MX2012006878A - Terapia combinada para enfermedad pulmonar obstructiva cronica (epoc). - Google Patents
Terapia combinada para enfermedad pulmonar obstructiva cronica (epoc).Info
- Publication number
- MX2012006878A MX2012006878A MX2012006878A MX2012006878A MX2012006878A MX 2012006878 A MX2012006878 A MX 2012006878A MX 2012006878 A MX2012006878 A MX 2012006878A MX 2012006878 A MX2012006878 A MX 2012006878A MX 2012006878 A MX2012006878 A MX 2012006878A
- Authority
- MX
- Mexico
- Prior art keywords
- copd
- combination therapy
- formoterol
- glycopyrronium bromide
- formulation further
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/008—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
- A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
- A61K9/124—Aerosols; Foams characterised by the propellant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M15/00—Inhalators
- A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B3/00—Packaging plastic material, semiliquids, liquids or mixed solids and liquids, in individual containers or receptacles, e.g. bags, sacks, boxes, cartons, cans, or jars
- B65B3/04—Methods of, or means for, filling the material into the containers or receptacles
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
- B65B31/003—Adding propellants in fluid form to aerosol containers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
- B65B7/00—Closing containers or receptacles after filling
- B65B7/16—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons
- B65B7/28—Closing semi-rigid or rigid containers or receptacles not deformed by, or not taking-up shape of, contents, e.g. boxes or cartons by applying separate preformed closures, e.g. lids, covers
- B65B7/2842—Securing closures on containers
- B65B7/285—Securing closures on containers by deformation of the closure
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Mechanical Engineering (AREA)
- Dispersion Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Otolaryngology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
Abstract
La invención se relaciona con una formulación en aerosol que es apropiada para administrar a pacientes de EPOC por medio de un inhalador presurizado de dosis medida (pMDI), que comprende bromuro de glicopirronio en combinación con formoterol. La formulación comprende además un propelente de HFA, un cosolvente, y una cantidad de ácido inorgánico que es suficiente para estabilizar tanto el componente de bromuro de glicopirronio como el de formoterol. Opcionalmente la formulación comprende además dipropionato de beclometasona.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09180671 | 2009-12-23 | ||
PCT/EP2010/070479 WO2011076843A2 (en) | 2009-12-23 | 2010-12-22 | Combination therapy for copd |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012006878A true MX2012006878A (es) | 2012-07-04 |
Family
ID=42107420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012006878A MX2012006878A (es) | 2009-12-23 | 2010-12-22 | Terapia combinada para enfermedad pulmonar obstructiva cronica (epoc). |
Country Status (39)
Country | Link |
---|---|
US (3) | US20110150782A1 (es) |
EP (1) | EP2515855B3 (es) |
JP (2) | JP5914354B2 (es) |
KR (2) | KR20170040392A (es) |
CN (2) | CN102665679B (es) |
AR (2) | AR079726A1 (es) |
AU (3) | AU2010334859A1 (es) |
BR (1) | BR112012015337B8 (es) |
CA (1) | CA2785321C (es) |
CL (1) | CL2012001705A1 (es) |
CO (1) | CO6541628A2 (es) |
CY (2) | CY1115116T1 (es) |
DK (1) | DK2515855T6 (es) |
EA (2) | EA027778B1 (es) |
ES (1) | ES2468840T7 (es) |
FI (1) | FI2515855T6 (es) |
GE (1) | GEP20156311B (es) |
HK (2) | HK1174566A1 (es) |
HR (1) | HRP20140582T4 (es) |
HU (1) | HUS1800001I1 (es) |
IL (1) | IL260932B (es) |
LT (1) | LTC2515855I2 (es) |
LU (1) | LUC00060I2 (es) |
MA (1) | MA33823B1 (es) |
MX (1) | MX2012006878A (es) |
MY (1) | MY156949A (es) |
NL (1) | NL300923I2 (es) |
NZ (1) | NZ600790A (es) |
PE (2) | PE20121396A1 (es) |
PL (1) | PL2515855T6 (es) |
PT (1) | PT2515855E (es) |
RS (1) | RS53391B2 (es) |
SG (1) | SG181868A1 (es) |
SI (1) | SI2515855T1 (es) |
TN (1) | TN2012000269A1 (es) |
TW (1) | TWI495468B (es) |
UA (1) | UA113832C2 (es) |
WO (1) | WO2011076843A2 (es) |
ZA (1) | ZA201204615B (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2515853B1 (en) * | 2009-12-23 | 2014-03-19 | Chiesi Farmaceutici S.p.A. | Combination therapy for COPD |
UA113832C2 (xx) * | 2009-12-23 | 2017-03-27 | Комбінаційна терапія для хозл | |
PE20121467A1 (es) | 2009-12-23 | 2012-11-07 | Chiesi Farma Spa | Formulacion de aerosol para la enfermedad pulmonar obstructiva cronica |
EP2675439A2 (en) * | 2011-02-17 | 2013-12-25 | Cipla Limited | Combination of glycopyrrolate and a beta2 -agonist |
CA2850084C (en) | 2011-10-11 | 2020-07-07 | Chiesi Farmaceutici S.P.A. | Crystalline microparticles of a beta-agonist coated with a fatty acid |
WO2014064410A2 (en) * | 2012-10-23 | 2014-05-01 | Cipla Limited | Pharmaceutical composition |
UA116907C2 (uk) | 2013-07-11 | 2018-05-25 | К'Єзі Фармачеутічі С.П.А. | Композиція у вигляді сухого порошку, яка містить антихолінергічний, кортикостероїдний та бета-адренергічний засіб, для інгаляцій |
CN111150728B (zh) * | 2013-12-30 | 2024-02-06 | 奇斯药制品公司 | 格隆溴铵和福莫特罗组合的稳定的加压气雾剂溶液组合物 |
NO3096737T3 (es) * | 2013-12-30 | 2018-09-01 | ||
US11039621B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US11039620B2 (en) | 2014-02-19 | 2021-06-22 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US9554992B2 (en) * | 2014-06-09 | 2017-01-31 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic |
GB201416909D0 (en) * | 2014-09-25 | 2014-11-12 | Prosonix Ltd | Method of forming concentrated solution |
US20160310410A1 (en) | 2015-04-24 | 2016-10-27 | Glenmark Specialty S.A. | Pharmaceutical compositions comprising arformoterol and glycopyrronium |
HUE049751T2 (hu) | 2015-11-16 | 2020-10-28 | Chiesi Farm Spa | Eljárás antikolinerg szert, kortikoszteroidot és béta-adrenerg szert tartalmazó száraz porkészítmény elõállítására |
GB2545025A (en) * | 2015-12-04 | 2017-06-07 | Mexichem Fluor Sa De Cv | Pharmaceutical composition |
WO2017167737A1 (en) | 2016-03-31 | 2017-10-05 | Chiesi Farmaceutici S.P.A. | Aerosol inhalation device |
US10098837B2 (en) * | 2016-07-28 | 2018-10-16 | Chiesi Farmaceutici S.P.A. | Combination therapy for COPD |
AU2017328910B2 (en) * | 2016-09-19 | 2020-04-09 | Mexichem Fluor S.A. De C.V. | Pharmaceutical composition |
ES2957459T3 (es) | 2016-09-19 | 2024-01-19 | Mexichem Fluor Sa De Cv | Composición farmacéutica que comprende glicopirrolato |
CN114712337A (zh) * | 2016-09-19 | 2022-07-08 | 墨西哥氟石股份公司 | 药物组合物 |
RU2742376C1 (ru) * | 2017-05-11 | 2021-02-05 | КЬЕЗИ ФАРМАЧЕУТИЧИ С.п.А. | Способ получения состава сухого порошка, содержащего антихолинергическое средство, кортикостероид и бета-адренергетик |
MX2019012930A (es) * | 2017-05-11 | 2020-01-14 | Chiesi Farm Spa | Proceso para preparacion de una formulacion de polvo seco que incluye un anticolinergico, un corticosteroide y un beta-adrenergico. |
AU2019477296A1 (en) | 2019-12-02 | 2022-04-14 | Chiesi Farmaceutici S.P.A. | Stainles steel can for pressurised metered dose inhalers |
JP2023540171A (ja) | 2020-07-31 | 2023-09-22 | ケモ リサーチ, エス.エル. | 吸入投与のための併用療法 |
CN116419749A (zh) | 2020-10-09 | 2023-07-11 | 奇斯药制品公司 | 用于加压定量吸入器的药物制剂 |
WO2023227781A1 (en) | 2022-05-27 | 2023-11-30 | Chiesi Farmaceutici S.P.A. | A pharmaceutical formulation for pressurised metered dose inhaler |
WO2023227783A1 (en) | 2022-05-27 | 2023-11-30 | Chiesi Farmaceutici S.P.A. | A pharmaceutical formulation for pressurised metered dose inhaler |
WO2023227782A1 (en) | 2022-05-27 | 2023-11-30 | Chiesi Farmaceutici S.P.A. | A pharmaceutical formulation for pressurised metered dose inhaler |
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US2956062A (en) | 1959-02-26 | 1960-10-11 | Robins Co Inc A H | Esters of amino alcohols |
SK280911B6 (sk) | 1992-12-09 | 2000-09-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Farmaceutický prostriedok |
DE59911149D1 (de) * | 1998-07-24 | 2004-12-30 | Jago Res Ag Muttenz | Medizinische aerosolformulierungen |
PT1102579E (pt) | 1998-08-04 | 2003-07-31 | Jago Res Ag | Formulacoes de aerossol medicinais |
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US20060257324A1 (en) * | 2000-05-22 | 2006-11-16 | Chiesi Farmaceutici S.P.A. | Pharmaceutical solution formulations for pressurised metered dose inhalers |
ME00220B (me) * | 2000-05-22 | 2010-10-10 | Chiesi Farm Spa | Stabilne farmaceutske formulacije rastvora za inhalatore odmjerene doze pod pritiskom |
AU2002234476B2 (en) | 2001-03-30 | 2006-04-27 | Jagotec Ag | Medical aerosol formulations |
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EP1321159A1 (en) | 2001-12-21 | 2003-06-25 | CHIESI FARMACEUTICI S.p.A. | Pressurized metered dose inhaler (pMDI) actuators with laser drilled orifices |
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AR041873A1 (es) * | 2003-10-30 | 2005-06-01 | Pablo Cassara Srl Lab | Una formulacion farmaceutica en aerosol adecuada para la inhalacion oral o nasal que contienen glucocorticoides en solucion estable al almacenamiento; un metodo para estabilzar formulaciones y uso de un agente estabilizante |
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WO2005074918A1 (en) | 2004-02-06 | 2005-08-18 | Benzstrasse 1 D-61352 Bad Homburd | The combination of anticholinergics and glucocorticoids for the long-term treatment of asthma and copd |
GB0410399D0 (en) | 2004-05-10 | 2004-06-16 | Arakis Ltd | The treatment of respiratory disease |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
EP1616567A1 (en) | 2004-07-16 | 2006-01-18 | Boehringer Ingelheim Pharma GmbH & Co.KG | Medicaments for inhalation comprising PDE IV inhibitors and glycopyrrolate salts |
GB0505545D0 (en) | 2005-03-17 | 2005-04-27 | Glaxo Group Ltd | Inhalation devices |
MX2007012084A (es) | 2005-03-30 | 2007-11-21 | Schering Corp | Medicamentos y metodos que combinan un anticolinergico, un corticosteroide y un agonista beta de accion prolongada. |
GB0523653D0 (en) | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
CN101232913B (zh) | 2005-08-01 | 2011-04-06 | 阿斯利康(瑞典)有限公司 | 吸入器阀 |
GB0523655D0 (en) | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
GB0523654D0 (en) * | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
GB0523656D0 (en) | 2005-11-21 | 2005-12-28 | Novartis Ag | Organic compounds |
JP5107933B2 (ja) * | 2005-12-21 | 2012-12-26 | メダ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 炎症性疾患の治療に使用する、抗コリン作用薬類、β2−アドレナリン受容体のアゴニスト類、抗ロイコトリエン(ロイコトリエン受容体のアンタゴニスト)類、グルココルチコイド類および/またはPDE4阻害剤類の新規配合薬 |
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ES2969237T3 (es) | 2007-10-18 | 2024-05-17 | Rose U Llc | Formulaciones tópicas de glicopirrolato y una toallita que contiene las mismas |
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KR20120106753A (ko) | 2009-12-23 | 2012-09-26 | 키에시 파르마슈티시 엣스. 피. 에이. | Copd용 에어로졸 제제 |
UA113832C2 (xx) * | 2009-12-23 | 2017-03-27 | Комбінаційна терапія для хозл | |
PE20121467A1 (es) * | 2009-12-23 | 2012-11-07 | Chiesi Farma Spa | Formulacion de aerosol para la enfermedad pulmonar obstructiva cronica |
EP2515853B1 (en) | 2009-12-23 | 2014-03-19 | Chiesi Farmaceutici S.p.A. | Combination therapy for COPD |
UA116907C2 (uk) * | 2013-07-11 | 2018-05-25 | К'Єзі Фармачеутічі С.П.А. | Композиція у вигляді сухого порошку, яка містить антихолінергічний, кортикостероїдний та бета-адренергічний засіб, для інгаляцій |
NO3096737T3 (es) | 2013-12-30 | 2018-09-01 | ||
CN111150728B (zh) * | 2013-12-30 | 2024-02-06 | 奇斯药制品公司 | 格隆溴铵和福莫特罗组合的稳定的加压气雾剂溶液组合物 |
US9554992B2 (en) * | 2014-06-09 | 2017-01-31 | Chiesi Farmaceutici S.P.A. | Inhalation particles comprising a combination of an anticholinergic, a corticosteroid and a beta-adrenergic |
US10098837B2 (en) * | 2016-07-28 | 2018-10-16 | Chiesi Farmaceutici S.P.A. | Combination therapy for COPD |
-
2010
- 2010-12-22 UA UAA201207626A patent/UA113832C2/uk unknown
- 2010-12-22 CN CN201080058048.8A patent/CN102665679B/zh active Active
- 2010-12-22 JP JP2012545323A patent/JP5914354B2/ja active Active
- 2010-12-22 EP EP10799030.1A patent/EP2515855B3/en active Active
- 2010-12-22 MX MX2012006878A patent/MX2012006878A/es active IP Right Grant
- 2010-12-22 PE PE2012000865A patent/PE20121396A1/es not_active Application Discontinuation
- 2010-12-22 GE GEAP201012756A patent/GEP20156311B/en unknown
- 2010-12-22 ES ES10799030T patent/ES2468840T7/es active Active
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