MX2013009757A - Metodo de seleccion rapida para vih variantes gp-120. - Google Patents
Metodo de seleccion rapida para vih variantes gp-120.Info
- Publication number
- MX2013009757A MX2013009757A MX2013009757A MX2013009757A MX2013009757A MX 2013009757 A MX2013009757 A MX 2013009757A MX 2013009757 A MX2013009757 A MX 2013009757A MX 2013009757 A MX2013009757 A MX 2013009757A MX 2013009757 A MX2013009757 A MX 2013009757A
- Authority
- MX
- Mexico
- Prior art keywords
- hiv
- variants
- selection method
- rapid selection
- ris
- Prior art date
Links
- 238000010187 selection method Methods 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
- C07K14/16—HIV-1 ; HIV-2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
- G01N2333/162—HIV-1, HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, DC4-Binding site
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Biotechnology (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- AIDS & HIV (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
Abstract
La invención se refiere a un método para la selección rápida de inmunógenos (RIS) basado en la unión de una librería de virus recombinantes que contienen variantes aleatorizadas de un polipéptido de superficie presentado a dichos anticuerpos neutralizantes. La invención se refiere también al uso de los inmunógenos aislados según el método RIS de la invención en medicina para el tratamiento de enfermedades causadas por un virus y en diagnóstico para la identificación de anticuerpos neutralizantes en un paciente.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161446595P | 2011-02-25 | 2011-02-25 | |
EP11382051A EP2492279A1 (en) | 2011-02-25 | 2011-02-25 | Rapid immunogen selection method using lentiviral display |
PCT/EP2012/053185 WO2012113921A1 (en) | 2011-02-25 | 2012-02-24 | Rapid selection method for hiv gp-120 variants |
Publications (2)
Publication Number | Publication Date |
---|---|
MX2013009757A true MX2013009757A (es) | 2013-12-02 |
MX348459B MX348459B (es) | 2017-06-14 |
Family
ID=44246584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013009757A MX348459B (es) | 2011-02-25 | 2012-02-24 | Metodo de seleccion rapida para vih variantes gp-120. |
Country Status (22)
Country | Link |
---|---|
US (1) | US9605030B2 (es) |
EP (2) | EP2492279A1 (es) |
JP (1) | JP6140614B2 (es) |
KR (1) | KR20140025356A (es) |
CN (1) | CN103459410B (es) |
AU (1) | AU2012219418C1 (es) |
CA (1) | CA2827967A1 (es) |
CY (1) | CY1119638T1 (es) |
DK (1) | DK2678351T3 (es) |
ES (1) | ES2651124T3 (es) |
HR (1) | HRP20171697T1 (es) |
HU (1) | HUE035432T2 (es) |
IL (1) | IL228094A0 (es) |
LT (1) | LT2678351T (es) |
ME (1) | ME03045B (es) |
MX (1) | MX348459B (es) |
PL (1) | PL2678351T3 (es) |
PT (1) | PT2678351T (es) |
RS (1) | RS56707B1 (es) |
RU (1) | RU2603732C2 (es) |
SI (1) | SI2678351T1 (es) |
WO (1) | WO2012113921A1 (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2492279A1 (en) | 2011-02-25 | 2012-08-29 | Laboratorios Del. Dr. Esteve, S.A. | Rapid immunogen selection method using lentiviral display |
EP2698377A1 (en) * | 2012-08-17 | 2014-02-19 | Laboratorios Del. Dr. Esteve, S.A. | Enhanced rapid immunogen selection method for HIV gp120 variants |
CN104697830B (zh) * | 2015-02-10 | 2018-06-15 | 深圳市新产业生物医学工程股份有限公司 | 用于hiv检测的酸性处理剂、样本预处理方法、试剂盒及检测方法 |
CN107988428B (zh) * | 2017-11-10 | 2021-04-06 | 杭州众测生物科技有限公司 | 虾虹彩病毒(siv)的raa恒温荧光检测方法及试剂 |
JP2019153618A (ja) * | 2018-02-28 | 2019-09-12 | 株式会社ジャパンディスプレイ | 光センサ装置 |
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RU2237065C2 (ru) * | 2002-10-03 | 2004-09-27 | Государственный научный центр вирусологии и биотехнологии "Вектор" | Иммуногенная библиотека химерных пептидов, мимикрирующая генетическое многообразие гипервариабельного района v3 белка оболочки gp120 вируса иммунодефицита человека |
EP1667714B1 (en) * | 2003-09-17 | 2018-01-03 | Duke University | Consensus/ancestral immunogens |
WO2009117661A2 (en) | 2008-03-20 | 2009-09-24 | United States Department Of The Army, As Represented By The Secretary Of The Army, On Behalf Of The Walter Reed Army Institute Of Research | Carrier neutralization assay |
SI3260136T1 (sl) | 2009-03-17 | 2021-05-31 | Theraclone Sciences, Inc. | Humani imunodeficientni virus (HIV)-nevtralizirajoča protitelesa |
CA2789483A1 (en) * | 2010-03-02 | 2011-09-09 | International Aids Vaccine Initiative | Novel hiv-1 envelope glycoprotein |
EP2492279A1 (en) | 2011-02-25 | 2012-08-29 | Laboratorios Del. Dr. Esteve, S.A. | Rapid immunogen selection method using lentiviral display |
-
2011
- 2011-02-25 EP EP11382051A patent/EP2492279A1/en not_active Withdrawn
-
2012
- 2012-02-24 PL PL12705689T patent/PL2678351T3/pl unknown
- 2012-02-24 US US14/000,924 patent/US9605030B2/en not_active Expired - Fee Related
- 2012-02-24 HU HUE12705689A patent/HUE035432T2/en unknown
- 2012-02-24 RS RS20171235A patent/RS56707B1/sr unknown
- 2012-02-24 ME MEP-2017-270A patent/ME03045B/me unknown
- 2012-02-24 CN CN201280016904.2A patent/CN103459410B/zh not_active Expired - Fee Related
- 2012-02-24 EP EP12705689.3A patent/EP2678351B1/en active Active
- 2012-02-24 DK DK12705689.3T patent/DK2678351T3/en active
- 2012-02-24 AU AU2012219418A patent/AU2012219418C1/en not_active Ceased
- 2012-02-24 KR KR1020137025232A patent/KR20140025356A/ko not_active Application Discontinuation
- 2012-02-24 SI SI201231116T patent/SI2678351T1/en unknown
- 2012-02-24 ES ES12705689.3T patent/ES2651124T3/es active Active
- 2012-02-24 RU RU2013143295/10A patent/RU2603732C2/ru not_active IP Right Cessation
- 2012-02-24 CA CA2827967A patent/CA2827967A1/en not_active Abandoned
- 2012-02-24 MX MX2013009757A patent/MX348459B/es active IP Right Grant
- 2012-02-24 LT LTEP12705689.3T patent/LT2678351T/lt unknown
- 2012-02-24 PT PT127056893T patent/PT2678351T/pt unknown
- 2012-02-24 WO PCT/EP2012/053185 patent/WO2012113921A1/en active Application Filing
- 2012-02-24 JP JP2013554913A patent/JP6140614B2/ja not_active Expired - Fee Related
-
2013
- 2013-08-22 IL IL228094A patent/IL228094A0/en unknown
-
2017
- 2017-11-06 HR HRP20171697TT patent/HRP20171697T1/hr unknown
- 2017-11-30 CY CY20171101255T patent/CY1119638T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
MX348459B (es) | 2017-06-14 |
HRP20171697T1 (hr) | 2018-01-26 |
CN103459410A (zh) | 2013-12-18 |
JP2015508279A (ja) | 2015-03-19 |
RU2013143295A (ru) | 2015-03-27 |
WO2012113921A1 (en) | 2012-08-30 |
EP2492279A1 (en) | 2012-08-29 |
PT2678351T (pt) | 2017-12-11 |
CN103459410B (zh) | 2016-05-25 |
HUE035432T2 (en) | 2018-05-02 |
NZ614753A (en) | 2015-10-30 |
EP2678351B1 (en) | 2017-09-13 |
CY1119638T1 (el) | 2018-04-04 |
RU2603732C2 (ru) | 2016-11-27 |
AU2012219418A1 (en) | 2013-09-19 |
EP2678351A1 (en) | 2014-01-01 |
AU2012219418C1 (en) | 2017-10-05 |
LT2678351T (lt) | 2018-01-25 |
RS56707B1 (sr) | 2018-03-30 |
ES2651124T3 (es) | 2018-01-24 |
US9605030B2 (en) | 2017-03-28 |
KR20140025356A (ko) | 2014-03-04 |
CA2827967A1 (en) | 2012-08-30 |
JP6140614B2 (ja) | 2017-05-31 |
IL228094A0 (en) | 2013-09-30 |
SI2678351T1 (en) | 2018-01-31 |
US20140037667A1 (en) | 2014-02-06 |
PL2678351T3 (pl) | 2018-03-30 |
AU2012219418B2 (en) | 2017-05-25 |
DK2678351T3 (en) | 2017-12-04 |
ME03045B (me) | 2018-10-20 |
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