MX2015001114A - Metodo para producir 4-[5-(piridin-4-il)-1h-1,2,4-triazol-3-il] piridina-2-carbonitrilo e intermediario del mismo. - Google Patents

Metodo para producir 4-[5-(piridin-4-il)-1h-1,2,4-triazol-3-il] piridina-2-carbonitrilo e intermediario del mismo.

Info

Publication number
MX2015001114A
MX2015001114A MX2015001114A MX2015001114A MX2015001114A MX 2015001114 A MX2015001114 A MX 2015001114A MX 2015001114 A MX2015001114 A MX 2015001114A MX 2015001114 A MX2015001114 A MX 2015001114A MX 2015001114 A MX2015001114 A MX 2015001114A
Authority
MX
Mexico
Prior art keywords
pyridin
intermediary
triazole
producing
carbonitrile
Prior art date
Application number
MX2015001114A
Other languages
English (en)
Other versions
MX362102B (es
Inventor
Junichiro Uda
Osamu Nagata
Yoshiyuki Iwabuchi
Sachiho Miyata
Original Assignee
Fujiyakuhin Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fujiyakuhin Co Ltd filed Critical Fujiyakuhin Co Ltd
Publication of MX2015001114A publication Critical patent/MX2015001114A/es
Publication of MX362102B publication Critical patent/MX362102B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/84—Nitriles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/86—Hydrazides; Thio or imino analogues thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

Proporcionar un método industrialmente útil para producir 4-[5-(piridin-4-il)-1H-1,2,4-triazol-3-iI]piridina-2-carbonitrilo farmacéuticamente útil, y un intermediario para producir el compuesto; el método para producir el compuesto representado por medio de la fórmula (1) está representado por el siguiente esquema de reacción, y el intermediario está representado por medio de la siguiente fórmula (4). (ver Fórmulas).
MX2015001114A 2012-07-25 2013-07-24 Método para producir 4-[5-(piridin-4-il)-1h-1,2,4-triazol-3-il]pir idina-2-carbonitrilo e intermediario del mismo. MX362102B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012177538 2012-07-25
PCT/JP2013/070005 WO2014017516A1 (ja) 2012-07-25 2013-07-24 ４－［５－（ピリジン－４－イル）－１ｈ－１，２，４－トリアゾール－３－イル］ピリジン－２－カルボニトリルの製造方法および中間体

Publications (2)

Publication Number Publication Date
MX2015001114A true MX2015001114A (es) 2015-04-08
MX362102B MX362102B (es) 2019-01-04

Family

ID=49997325

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015001114A MX362102B (es) 2012-07-25 2013-07-24 Método para producir 4-[5-(piridin-4-il)-1h-1,2,4-triazol-3-il]pir idina-2-carbonitrilo e intermediario del mismo.

Country Status (19)

Country Link
US (1) US9428488B2 (es)
EP (1) EP2878595A4 (es)
JP (1) JP5827407B2 (es)
KR (1) KR101719891B1 (es)
CN (1) CN104411686B (es)
AU (1) AU2013293974B2 (es)
BR (1) BR112014032229B1 (es)
CA (1) CA2876268C (es)
HK (1) HK1204788A1 (es)
IL (1) IL236081A (es)
IN (1) IN2014DN10530A (es)
MX (1) MX362102B (es)
MY (1) MY185203A (es)
NZ (1) NZ702797A (es)
PH (1) PH12015500160A1 (es)
RU (1) RU2644766C2 (es)
TW (1) TWI580675B (es)
WO (1) WO2014017516A1 (es)
ZA (1) ZA201500462B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105367490B (zh) * 2014-08-18 2019-01-04 上海医药工业研究院 合成托吡司他的新中间体及其制备方法
WO2016134854A1 (en) 2015-02-25 2016-09-01 Pharmathen S.A. Methods for the preparation of topiroxostat and intermediates thereof
CN105693699B (zh) * 2015-03-30 2019-06-18 苏州晶云药物科技股份有限公司 托吡司他的晶型及其制备方法
CN104758263B (zh) * 2015-04-22 2017-08-22 青岛正大海尔制药有限公司 一种托匹司他片及其制备方法
CN105294656A (zh) * 2015-10-10 2016-02-03 大道隆达（北京）医药科技发展有限公司 一种托匹司他的制备工艺和方法
CN106008465A (zh) * 2016-03-16 2016-10-12 江苏悦兴药业有限公司 一种托匹司他杂质的合成方法
CN108101840A (zh) * 2018-01-26 2018-06-01 南京华威医药科技集团有限公司 托吡司他及其中间体制备方法
CN115093399A (zh) * 2022-07-29 2022-09-23 武汉工程大学 一种抗痛风药物托匹司他的制备方法

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3947577A (en) * 1973-05-21 1976-03-30 Merck & Co., Inc. Anti-hyperuricemia composition
US4097599A (en) * 1973-11-13 1978-06-27 Commonwealth Scientific And Industrial Research Organization Triazoles
ZA859576B (en) * 1984-12-21 1986-08-27 Hoffmann La Roche Heterocyclic compounds
AR241530A1 (es) * 1984-12-21 1992-08-31 Ciba Geigy A G Cesionaria De F 1,2,4-triazoles, composicion para el control de pestes y procedimiento para la preparacion de 1,2,4-triazoles.
JP3217846B2 (ja) * 1992-03-04 2001-10-15 クミアイ化学工業株式会社 トリアゾール誘導体及び殺虫剤
BR9915534B1 (pt) * 1998-10-23 2011-04-19 1-piridil substituìdo)-1,2,4-triazóis inseticidas.
JP2003064410A (ja) 2001-08-22 2003-03-05 Nippon Steel Corp 転炉吹錬方法および上吹きランス
JP3600832B2 (ja) * 2002-01-28 2004-12-15 株式会社富士薬品 新規１，２，４−トリアゾール系化合物
JP2005009991A (ja) 2003-06-18 2005-01-13 Alpine Electronics Inc 車載用ナビゲーション装置及び車載用ナビゲーション装置の表示方法
EP1650204A4 (en) * 2003-07-24 2008-06-18 Fujiyakuhin Co Ltd PROCESS FOR PREPARING A 1,2,4-TRIAZOL COMPOUND AND INTERMEDIATE PRODUCTS THEREFOR
JP2005041802A (ja) 2003-07-25 2005-02-17 Fujiyakuhin Co Ltd １，２，４−トリアゾール化合物の製造方法
US20060189811A1 (en) 2004-07-23 2006-08-24 Fujiyakuhin Co., Ltd. Process for producing 1,2,4-triazole compound and intermediate therefor

Also Published As

Publication number Publication date
PH12015500160B1 (en) 2015-03-16
CA2876268C (en) 2016-12-20
KR101719891B1 (ko) 2017-03-24
AU2013293974B2 (en) 2017-06-01
TW201408642A (zh) 2014-03-01
EP2878595A4 (en) 2015-12-09
EP2878595A1 (en) 2015-06-03
HK1204788A1 (en) 2015-12-04
PH12015500160A1 (en) 2015-03-16
CN104411686B (zh) 2016-08-31
BR112014032229A2 (pt) 2017-06-27
RU2015106138A (ru) 2016-09-10
US9428488B2 (en) 2016-08-30
NZ702797A (en) 2017-03-31
IL236081A (en) 2017-11-30
MX362102B (es) 2019-01-04
IL236081A0 (en) 2015-02-01
TWI580675B (zh) 2017-05-01
CN104411686A (zh) 2015-03-11
US20150166510A1 (en) 2015-06-18
WO2014017516A1 (ja) 2014-01-30
CA2876268A1 (en) 2014-01-30
MY185203A (en) 2021-04-30
KR20150035586A (ko) 2015-04-06
IN2014DN10530A (es) 2015-08-21
AU2013293974A1 (en) 2015-01-22
JPWO2014017516A1 (ja) 2016-07-11
ZA201500462B (en) 2016-10-26
RU2644766C2 (ru) 2018-02-14
BR112014032229B1 (pt) 2021-02-09
JP5827407B2 (ja) 2015-12-02

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