PL401195A1 - Sposób wytwarzania witaminy K2 w formie MK-7 - Google Patents
Sposób wytwarzania witaminy K2 w formie MK-7Info
- Publication number
- PL401195A1 PL401195A1 PL401195A PL40119512A PL401195A1 PL 401195 A1 PL401195 A1 PL 401195A1 PL 401195 A PL401195 A PL 401195A PL 40119512 A PL40119512 A PL 40119512A PL 401195 A1 PL401195 A1 PL 401195A1
- Authority
- PL
- Poland
- Prior art keywords
- hexaprenyl
- formula
- alkylation reaction
- halide
- vitamin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/527—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings
- C07C49/553—Unsaturated compounds containing keto groups bound to rings other than six-membered aromatic rings polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C315/00—Preparation of sulfones; Preparation of sulfoxides
- C07C315/04—Preparation of sulfones; Preparation of sulfoxides by reactions not involving the formation of sulfone or sulfoxide groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
- C07C41/01—Preparation of ethers
- C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Sposób wytwarzania witaminy K2 w formie MK-7 polega na dołączeniu łańcucha heksaprenylowego o konfiguracji "all-trans" do pochodnej monoprenylowej menadiolu zgodnie ze strategią "1+6". Karboanion ?-sulfonylowy generowany z zabezpieczonego monoprenylomenadiolu o wzorze (II) pod działaniem silnej zasady metaloorganicznej poddaje się in situ reakcji alkilowania halogenkiem heksaprenylu o wzorze (VII), w którym X oznacza atom fluorowca, korzystnie brom, jeden z podstawników Z' i Z" oznacza atom wodoru, a drugi grupę fenylosulfonylową -SO2Ph, przy czym halogenek heksaprenylu otrzymuje się w wyniku połączenia dwu jednostek triprenylowych w reakcji alkilowania, z, lub bez wyodrębniania związków pośrednich.
Priority Applications (20)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL401195A PL401195A1 (pl) | 2012-10-12 | 2012-10-12 | Sposób wytwarzania witaminy K2 w formie MK-7 |
PL13792773T PL2917171T3 (pl) | 2012-10-12 | 2013-10-11 | Sposób wytwarzania witaminy K<sub>2</sub> w formie MK-7 |
RU2015117398A RU2015117398A (ru) | 2012-10-12 | 2013-10-11 | Способ получения мк-7 типа витамина к2 |
ES13792773T ES2701808T3 (es) | 2012-10-12 | 2013-10-11 | Procedimiento de preparación de vitamina K2 del tipo MK-7 |
JP2015536739A JP2015531404A (ja) | 2012-10-12 | 2013-10-11 | ビタミンk2のmk−7型の調整方法 |
CN201380063042.3A CN104903282B (zh) | 2012-10-12 | 2013-10-11 | 用于制备mk-7类型的维生素k2的方法 |
DK13792773.7T DK2917171T3 (en) | 2012-10-12 | 2013-10-11 | METHOD FOR PREPARING MK-7 TYPE OF K2 VITAMIN |
TR2018/18397T TR201818397T4 (tr) | 2012-10-12 | 2013-10-11 | Mk-7 tipi k2 vitamininin hazirlanmasina yönelik proses. |
AU2013330517A AU2013330517B2 (en) | 2012-10-12 | 2013-10-11 | Process for preparation of MK-7 type of vitamin K2 |
US14/435,260 US9828323B2 (en) | 2012-10-12 | 2013-10-11 | Process for preparation of MK-7 type of vitamin K2 |
MX2015004618A MX2015004618A (es) | 2012-10-12 | 2013-10-11 | Proceso de preparacion de vitamina k2 del tipo mk-7. |
LTEP13792773.7T LT2917171T (lt) | 2012-10-12 | 2013-10-11 | Vitamino k2 mk-7 tipo gamybos būdas |
PCT/PL2013/000132 WO2014058330A2 (en) | 2012-10-12 | 2013-10-11 | Process for preparation of mk-7 type of vitamin k2 |
KR1020157012230A KR102229841B1 (ko) | 2012-10-12 | 2013-10-11 | 비타민 k2의 mk-7 타입의 제조를 위한 방법 |
EP13792773.7A EP2917171B1 (en) | 2012-10-12 | 2013-10-11 | Process for preparation of mk-7 type of vitamin k2 |
CA2888010A CA2888010C (en) | 2012-10-12 | 2013-10-11 | Process for preparation of mk-7 type of vitamin k2 |
BR112015008021A BR112015008021A2 (pt) | 2012-10-12 | 2013-10-11 | processo para preparação do tipo mk-7 de vitamina k |
TNP2015000137A TN2015000137A1 (en) | 2012-10-12 | 2015-04-10 | Process for preparation of mk-7 type of vitamin k2 |
IL238199A IL238199A (en) | 2012-10-12 | 2015-04-12 | A process for making vitamin k2 type MK-7 |
CY191100035T CY1121117T1 (el) | 2012-10-12 | 2019-01-14 | Μεθοδος για την παρασκευη βιταμινης κ2 του τυπου μκ-7 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL401195A PL401195A1 (pl) | 2012-10-12 | 2012-10-12 | Sposób wytwarzania witaminy K2 w formie MK-7 |
Publications (1)
Publication Number | Publication Date |
---|---|
PL401195A1 true PL401195A1 (pl) | 2014-04-14 |
Family
ID=50442211
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL401195A PL401195A1 (pl) | 2012-10-12 | 2012-10-12 | Sposób wytwarzania witaminy K2 w formie MK-7 |
PL13792773T PL2917171T3 (pl) | 2012-10-12 | 2013-10-11 | Sposób wytwarzania witaminy K<sub>2</sub> w formie MK-7 |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL13792773T PL2917171T3 (pl) | 2012-10-12 | 2013-10-11 | Sposób wytwarzania witaminy K<sub>2</sub> w formie MK-7 |
Country Status (19)
Country | Link |
---|---|
US (1) | US9828323B2 (pl) |
EP (1) | EP2917171B1 (pl) |
JP (1) | JP2015531404A (pl) |
KR (1) | KR102229841B1 (pl) |
CN (1) | CN104903282B (pl) |
AU (1) | AU2013330517B2 (pl) |
BR (1) | BR112015008021A2 (pl) |
CA (1) | CA2888010C (pl) |
CY (1) | CY1121117T1 (pl) |
DK (1) | DK2917171T3 (pl) |
ES (1) | ES2701808T3 (pl) |
IL (1) | IL238199A (pl) |
LT (1) | LT2917171T (pl) |
MX (1) | MX2015004618A (pl) |
PL (2) | PL401195A1 (pl) |
RU (1) | RU2015117398A (pl) |
TN (1) | TN2015000137A1 (pl) |
TR (1) | TR201818397T4 (pl) |
WO (1) | WO2014058330A2 (pl) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL424875A1 (pl) * | 2018-03-12 | 2019-09-23 | Vitasynth Spółka Z Ograniczoną Odpowiedzialnością | Sposób syntezy witaminy K2 |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0817528D0 (en) | 2008-09-24 | 2008-10-29 | Syntavit As | Process |
US11407704B2 (en) | 2018-04-06 | 2022-08-09 | Siec Badawcza Lukasiewicz-Instytut Chemii Przemyslowej Imienia Profesora Ignacego Moscickiego | Process of vitamin K2 derivatives preparation |
WO2021071372A1 (en) | 2019-10-07 | 2021-04-15 | Sieć Badawcza Łukasiewicz - Instytut Farmaceutyczny | Process of vitamin k2 derivatives preparation |
PL243187B1 (pl) | 2020-07-16 | 2023-07-10 | Vitasynth Spolka Z Ograniczona Odpowiedzialnoscia | Sposób i związki pośrednie do otrzymywania menachinonu MK-7 |
CN113403348B (zh) * | 2021-06-18 | 2022-03-22 | 山东润德生物科技有限公司 | 一种维生素k2的制备方法 |
WO2023031841A1 (en) * | 2021-09-03 | 2023-03-09 | Synergia Life Sciences Pvt. Ltd. | A process for the stereospecific synthesis of vitamin k2 and its intermediates |
CN114149314B (zh) * | 2021-11-26 | 2024-05-28 | 安徽先和医药研究有限公司 | Vk2的合成方法 |
WO2024013633A1 (en) * | 2022-07-11 | 2024-01-18 | Synergia Life Sciences Pvt. Ltd. | Process for the synthesis of vitamin k2 |
CN117867044B (zh) * | 2023-12-27 | 2024-07-30 | 杭州微远生物科技有限公司 | 一种维生素mk-4的生物酶法制备工艺 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1091680A (en) | 1976-10-19 | 1980-12-16 | Shinji Terao | Method for production of quinones |
FR2435466A1 (fr) * | 1978-08-02 | 1980-04-04 | Kuraray Co | Derives de l'hydroquinone et leur procede de preparation |
US8414565B2 (en) * | 2002-12-16 | 2013-04-09 | The Ohio State University | Parametric model based ablative surgical systems and methods |
FR2925908A1 (fr) * | 2007-12-27 | 2009-07-03 | Bmuestar Silicones France Sas | Composition reticulable/polymerisable par voie cationique comprenant un borate de iodonium et degageant une odeur acceptable |
DE202008008134U1 (de) | 2008-06-17 | 2009-06-25 | Bischof + Klein Gmbh & Co. Kg | Seitenfaltenbeutel |
GB0817528D0 (en) | 2008-09-24 | 2008-10-29 | Syntavit As | Process |
GB201004876D0 (en) * | 2010-03-23 | 2010-05-05 | Syntavit As | Process for the preparation of vitamin K2 |
-
2012
- 2012-10-12 PL PL401195A patent/PL401195A1/pl unknown
-
2013
- 2013-10-11 JP JP2015536739A patent/JP2015531404A/ja active Pending
- 2013-10-11 MX MX2015004618A patent/MX2015004618A/es unknown
- 2013-10-11 BR BR112015008021A patent/BR112015008021A2/pt not_active IP Right Cessation
- 2013-10-11 CA CA2888010A patent/CA2888010C/en active Active
- 2013-10-11 RU RU2015117398A patent/RU2015117398A/ru unknown
- 2013-10-11 KR KR1020157012230A patent/KR102229841B1/ko active IP Right Grant
- 2013-10-11 LT LTEP13792773.7T patent/LT2917171T/lt unknown
- 2013-10-11 DK DK13792773.7T patent/DK2917171T3/en active
- 2013-10-11 ES ES13792773T patent/ES2701808T3/es active Active
- 2013-10-11 WO PCT/PL2013/000132 patent/WO2014058330A2/en active Application Filing
- 2013-10-11 TR TR2018/18397T patent/TR201818397T4/tr unknown
- 2013-10-11 EP EP13792773.7A patent/EP2917171B1/en active Active
- 2013-10-11 PL PL13792773T patent/PL2917171T3/pl unknown
- 2013-10-11 CN CN201380063042.3A patent/CN104903282B/zh active Active
- 2013-10-11 AU AU2013330517A patent/AU2013330517B2/en active Active
- 2013-10-11 US US14/435,260 patent/US9828323B2/en active Active
-
2015
- 2015-04-10 TN TNP2015000137A patent/TN2015000137A1/fr unknown
- 2015-04-12 IL IL238199A patent/IL238199A/en active IP Right Grant
-
2019
- 2019-01-14 CY CY191100035T patent/CY1121117T1/el unknown
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PL424875A1 (pl) * | 2018-03-12 | 2019-09-23 | Vitasynth Spółka Z Ograniczoną Odpowiedzialnością | Sposób syntezy witaminy K2 |
Also Published As
Publication number | Publication date |
---|---|
JP2015531404A (ja) | 2015-11-02 |
AU2013330517A1 (en) | 2015-05-28 |
KR20150091469A (ko) | 2015-08-11 |
DK2917171T3 (en) | 2019-01-07 |
AU2013330517B2 (en) | 2017-07-20 |
KR102229841B1 (ko) | 2021-03-22 |
IL238199A (en) | 2017-04-30 |
TR201818397T4 (tr) | 2019-01-21 |
CY1121117T1 (el) | 2019-12-11 |
PL2917171T3 (pl) | 2019-04-30 |
US20150291498A1 (en) | 2015-10-15 |
CN104903282B (zh) | 2018-10-23 |
US9828323B2 (en) | 2017-11-28 |
WO2014058330A3 (en) | 2014-06-19 |
WO2014058330A2 (en) | 2014-04-17 |
EP2917171A2 (en) | 2015-09-16 |
MX2015004618A (es) | 2016-06-10 |
TN2015000137A1 (en) | 2016-10-03 |
CN104903282A (zh) | 2015-09-09 |
BR112015008021A2 (pt) | 2017-07-04 |
CA2888010A1 (en) | 2014-04-17 |
EP2917171B1 (en) | 2018-11-07 |
ES2701808T3 (es) | 2019-02-26 |
RU2015117398A (ru) | 2016-11-27 |
CA2888010C (en) | 2021-05-25 |
LT2917171T (lt) | 2019-01-25 |
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