CY1119638T1 - Παραλλαγη gp-120 του ηiv - Google Patents
Παραλλαγη gp-120 του ηivInfo
- Publication number
- CY1119638T1 CY1119638T1 CY20171101255T CY171101255T CY1119638T1 CY 1119638 T1 CY1119638 T1 CY 1119638T1 CY 20171101255 T CY20171101255 T CY 20171101255T CY 171101255 T CY171101255 T CY 171101255T CY 1119638 T1 CY1119638 T1 CY 1119638T1
- Authority
- CY
- Cyprus
- Prior art keywords
- hiv
- ris
- neutralizing antibodies
- relates
- difference
- Prior art date
Links
- 241000700605 Viruses Species 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 230000003472 neutralizing effect Effects 0.000 abstract 2
- 238000003745 diagnosis Methods 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 230000002163 immunogen Effects 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
- C07K14/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- C07K14/16—HIV-1 ; HIV-2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/21—Retroviridae, e.g. equine infectious anemia virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
- C12N15/1034—Isolating an individual clone by screening libraries
- C12N15/1037—Screening libraries presented on the surface of microorganisms, e.g. phage display, E. coli display
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
- G01N33/56983—Viruses
- G01N33/56988—HIV or HTLV
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16041—Use of virus, viral particle or viral elements as a vector
- C12N2740/16043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2799/00—Uses of viruses
- C12N2799/02—Uses of viruses as vector
- C12N2799/021—Uses of viruses as vector for the expression of a heterologous nucleic acid
- C12N2799/027—Uses of viruses as vector for the expression of a heterologous nucleic acid where the vector is derived from a retrovirus
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
- G01N2333/08—RNA viruses
- G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
- G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
- G01N2333/16—HIV-1, HIV-2
- G01N2333/162—HIV-1, HIV-2 env, e.g. gp160, gp110/120, gp41, V3, peptid T, DC4-Binding site
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2469/00—Immunoassays for the detection of microorganisms
- G01N2469/20—Detection of antibodies in sample from host which are directed against antigens from microorganisms
Abstract
Η εφεύρεση αναφέρεται σε μια μέθοδο για την ταχεία επιλογή ανοσογόνου (RIS) με βάση την πρόσδεση μιας βιβλιοθήκης ανασυνδυασμένων ιών που περιέχει τυχαιοποιημένες παραλλαγές gp120 του HIV ενός επιφανειακού πολυπεπτιδίου που εμφανίζεται στα εν λόγω εξουδετερωτικά αντισώματα. Η εφεύρεση σχετίζεται επίσης με τη χρήση ανοσογόνων gp120 του HIV που απομονώνονται σύμφωνα με τη μέθοδο RIS της εφεύρεσης στην ιατρική για τη θεραπεία νόσων που προκαλούνται από έναν ιό και στη διάγνωση για την ταυτοποίηση εξουδετερωτικών αντισωμάτων σε έναν ασθενή.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161446595P | 2011-02-25 | 2011-02-25 | |
EP11382051A EP2492279A1 (en) | 2011-02-25 | 2011-02-25 | Rapid immunogen selection method using lentiviral display |
PCT/EP2012/053185 WO2012113921A1 (en) | 2011-02-25 | 2012-02-24 | Rapid selection method for hiv gp-120 variants |
EP12705689.3A EP2678351B1 (en) | 2011-02-25 | 2012-02-24 | Hiv gp-120 variant |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1119638T1 true CY1119638T1 (el) | 2018-04-04 |
Family
ID=44246584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20171101255T CY1119638T1 (el) | 2011-02-25 | 2017-11-30 | Παραλλαγη gp-120 του ηiv |
Country Status (22)
Country | Link |
---|---|
US (1) | US9605030B2 (el) |
EP (2) | EP2492279A1 (el) |
JP (1) | JP6140614B2 (el) |
KR (1) | KR20140025356A (el) |
CN (1) | CN103459410B (el) |
AU (1) | AU2012219418C1 (el) |
CA (1) | CA2827967A1 (el) |
CY (1) | CY1119638T1 (el) |
DK (1) | DK2678351T3 (el) |
ES (1) | ES2651124T3 (el) |
HR (1) | HRP20171697T1 (el) |
HU (1) | HUE035432T2 (el) |
IL (1) | IL228094A0 (el) |
LT (1) | LT2678351T (el) |
ME (1) | ME03045B (el) |
MX (1) | MX348459B (el) |
PL (1) | PL2678351T3 (el) |
PT (1) | PT2678351T (el) |
RS (1) | RS56707B1 (el) |
RU (1) | RU2603732C2 (el) |
SI (1) | SI2678351T1 (el) |
WO (1) | WO2012113921A1 (el) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2492279A1 (en) | 2011-02-25 | 2012-08-29 | Laboratorios Del. Dr. Esteve, S.A. | Rapid immunogen selection method using lentiviral display |
EP2698377A1 (en) * | 2012-08-17 | 2014-02-19 | Laboratorios Del. Dr. Esteve, S.A. | Enhanced rapid immunogen selection method for HIV gp120 variants |
CN104697830B (zh) * | 2015-02-10 | 2018-06-15 | 深圳市新产业生物医学工程股份有限公司 | 用于hiv检测的酸性处理剂、样本预处理方法、试剂盒及检测方法 |
CN107988428B (zh) * | 2017-11-10 | 2021-04-06 | 杭州众测生物科技有限公司 | 虾虹彩病毒(siv)的raa恒温荧光检测方法及试剂 |
JP2019153618A (ja) * | 2018-02-28 | 2019-09-12 | 株式会社ジャパンディスプレイ | 光センサ装置 |
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2011
- 2011-02-25 EP EP11382051A patent/EP2492279A1/en not_active Withdrawn
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2012
- 2012-02-24 LT LTEP12705689.3T patent/LT2678351T/lt unknown
- 2012-02-24 SI SI201231116T patent/SI2678351T1/en unknown
- 2012-02-24 MX MX2013009757A patent/MX348459B/es active IP Right Grant
- 2012-02-24 RS RS20171235A patent/RS56707B1/sr unknown
- 2012-02-24 KR KR1020137025232A patent/KR20140025356A/ko not_active Application Discontinuation
- 2012-02-24 CA CA2827967A patent/CA2827967A1/en not_active Abandoned
- 2012-02-24 PL PL12705689T patent/PL2678351T3/pl unknown
- 2012-02-24 JP JP2013554913A patent/JP6140614B2/ja not_active Expired - Fee Related
- 2012-02-24 DK DK12705689.3T patent/DK2678351T3/en active
- 2012-02-24 EP EP12705689.3A patent/EP2678351B1/en active Active
- 2012-02-24 US US14/000,924 patent/US9605030B2/en not_active Expired - Fee Related
- 2012-02-24 PT PT127056893T patent/PT2678351T/pt unknown
- 2012-02-24 AU AU2012219418A patent/AU2012219418C1/en not_active Ceased
- 2012-02-24 HU HUE12705689A patent/HUE035432T2/en unknown
- 2012-02-24 RU RU2013143295/10A patent/RU2603732C2/ru not_active IP Right Cessation
- 2012-02-24 ES ES12705689.3T patent/ES2651124T3/es active Active
- 2012-02-24 WO PCT/EP2012/053185 patent/WO2012113921A1/en active Application Filing
- 2012-02-24 ME MEP-2017-270A patent/ME03045B/me unknown
- 2012-02-24 CN CN201280016904.2A patent/CN103459410B/zh not_active Expired - Fee Related
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2013
- 2013-08-22 IL IL228094A patent/IL228094A0/en unknown
-
2017
- 2017-11-06 HR HRP20171697TT patent/HRP20171697T1/hr unknown
- 2017-11-30 CY CY20171101255T patent/CY1119638T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
RU2013143295A (ru) | 2015-03-27 |
AU2012219418A1 (en) | 2013-09-19 |
AU2012219418B2 (en) | 2017-05-25 |
EP2678351A1 (en) | 2014-01-01 |
SI2678351T1 (en) | 2018-01-31 |
HUE035432T2 (en) | 2018-05-02 |
JP2015508279A (ja) | 2015-03-19 |
CN103459410B (zh) | 2016-05-25 |
MX348459B (es) | 2017-06-14 |
MX2013009757A (es) | 2013-12-02 |
ME03045B (me) | 2018-10-20 |
PT2678351T (pt) | 2017-12-11 |
KR20140025356A (ko) | 2014-03-04 |
JP6140614B2 (ja) | 2017-05-31 |
EP2492279A1 (en) | 2012-08-29 |
DK2678351T3 (en) | 2017-12-04 |
EP2678351B1 (en) | 2017-09-13 |
ES2651124T3 (es) | 2018-01-24 |
IL228094A0 (en) | 2013-09-30 |
CA2827967A1 (en) | 2012-08-30 |
RU2603732C2 (ru) | 2016-11-27 |
AU2012219418C1 (en) | 2017-10-05 |
LT2678351T (lt) | 2018-01-25 |
US9605030B2 (en) | 2017-03-28 |
WO2012113921A1 (en) | 2012-08-30 |
HRP20171697T1 (hr) | 2018-01-26 |
CN103459410A (zh) | 2013-12-18 |
NZ614753A (en) | 2015-10-30 |
RS56707B1 (sr) | 2018-03-30 |
PL2678351T3 (pl) | 2018-03-30 |
US20140037667A1 (en) | 2014-02-06 |
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