MX2010013841A - Derivados de triazolo[4,5-d]pirimidina y su uso como antagonistas del receptor de purina. - Google Patents
Derivados de triazolo[4,5-d]pirimidina y su uso como antagonistas del receptor de purina.Info
- Publication number
- MX2010013841A MX2010013841A MX2010013841A MX2010013841A MX2010013841A MX 2010013841 A MX2010013841 A MX 2010013841A MX 2010013841 A MX2010013841 A MX 2010013841A MX 2010013841 A MX2010013841 A MX 2010013841A MX 2010013841 A MX2010013841 A MX 2010013841A
- Authority
- MX
- Mexico
- Prior art keywords
- triazolo
- amine
- pyrimidin
- ylmethyl
- pyrid
- Prior art date
Links
- 102000000033 Purinergic Receptors Human genes 0.000 title claims abstract description 7
- 108010080192 Purinergic Receptors Proteins 0.000 title claims abstract description 7
- 229940044551 receptor antagonist Drugs 0.000 title abstract description 4
- 239000002464 receptor antagonist Substances 0.000 title abstract description 4
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical class C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 title description 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 76
- 238000000034 method Methods 0.000 claims abstract description 43
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- VJCQEPWQSBKWTE-UHFFFAOYSA-N 2h-triazolo[4,5-d]pyrimidin-5-amine Chemical compound N1=C(N)N=CC2=NNN=C21 VJCQEPWQSBKWTE-UHFFFAOYSA-N 0.000 claims description 30
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
- 125000000217 alkyl group Chemical group 0.000 claims description 23
- 239000002126 C01EB10 - Adenosine Substances 0.000 claims description 20
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 7
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- 125000006514 pyridin-2-ylmethyl group Chemical group [H]C1=C([H])C([H])=C([H])C(=N1)C([H])([H])* 0.000 description 14
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- 230000014759 maintenance of location Effects 0.000 description 12
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- 239000005557 antagonist Substances 0.000 description 10
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- 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 10
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 8
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Classifications
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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| US7553808P | 2008-06-25 | 2008-06-25 | |
| GBGB0906579.8A GB0906579D0 (en) | 2009-04-16 | 2009-04-16 | Pharmaceuticals, compositions and methods of making and using the same |
| PCT/GB2009/001605 WO2009156737A1 (en) | 2008-06-25 | 2009-06-25 | Triazolo [4, 5-d] pyramidine derivatives and their use as purine receptor antagonists |
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| MX2010013841A true MX2010013841A (es) | 2011-02-25 |
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| CN119546638A (zh) | 2022-06-22 | 2025-02-28 | 朱诺治疗学股份有限公司 | 用于cd19靶向的car t细胞的二线疗法的治疗方法 |
| JP2025525937A (ja) | 2022-08-05 | 2025-08-07 | ジュノー セラピューティクス インコーポレイテッド | Ｇｐｒｃ５ｄおよびｂｃｍａに特異的なキメラ抗原受容体 |
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