MX2010009445A - Moduladores de proteina kinasa. - Google Patents
Moduladores de proteina kinasa.Info
- Publication number
- MX2010009445A MX2010009445A MX2010009445A MX2010009445A MX2010009445A MX 2010009445 A MX2010009445 A MX 2010009445A MX 2010009445 A MX2010009445 A MX 2010009445A MX 2010009445 A MX2010009445 A MX 2010009445A MX 2010009445 A MX2010009445 A MX 2010009445A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- lcms
- cancer
- molecular weight
- mixture
- Prior art date
Links
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- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 description 1
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- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US6784508P | 2008-02-29 | 2008-02-29 | |
| US10390808P | 2008-10-08 | 2008-10-08 | |
| PCT/US2009/035609 WO2009108912A1 (en) | 2008-02-29 | 2009-02-28 | Protein kinase modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2010009445A true MX2010009445A (es) | 2011-05-25 |
Family
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Family Applications (1)
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| MX2010009445A MX2010009445A (es) | 2008-02-29 | 2009-02-28 | Moduladores de proteina kinasa. |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US8168651B2 (enExample) |
| EP (1) | EP2259678A4 (enExample) |
| JP (1) | JP2011515337A (enExample) |
| CN (1) | CN102036561A (enExample) |
| AU (1) | AU2009219154A1 (enExample) |
| CA (1) | CA2716755A1 (enExample) |
| MX (1) | MX2010009445A (enExample) |
| WO (1) | WO2009108912A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7956064B2 (en) * | 2006-09-01 | 2011-06-07 | Cylene Pharmaceuticals, Inc. | Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators |
| PL2268618T3 (pl) | 2008-03-03 | 2015-11-30 | Novartis Ag | Związki i kompozycje jako modulatory aktywności receptorów TLR |
| US20100173013A1 (en) * | 2009-01-08 | 2010-07-08 | Denis Drygin | Treatment of neoplastic disorders using combination therapies |
| US20100267753A1 (en) * | 2009-04-17 | 2010-10-21 | Mustapha Haddach | Methods of treating disorders associated with protein kinase ck2 activity |
| US9968574B2 (en) * | 2009-05-15 | 2018-05-15 | The University Of Kentucky Research Foundation | Treatment of MCI and Alzheimer's disease |
| IN2012DN02596A (enExample) * | 2009-08-26 | 2015-08-28 | Cylene Pharmaceuticals Inc | |
| DK2473510T3 (da) * | 2009-09-03 | 2014-10-20 | Bristol Myers Squibb Co | Jak-2-hæmmere og anvendelse heraf til behandling af myeloproliferativesygdomme og cancer |
| AU2010295622A1 (en) * | 2009-09-16 | 2012-05-10 | Cylene Pharmaceuticals, Inc. | Tricyclic compounds and pharmaceutical uses thereof |
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| HRP20171537T1 (hr) | 2009-11-05 | 2017-12-15 | Rhizen Pharmaceuticals S.A. | Novi modulatori benzopiran kinaze |
| US8853235B2 (en) * | 2009-11-23 | 2014-10-07 | Senhwa Biosciences, Inc. | Polymorphs and salts of a kinase inhibitor |
| HUE045270T2 (hu) | 2010-01-05 | 2019-12-30 | Inst Nat Sante Rech Med | FLT3 receptor anatgonisták fájdalom rendellenességek kezelésére |
| US10106798B2 (en) | 2010-01-05 | 2018-10-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | FLT3 receptor antagonists for the treatment or the prevention of pain disorders |
| TWI503323B (zh) | 2010-03-29 | 2015-10-11 | Oncotherapy Science Inc | 三環化合物以及含此化合物之pbk抑制劑 |
| KR101992311B1 (ko) | 2011-05-04 | 2019-09-27 | 리젠 파마슈티컬스 소시에떼 아노님 | 단백질 키나아제의 조절제로서 신규한 화합물 |
| CN102731431A (zh) * | 2012-06-20 | 2012-10-17 | 盛世泰科生物医药技术(苏州)有限公司 | 一种5-溴噻唑-4-甲酸的制备方法 |
| LT2870157T (lt) | 2012-07-04 | 2017-12-11 | Rhizen Pharmaceuticals S.A. | Selektyvieji pi3k delta inhibitoriai |
| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションIncyte Holdings Corporation | Pimキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
| LT2945939T (lt) | 2013-01-15 | 2020-07-27 | Incyte Holdings Corporation | Triazolkarboksamidai ir piridinkarboksamido junginiai, naudotini kaip pim kinazės inhibitoriai |
| CA2928568A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Combinatorial methods to improve the therapeutic benefit of bisantrene |
| EP3036238A1 (en) | 2013-08-23 | 2016-06-29 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9822124B2 (en) | 2014-07-14 | 2017-11-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as Pim kinase inhibitors |
| US9540347B2 (en) | 2015-05-29 | 2017-01-10 | Incyte Corporation | Pyridineamine compounds useful as Pim kinase inhibitors |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| CN108341774B (zh) * | 2017-01-25 | 2022-07-19 | 首药控股(北京)股份有限公司 | 取代的喹啉酮类抑制剂 |
| WO2019090205A1 (en) | 2017-11-06 | 2019-05-09 | Snap Bio, Inc. | Pim kinase inhibitor compositions, methods, and uses thereof |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
| ES2971712T3 (es) | 2017-12-22 | 2024-06-06 | Hibercell Inc | Derivados de cromenopiridina como inhibidores de la fosfatidilinositol fosfato cinasa |
| US11071727B2 (en) | 2018-01-26 | 2021-07-27 | Northwestern University | Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors |
| JP7143437B2 (ja) * | 2018-04-03 | 2022-09-28 | 碩英生醫股フン有限公司 | Fms様チロシンキナーゼ阻害剤 |
| WO2020100959A1 (ja) * | 2018-11-15 | 2020-05-22 | 日本新薬株式会社 | 1,3,4-オキサジアゾロン化合物及び医薬 |
| CN109369526A (zh) * | 2018-12-19 | 2019-02-22 | 桂林理工大学 | 一种两面针碱衍生物的合成方法及其抗肿瘤应用 |
| GB201902759D0 (en) | 2019-02-28 | 2019-04-17 | Benevolentai Bio Ltd | Compositions and uses thereof |
| TW202112784A (zh) | 2019-06-17 | 2021-04-01 | 美商佩特拉製藥公司 | 作為磷脂酸肌醇磷酸激酶抑制劑之𠳭唏并嘧啶衍生物 |
| CN111320605A (zh) * | 2020-03-09 | 2020-06-23 | 吉林工程技术师范学院 | 一种银催化的含氟菲啶衍生物的制备方法 |
| CN113444085B (zh) * | 2020-03-26 | 2022-04-08 | 东南大学 | 一种具有克服顺铂耐药的抗肿瘤化合物及其制备与应用 |
| CN113444084A (zh) * | 2020-03-26 | 2021-09-28 | 东南大学 | 一类抗肿瘤化合物及其制备与用途 |
| KR20230004550A (ko) * | 2020-03-30 | 2023-01-06 | 센화 바이오사이언시즈 인코포레이티드 | 간친화성 바이러스 감염증, 특히, 간염 b 및 간염 d를 치료하기 위한 항바이러스성 화합물 및 방법 |
| EP3967307A1 (en) | 2020-09-15 | 2022-03-16 | Instytut Hematologii I Transfuzologii | Use of pim kinase inhibitors to augment the efficacy of anti-cd20 antibody-based therapies in hematologic malignancies and non-malignant conditions |
| US20240025899A1 (en) * | 2020-10-16 | 2024-01-25 | Shanghai De Novo Pharmatech Co., Ltd. | Triheterocyclic derivative, and pharmaceutical composition and application thereof |
| GB202102895D0 (en) * | 2021-03-01 | 2021-04-14 | Cambridge Entpr Ltd | Novel compounds, compositions and therapeutic uses thereof |
| WO2023126951A1 (en) * | 2022-01-03 | 2023-07-06 | Yeda Research And Development Co. Ltd. | Inhibitors of autophagy-related protein-protein interactions |
| WO2023225586A2 (en) * | 2022-05-19 | 2023-11-23 | 4M Therapeutics Inc. | Novel azaphenantrhene derivatives as inhibitors of glycogen synthase kinase 3 for therapeutic use |
| IL322451A (en) * | 2023-02-03 | 2025-09-01 | Mirati Therapeutics Inc | Substituted tricyclic compounds |
| US11987581B1 (en) | 2023-12-19 | 2024-05-21 | King Faisal University | Imidazo[1,2-c]pyrido[3,4-e]pyrimidine-2-carboxylic acids as CK2 inhibitors |
| US12024518B1 (en) | 2023-12-20 | 2024-07-02 | King Faisal University | Pyrazolo[4,3-C][1,6]naphthyridines as CK2 inhibitors |
| US12012414B1 (en) | 2024-01-04 | 2024-06-18 | King Faisal University | Imidazo[1,5-a]pyrido[4,3-e]pyrimidines as CK2 inhibitors |
| US11964974B1 (en) | 2024-01-08 | 2024-04-23 | King Faisal University | Imidazo[1,2-c]pyrido[3,4-e]pyrimidine-3-carboxylic acids as CK2 inhibitors |
| US11981676B1 (en) | 2024-01-16 | 2024-05-14 | King Faisal University | Pyrazolo[4,3-c][2,6]naphthyridines as CK2 inhibitors |
| US12187726B1 (en) | 2024-02-06 | 2025-01-07 | King Faisal University | Imidazo[1,5-a]pyrido[4,3-e]pyrazines as CK2 inhibitors |
Family Cites Families (10)
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| US3991064A (en) * | 1975-01-17 | 1976-11-09 | Warner-Lambert Company | Benzonaphthyridines |
| US5624677A (en) * | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| WO2005105814A1 (en) | 2004-04-28 | 2005-11-10 | Incyte Corporation | Tetracyclic inhibitors of janus kinases |
| MY148521A (en) * | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| WO2007007152A2 (en) | 2005-07-11 | 2007-01-18 | Pfizer Limited | Anti-madcam antibodies to treat metastatic cancers and chloroma |
| RU2008109908A (ru) * | 2005-08-16 | 2009-09-27 | Айрм Ллк (Bm) | Соединения и композиции в качестве ингибиторов протеинкиназы |
| BRPI0619785A2 (pt) * | 2005-12-13 | 2011-10-18 | Wyeth Corp | composto, composição e método para o tratamento de um transtorno proliferativo e método de prepraração |
| US7956064B2 (en) * | 2006-09-01 | 2011-06-07 | Cylene Pharmaceuticals, Inc. | Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators |
| US8088767B2 (en) | 2006-09-28 | 2012-01-03 | Exelixis, Inc. | JAK-2 modulators and methods of use |
| WO2008109613A1 (en) * | 2007-03-05 | 2008-09-12 | Wyeth | Benzo[c][2,7]naphthyridine derivatives, and their use as kinase inhibitors |
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2009
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- 2009-02-28 CA CA2716755A patent/CA2716755A1/en not_active Abandoned
- 2009-02-28 EP EP09714461A patent/EP2259678A4/en not_active Withdrawn
- 2009-02-28 AU AU2009219154A patent/AU2009219154A1/en not_active Abandoned
- 2009-02-28 JP JP2010548932A patent/JP2011515337A/ja not_active Withdrawn
- 2009-02-28 WO PCT/US2009/035609 patent/WO2009108912A1/en not_active Ceased
- 2009-02-28 MX MX2010009445A patent/MX2010009445A/es not_active Application Discontinuation
- 2009-03-02 US US12/396,084 patent/US8168651B2/en not_active Expired - Fee Related
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2011
- 2011-12-08 US US13/315,103 patent/US20120208792A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011515337A (ja) | 2011-05-19 |
| WO2009108912A1 (en) | 2009-09-03 |
| US20120208792A1 (en) | 2012-08-16 |
| EP2259678A4 (en) | 2011-07-27 |
| AU2009219154A1 (en) | 2009-09-03 |
| EP2259678A1 (en) | 2010-12-15 |
| US20090239859A1 (en) | 2009-09-24 |
| US8168651B2 (en) | 2012-05-01 |
| CA2716755A1 (en) | 2009-09-03 |
| CN102036561A (zh) | 2011-04-27 |
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| Date | Code | Title | Description |
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| FA | Abandonment or withdrawal |