EA201491251A1 - Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-она в качестве модуляторов потенциалзависимых натриевых каналов - Google Patents

Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-она в качестве модуляторов потенциалзависимых натриевых каналов

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Publication number
EA201491251A1
EA201491251A1 EA201491251A EA201491251A EA201491251A1 EA 201491251 A1 EA201491251 A1 EA 201491251A1 EA 201491251 A EA201491251 A EA 201491251A EA 201491251 A EA201491251 A EA 201491251A EA 201491251 A1 EA201491251 A1 EA 201491251A1
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Eurasian Patent Office
Prior art keywords
diazaspiro
nonan
modulators
sodium channels
pyridine
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EA201491251A
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English (en)
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EA026500B1 (ru
Inventor
Дэвид Р. Витти
Дэвид Т. Макферсон
Джерард М.П. Гиблин
Стивен Дж. Стэнвэй
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Конвердженс Фармасьютикалз Лимитед
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Publication of EA201491251A1 publication Critical patent/EA201491251A1/ru
Publication of EA026500B1 publication Critical patent/EA026500B1/ru

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  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Настоящее изобретение относится к спиропроизводному формулы (I), к применению указанного производного для лечения заболеваний или состояний, опосредуемых модулированием потенциал-зависимых натриевых каналов, к композициям, содержащим подобное производное, и к способам их получения.
EA201491251A 2011-12-22 2012-12-21 Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-он в качестве модулятора потенциал-зависимых натриевых каналов EA026500B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161579613P 2011-12-22 2011-12-22
GBGB1122113.2A GB201122113D0 (en) 2011-12-22 2011-12-22 Novel compounds
PCT/GB2012/053233 WO2013093496A1 (en) 2011-12-22 2012-12-21 2 - (pyridin- 2yl) - 1, 7 -diaza-spiro [4.4] nonane- 6 -one compound as voltage-gated sodium channels modulator

Publications (2)

Publication Number Publication Date
EA201491251A1 true EA201491251A1 (ru) 2014-11-28
EA026500B1 EA026500B1 (ru) 2017-04-28

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EA201491251A EA026500B1 (ru) 2011-12-22 2012-12-21 Соединение 2-(пиридин-2-ил)-1,7-диазаспиро[4.4]нонан-6-он в качестве модулятора потенциал-зависимых натриевых каналов

Country Status (18)

Country Link
US (3) US9303032B2 (ru)
EP (2) EP2794612B1 (ru)
JP (2) JP2015502394A (ru)
KR (1) KR20140113692A (ru)
CN (1) CN104271581B (ru)
AU (1) AU2012356386A1 (ru)
BR (1) BR112014014940A2 (ru)
CA (1) CA2858938C (ru)
EA (1) EA026500B1 (ru)
ES (1) ES2581327T3 (ru)
GB (1) GB201122113D0 (ru)
HK (2) HK1203492A1 (ru)
IL (1) IL233215A0 (ru)
IN (1) IN2014MN01469A (ru)
MX (1) MX2014007637A (ru)
SG (1) SG11201403356YA (ru)
WO (2) WO2013093497A1 (ru)
ZA (1) ZA201404269B (ru)

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GB201122113D0 (en) 2011-12-22 2012-02-01 Convergence Pharmaceuticals Novel compounds
GB201209015D0 (en) 2012-05-22 2012-07-04 Convergence Pharmaceuticals Novel compounds
RU2650523C1 (ru) 2017-07-24 2018-04-16 федеральное государственное автономное образовательное учреждение высшего образования "Казанский (Приволжский) федеральный университет" (ФГАОУ ВО КФУ) Производное пиридоксина для лечения эпилепсии
KR20200068678A (ko) * 2017-10-10 2020-06-15 바이오젠 인크. 스피로 유도체를 제조하기 위한 공정
WO2019097318A1 (en) 2017-11-17 2019-05-23 Cellix Bio Private Limited Compositions and methods for the treatment of eye disorders
CN113563258A (zh) * 2021-07-29 2021-10-29 派普医药(江苏)有限公司 一种4-溴-2-(二氟甲基)-5-甲基吡啶的制备方法
WO2023044364A1 (en) 2021-09-15 2023-03-23 Enko Chem, Inc. Protoporphyrinogen oxidase inhibitors

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Also Published As

Publication number Publication date
JP2015502394A (ja) 2015-01-22
EP2794612A1 (en) 2014-10-29
WO2013093496A1 (en) 2013-06-27
HK1203501A1 (en) 2015-10-30
GB201122113D0 (en) 2012-02-01
CN104271581A (zh) 2015-01-07
US20140350040A1 (en) 2014-11-27
US9376436B2 (en) 2016-06-28
ES2581327T3 (es) 2016-09-05
AU2012356386A1 (en) 2014-07-10
EP2797922B1 (en) 2016-04-06
HK1203492A1 (en) 2015-10-30
BR112014014940A2 (pt) 2017-06-13
EP2797922A1 (en) 2014-11-05
KR20140113692A (ko) 2014-09-24
US9303032B2 (en) 2016-04-05
EP2794612B1 (en) 2016-04-06
WO2013093497A1 (en) 2013-06-27
EA026500B1 (ru) 2017-04-28
ZA201404269B (en) 2016-06-29
CA2858938A1 (en) 2013-06-27
US20160185758A1 (en) 2016-06-30
JP2015502395A (ja) 2015-01-22
MX2014007637A (es) 2014-09-26
CA2858938C (en) 2020-03-10
IL233215A0 (en) 2014-08-31
SG11201403356YA (en) 2014-07-30
US20150225400A1 (en) 2015-08-13
IN2014MN01469A (ru) 2015-04-17
CN104271581B (zh) 2016-08-31

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