MX2010011047A - Derivados de tienopiridonas como activadores de proteina cinasa activada por amp (ampk). - Google Patents

Derivados de tienopiridonas como activadores de proteina cinasa activada por amp (ampk).

Info

Publication number
MX2010011047A
MX2010011047A MX2010011047A MX2010011047A MX2010011047A MX 2010011047 A MX2010011047 A MX 2010011047A MX 2010011047 A MX2010011047 A MX 2010011047A MX 2010011047 A MX2010011047 A MX 2010011047A MX 2010011047 A MX2010011047 A MX 2010011047A
Authority
MX
Mexico
Prior art keywords
ampk
activators
protein kinase
activated protein
thienopyridone derivatives
Prior art date
Application number
MX2010011047A
Other languages
English (en)
Spanish (es)
Inventor
Daniel Cravo
Sophie Hallakou-Bozec
Christine Charon
Franck Lepifre
Original Assignee
Merck Patent Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40671017&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2010011047(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh
Publication of MX2010011047A publication Critical patent/MX2010011047A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX2010011047A 2008-04-11 2009-03-17 Derivados de tienopiridonas como activadores de proteina cinasa activada por amp (ampk). MX2010011047A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290364 2008-04-11
PCT/EP2009/001937 WO2009124636A1 (en) 2008-04-11 2009-03-17 Thienopyridone derivatives as amp-activated protein kinase (ampk) activators

Publications (1)

Publication Number Publication Date
MX2010011047A true MX2010011047A (es) 2010-10-26

Family

ID=40671017

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010011047A MX2010011047A (es) 2008-04-11 2009-03-17 Derivados de tienopiridonas como activadores de proteina cinasa activada por amp (ampk).

Country Status (25)

Country Link
US (1) US8563729B2 (enExample)
EP (1) EP2262500B1 (enExample)
JP (1) JP5592348B2 (enExample)
KR (1) KR101630466B1 (enExample)
CN (1) CN101998853B (enExample)
AU (1) AU2009235784B2 (enExample)
BR (1) BRPI0910439B8 (enExample)
CA (1) CA2721025C (enExample)
CO (1) CO6300954A2 (enExample)
DK (1) DK2262500T3 (enExample)
EA (1) EA017756B1 (enExample)
EC (1) ECSP10010599A (enExample)
ES (1) ES2584278T3 (enExample)
HR (1) HRP20160907T1 (enExample)
HU (1) HUE027857T2 (enExample)
IL (1) IL208067A (enExample)
MX (1) MX2010011047A (enExample)
MY (1) MY155836A (enExample)
NZ (1) NZ589136A (enExample)
PL (1) PL2262500T3 (enExample)
PT (1) PT2262500T (enExample)
SI (1) SI2262500T1 (enExample)
UA (1) UA103321C2 (enExample)
WO (1) WO2009124636A1 (enExample)
ZA (1) ZA201008050B (enExample)

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Publication number Priority date Publication date Assignee Title
MX2010011916A (es) * 2008-05-05 2010-11-26 Merck Patent Gmbh Derivados de tienopiridonas como activadores de proteinas cinasa activados por amp (ampk).
CN102803269B (zh) * 2009-12-29 2016-01-13 珀科赛尔 Ampk的噻吩并[2,3-b]嘧啶二酮活化剂及其治疗用途
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
WO2011121109A1 (en) 2010-04-02 2011-10-06 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions comprising ampk activator (metformin/troglitazone) for the treatment of myotonic dystrophy type 1 (dm1)
US8530413B2 (en) 2010-06-21 2013-09-10 Sanofi Heterocyclically substituted methoxyphenyl derivatives with an oxo group, processes for preparation thereof and use thereof as medicaments
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
EP2611801B1 (de) 2010-09-01 2016-05-04 Bayer Intellectual Property GmbH Herbizid wirksame ketosultame und diketopyridine
CN103517896B (zh) * 2011-03-07 2016-09-21 葛兰素史密斯克莱有限责任公司 喹啉酮衍生物
WO2013037390A1 (en) 2011-09-12 2013-03-21 Sanofi 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2679591A1 (en) 2012-06-29 2014-01-01 Poxel Thienopyridone derivatives useful as activators of AMPK
CA2905242C (en) 2013-03-15 2016-11-29 Pfizer Inc. Indole compounds that activate ampk
WO2015002818A1 (en) 2013-07-01 2015-01-08 Emory University Treating or preventing nephrogenic diabetes insipidus
US10143703B2 (en) 2014-01-02 2018-12-04 Massachusetts Eye And Ear Infirmary Treating ocular neovascularization
CN104945369A (zh) * 2015-06-23 2015-09-30 佛山市赛维斯医药科技有限公司 一种含六甲基苯环和硝基苯结构的黄原酸酯类化合物、其制备方法及用途
CN105037321A (zh) * 2015-06-23 2015-11-11 佛山市赛维斯医药科技有限公司 含六甲基苯环的黄原酸酯类的ampk激活剂、制备方法及用途
CN105037322A (zh) * 2015-06-23 2015-11-11 佛山市赛维斯医药科技有限公司 含六甲基苯环和烷氧苯结构的黄原酸酯类化合物、其制备方法及用途
CN104945370A (zh) * 2015-06-23 2015-09-30 佛山市赛维斯医药科技有限公司 含卤代噻吩和硝苯六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN104892568A (zh) * 2015-06-23 2015-09-09 佛山市赛维斯医药科技有限公司 一种含六甲基苯环和腈基苯结构的黄原酸酯类化合物、其制备方法及用途
CN104892569A (zh) * 2015-06-23 2015-09-09 佛山市赛维斯医药科技有限公司 末端取代的硝苯六甲苯黄原酸酯类的化合物、制备方法及用途
CN105001181A (zh) * 2015-06-24 2015-10-28 佛山市赛维斯医药科技有限公司 一类双酰基苄胺类的ampk激活剂、其制备方法及用途
CN104926757A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 含烷氧苯基的双酰基苄胺类ampk激活剂、其制备方法及用途
CN104926755A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 硝苯双酰基苄胺类ampk激活剂、其制备方法及用途
CN104926756A (zh) * 2015-06-24 2015-09-23 佛山市赛维斯医药科技有限公司 一类含腈基苯的双酰基苄胺类化合物、其制备方法及用途
CN105001194A (zh) * 2015-06-24 2015-10-28 佛山市赛维斯医药科技有限公司 一种含氨基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN104945371A (zh) * 2015-06-24 2015-09-30 佛山市赛维斯医药科技有限公司 一种含腈基噻吩以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
CN105037296A (zh) * 2015-06-24 2015-11-11 佛山市赛维斯医药科技有限公司 一类卤代苯双酰基苄胺类的ampk激活剂、其制备方法及用途
CN104945372A (zh) * 2015-06-24 2015-09-30 佛山市赛维斯医药科技有限公司 一种含二硝基以及六甲苯结构的黄原酸酯类化合物、制备方法及用途
WO2016205942A1 (en) * 2015-06-25 2016-12-29 University Health Network Hpk1 inhibitors and methods of using same
EP3355876A2 (en) 2015-09-30 2018-08-08 Instituto de Medicina Molecular Methods for attenuating parasite virulence
WO2018002215A1 (en) 2016-06-30 2018-01-04 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of cardiomyopathies
SG11202104813VA (en) * 2018-11-16 2021-06-29 Poxel Monohydrate potassium salt of a thienopyridone derivative and its preparation process
WO2020201263A1 (en) 2019-04-01 2020-10-08 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment and prevention of cardiac remodeling
KR20220160030A (ko) * 2020-03-26 2022-12-05 폭셀 부신백색질형성장애증 또는 부신척수신경병증의 치료에 있어서의 티에노피리돈 유도체의 용도
DK4125887T3 (da) * 2020-04-02 2024-05-06 Poxel Anvendelse af et thienopyridonderivat til behandling af en autosomal dominant polycystisk nyresygdom (adpkd)
CA3178994A1 (en) 2020-05-19 2021-11-25 Iyassu Sebhat Ampk activators
WO2021263039A1 (en) 2020-06-26 2021-12-30 Kallyope, Inc. Ampk activators
CN116322663A (zh) 2020-09-30 2023-06-23 比奥维拉迪维治疗股份有限公司 Ampk激活剂及其使用方法
WO2022106892A1 (en) 2020-11-17 2022-05-27 Instituto De Medicina Molecular Anti-malarial compounds
AU2022391025A1 (en) 2021-11-19 2024-06-06 The Brigham And Women's Hospital, Inc. Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof

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AU626418B2 (en) 1989-05-16 1992-07-30 Merrell Pharmaceuticals Inc. Excitatory amino acid antagonists
DE4444815A1 (de) 1994-12-15 1996-06-20 Merck Patent Gmbh Thienopyridone
GB0214268D0 (en) 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
US7119205B2 (en) * 2003-05-16 2006-10-10 Abbott Laboratories Thienopyridones as AMPK activators for the treatment of diabetes and obesity
EP1754483A1 (en) * 2005-08-18 2007-02-21 Merck Sante Use of thienopyridone derivatives as AMPK activators and pharmaceutical compositions containing them
JP5525456B2 (ja) 2008-02-04 2014-06-18 マーキュリー セラピューティクス，インコーポレイテッド Ａｍｐｋ調節因子

Also Published As

Publication number Publication date
AU2009235784A1 (en) 2009-10-15
US20110034505A1 (en) 2011-02-10
BRPI0910439B8 (pt) 2021-05-25
BRPI0910439B1 (pt) 2020-10-20
CN101998853A (zh) 2011-03-30
EA201001585A1 (ru) 2011-06-30
WO2009124636A1 (en) 2009-10-15
IL208067A (en) 2015-05-31
SI2262500T1 (sl) 2016-09-30
KR101630466B1 (ko) 2016-06-14
JP2011516510A (ja) 2011-05-26
MY155836A (en) 2015-12-15
IL208067A0 (en) 2010-12-30
PL2262500T3 (pl) 2016-09-30
CA2721025A1 (en) 2009-10-15
ECSP10010599A (es) 2010-12-30
EP2262500A1 (en) 2010-12-22
AU2009235784B2 (en) 2013-09-19
JP5592348B2 (ja) 2014-09-17
PT2262500T (pt) 2016-08-16
CN101998853B (zh) 2015-02-11
EP2262500B1 (en) 2016-04-27
HRP20160907T1 (hr) 2016-09-23
KR20100137563A (ko) 2010-12-30
CA2721025C (en) 2016-07-26
ZA201008050B (en) 2011-07-27
NZ589136A (en) 2012-06-29
CO6300954A2 (es) 2011-07-21
EA017756B1 (ru) 2013-02-28
HK1155955A1 (en) 2012-06-01
ES2584278T3 (es) 2016-09-26
UA103321C2 (ru) 2013-10-10
DK2262500T3 (en) 2016-08-15
US8563729B2 (en) 2013-10-22
BRPI0910439A2 (pt) 2015-09-29
HUE027857T2 (en) 2016-11-28

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