MX2011009781A - Composiciones de monogliceridos de acidos grasos. - Google Patents
Composiciones de monogliceridos de acidos grasos.Info
- Publication number
- MX2011009781A MX2011009781A MX2011009781A MX2011009781A MX2011009781A MX 2011009781 A MX2011009781 A MX 2011009781A MX 2011009781 A MX2011009781 A MX 2011009781A MX 2011009781 A MX2011009781 A MX 2011009781A MX 2011009781 A MX2011009781 A MX 2011009781A
- Authority
- MX
- Mexico
- Prior art keywords
- group
- composition
- present
- amount
- weight
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 91
- 235000014113 dietary fatty acids Nutrition 0.000 title claims abstract description 24
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- 150000004665 fatty acids Chemical class 0.000 title claims abstract description 12
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 title 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 54
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- 208000010195 Onychomycosis Diseases 0.000 claims abstract description 9
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- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 33
- -1 Glycerol fatty acid Chemical class 0.000 claims description 29
- 239000004094 surface-active agent Substances 0.000 claims description 29
- 238000011282 treatment Methods 0.000 claims description 24
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 21
- 235000011187 glycerol Nutrition 0.000 claims description 20
- 239000013543 active substance Substances 0.000 claims description 19
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- 125000004432 carbon atom Chemical group C* 0.000 claims description 11
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- CKGQJOFAVYEVFG-KXQOOQHDSA-N 2-fluoro-4-[[(1R)-6-[2-[4-[1-(4-methoxyphenyl)-5-methyl-6-oxopyridazin-3-yl]triazol-1-yl]ethoxy]-1-methyl-1-[2-oxo-2-(1,3-thiazol-2-ylamino)ethyl]-3,4-dihydro-2H-isoquinolin-7-yl]oxy]benzoic acid Chemical compound COc1ccc(cc1)-n1nc(cc(C)c1=O)-c1cn(CCOc2cc3CCN[C@](C)(CC(=O)Nc4nccs4)c3cc2Oc2ccc(C(O)=O)c(F)c2)nn1 CKGQJOFAVYEVFG-KXQOOQHDSA-N 0.000 claims description 7
- 239000002253 acid Substances 0.000 claims description 7
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- UHIXWHUVLCAJQL-MPBGBICISA-N albaconazole Chemical group C([C@@](O)([C@H](N1C(C2=CC=C(Cl)C=C2N=C1)=O)C)C=1C(=CC(F)=CC=1)F)N1C=NC=N1 UHIXWHUVLCAJQL-MPBGBICISA-N 0.000 claims description 6
- 229950006816 albaconazole Drugs 0.000 claims description 6
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- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 claims description 4
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 claims description 4
- 229930003316 Vitamin D Natural products 0.000 claims description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims description 4
- 125000005907 alkyl ester group Chemical group 0.000 claims description 4
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 claims description 4
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 claims description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 claims description 4
- 235000019166 vitamin D Nutrition 0.000 claims description 4
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- 229940046008 vitamin d Drugs 0.000 claims description 4
- YHHHHJCAVQSFMJ-FNORWQNLSA-N (3e)-deca-1,3-diene Chemical compound CCCCCC\C=C\C=C YHHHHJCAVQSFMJ-FNORWQNLSA-N 0.000 claims description 3
- ZKYCLDTVJCJYIB-UHFFFAOYSA-N 2-methylidenedecanamide Chemical compound CCCCCCCCC(=C)C(N)=O ZKYCLDTVJCJYIB-UHFFFAOYSA-N 0.000 claims description 3
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims description 3
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 3
- 229920001800 Shellac Polymers 0.000 claims description 3
- 229920002125 Sokalan® Polymers 0.000 claims description 3
- 229920003144 amino alkyl methacrylate copolymer Polymers 0.000 claims description 3
- 229960001631 carbomer Drugs 0.000 claims description 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims description 3
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- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 3
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- ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 claims description 3
- 235000013874 shellac Nutrition 0.000 claims description 3
- 239000007921 spray Substances 0.000 claims description 3
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- POAOYUHQDCAZBD-UHFFFAOYSA-N 2-butoxyethanol Chemical compound CCCCOCCO POAOYUHQDCAZBD-UHFFFAOYSA-N 0.000 claims description 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 claims description 2
- 208000002474 Tinea Diseases 0.000 claims description 2
- KYKAJFCTULSVSH-UHFFFAOYSA-N chloro(fluoro)methane Chemical compound F[C]Cl KYKAJFCTULSVSH-UHFFFAOYSA-N 0.000 claims description 2
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- 229940079593 drug Drugs 0.000 claims description 2
- 239000000975 dye Substances 0.000 claims description 2
- 239000003974 emollient agent Substances 0.000 claims description 2
- 239000003623 enhancer Substances 0.000 claims description 2
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- 239000003205 fragrance Substances 0.000 claims description 2
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- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 claims description 2
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- 238000000034 method Methods 0.000 abstract description 9
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- SCKYRAXSEDYPSA-UHFFFAOYSA-N ciclopirox Chemical compound ON1C(=O)C=C(C)C=C1C1CCCCC1 SCKYRAXSEDYPSA-UHFFFAOYSA-N 0.000 description 11
- 150000003839 salts Chemical class 0.000 description 11
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- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 7
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- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 6
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- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
- 230000037304 dermatophytes Effects 0.000 description 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 6
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- 239000002585 base Substances 0.000 description 5
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 4
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- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 description 1
- BCEHBSKCWLPMDN-MGPLVRAMSA-N voriconazole Chemical compound C1([C@H](C)[C@](O)(CN2N=CN=C2)C=2C(=CC(F)=CC=2)F)=NC=NC=C1F BCEHBSKCWLPMDN-MGPLVRAMSA-N 0.000 description 1
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/12—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Dispersion Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Communicable Diseases (AREA)
- Dermatology (AREA)
- Emergency Medicine (AREA)
- Pest Control & Pesticides (AREA)
- Agronomy & Crop Science (AREA)
- Plant Pathology (AREA)
- Dentistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20263509P | 2009-03-20 | 2009-03-20 | |
| US21331309P | 2009-05-28 | 2009-05-28 | |
| PCT/US2010/027905 WO2010108060A1 (en) | 2009-03-20 | 2010-03-19 | Fatty acid monoglyceride compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011009781A true MX2011009781A (es) | 2011-10-17 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011009781A MX2011009781A (es) | 2009-03-20 | 2010-03-19 | Composiciones de monogliceridos de acidos grasos. |
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| Country | Link |
|---|---|
| US (2) | US20110305646A1 (enExample) |
| EP (1) | EP2408299B1 (enExample) |
| JP (1) | JP5992324B2 (enExample) |
| KR (1) | KR101506369B1 (enExample) |
| CN (1) | CN102368904B (enExample) |
| AU (1) | AU2010226476B2 (enExample) |
| BR (1) | BRPI1014529A2 (enExample) |
| CA (1) | CA2756047C (enExample) |
| CL (1) | CL2011002302A1 (enExample) |
| EA (1) | EA022569B1 (enExample) |
| ES (1) | ES2437395T3 (enExample) |
| IL (1) | IL214887A (enExample) |
| MX (1) | MX2011009781A (enExample) |
| PL (1) | PL2408299T3 (enExample) |
| WO (1) | WO2010108060A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010254064B2 (en) * | 2009-05-29 | 2015-01-22 | Palau Pharma, S.L.U | Azole antifungal compositions |
| CA2775393C (en) * | 2012-05-02 | 2014-04-29 | Samy Saad | Topical non-aqueous pharmaceutical formulations |
| US9433680B2 (en) | 2013-01-31 | 2016-09-06 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9446131B2 (en) | 2013-01-31 | 2016-09-20 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US8778365B1 (en) | 2013-01-31 | 2014-07-15 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| US9452173B2 (en) | 2013-01-31 | 2016-09-27 | Merz Pharmaceuticals, Llc | Topical compositions and methods for making and using same |
| JP6125718B2 (ja) * | 2014-03-26 | 2017-05-10 | 株式会社マンダム | デオドラント組成物及びデオドラント剤 |
| CN104672506A (zh) * | 2015-02-02 | 2015-06-03 | 安徽玉堂雨具有限公司 | 一种抗菌防霉生物降解塑料及其制备方法 |
| KR20190037229A (ko) * | 2016-06-13 | 2019-04-05 | 바이옴 테라퓨틱스 리미티드 | 상승효과적 항진균 조성물 및 그의 방법 |
| WO2017216722A2 (en) * | 2016-06-13 | 2017-12-21 | Vyome Biosciences Pvt. Ltd. | Synergistic antifungal compositions and methods thereof |
| KR20220118492A (ko) * | 2019-12-20 | 2022-08-25 | 글락소스미스클라인 컨슈머 헬스케어 홀딩스 (유에스) 엘엘씨 | 조갑진균증을 치료하기 위한 국소 제약 조성물 |
| KR102442047B1 (ko) * | 2020-09-10 | 2022-09-08 | 서울대학교산학협력단 | 설페이트와 아민기를 함유하는 지방산 글리세리드 화합물, 이의 생산 방법, 및 용도 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4067997A (en) * | 1975-05-21 | 1978-01-10 | Med-Chem Laboratories | Synergistic microbecidal composition and method |
| FR2613227B1 (fr) * | 1987-04-01 | 1990-12-28 | Oreal | Compositions pharmaceutiques a base de nitrate de miconazole ou de nitrate d'econazole dans le traitement des infections fongiques des ongles |
| FI912955A7 (fi) * | 1990-06-25 | 1991-12-26 | Res Foundation For Mental Hygiene | Antimikrobiset rasvahappokoostumukset |
| HU219480B (hu) * | 1991-05-23 | 2001-04-28 | Novartis Ag. | Eljárás gombás körömmegbetegségek ellen helyileg alkalmazható, allil-amin-származékot tartalmazó gyógyászati készítmények előállítására |
| DE4434781A1 (de) * | 1994-09-29 | 1996-04-04 | Beiersdorf Ag | Verwendung von Fettsäureestern zur Bekämpfung von Superinfektionen |
| RU2122402C1 (ru) * | 1995-07-18 | 1998-11-27 | Научно-производственная фирма "Фаркос" Товарищество с ограниченной ответственностью | Средство для лечения и профилактики грибковых заболеваний кожи на основе гризеофульвина |
| DE19540465A1 (de) * | 1995-10-30 | 1997-05-07 | Beiersdorf Ag | Antimycotische Zubereitungen mit einem wirksamen Gehalt an Fettsäurepartialglyceriden |
| CA2278328C (en) * | 1998-02-09 | 2008-07-22 | Macrochem Corporation | Antifungal nail lacquer and method using same |
| JP2005503318A (ja) * | 2000-02-16 | 2005-02-03 | ベントレー ファーマシューティカルズ インコーポレイテッド | 医薬組成物 |
| JP2004043336A (ja) * | 2002-07-10 | 2004-02-12 | Naris Cosmetics Co Ltd | 抗菌剤及びそれを配合してなる化粧料 |
| AU2003246697A1 (en) * | 2002-07-22 | 2004-02-09 | Ciba Specialty Chemicals Holding Inc. | Copolymers and their use in personal care compositions |
| US20050165104A1 (en) * | 2002-07-24 | 2005-07-28 | Holwerda James G. | Biocidal agents and veterinary methods |
| EP1633818A2 (en) * | 2003-04-18 | 2006-03-15 | MERCK PATENT GmbH | Antimicrobial pigments |
| US20050058673A1 (en) * | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Antimicrobial compositions and methods |
| US8796332B2 (en) * | 2004-08-03 | 2014-08-05 | Regents Of The University Of Minnesota | Compositions and methods for controlling infections |
| RU2337689C1 (ru) * | 2007-04-18 | 2008-11-10 | Общество с ограниченной ответственностью "Фармацевтические технологии" | Средство для лечения поверхностных микозов |
| US8226965B2 (en) * | 2008-04-25 | 2012-07-24 | Nanobio Corporation | Methods of treating fungal, yeast and mold infections |
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2010
- 2010-03-19 AU AU2010226476A patent/AU2010226476B2/en active Active
- 2010-03-19 BR BRPI1014529-0A patent/BRPI1014529A2/pt not_active Application Discontinuation
- 2010-03-19 EA EA201171150A patent/EA022569B1/ru not_active IP Right Cessation
- 2010-03-19 CA CA2756047A patent/CA2756047C/en not_active Expired - Fee Related
- 2010-03-19 KR KR1020117021776A patent/KR101506369B1/ko active Active
- 2010-03-19 EP EP10754148.4A patent/EP2408299B1/en active Active
- 2010-03-19 WO PCT/US2010/027905 patent/WO2010108060A1/en not_active Ceased
- 2010-03-19 US US13/202,780 patent/US20110305646A1/en not_active Abandoned
- 2010-03-19 MX MX2011009781A patent/MX2011009781A/es active IP Right Grant
- 2010-03-19 CN CN201080012652.7A patent/CN102368904B/zh active Active
- 2010-03-19 PL PL10754148T patent/PL2408299T3/pl unknown
- 2010-03-19 JP JP2012500982A patent/JP5992324B2/ja active Active
- 2010-03-19 ES ES10754148.4T patent/ES2437395T3/es active Active
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| Publication number | Publication date |
|---|---|
| EP2408299A4 (en) | 2012-08-15 |
| EP2408299A1 (en) | 2012-01-25 |
| BRPI1014529A2 (pt) | 2015-08-25 |
| EP2408299B1 (en) | 2013-10-23 |
| KR101506369B1 (ko) | 2015-03-30 |
| CA2756047C (en) | 2016-04-26 |
| JP5992324B2 (ja) | 2016-09-14 |
| CL2011002302A1 (es) | 2012-06-22 |
| WO2010108060A8 (en) | 2011-12-29 |
| AU2010226476B2 (en) | 2013-02-07 |
| IL214887A0 (en) | 2011-11-30 |
| PL2408299T3 (pl) | 2014-03-31 |
| US20180360791A1 (en) | 2018-12-20 |
| CA2756047A1 (en) | 2010-09-23 |
| ES2437395T3 (es) | 2014-01-10 |
| EA022569B1 (ru) | 2016-01-29 |
| US20110305646A1 (en) | 2011-12-15 |
| EA201171150A1 (ru) | 2012-03-30 |
| KR20120014553A (ko) | 2012-02-17 |
| CN102368904A (zh) | 2012-03-07 |
| IL214887A (en) | 2015-09-24 |
| AU2010226476A1 (en) | 2011-09-22 |
| WO2010108060A1 (en) | 2010-09-23 |
| CN102368904B (zh) | 2014-03-26 |
| JP2012521351A (ja) | 2012-09-13 |
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