JP2011515337A - プロテインキナーゼモジュレーター - Google Patents
プロテインキナーゼモジュレーター Download PDFInfo
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- JP2011515337A JP2011515337A JP2010548932A JP2010548932A JP2011515337A JP 2011515337 A JP2011515337 A JP 2011515337A JP 2010548932 A JP2010548932 A JP 2010548932A JP 2010548932 A JP2010548932 A JP 2010548932A JP 2011515337 A JP2011515337 A JP 2011515337A
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
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- Enzymes And Modification Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
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| US10390808P | 2008-10-08 | 2008-10-08 | |
| US61/103,908 | 2008-10-08 | ||
| PCT/US2009/035609 WO2009108912A1 (en) | 2008-02-29 | 2009-02-28 | Protein kinase modulators |
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| JP2011515337A true JP2011515337A (ja) | 2011-05-19 |
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| US (2) | US8168651B2 (enExample) |
| EP (1) | EP2259678A4 (enExample) |
| JP (1) | JP2011515337A (enExample) |
| CN (1) | CN102036561A (enExample) |
| AU (1) | AU2009219154A1 (enExample) |
| CA (1) | CA2716755A1 (enExample) |
| MX (1) | MX2010009445A (enExample) |
| WO (1) | WO2009108912A1 (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2020100959A1 (ja) * | 2018-11-15 | 2020-05-22 | 日本新薬株式会社 | １，３，４－オキサジアゾロン化合物及び医薬 |
| JP2023520883A (ja) * | 2020-03-30 | 2023-05-22 | センホア・バイオサイエンシーズ・インコーポレイテッド | Ｒｎａウイルス感染症、特にｃｏｖｉｄ－１９を処置するための抗ウイルス化合物および方法 |
| JP2023545196A (ja) * | 2020-10-16 | 2023-10-26 | シャンハイ ドーァ ノボ ファーマテック カンパニー，リミティド | 三複素環誘導体、その医薬組成物及び使用 |
| JP2024508547A (ja) * | 2021-03-01 | 2024-02-27 | ケンブリッジ・エンタープライズ・リミテッド | ベンゾ［ｃ］［２，６］ナフチリジン誘導体、組成物およびその治療的使用 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7956064B2 (en) * | 2006-09-01 | 2011-06-07 | Cylene Pharmaceuticals, Inc. | Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators |
| PL2268618T3 (pl) | 2008-03-03 | 2015-11-30 | Novartis Ag | Związki i kompozycje jako modulatory aktywności receptorów TLR |
| US20100173013A1 (en) * | 2009-01-08 | 2010-07-08 | Denis Drygin | Treatment of neoplastic disorders using combination therapies |
| US20100267753A1 (en) * | 2009-04-17 | 2010-10-21 | Mustapha Haddach | Methods of treating disorders associated with protein kinase ck2 activity |
| US9968574B2 (en) * | 2009-05-15 | 2018-05-15 | The University Of Kentucky Research Foundation | Treatment of MCI and Alzheimer's disease |
| IN2012DN02596A (enExample) * | 2009-08-26 | 2015-08-28 | Cylene Pharmaceuticals Inc | |
| DK2473510T3 (da) * | 2009-09-03 | 2014-10-20 | Bristol Myers Squibb Co | Jak-2-hæmmere og anvendelse heraf til behandling af myeloproliferativesygdomme og cancer |
| AU2010295622A1 (en) * | 2009-09-16 | 2012-05-10 | Cylene Pharmaceuticals, Inc. | Tricyclic compounds and pharmaceutical uses thereof |
| WO2011049625A1 (en) | 2009-10-20 | 2011-04-28 | Mansour Samadpour | Method for aflatoxin screening of products |
| HRP20171537T1 (hr) | 2009-11-05 | 2017-12-15 | Rhizen Pharmaceuticals S.A. | Novi modulatori benzopiran kinaze |
| US8853235B2 (en) * | 2009-11-23 | 2014-10-07 | Senhwa Biosciences, Inc. | Polymorphs and salts of a kinase inhibitor |
| HUE045270T2 (hu) | 2010-01-05 | 2019-12-30 | Inst Nat Sante Rech Med | FLT3 receptor anatgonisták fájdalom rendellenességek kezelésére |
| US10106798B2 (en) | 2010-01-05 | 2018-10-23 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | FLT3 receptor antagonists for the treatment or the prevention of pain disorders |
| TWI503323B (zh) | 2010-03-29 | 2015-10-11 | Oncotherapy Science Inc | 三環化合物以及含此化合物之ｐｂｋ抑制劑 |
| KR101992311B1 (ko) | 2011-05-04 | 2019-09-27 | 리젠 파마슈티컬스 소시에떼 아노님 | 단백질 키나아제의 조절제로서 신규한 화합물 |
| CN102731431A (zh) * | 2012-06-20 | 2012-10-17 | 盛世泰科生物医药技术(苏州)有限公司 | 一种5-溴噻唑-4-甲酸的制备方法 |
| LT2870157T (lt) | 2012-07-04 | 2017-12-11 | Rhizen Pharmaceuticals S.A. | Selektyvieji pi3k delta inhibitoriai |
| JP6437452B2 (ja) | 2013-01-14 | 2018-12-12 | インサイト・ホールディングス・コーポレイションＩｎｃｙｔｅ Ｈｏｌｄｉｎｇｓ Ｃｏｒｐｏｒａｔｉｏｎ | Ｐｉｍキナーゼ阻害剤として有用な二環式芳香族カルボキサミド化合物 |
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| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
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| CN113444085B (zh) * | 2020-03-26 | 2022-04-08 | 东南大学 | 一种具有克服顺铂耐药的抗肿瘤化合物及其制备与应用 |
| CN113444084A (zh) * | 2020-03-26 | 2021-09-28 | 东南大学 | 一类抗肿瘤化合物及其制备与用途 |
| EP3967307A1 (en) | 2020-09-15 | 2022-03-16 | Instytut Hematologii I Transfuzologii | Use of pim kinase inhibitors to augment the efficacy of anti-cd20 antibody-based therapies in hematologic malignancies and non-malignant conditions |
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| US12024518B1 (en) | 2023-12-20 | 2024-07-02 | King Faisal University | Pyrazolo[4,3-C][1,6]naphthyridines as CK2 inhibitors |
| US12012414B1 (en) | 2024-01-04 | 2024-06-18 | King Faisal University | Imidazo[1,5-a]pyrido[4,3-e]pyrimidines as CK2 inhibitors |
| US11964974B1 (en) | 2024-01-08 | 2024-04-23 | King Faisal University | Imidazo[1,2-c]pyrido[3,4-e]pyrimidine-3-carboxylic acids as CK2 inhibitors |
| US11981676B1 (en) | 2024-01-16 | 2024-05-14 | King Faisal University | Pyrazolo[4,3-c][2,6]naphthyridines as CK2 inhibitors |
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| WO2008109613A1 (en) * | 2007-03-05 | 2008-09-12 | Wyeth | Benzo[c][2,7]naphthyridine derivatives, and their use as kinase inhibitors |
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2009
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- 2009-02-28 CA CA2716755A patent/CA2716755A1/en not_active Abandoned
- 2009-02-28 EP EP09714461A patent/EP2259678A4/en not_active Withdrawn
- 2009-02-28 AU AU2009219154A patent/AU2009219154A1/en not_active Abandoned
- 2009-02-28 JP JP2010548932A patent/JP2011515337A/ja not_active Withdrawn
- 2009-02-28 WO PCT/US2009/035609 patent/WO2009108912A1/en not_active Ceased
- 2009-02-28 MX MX2010009445A patent/MX2010009445A/es not_active Application Discontinuation
- 2009-03-02 US US12/396,084 patent/US8168651B2/en not_active Expired - Fee Related
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- 2011-12-08 US US13/315,103 patent/US20120208792A1/en not_active Abandoned
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| WO2020100959A1 (ja) * | 2018-11-15 | 2020-05-22 | 日本新薬株式会社 | １，３，４－オキサジアゾロン化合物及び医薬 |
| JPWO2020100959A1 (ja) * | 2018-11-15 | 2021-10-07 | 日本新薬株式会社 | １，３，４−オキサジアゾロン化合物及び医薬 |
| JP7434172B2 (ja) | 2018-11-15 | 2024-02-20 | 日本新薬株式会社 | １，３，４－オキサジアゾロン化合物及び医薬 |
| TWI840448B (zh) * | 2018-11-15 | 2024-05-01 | 日商日本新藥股份有限公司 | 二唑酮化合物及醫藥 |
| AU2019381493B2 (en) * | 2018-11-15 | 2024-10-31 | Nippon Shinyaku Co., Ltd. | 1,3,4-oxadiazolone compound and medicine |
| JP2023520883A (ja) * | 2020-03-30 | 2023-05-22 | センホア・バイオサイエンシーズ・インコーポレイテッド | Ｒｎａウイルス感染症、特にｃｏｖｉｄ－１９を処置するための抗ウイルス化合物および方法 |
| JP2023545196A (ja) * | 2020-10-16 | 2023-10-26 | シャンハイ ドーァ ノボ ファーマテック カンパニー，リミティド | 三複素環誘導体、その医薬組成物及び使用 |
| JP7774621B2 (ja) | 2020-10-16 | 2025-11-21 | シャンハイ ドーァ ノボ ファーマテック カンパニー，リミティド | 三複素環誘導体、その医薬組成物及び使用 |
| JP2024508547A (ja) * | 2021-03-01 | 2024-02-27 | ケンブリッジ・エンタープライズ・リミテッド | ベンゾ［ｃ］［２，６］ナフチリジン誘導体、組成物およびその治療的使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2010009445A (es) | 2011-05-25 |
| WO2009108912A1 (en) | 2009-09-03 |
| US20120208792A1 (en) | 2012-08-16 |
| EP2259678A4 (en) | 2011-07-27 |
| AU2009219154A1 (en) | 2009-09-03 |
| EP2259678A1 (en) | 2010-12-15 |
| US20090239859A1 (en) | 2009-09-24 |
| US8168651B2 (en) | 2012-05-01 |
| CA2716755A1 (en) | 2009-09-03 |
| CN102036561A (zh) | 2011-04-27 |
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