MX2011011436A - Concatemeros para inmunomodulacion. - Google Patents
Concatemeros para inmunomodulacion.Info
- Publication number
- MX2011011436A MX2011011436A MX2011011436A MX2011011436A MX2011011436A MX 2011011436 A MX2011011436 A MX 2011011436A MX 2011011436 A MX2011011436 A MX 2011011436A MX 2011011436 A MX2011011436 A MX 2011011436A MX 2011011436 A MX2011011436 A MX 2011011436A
- Authority
- MX
- Mexico
- Prior art keywords
- nucleic acid
- coding nucleic
- polymeric
- acid molecules
- molecules
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/117—Nucleic acids having immunomodulatory properties, e.g. containing CpG-motifs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/713—Double-stranded nucleic acids or oligonucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/17—Immunomodulatory nucleic acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/51—Physical structure in polymeric form, e.g. multimers, concatemers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/50—Physical structure
- C12N2310/53—Physical structure partially self-complementary or closed
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/31—Combination therapy
Abstract
La invención se refiere a una molécula polimérica de ácido nucleico no codificante para la modulación de la actividad del sistema inmune humano y animal, así como a un procedimiento para la fabricación de la misma y a una vacuna, que comprende la molécula polimérica de ácido nucleico no codificante, en la que las moléculas poliméricas de ácido nucleico no codificantes pueden entenderse como moléculas de ácido nucleico no codificantes, que comprenden al menos cuatro moléculas unidas covalentemente (tetrámero) o son ensamblajes de más moléculas de ácido nucleico no codificantes (polímeros de alto peso molecular) que están unidas covalentemente entre sí.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP09075220A EP2246433A1 (de) | 2009-04-30 | 2009-04-30 | Concatemere zur Immunmodulation |
PCT/EP2010/055903 WO2010125182A1 (en) | 2009-04-30 | 2010-04-30 | Concatamers for immunemodulation |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2011011436A true MX2011011436A (es) | 2011-11-18 |
Family
ID=41582158
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2011011436A MX2011011436A (es) | 2009-04-30 | 2010-04-30 | Concatemeros para inmunomodulacion. |
Country Status (16)
Country | Link |
---|---|
US (1) | US20120093804A1 (es) |
EP (2) | EP2246433A1 (es) |
JP (1) | JP5873794B2 (es) |
KR (1) | KR101410146B1 (es) |
CN (1) | CN102421901B (es) |
AU (1) | AU2010243546B2 (es) |
BR (1) | BRPI1014638A2 (es) |
CA (1) | CA2759165A1 (es) |
HK (1) | HK1169669A1 (es) |
IL (1) | IL216039A (es) |
MX (1) | MX2011011436A (es) |
MY (1) | MY160401A (es) |
RU (1) | RU2556119C2 (es) |
SG (1) | SG175209A1 (es) |
TW (1) | TWI454277B (es) |
WO (1) | WO2010125182A1 (es) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB201021867D0 (en) * | 2010-12-23 | 2011-02-02 | Mologen Ag | Non-coding immunomodulatory DNA construct |
GB2523187A (en) | 2014-02-18 | 2015-08-19 | Mologen Ag | Covalently closed non-coding immunomodulatory DNA construct |
TR201908550T4 (tr) | 2014-06-04 | 2019-07-22 | Exicure Inc | Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi. |
US11213593B2 (en) | 2014-11-21 | 2022-01-04 | Northwestern University | Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
LU92821B1 (en) | 2015-09-09 | 2017-03-20 | Mologen Ag | Combination comprising immunostimulatory oligonucleotides |
GB2542425A (en) | 2015-09-21 | 2017-03-22 | Mologen Ag | Means for the treatment of HIV |
JP6407357B2 (ja) * | 2016-06-03 | 2018-10-17 | 日新製鋼株式会社 | Tig溶接ステンレス鋼管の製造方法、tig溶接ステンレス鋼管、およびtig溶接ステンレス部材 |
WO2018039629A2 (en) | 2016-08-25 | 2018-03-01 | Northwestern University | Micellar spherical nucleic acids from thermoresponsive, traceless templates |
CN117224710A (zh) * | 2017-02-01 | 2023-12-15 | 莫得纳特斯公司 | 编码活化致癌基因突变肽的免疫调节治疗性mrna组合物 |
US11433131B2 (en) | 2017-05-11 | 2022-09-06 | Northwestern University | Adoptive cell therapy using spherical nucleic acids (SNAs) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19935756A1 (de) | 1999-07-27 | 2001-02-08 | Mologen Forschungs Entwicklung | Kovalent geschlossenes Nukleinsäuremolekül zur Immunstimulation |
JP2003532380A (ja) * | 1999-12-02 | 2003-11-05 | モレキュラー ステージング,インコーポレイテッド | 線状自己アニーリングセグメントからの一本鎖環状dnaの産出 |
WO2006015560A1 (de) * | 2004-08-09 | 2006-02-16 | Mologen Ag | Immunmodulierendes mittel in verbindung mit chemotherapeutischen massnahmen |
CN101490257A (zh) | 2006-05-11 | 2009-07-22 | 莫洛根股份公司 | 用于免疫刺激的多聚体 |
EP2058397A1 (de) * | 2007-11-07 | 2009-05-13 | Mologen AG | Multimeres Assemblat zur Immunstimulation |
-
2009
- 2009-04-30 EP EP09075220A patent/EP2246433A1/de not_active Withdrawn
-
2010
- 2010-04-30 BR BRPI1014638A patent/BRPI1014638A2/pt not_active IP Right Cessation
- 2010-04-30 SG SG2011074739A patent/SG175209A1/en unknown
- 2010-04-30 TW TW099113941A patent/TWI454277B/zh not_active IP Right Cessation
- 2010-04-30 EP EP10715870A patent/EP2424988A1/en not_active Withdrawn
- 2010-04-30 CN CN201080019291.9A patent/CN102421901B/zh not_active Expired - Fee Related
- 2010-04-30 JP JP2012507779A patent/JP5873794B2/ja not_active Expired - Fee Related
- 2010-04-30 MY MYPI2011005014A patent/MY160401A/en unknown
- 2010-04-30 KR KR1020117025614A patent/KR101410146B1/ko not_active IP Right Cessation
- 2010-04-30 AU AU2010243546A patent/AU2010243546B2/en not_active Ceased
- 2010-04-30 RU RU2011148511/10A patent/RU2556119C2/ru not_active IP Right Cessation
- 2010-04-30 MX MX2011011436A patent/MX2011011436A/es active IP Right Grant
- 2010-04-30 CA CA2759165A patent/CA2759165A1/en not_active Abandoned
- 2010-04-30 US US13/266,905 patent/US20120093804A1/en not_active Abandoned
- 2010-04-30 WO PCT/EP2010/055903 patent/WO2010125182A1/en active Application Filing
-
2011
- 2011-10-30 IL IL216039A patent/IL216039A/en not_active IP Right Cessation
-
2012
- 2012-10-17 HK HK12110251.9A patent/HK1169669A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
US20120093804A1 (en) | 2012-04-19 |
EP2246433A1 (de) | 2010-11-03 |
KR101410146B1 (ko) | 2014-06-19 |
EP2424988A1 (en) | 2012-03-07 |
IL216039A (en) | 2016-10-31 |
IL216039A0 (en) | 2012-01-31 |
AU2010243546B2 (en) | 2013-10-17 |
AU2010243546A1 (en) | 2011-11-10 |
SG175209A1 (en) | 2011-11-28 |
WO2010125182A1 (en) | 2010-11-04 |
HK1169669A1 (en) | 2013-02-01 |
MY160401A (en) | 2017-03-15 |
KR20120007519A (ko) | 2012-01-20 |
RU2556119C2 (ru) | 2015-07-10 |
TWI454277B (zh) | 2014-10-01 |
CN102421901B (zh) | 2015-04-08 |
JP2012525132A (ja) | 2012-10-22 |
TW201038281A (en) | 2010-11-01 |
CA2759165A1 (en) | 2010-11-04 |
RU2011148511A (ru) | 2013-06-10 |
JP5873794B2 (ja) | 2016-03-01 |
BRPI1014638A2 (pt) | 2016-04-05 |
CN102421901A (zh) | 2012-04-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |