DE69332744T2 - Humaner neutralisierender monoklonaler antikörper gegen den die immunschwäche beim menschen hervorringenden virus - Google Patents
Humaner neutralisierender monoklonaler antikörper gegen den die immunschwäche beim menschen hervorringenden virus Download PDFInfo
- Publication number
- DE69332744T2 DE69332744T2 DE69332744T DE69332744T DE69332744T2 DE 69332744 T2 DE69332744 T2 DE 69332744T2 DE 69332744 T DE69332744 T DE 69332744T DE 69332744 T DE69332744 T DE 69332744T DE 69332744 T2 DE69332744 T2 DE 69332744T2
- Authority
- DE
- Germany
- Prior art keywords
- human
- monoclonal antibodies
- antibodies against
- weakness
- neutralizing monoclonal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 241000700605 Viruses Species 0.000 title 1
- 230000003472 neutralizing effect Effects 0.000 title 1
- 241000725303 Human immunodeficiency virus Species 0.000 abstract 2
- 238000002405 diagnostic procedure Methods 0.000 abstract 1
- 230000001024 immunotherapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/14—Peptides, e.g. proteins
- A61K49/16—Antibodies; Immunoglobulins; Fragments thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/035—Fusion polypeptide containing a localisation/targetting motif containing a signal for targeting to the external surface of a cell, e.g. to the outer membrane of Gram negative bacteria, GPI- anchored eukaryote proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US95414892A | 1992-09-30 | 1992-09-30 | |
PCT/US1993/009328 WO1994007922A1 (en) | 1992-09-30 | 1993-09-30 | Human neutralizing monoclonal antibodies to human immunodeficiency virus |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69332744D1 DE69332744D1 (de) | 2003-04-10 |
DE69332744T2 true DE69332744T2 (de) | 2004-01-15 |
Family
ID=25495000
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69332744T Expired - Fee Related DE69332744T2 (de) | 1992-09-30 | 1993-09-30 | Humaner neutralisierender monoklonaler antikörper gegen den die immunschwäche beim menschen hervorringenden virus |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP0675904B1 (de) |
JP (1) | JPH08502260A (de) |
AT (1) | ATE233814T1 (de) |
AU (1) | AU681360B2 (de) |
CA (1) | CA2145757A1 (de) |
DE (1) | DE69332744T2 (de) |
ES (1) | ES2194015T3 (de) |
FI (1) | FI951488A (de) |
NO (1) | NO951212L (de) |
WO (1) | WO1994007922A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE300610T1 (de) | 1994-01-31 | 2005-08-15 | Univ Boston | Bibliotheken aus polyklonalen antikörpern |
US6987096B1 (en) | 1995-04-27 | 2006-01-17 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides, DNA coding sequences therefor, and uses thereof |
US5843882A (en) | 1995-04-27 | 1998-12-01 | The United States Of America As Represented By The Department Of Health And Human Services | Antiviral proteins and peptides |
US6428790B1 (en) | 1995-04-27 | 2002-08-06 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use |
US6193982B1 (en) | 1995-04-27 | 2001-02-27 | The United States Of America As Represented By The Department Of Health & Human Services | Anti-cyanovirin antibody with an internal image of gp120, a method of use thereof, and a method of using a cyanovirin to induce an immune response to gp120 |
US6780847B2 (en) | 1995-04-27 | 2004-08-24 | The United States Of America As Represented By The Department Of Health And Human Services | Glycosylation-resistant cyanovirins and related conjugates, compositions, nucleic acids, vectors, host cells, methods of production and methods of using nonglycosylated cyanovirins |
US7048935B2 (en) | 1995-04-27 | 2006-05-23 | The United States Of America As Represented By The Department Of Health And Human Services | Cyanovirin conjugates and matrix-anchored cyanovirin and related compositions and methods of use |
US6255455B1 (en) | 1996-10-11 | 2001-07-03 | The Trustees Of The University Of Pennsylvania | Rh(D)-binding proteins and magnetically activated cell sorting method for production thereof |
DE19809785C2 (de) * | 1998-03-08 | 2000-02-10 | Wolfgang Bergter | Radioimmunpharmakon zur Behandlung der HIV-1-Infektion |
ES2212607T3 (es) * | 1998-06-29 | 2004-07-16 | Wolfgang Bergter | Medicamentos antivirales y antirretrovirales radioinmunologicos basados en emisores de rayos alfa y beta. |
CA2358385C (en) | 1998-12-31 | 2013-08-06 | Chiron Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
GB9908533D0 (en) | 1999-04-14 | 1999-06-09 | Novartis Ag | Organic compounds |
DK2199393T3 (da) | 2000-04-17 | 2012-11-26 | Dyax Corp | Hidtil ukendte fremgangsmåder til opbygning af biblioteker over genetiske pakker, der kollektivt viser medlemmerne af en forskelligartet familie af peptider, polypeptider eller proteiner |
US8288322B2 (en) | 2000-04-17 | 2012-10-16 | Dyax Corp. | Methods of constructing libraries comprising displayed and/or expressed members of a diverse family of peptides, polypeptides or proteins and the novel libraries |
PT2316940E (pt) | 2000-12-18 | 2013-10-16 | Dyax Corp | Bibliotecas orientadas de pacotes genéticos |
ATE369427T1 (de) | 2001-03-22 | 2007-08-15 | Us Health | Glykosylierungsresistente cyanovirine und damit verbundene konjugate, zusammensetzungen, nukleinsäuren, vektoren, wirtszellen, herstellungsverfahren sowie verfahren zur verwendung nichtglykosylierter cyanovirine |
WO2003004620A2 (en) | 2001-07-05 | 2003-01-16 | Chiron, Corporation | Polynucleotides encoding antigenic hiv type c polypeptides, polypeptides and uses thereof |
CA2463931A1 (en) | 2001-10-16 | 2003-04-24 | The Government Of The United States Of America, Represented By The Secre Tary, Department Of Health And Human Services | Broadly cross-reactive neutralizing antibodies against human immunodeficiency virus selected by env-cd4-co-receptor complexes |
WO2003092630A2 (en) | 2002-05-06 | 2003-11-13 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Identification of novel broadly cross-reactive neutralizing human monoclonal antibodies using sequential antigen panning of phage display libraries |
US7566451B2 (en) | 2002-05-06 | 2009-07-28 | The United States Of America As Represented By The Department Of Health And Human Services | Human immunodeficiency virus-neutralizing human antibodies with improved breadth and potency |
US20040067532A1 (en) | 2002-08-12 | 2004-04-08 | Genetastix Corporation | High throughput generation and affinity maturation of humanized antibody |
WO2006050219A2 (en) * | 2004-10-29 | 2006-05-11 | Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Broadly cross-reactive hiv-1 neutralizing human monoclonal antibodies |
US8877688B2 (en) | 2007-09-14 | 2014-11-04 | Adimab, Llc | Rationally designed, synthetic antibody libraries and uses therefor |
BRPI0816785A2 (pt) | 2007-09-14 | 2017-05-02 | Adimab Inc | bibliotecas de anticorpos sintéticos racionalmente desenhadas, e, usos para as mesmas |
US9873957B2 (en) | 2008-03-13 | 2018-01-23 | Dyax Corp. | Libraries of genetic packages comprising novel HC CDR3 designs |
CA2722409C (en) | 2008-04-24 | 2017-12-12 | Dyax Corp. | Libraries of genetic packages comprising novel hc cdr1, cdr2, and cdr3 and novel lc cdr1, cdr2, and cdr3 designs |
EP3741883B1 (de) | 2010-07-16 | 2022-12-14 | Adimab, LLC | Antikörperbibliotheken |
EP2492279A1 (de) | 2011-02-25 | 2012-08-29 | Laboratorios Del. Dr. Esteve, S.A. | Schnelles immunogenes Auswahlverfahren mittels Lentivirenanzeige |
EP2698377A1 (de) | 2012-08-17 | 2014-02-19 | Laboratorios Del. Dr. Esteve, S.A. | Verbessertes schnelles Immunogene Auswahlverfahren für HIV gp120 Varianten |
KR20210097833A (ko) * | 2017-11-17 | 2021-08-09 | 그리폴스 다이어그노스틱 솔루션즈 인크. | 신규한 포유동물 발현 인간 면역결핍 바이러스 외피 단백질 항원 |
WO2021132427A1 (ja) | 2019-12-27 | 2021-07-01 | 株式会社カイオム・バイオサイエンス | 抗cdcp1抗体 |
WO2022049867A1 (ja) | 2020-09-02 | 2022-03-10 | 国立大学法人東京大学 | がん免疫微小環境の調節物質およびそれによる予防・診断・治療的利用 |
CN112521492B (zh) * | 2020-12-18 | 2022-05-20 | 杭州贤至生物科技有限公司 | 乙肝表面抗原单克隆抗体的制备 |
-
1993
- 1993-09-30 DE DE69332744T patent/DE69332744T2/de not_active Expired - Fee Related
- 1993-09-30 AU AU53501/94A patent/AU681360B2/en not_active Ceased
- 1993-09-30 ES ES93923749T patent/ES2194015T3/es not_active Expired - Lifetime
- 1993-09-30 AT AT93923749T patent/ATE233814T1/de not_active IP Right Cessation
- 1993-09-30 WO PCT/US1993/009328 patent/WO1994007922A1/en active IP Right Grant
- 1993-09-30 JP JP6509318A patent/JPH08502260A/ja not_active Ceased
- 1993-09-30 CA CA002145757A patent/CA2145757A1/en not_active Abandoned
- 1993-09-30 EP EP93923749A patent/EP0675904B1/de not_active Expired - Lifetime
-
1995
- 1995-03-29 FI FI951488A patent/FI951488A/fi not_active Application Discontinuation
- 1995-03-29 NO NO951212A patent/NO951212L/no unknown
Also Published As
Publication number | Publication date |
---|---|
AU681360B2 (en) | 1997-08-28 |
AU5350194A (en) | 1994-04-26 |
EP0675904B1 (de) | 2003-03-05 |
ES2194015T3 (es) | 2003-11-16 |
WO1994007922A1 (en) | 1994-04-14 |
EP0675904A4 (de) | 1996-08-21 |
FI951488A0 (fi) | 1995-03-29 |
NO951212L (no) | 1995-05-29 |
EP0675904A1 (de) | 1995-10-11 |
FI951488A (fi) | 1995-05-23 |
JPH08502260A (ja) | 1996-03-12 |
NO951212D0 (no) | 1995-03-29 |
ATE233814T1 (de) | 2003-03-15 |
CA2145757A1 (en) | 1994-04-14 |
DE69332744D1 (de) | 2003-04-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |