010-08-20 2012-02-23 Boehringer Ingelheim International Gmbh Dérivés de pyridazine en tant qu'antagonistes du récepteur de la bradykinine b1

Also Published As

Publication number Publication date
MY156233A (en) 2016-01-29
MX2013001965A (es) 2013-05-09
ECSP13012495A (es) 2013-04-30
UA108765C2 (xx) 2015-06-10
EA201201662A1 (ru) 2013-07-30
CO6680689A2 (es) 2013-05-31
CN103068817A (zh) 2013-04-24
CA2807086A1 (fr) 2012-02-23
ME01899B (me) 2014-12-20
TW201305145A (zh) 2013-02-01
BR112013003752A2 (pt) 2016-05-31
US20120208823A1 (en) 2012-08-16
KR20130114082A (ko) 2013-10-16
SI2606042T1 (sl) 2014-12-31
NZ607435A (en) 2015-07-31
SG187835A1 (en) 2013-03-28
PT2606042E (pt) 2014-10-15
HK1178902A1 (en) 2013-09-19
DK2606042T3 (da) 2014-12-08
GEP20146196B (en) 2014-11-10
EP2606042A1 (fr) 2013-06-26
AP2012006630A0 (en) 2012-12-31
PE20130810A1 (es) 2013-07-25
WO2012022795A1 (fr) 2012-02-23
ES2525296T3 (es) 2014-12-19
AR082507A1 (es) 2012-12-12
CY1115933T1 (el) 2017-01-25
UY33565A (es) 2012-03-30
PL2606042T3 (pl) 2015-03-31
RS53622B1 (en) 2015-04-30
TWI548632B (zh) 2016-09-11
IL224039A (en) 2016-03-31
AU2011290727A1 (en) 2013-03-14
EP2606042B1 (fr) 2014-09-03
US8937073B2 (en) 2015-01-20
AU2011290727B2 (en) 2015-07-16
KR101822371B1 (ko) 2018-01-31
CL2013000310A1 (es) 2013-04-01
HRP20141172T1 (hr) 2015-02-13
EA022787B1 (ru) 2016-03-31
JP5727011B2 (ja) 2015-06-03
CN103068817B (zh) 2014-10-29
MX352548B (es) 2017-11-29
JP2013534238A (ja) 2013-09-02

Similar Documents

Publication Publication Date Title
MA34578B1 (fr) Composés de tétrahydrofuranyl disubstitués en tant qu'antagonistes du récepteur de la bradykinine b1
MA37940A2 (fr) Nouveaux dérivés bicycliques
MA35089B1 (fr) Inhibiteurs de la production de leucotrienes de type benzodioxane
MA35049B1 (fr) Triazolopyridines
MA37519A1 (fr) Composés et compositions pour inhiber l'activité d'abl1, abl2 et bcr-abl1
MA35086B1 (fr) Compose de triazolopyridine
MA35819B1 (fr) Composés hétéroaryl pyridones et aza-pyridones en tant qu'inhibiteurs de l'activité btk
MA35926B1 (fr) Pyrrolidine-2-carboxamides substitués
CO6852084A2 (es) Nuevos compuestos sustituidos con halógeno
CR20130369A (es) Novedosos derivados heterocíclicos
UY34825A (es) Síntesis de compuestos heterocíclicos
MA37142A3 (fr) Dérivés de dihydro-benzo-oxazine et de dihydro-pyrido-oxazine
CR20130501A (es) Derivados novedosos de cefalosporinas y composiciones farmacéuticas de estos
IN2014MN01521A (fr)
MA38645B1 (fr) Nouveaux inhibiteurs de cyp17/antiandrogènes
MX2016007128A (es) Compuestos del receptor 6 de quimiocina (ccr6).
MA37943B1 (fr) 2-oxo-2,3-dihydro-indoles destinés au traitement de troubles du snc
EA201591815A1 (ru) Бицикло [2.2.2] кислоты - модуляторы gpr120
MA37686A1 (fr) Composés phénoxyéthyl pipéridine
EA201491251A1 (ru) Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-она в качестве модуляторов потенциалзависимых натриевых каналов
MA35742B1 (fr) Dérivés de n- (4 -quinolinylmethyl) sulfonamide et leur utilisation en tant qu'antihelminthiques
EA201101675A1 (ru) Спироэпоксиды как промежуточные продукты синтеза
UY32744A (es) Derivados de 2-carboxamida-7-piperazinil-benzofurano 774
EA201170997A1 (ru) Производные индола в качестве противораковых агентов
MA39305A3 (fr) Dérivés d'éthynyle