MX2011005577A - Derivados de acido carbonico substituidos con pirazolilo como moduladores del receptor de prostaciclina (pgi2) utiles para el tratamiento de trastornos relacionados con estos. - Google Patents

Derivados de acido carbonico substituidos con pirazolilo como moduladores del receptor de prostaciclina (pgi2) utiles para el tratamiento de trastornos relacionados con estos.

Info

Publication number
MX2011005577A
MX2011005577A MX2011005577A MX2011005577A MX2011005577A MX 2011005577 A MX2011005577 A MX 2011005577A MX 2011005577 A MX2011005577 A MX 2011005577A MX 2011005577 A MX2011005577 A MX 2011005577A MX 2011005577 A MX2011005577 A MX 2011005577A
Authority
MX
Mexico
Prior art keywords
methyl
phenyl
methoxy
cyclohexyl
pyrazol
Prior art date
Application number
MX2011005577A
Other languages
English (en)
Spanish (es)
Inventor
Young-Jun Shin
Jason B Ibarra
Thuy-Anh Tran
Ning Zou
Brett Ullman
Xi Zeng
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of MX2011005577A publication Critical patent/MX2011005577A/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D231/18—One oxygen or sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
MX2011005577A 2008-11-26 2009-11-24 Derivados de acido carbonico substituidos con pirazolilo como moduladores del receptor de prostaciclina (pgi2) utiles para el tratamiento de trastornos relacionados con estos. MX2011005577A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US20039308P 2008-11-26 2008-11-26
PCT/US2009/006251 WO2010068242A1 (en) 2008-11-26 2009-11-24 Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto

Publications (1)

Publication Number Publication Date
MX2011005577A true MX2011005577A (es) 2011-08-03

Family

ID=41718771

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2011005577A MX2011005577A (es) 2008-11-26 2009-11-24 Derivados de acido carbonico substituidos con pirazolilo como moduladores del receptor de prostaciclina (pgi2) utiles para el tratamiento de trastornos relacionados con estos.

Country Status (15)

Country Link
US (6) US20110224262A1 (enExample)
EP (2) EP2367797A1 (enExample)
JP (1) JP5603343B2 (enExample)
KR (1) KR101707247B1 (enExample)
CN (1) CN102292321B (enExample)
AU (1) AU2009325117C1 (enExample)
BR (1) BRPI0921369B8 (enExample)
CA (1) CA2744124C (enExample)
EA (1) EA022799B1 (enExample)
IL (1) IL212966A (enExample)
MX (1) MX2011005577A (enExample)
NZ (1) NZ593002A (enExample)
SG (1) SG171413A1 (enExample)
WO (1) WO2010068242A1 (enExample)
ZA (1) ZA201103813B (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8895776B2 (en) 2008-03-18 2014-11-25 Arena Pharmaceuticals, Inc. Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto
EP2367797A1 (en) 2008-11-26 2011-09-28 Arena Pharmaceuticals, Inc. Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto
PT2370413E (pt) 2008-12-08 2015-10-23 Arena Pharm Inc Moduladores do recetor da prostaciclina (pgi2) úteis para o tratamento de distúrbios relacionados com o mesmo
KR20140072061A (ko) 2011-09-30 2014-06-12 니폰 가세이 가부시키가이샤 중합성 무기 입자 분산제, 그 중합성 무기 입자 분산제를 포함하는 무기 유기 복합 입자, 및 무기 유기 수지 복합재
UA114490C2 (uk) 2011-10-06 2017-06-26 Байєр Інтеллектуал Проперті Гмбх Гетероциклілпіри(mі)динілпіразоли як фунгіциди
IN2014CN02475A (enExample) 2011-10-06 2015-06-19 Bayer Ip Gmbh
KR102441249B1 (ko) 2014-10-23 2022-09-08 아레나 파마슈티칼스, 인크. Pgi2 수용체 관련 병태의 치료 방법
IL266518B2 (en) 2016-11-10 2026-05-01 Arena Pharm Inc Methods for treating pulmonary hypertension with combinations of relinfag and other substances
IL268997B2 (en) 2017-03-01 2023-09-01 Arena Pharm Inc Preparations containing pgi2 receptor agonists and processes for their preparation
CN111699175B (zh) * 2018-02-07 2022-03-29 南京明德新药研发有限公司 前列环素受体受体激动剂
US12433865B2 (en) 2018-05-16 2025-10-07 Arena Pharmaceuticals, Inc. Compositions comprising PGI2-receptor agonists and processes for the preparation thereof
WO2023158634A1 (en) 2022-02-15 2023-08-24 United Therapeutics Corporation Crystalline prostacyclin (ip) receptor agonist and uses thereof
JP2025531869A (ja) 2022-09-09 2025-09-25 イノヴォ セラピューティクス、インコーポレイテッド CK1αおよびDUAL CK1α/GSPT1分解化合物

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Also Published As

Publication number Publication date
WO2010068242A1 (en) 2010-06-17
CA2744124A1 (en) 2010-06-17
BRPI0921369B8 (pt) 2021-05-25
NZ593002A (en) 2013-08-30
EA201100846A1 (ru) 2012-01-30
AU2009325117C1 (en) 2014-12-18
US20150191455A1 (en) 2015-07-09
JP2012509936A (ja) 2012-04-26
JP5603343B2 (ja) 2014-10-08
US10689372B2 (en) 2020-06-23
CA2744124C (en) 2018-05-01
EP3342767B1 (en) 2021-04-14
EP3342767A1 (en) 2018-07-04
KR20110095914A (ko) 2011-08-25
AU2009325117B2 (en) 2014-07-10
US20110224262A1 (en) 2011-09-15
BRPI0921369B1 (pt) 2020-09-29
IL212966A0 (en) 2011-07-31
US20190270731A1 (en) 2019-09-05
SG171413A1 (en) 2011-07-28
US9012478B2 (en) 2015-04-21
KR101707247B1 (ko) 2017-02-15
CN102292321A (zh) 2011-12-21
US20180030039A1 (en) 2018-02-01
IL212966A (en) 2015-03-31
US9663500B2 (en) 2017-05-30
AU2009325117A1 (en) 2010-06-17
US10214518B2 (en) 2019-02-26
EP2367797A1 (en) 2011-09-28
ZA201103813B (en) 2012-10-31
HK1257652A1 (en) 2019-10-25
US11098034B2 (en) 2021-08-24
CN102292321B (zh) 2015-08-12
US20140171469A1 (en) 2014-06-19
EA022799B1 (ru) 2016-03-31
BRPI0921369A2 (pt) 2015-12-29
US20200392123A1 (en) 2020-12-17

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