MX2013005205A - Virus del sindrome reproductivo y respiratorio porcino (prrs) de los estados unidos y sus usos. - Google Patents

Virus del sindrome reproductivo y respiratorio porcino (prrs) de los estados unidos y sus usos.

Info

Publication number
MX2013005205A
MX2013005205A MX2013005205A MX2013005205A MX2013005205A MX 2013005205 A MX2013005205 A MX 2013005205A MX 2013005205 A MX2013005205 A MX 2013005205A MX 2013005205 A MX2013005205 A MX 2013005205A MX 2013005205 A MX2013005205 A MX 2013005205A
Authority
MX
Mexico
Prior art keywords
virus
north american
prrs
respiratory syndrome
porcine reproductive
Prior art date
Application number
MX2013005205A
Other languages
English (en)
Other versions
MX350695B (es
Inventor
Jay Gregory Calvert
Siao-Kun Wan Welch
David Ewell Slade
Original Assignee
Zoetis Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zoetis Llc filed Critical Zoetis Llc
Publication of MX2013005205A publication Critical patent/MX2013005205A/es
Publication of MX350695B publication Critical patent/MX350695B/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • A61P31/14Antivirals for RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08RNA viruses
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/08Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844Nucleic acid amplification reactions
    • C12Q1/686Polymerase chain reaction [PCR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/70Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving virus or bacteriophage
    • C12Q1/701Specific hybridization probes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/51Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525Virus
    • A61K2039/5254Virus avirulent or attenuated
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/55Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552Veterinary vaccine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/57Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10022New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10034Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10041Use of virus, viral particle or viral elements as a vector
    • C12N2770/10043Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10051Methods of production or purification of viral material
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10061Methods of inactivation or attenuation
    • C12N2770/10062Methods of inactivation or attenuation by genetic engineering
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10061Methods of inactivation or attenuation
    • C12N2770/10064Methods of inactivation or attenuation by serial passage
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011Details
    • C12N2770/10011Arteriviridae
    • C12N2770/10071Demonstrated in vivo effect

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Analytical Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención provee moléculas de polinucleótidos aisladas que comprenden una secuencia de ADN que codifica una secuencia de ARN infecciosa que codifica un virus PRRS de los Estados Unidos genéticamente modificado, métodos para obtenerlas, y polipéptidos, polinucleótidos y varios componentes relacionados; también se proveen vacunas que comprenden los virus y polinucleótidos genéticamente modificados, y un kit de diagnóstico para diferenciar animales naturalmente infectados de animales vacunados.
MX2013005205A 2010-11-10 2011-11-09 Virus del sindrome reproductivo y respiratorio porcino (prrs) de los estados unidos y sus usos. MX350695B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US41200610P 2010-11-10 2010-11-10
PCT/IB2011/055003 WO2012063212A1 (en) 2010-11-10 2011-11-09 North american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof

Publications (2)

Publication Number Publication Date
MX2013005205A true MX2013005205A (es) 2013-11-04
MX350695B MX350695B (es) 2017-09-13

Family

ID=45401109

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2013005205A MX350695B (es) 2010-11-10 2011-11-09 Virus del sindrome reproductivo y respiratorio porcino (prrs) de los estados unidos y sus usos.

Country Status (20)

Country Link
US (4) US9566324B2 (es)
EP (1) EP2637688B1 (es)
JP (3) JP5793197B2 (es)
KR (1) KR101728202B1 (es)
CN (3) CN107964546B (es)
AR (1) AR083839A1 (es)
AU (1) AU2011327760B2 (es)
BR (1) BR112013011606A2 (es)
CA (1) CA2817486C (es)
DK (1) DK2637688T3 (es)
HK (1) HK1254832A1 (es)
HU (1) HUE031891T2 (es)
MX (1) MX350695B (es)
MY (1) MY173789A (es)
NZ (1) NZ610376A (es)
RU (1) RU2592667C2 (es)
TW (2) TW201518317A (es)
UA (1) UA108902C2 (es)
WO (1) WO2012063212A1 (es)
ZA (1) ZA201304204B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7618797B2 (en) * 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
UA108902C2 (uk) * 2010-11-10 2015-06-25 Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування
US9120859B2 (en) 2012-04-04 2015-09-01 Zoetis Services Llc Mycoplasma hyopneumoniae vaccine
UA114503C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv та mycoplasma hyopneumoniae
UA114504C2 (uk) 2012-04-04 2017-06-26 Зоетіс Сервісіз Ллс Комбінована вакцина pcv, mycoplasma hyopneumoniae та prrs
WO2013173443A1 (en) 2012-05-17 2013-11-21 Zoetis Llc Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
WO2014015116A2 (en) * 2012-07-18 2014-01-23 South Dakota Board Of Regents Novel arterivirus protein and expression mechanisms
US9457073B2 (en) 2012-09-26 2016-10-04 University Of Manitoba Live attenuated replication-competent arteriviruses having decreased dub/deisgylating activity
KR20170002393A (ko) * 2014-03-21 2017-01-06 엔유테크 벤처스 비자연적으로 발생하는 돼지생식기호흡기증후군 바이러스 및 사용방법
KR102602018B1 (ko) * 2016-12-14 2023-11-15 조에티스 서비시즈 엘엘씨 젖떼기 전, 유럽의 돼지 생식기 및 호흡기 증후군 (prrs) 균주 바이러스에 대한 효과적인 백신접종
JP7050446B2 (ja) 2017-09-25 2022-04-08 日本電産サンキョー株式会社 回転伝達機構およびダンパ装置
CN109468413B (zh) * 2018-12-14 2021-09-10 湖南中净生物科技有限公司 一种母猪繁殖障碍病原检测引物、试剂盒、病原检测方法和应用
CN111996213A (zh) * 2020-02-06 2020-11-27 广西大学 猪繁殖与呼吸综合征病毒双荧光标记基因重组毒株的构建方法

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3137631A (en) 1959-12-01 1964-06-16 Faberge Inc Encapsulation in natural products
US3959457A (en) 1970-06-05 1976-05-25 Temple University Microparticulate material and method of making such material
JPS5186117A (en) 1975-01-27 1976-07-28 Tanabe Seiyaku Co Johoseibiryushiseizainoseiho
US4205060A (en) 1978-12-20 1980-05-27 Pennwalt Corporation Microcapsules containing medicament-polymer salt having a water-insoluble polymer sheath, their production and their use
US4452747A (en) 1982-03-22 1984-06-05 Klaus Gersonde Method of and arrangement for producing lipid vesicles
US4744933A (en) 1984-02-15 1988-05-17 Massachusetts Institute Of Technology Process for encapsulation and encapsulated active material system
US5008050A (en) 1984-06-20 1991-04-16 The Liposome Company, Inc. Extrusion technique for producing unilamellar vesicles
US4921706A (en) 1984-11-20 1990-05-01 Massachusetts Institute Of Technology Unilamellar lipid vesicles and method for their formation
US4606940A (en) 1984-12-21 1986-08-19 The Ohio State University Research Foundation Small particle formation and encapsulation
US5009956A (en) 1987-02-24 1991-04-23 Univ Minnesota Phospholipase A2-resistant liposomes
US4927637A (en) 1989-01-17 1990-05-22 Liposome Technology, Inc. Liposome extrusion method
US4944948A (en) 1989-02-24 1990-07-31 Liposome Technology, Inc. EGF/Liposome gel composition and method
US5132117A (en) 1990-01-11 1992-07-21 Temple University Aqueous core microcapsules and method for their preparation
CA2290906C (en) 1991-06-06 2003-04-01 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
JPH0513188A (ja) 1991-06-28 1993-01-22 Toshiba Lighting & Technol Corp 放電灯点灯用電源回路
US6042830A (en) 1992-08-05 2000-03-28 Boehringer Ingelheim Vetmedica, Inc. Viral agent associated with mystery swine disease
DE69214657T4 (de) 1991-08-26 2003-07-17 Boehringer Ingelheim Vetmed Vakzine gegen und diagnosemethode für das schweine-unfruchtbarkeits- und atmungs-syndrom (suas)
US6592873B1 (en) 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
US6251397B1 (en) 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
US20040087521A1 (en) 1993-03-18 2004-05-06 Merck & Co., Inc. Nucleic acid pharmaceuticals-influenza matrix
US6015686A (en) 1993-09-15 2000-01-18 Chiron Viagene, Inc. Eukaryotic layered vector initiation systems
US5789543A (en) 1993-12-30 1998-08-04 President And Fellows Of Harvard College Vertebrate embryonic pattern-inducing proteins and uses related thereto
DE69530227T2 (de) 1994-04-15 2004-04-01 Temple University Methode zum einkapseln mittels eines wässrigen lösungsmittels und mikrokapseln
DK0702085T4 (da) 1994-07-18 2010-04-06 Conzelmann Karl Klaus Prof Dr Rekombinant infektiøs ikke-segmenteret negativ-strenget RNA-virus
PT783321E (pt) 1994-08-05 2006-08-31 Univ Minnesota Sequencia nucleotidica viral vr-2332 e metodos de utilizacao
US6694021B1 (en) 1995-12-14 2004-02-17 Joseph G Julian Telephone handset sanitary guard
EP0839912A1 (en) 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof
WO1998055626A2 (en) 1997-06-05 1998-12-10 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
US7132106B2 (en) 1998-12-22 2006-11-07 Pfizer Inc. Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7691389B2 (en) * 1998-12-22 2010-04-06 Pfizer Inc Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
NZ513289A (en) * 1998-12-22 2003-04-29 Pfizer Prod Inc Infectious cDNA clone of north american procine reproductive and respiratory syndrome (PRRS) virus and uses thereof
US7618797B2 (en) 1998-12-22 2009-11-17 Pfizer Inc Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof
CA2396454A1 (en) * 2000-01-26 2001-08-02 Boehringer Ingelheim Vetmedica Gmbh Recombinant attenuation of prrsv
JP5273642B2 (ja) * 2004-04-23 2013-08-28 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー ウイルスに対する細胞性の許容性因子、および該因子の使用
PL1833508T3 (pl) * 2004-11-19 2011-02-28 Intervet Int Bv Szczepy świńskiego wirusa zespołu rozrodczo-oddechowego i ich kompozycje
EP1856141A1 (en) * 2005-02-25 2007-11-21 Pfizer Products Inc. N protein mutants of porcine reproductive and respiratory syndrome virus
ES2386973T3 (es) * 2005-06-24 2012-09-10 Regents Of The University Of Minnesota Virus PRRS, clones infecciosos, mutantes de los mismos, y métodos de utilización
CN101300363A (zh) * 2005-08-30 2008-11-05 内布拉斯加大学董事会 用于用具有改善的免疫原性的prrsv抗原免疫接种动物的方法和组合物
JP2010531143A (ja) * 2007-06-25 2010-09-24 サウス ダコタ ステート ユニバーシティー 組換え北アメリカ1型ブタ生殖器呼吸器症候群ウイルス及び使用方法
CN101633909B (zh) * 2009-08-13 2012-05-09 华威特(北京)生物科技有限公司 预防猪感染猪繁殖与呼吸综合征的减毒活疫苗
UA108902C2 (uk) * 2010-11-10 2015-06-25 Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування
WO2013173443A1 (en) * 2012-05-17 2013-11-21 Zoetis Llc Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning

Also Published As

Publication number Publication date
WO2012063212A1 (en) 2012-05-18
EP2637688A1 (en) 2013-09-18
CN107964546B (zh) 2021-08-17
US20140072589A1 (en) 2014-03-13
US20200197507A1 (en) 2020-06-25
EP2637688B1 (en) 2017-01-11
NZ610376A (en) 2015-05-29
UA108902C2 (uk) 2015-06-25
AU2011327760A1 (en) 2013-05-23
US9566324B2 (en) 2017-02-14
US20220305110A1 (en) 2022-09-29
KR20130084692A (ko) 2013-07-25
TW201249864A (en) 2012-12-16
AU2011327760B2 (en) 2017-07-13
TWI458735B (zh) 2014-11-01
JP2014500721A (ja) 2014-01-16
KR101728202B1 (ko) 2017-05-02
RU2013120979A (ru) 2014-12-20
US11351243B2 (en) 2022-06-07
HK1254832A1 (zh) 2019-07-26
BR112013011606A2 (pt) 2021-05-25
CA2817486C (en) 2019-07-23
JP2017104121A (ja) 2017-06-15
AR083839A1 (es) 2013-03-27
TW201518317A (zh) 2015-05-16
RU2592667C2 (ru) 2016-07-27
JP5793197B2 (ja) 2015-10-14
US20170136116A1 (en) 2017-05-18
CN107974452B (zh) 2021-08-13
MX350695B (es) 2017-09-13
DK2637688T3 (en) 2017-03-13
HUE031891T2 (en) 2017-08-28
CN107974452A (zh) 2018-05-01
ZA201304204B (en) 2014-02-26
US11904011B2 (en) 2024-02-20
CN103517715A (zh) 2014-01-15
JP2016019533A (ja) 2016-02-04
CA2817486A1 (en) 2012-05-18
CN107964546A (zh) 2018-04-27
MY173789A (en) 2020-02-21

Similar Documents

Publication Publication Date Title
PH12014502534A1 (en) Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
MY173789A (en) North american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof
PH12018501602A1 (en) Subunit immersion vaccines for fish
WO2017015463A3 (en) Infectious disease vaccines
MX2016007737A (es) Variante del virus prrs, clon de adnc del virus europeo y sus usos.
NZ758021A (en) Methods of predicting ancestral virus sequences and uses thereof
EP2576789A4 (en) INTENSE ATTENUATED LIVE VACCINES AND SUBUNITARY VACCINES CREATED BY RANDOM DNA RECOMBINATION ("DNA SHUFFLING") AGAINST PORCINE RESPIRATORY AND REPRODUCTIVE SYNDROME VIRUS (VSRRP)
EA201491752A1 (ru) Вакцина против rsv
DE602006017725D1 (de) Nukleinsäuren, kodierend für impfstoffe gegen den reproduktiven und respiratorischen syndrom virus (prrsv)
EP2498814A4 (en) CONSUMER PROTEINS FOR MOUSE AND CLAUSE DISEASE VIRUSES, VACCINATING SEQUENCES AND VACCINES MANUFACTURED THEREFROM
WO2012027365A3 (en) Targeted multi-epitope dosage forms for induction of an immune response to antigens
MX2016007939A (es) Nueva vacuna de adn dirigida contra msln para la inmunoterapia de cancer.
MX2017005661A (es) Celulas de mamifero que expresan antigenos de citomegalovirus.
EA201001045A1 (ru) Модифицированный вирус гриппа
NZ630869A (en) Compositions and methods for dengue virus chimeric constructs in vaccines
WO2014150822A3 (en) Porcine reproductive and respiratory syndrome virus, compositions, vaccine and methods of use
EP2968519A4 (en) PROTEINS CONSENSUS OF FOOT AND MOUTH DISEASE (FMDV), SEQUENCES ENCODING THEREOF AND VACCINES OBTAINED THEREFROM
BR112018012642A2 (pt) vacina de calicivírus felino
WO2016116905A9 (en) Cmv antigens and uses thereof
ZA201603187B (en) Compositions and methods vectors for inducing an enhanced immune response using poxvirus vectors
CL2012002900A1 (es) Secuencias de acido nucleico procedente de un virus causante del sindrome de miocardiopatia (cms) en peces; vector; celula huesped; vacuna de adn; proteina recombinante codificada; vacuna recombinante; inmunoensayo para la deteccion de dicho virus; kit de diagnostico; y uso de las mismas.
MX2016013584A (es) Parvovirus porcino.
PH12017501100A1 (en) Recombinant swinepox virus and vaccines
MX2016009952A (es) Proteinas y antigenos del virus de diarrea epidemica porcino (pedv).
WO2010059899A3 (en) Vaccine for runting-stunting syndrome

Legal Events

Date Code Title Description
GB Transfer or rights

Owner name: ZOETIS SERVICES LLC

FG Grant or registration