MX2011000843A - Inhibidores de pirazolopiridin cinasa triciclicos. - Google Patents
Inhibidores de pirazolopiridin cinasa triciclicos.Info
- Publication number
- MX2011000843A MX2011000843A MX2011000843A MX2011000843A MX2011000843A MX 2011000843 A MX2011000843 A MX 2011000843A MX 2011000843 A MX2011000843 A MX 2011000843A MX 2011000843 A MX2011000843 A MX 2011000843A MX 2011000843 A MX2011000843 A MX 2011000843A
- Authority
- MX
- Mexico
- Prior art keywords
- independently
- optionally
- ring
- substituted
- independently substituted
- Prior art date
Links
- 229940043355 kinase inhibitor Drugs 0.000 title description 4
- 239000003757 phosphotransferase inhibitor Substances 0.000 title description 2
- AMFYRKOUWBAGHV-UHFFFAOYSA-N 1h-pyrazolo[4,3-b]pyridine Chemical compound C1=CN=C2C=NNC2=C1 AMFYRKOUWBAGHV-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 278
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- 238000000034 method Methods 0.000 claims abstract description 43
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- -1 pyrrolopyrazinyl Chemical group 0.000 claims description 111
- 125000001931 aliphatic group Chemical group 0.000 claims description 81
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 79
- 229910052736 halogen Inorganic materials 0.000 claims description 70
- 229910052757 nitrogen Inorganic materials 0.000 claims description 70
- 150000003839 salts Chemical class 0.000 claims description 67
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- 229920006395 saturated elastomer Polymers 0.000 claims description 57
- 125000005842 heteroatom Chemical group 0.000 claims description 54
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 50
- 229910052717 sulfur Chemical group 0.000 claims description 50
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 49
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- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 7
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- 125000003453 indazolyl group Chemical group N1N=C(C2=C1C=CC=C2)* 0.000 claims description 2
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- General Health & Medical Sciences (AREA)
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- Oncology (AREA)
- Endocrinology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8291908P | 2008-07-23 | 2008-07-23 | |
| US11603208P | 2008-11-19 | 2008-11-19 | |
| US14010008P | 2008-12-23 | 2008-12-23 | |
| US16315209P | 2009-03-25 | 2009-03-25 | |
| PCT/US2009/051437 WO2010011772A2 (en) | 2008-07-23 | 2009-07-22 | Tri-cyclic pyrazolopyridine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2011000843A true MX2011000843A (es) | 2011-04-11 |
Family
ID=41137604
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2011000843A MX2011000843A (es) | 2008-07-23 | 2009-07-22 | Inhibidores de pirazolopiridin cinasa triciclicos. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP2318408B1 (OSRAM) |
| JP (2) | JP2011529066A (OSRAM) |
| KR (1) | KR20110033299A (OSRAM) |
| CN (1) | CN102159574A (OSRAM) |
| AR (1) | AR074171A1 (OSRAM) |
| AU (1) | AU2009274027A1 (OSRAM) |
| BR (1) | BRPI0916295A2 (OSRAM) |
| CA (1) | CA2731432A1 (OSRAM) |
| IL (1) | IL210822A0 (OSRAM) |
| MX (1) | MX2011000843A (OSRAM) |
| TW (1) | TW201018680A (OSRAM) |
| WO (1) | WO2010011772A2 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3140759B2 (ja) | 1990-04-02 | 2001-03-05 | キンセキ株式会社 | 弾性表面波素子の製造方法 |
| JP3362860B2 (ja) | 1991-01-09 | 2003-01-07 | 大日本印刷株式会社 | 表面弾性波素子の製造方法 |
| JP2013518114A (ja) * | 2010-01-27 | 2013-05-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | ピラゾロピリミジンキナーゼ阻害剤 |
| MX2012008642A (es) * | 2010-01-27 | 2012-11-23 | Vertex Pharma | Inhibidores de cinasas de pirazolopiridinas. |
| AU2011209649A1 (en) * | 2010-01-27 | 2012-08-09 | Vertex Pharmaceuticals Incorporated | Pyrazolopyrazine kinase inhibitors |
| CN102858769A (zh) * | 2010-01-27 | 2013-01-02 | 沃泰克斯药物股份有限公司 | 吡唑并吡啶激酶抑制剂 |
| US20130096160A1 (en) * | 2010-04-14 | 2013-04-18 | Secretary, Department Of Health And Human Services | Arylthiazolyl piperidines and related compounds as modulators of survival motor neuron (smn) protein production |
| KR20130128435A (ko) | 2010-12-16 | 2013-11-26 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
| CN103492382A (zh) | 2010-12-16 | 2014-01-01 | 沃泰克斯药物股份有限公司 | 流感病毒复制的抑制剂 |
| AU2011343642A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
| WO2013037390A1 (en) * | 2011-09-12 | 2013-03-21 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US8846712B2 (en) | 2011-09-12 | 2014-09-30 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| EP2567959B1 (en) * | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013045413A1 (en) * | 2011-09-27 | 2013-04-04 | Sanofi | 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013060636A1 (en) * | 2011-10-25 | 2013-05-02 | Sanofi | 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| WO2013167403A1 (en) * | 2012-05-09 | 2013-11-14 | Sanofi | Substituted 6-(4-hydroxy-phenyl)-1h-pyrazolo[3,4-b]pyridine derivatives as kinase inhibitors |
| WO2013184985A1 (en) | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
| WO2014181813A1 (ja) * | 2013-05-10 | 2014-11-13 | 武田薬品工業株式会社 | 複素環化合物 |
| JP6878316B2 (ja) * | 2015-06-19 | 2021-05-26 | ノバルティス アーゲー | Ｓｈｐ２の活性を阻害するための化合物および組成物 |
| JP6828271B2 (ja) | 2016-05-18 | 2021-02-10 | ソニー株式会社 | 通信装置、通信方法、プログラム、および、通信システム |
| KR102642378B1 (ko) * | 2017-03-24 | 2024-02-28 | 픽사이 인코포레이티드 | 유용한 약학적 적용을 갖는 융합된 트리아졸로-피리미딘 화합물 |
| CN111032045B (zh) * | 2017-08-15 | 2023-08-15 | 安吉奥斯医药品有限公司 | 用于治疗血液病症的丙酮酸激酶激活剂 |
| CN111620866A (zh) * | 2019-02-27 | 2020-09-04 | 南京药石科技股份有限公司 | 一种顺式-7,7-二氟-六氢-1H 吡咯并[3,4-c]吡啶衍生物及其制备方法 |
| KR20240157788A (ko) * | 2022-02-08 | 2024-11-01 | 테라스, 인크. | 암 및 기타 적응증의 치료에 사용하기 위한 적어도 4개의 환에 의해서 형성된 t 구조를 갖는 화합물 |
| CN118834206A (zh) * | 2023-04-24 | 2024-10-25 | 北京宇繁科技有限责任公司 | 一种map4k4抑制剂及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10222550A1 (de) * | 2002-05-17 | 2003-11-27 | Bayer Ag | Substituierte Benzyl-pyrazolopyridine |
| MXPA05001688A (es) * | 2002-08-12 | 2005-04-19 | Sugen Inc | 3-pirrolil-piridopirazoles y 3-pirrolil-indazoles como inhibidores de cinasa novedosos. |
| US7507826B2 (en) * | 2004-03-30 | 2009-03-24 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of JAK and other protein kinases |
| WO2005103050A2 (en) * | 2004-04-02 | 2005-11-03 | Vertex Pharmaceuticals Incorporated | Azaindoles useful as inhibitors of rock and other protein kinases |
| BRPI0610828A2 (pt) * | 2005-05-16 | 2010-07-27 | Irm Llc | compostos e composições como inibidores de proteìna quinase |
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2009
- 2009-07-22 EP EP09790736.4A patent/EP2318408B1/en active Active
- 2009-07-22 BR BRPI0916295A patent/BRPI0916295A2/pt not_active IP Right Cessation
- 2009-07-22 KR KR1020117004087A patent/KR20110033299A/ko not_active Withdrawn
- 2009-07-22 JP JP2011520175A patent/JP2011529066A/ja not_active Withdrawn
- 2009-07-22 AU AU2009274027A patent/AU2009274027A1/en not_active Abandoned
- 2009-07-22 CN CN2009801367212A patent/CN102159574A/zh active Pending
- 2009-07-22 MX MX2011000843A patent/MX2011000843A/es not_active Application Discontinuation
- 2009-07-22 CA CA2731432A patent/CA2731432A1/en not_active Abandoned
- 2009-07-22 WO PCT/US2009/051437 patent/WO2010011772A2/en not_active Ceased
- 2009-07-23 TW TW098124909A patent/TW201018680A/zh unknown
- 2009-07-23 AR ARP090102815A patent/AR074171A1/es unknown
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2011
- 2011-01-23 IL IL210822A patent/IL210822A0/en unknown
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2014
- 2014-08-11 JP JP2014163360A patent/JP5931976B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010011772A3 (en) | 2010-04-29 |
| EP2318408B1 (en) | 2016-02-17 |
| BRPI0916295A2 (pt) | 2019-09-24 |
| AR074171A1 (es) | 2010-12-29 |
| KR20110033299A (ko) | 2011-03-30 |
| JP2014208710A (ja) | 2014-11-06 |
| JP5931976B2 (ja) | 2016-06-08 |
| CA2731432A1 (en) | 2010-01-28 |
| WO2010011772A2 (en) | 2010-01-28 |
| AU2009274027A1 (en) | 2010-01-28 |
| EP2318408A2 (en) | 2011-05-11 |
| JP2011529066A (ja) | 2011-12-01 |
| TW201018680A (en) | 2010-05-16 |
| CN102159574A (zh) | 2011-08-17 |
| IL210822A0 (en) | 2011-04-28 |
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