AU2009325117C1 - Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto - Google Patents
Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto Download PDFInfo
- Publication number
- AU2009325117C1 AU2009325117C1 AU2009325117A AU2009325117A AU2009325117C1 AU 2009325117 C1 AU2009325117 C1 AU 2009325117C1 AU 2009325117 A AU2009325117 A AU 2009325117A AU 2009325117 A AU2009325117 A AU 2009325117A AU 2009325117 C1 AU2009325117 C1 AU 2009325117C1
- Authority
- AU
- Australia
- Prior art keywords
- methyl
- methoxy
- pyrazol
- cyclohexyl
- acetic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/18—One oxygen or sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20039308P | 2008-11-26 | 2008-11-26 | |
| US61/200,393 | 2008-11-26 | ||
| PCT/US2009/006251 WO2010068242A1 (en) | 2008-11-26 | 2009-11-24 | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| AU2009325117A1 AU2009325117A1 (en) | 2010-06-17 |
| AU2009325117B2 AU2009325117B2 (en) | 2014-07-10 |
| AU2009325117C1 true AU2009325117C1 (en) | 2014-12-18 |
Family
ID=41718771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2009325117A Active AU2009325117C1 (en) | 2008-11-26 | 2009-11-24 | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US20110224262A1 (enExample) |
| EP (2) | EP2367797A1 (enExample) |
| JP (1) | JP5603343B2 (enExample) |
| KR (1) | KR101707247B1 (enExample) |
| CN (1) | CN102292321B (enExample) |
| AU (1) | AU2009325117C1 (enExample) |
| BR (1) | BRPI0921369B8 (enExample) |
| CA (1) | CA2744124C (enExample) |
| EA (1) | EA022799B1 (enExample) |
| IL (1) | IL212966A (enExample) |
| MX (1) | MX2011005577A (enExample) |
| NZ (1) | NZ593002A (enExample) |
| SG (1) | SG171413A1 (enExample) |
| WO (1) | WO2010068242A1 (enExample) |
| ZA (1) | ZA201103813B (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2280696B9 (en) * | 2008-03-18 | 2015-12-09 | Arena Pharmaceuticals, Inc. | Modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto |
| EP2367797A1 (en) | 2008-11-26 | 2011-09-28 | Arena Pharmaceuticals, Inc. | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto |
| US8940891B2 (en) * | 2008-12-08 | 2015-01-27 | Arena Pharmaceuticals, Inc. | Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto |
| CN103842066B (zh) | 2011-09-30 | 2016-08-24 | 日本化成株式会社 | 聚合性无机颗粒分散剂、含有该聚合性无机颗粒分散剂的无机有机复合颗粒以及无机有机树脂复合材料 |
| US9314026B2 (en) | 2011-10-06 | 2016-04-19 | Bayer Intellectual Property Gmbh | Heterocyclylpyri(mi)dinylpyrazole |
| PL2763987T3 (pl) | 2011-10-06 | 2019-01-31 | Bayer Cropscience Ag | Heterocyklilopiry(mi)dynylopirazole jako środki grzybobójcze |
| NZ731751A (en) | 2014-10-23 | 2023-07-28 | Arena Pharm Inc | Method of treating conditions related to the pgi2 receptor |
| JP2019533713A (ja) | 2016-11-10 | 2019-11-21 | アレーナ ファーマシューティカルズ，インク． | ラリンパグと他の薬剤とを組み合わせた肺動脈高血圧症を処置する方法 |
| CN110582271B (zh) * | 2017-03-01 | 2022-06-14 | 阿瑞那制药公司 | 包含pgi2受体激动剂的组合物及其制备方法 |
| WO2019154363A1 (zh) * | 2018-02-07 | 2019-08-15 | 南京明德新药研发有限公司 | 前列环素受体受体激动剂 |
| WO2019222764A1 (en) | 2018-05-16 | 2019-11-21 | Arena Pharmaceuticals, Inc. | Compositions comprising pgi2-receptor agonists and processes for the preparation thereof |
| AU2023222747A1 (en) | 2022-02-15 | 2024-08-22 | United Therapeutics Corporation | Crystalline prostacyclin (ip) receptor agonist and uses thereof |
| IL319458A (en) | 2022-09-09 | 2025-05-01 | Innovo Therapeutics Inc | Compounds that reduce ck1α and dual ck1α/gspt1 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849919A (en) * | 1991-12-27 | 1998-12-15 | Ono Pharmaceutical Co., Ltd. | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity |
| US20060258728A1 (en) * | 2001-08-09 | 2006-11-16 | Kousuke Tani | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1021451A (en) | 1911-04-22 | 1912-03-26 | James F Craven | Receptacle for containing and discharging semisolid and pasty substances. |
| DE2945530A1 (de) | 1979-11-10 | 1981-06-04 | Chemische Werke Hüls AG, 4370 Marl | Harnstoffe mit cyclischen substituenten, ihre herstellung und verwendung als herbizide |
| JPH03160438A (ja) | 1989-11-20 | 1991-07-10 | Konica Corp | ハロゲン化銀カラー写真感光材料 |
| CA2036192A1 (en) | 1990-02-13 | 1991-08-14 | Nicholas Meanwell | Heterocyclic carboxylic acids and esters |
| JPH06329598A (ja) | 1993-05-19 | 1994-11-29 | Daicel Chem Ind Ltd | エステルの製造方法 |
| DE4318889A1 (de) | 1993-06-07 | 1994-12-08 | Bayer Ag | Verfahren zur Herstellung von organischen Carbamaten |
| JP3160438B2 (ja) | 1993-09-29 | 2001-04-25 | 株式会社東芝 | 交通流予測装置 |
| JPH11269138A (ja) | 1998-03-20 | 1999-10-05 | Mitsubishi Paper Mills Ltd | 有機塩基発生剤 |
| EP1046631A1 (en) | 1999-04-19 | 2000-10-25 | Rolic AG | Liquid crystalline compounds |
| GB9908934D0 (en) * | 1999-04-19 | 1999-06-16 | Rolic Ag | Liquid crystalline compounds |
| US20040048844A1 (en) * | 1999-10-20 | 2004-03-11 | Bristol-Myers Squibb Pharma Company | Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents |
| WO2002055484A1 (en) | 2001-01-12 | 2002-07-18 | Takeda Chemical Industries, Ltd. | Biaryl compound, process for producing the same, and agent |
| WO2003007888A2 (en) * | 2001-07-20 | 2003-01-30 | Adipogenix, Inc. | Fat accumulation-modulating compounds |
| TW200307539A (en) * | 2002-02-01 | 2003-12-16 | Bristol Myers Squibb Co | Cycloalkyl inhibitors of potassium channel function |
| TWI293715B (en) * | 2002-10-10 | 2008-02-21 | Sipix Imaging Inc | A method for inducing or enhancing the threshold of an electrophoretic display, an electrophoretic fluid and an electrophoretic display |
| MXPA05008450A (es) * | 2003-02-10 | 2005-10-18 | Vertex Pharma | Procesos para la preparacion de n-heteroaril-n-aril-aminas mediante reaccion de un ester de acido n-aril-carbamico con un halo-heteroarilo y procesos analogos. |
| JP4402413B2 (ja) | 2003-09-29 | 2010-01-20 | 財団法人２１あおもり産業総合支援センター | Ｕ字型化合物およびこれを含む液晶組成物 |
| DE102004006785A1 (de) | 2004-02-11 | 2005-09-08 | Mayr, Herbert, Prof. Dr. | Verfahren zur CC-Bindungsknüpfung zwischen elektrophilen Substraten und TT-Verbindungen in neutralen bis basischen wässrigen oder alkoholischen Lösungsmitteln ohne den Einsatz einer Lewis- oder Protonensäure |
| CA2576971A1 (en) * | 2004-08-20 | 2006-03-02 | Entremed, Inc. | Compositions and methods comprising proteinase activated receptor antagonists |
| TW200621261A (en) * | 2004-08-26 | 2006-07-01 | Encysive Pharmaceuticals | Endothelin a receptor antagonists in combination with phosphodiesterase 5 inhibitors and uses thereof |
| JP2006083085A (ja) | 2004-09-15 | 2006-03-30 | Kyowa Hakko Kogyo Co Ltd | 二環性ピリミジン誘導体の製造法およびその合成中間体 |
| JP4792731B2 (ja) | 2004-11-12 | 2011-10-12 | Ｄｉｃ株式会社 | 重合性液晶組成物及び当該組成物の硬化物 |
| WO2007051255A1 (en) | 2005-11-04 | 2007-05-10 | The University Of Sydney | Process for the preparation of compounds containing an azacyclic ring system |
| JP2007161867A (ja) | 2005-12-14 | 2007-06-28 | Toyo Ink Mfg Co Ltd | インキ組成物 |
| GB0603684D0 (en) | 2006-02-23 | 2006-04-05 | Novartis Ag | Organic compounds |
| BRPI0713096A2 (pt) | 2006-05-09 | 2012-10-16 | Hemaquest Pharmaceuticals Inc | métodos para tratar distúrbios sangüìneos |
| EP2280696B9 (en) | 2008-03-18 | 2015-12-09 | Arena Pharmaceuticals, Inc. | Modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto |
| EP2367797A1 (en) | 2008-11-26 | 2011-09-28 | Arena Pharmaceuticals, Inc. | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto |
| US8940891B2 (en) * | 2008-12-08 | 2015-01-27 | Arena Pharmaceuticals, Inc. | Modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto |
| US20120225937A1 (en) | 2009-09-23 | 2012-09-06 | Arena Pharmaceuticals, Inc. | Crystalline forms and processes for the preparation of pg12 receptor agonists |
| WO2019032626A1 (en) | 2017-08-07 | 2019-02-14 | Arena Pharmaceuticals, Inc. | Methods of treatment |
-
2009
- 2009-11-24 EP EP09768563A patent/EP2367797A1/en not_active Withdrawn
- 2009-11-24 NZ NZ593002A patent/NZ593002A/xx unknown
- 2009-11-24 EA EA201100846A patent/EA022799B1/ru not_active IP Right Cessation
- 2009-11-24 EP EP17183750.3A patent/EP3342767B1/en active Active
- 2009-11-24 CN CN200980155333.9A patent/CN102292321B/zh active Active
- 2009-11-24 AU AU2009325117A patent/AU2009325117C1/en active Active
- 2009-11-24 JP JP2011538598A patent/JP5603343B2/ja active Active
- 2009-11-24 SG SG2011037926A patent/SG171413A1/en unknown
- 2009-11-24 US US13/131,203 patent/US20110224262A1/en not_active Abandoned
- 2009-11-24 MX MX2011005577A patent/MX2011005577A/es active IP Right Grant
- 2009-11-24 KR KR1020117014566A patent/KR101707247B1/ko active Active
- 2009-11-24 CA CA2744124A patent/CA2744124C/en active Active
- 2009-11-24 WO PCT/US2009/006251 patent/WO2010068242A1/en not_active Ceased
- 2009-11-24 BR BRPI0921369A patent/BRPI0921369B8/pt active IP Right Grant
-
2011
- 2011-05-17 IL IL212966A patent/IL212966A/en active IP Right Grant
- 2011-05-24 ZA ZA2011/03813A patent/ZA201103813B/en unknown
-
2013
- 2013-07-03 US US13/934,439 patent/US9012478B2/en active Active
-
2015
- 2015-03-16 US US14/659,293 patent/US9663500B2/en active Active
-
2017
- 2017-04-13 US US15/486,600 patent/US10214518B2/en active Active
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2018
- 2018-11-06 US US16/181,457 patent/US10689372B2/en active Active
-
2020
- 2020-04-30 US US16/863,625 patent/US11098034B2/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5849919A (en) * | 1991-12-27 | 1998-12-15 | Ono Pharmaceutical Co., Ltd. | Fused benzeneoxyacetic acid derivatives which have PGI2 receptor anonist activity |
| US20060258728A1 (en) * | 2001-08-09 | 2006-11-16 | Kousuke Tani | Carboxylic acid derivative compounds and drugs comprising these compounds as the active ingredient |
Also Published As
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| Publication | Publication Date | Title |
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| AU2009325117C1 (en) | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (PGI2) receptor useful for the treatment of disorders related thereto | |
| US10793529B2 (en) | Substituted pyridazines and 1,2,4-triazines as prostacyclin receptor modulators | |
| KR101670089B1 (ko) | 프로스타시클린 （ｐｇｉ２） 수용체와 관련된 장애의 치료에 유용한 상기 수용체의 조절제 | |
| HK1257652B (en) | Pyrazolyl substituted carbonic acid derivatives as modulators of the prostacyclin (pgi2) receptor useful for the treatment of disorders related thereto |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| DA2 | Applications for amendment section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 15 AUG 2014 . |
|
| DA3 | Amendments made section 104 |
Free format text: THE NATURE OF THE AMENDMENT IS AS SHOWN IN THE STATEMENT(S) FILED 15 AUG 2014 |
|
| FGA | Letters patent sealed or granted (standard patent) |