MX2010008998A - Implantes lagrimales y metodos relacionados. - Google Patents
Implantes lagrimales y metodos relacionados.Info
- Publication number
- MX2010008998A MX2010008998A MX2010008998A MX2010008998A MX2010008998A MX 2010008998 A MX2010008998 A MX 2010008998A MX 2010008998 A MX2010008998 A MX 2010008998A MX 2010008998 A MX2010008998 A MX 2010008998A MX 2010008998 A MX2010008998 A MX 2010008998A
- Authority
- MX
- Mexico
- Prior art keywords
- lacrimal
- implant
- fluid
- retention
- hydrogel
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
- A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00772—Apparatus for restoration of tear ducts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M29/00—Dilators with or without means for introducing media, e.g. remedies
- A61M29/02—Dilators made of swellable material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
- A61M31/002—Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/12—Surgical instruments, devices or methods for ligaturing or otherwise compressing tubular parts of the body, e.g. blood vessels or umbilical cord
- A61B17/12022—Occluding by internal devices, e.g. balloons or releasable wires
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0061—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof swellable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
- A61F9/007—Methods or devices for eye surgery
- A61F9/00781—Apparatus for modifying intraocular pressure, e.g. for glaucoma treatment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
- A61K9/0051—Ocular inserts, ocular implants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2210/00—Anatomical parts of the body
- A61M2210/06—Head
- A61M2210/0612—Eyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M31/00—Devices for introducing or retaining media, e.g. remedies, in cavities of the body
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Vascular Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Plastic & Reconstructive Surgery (AREA)
- Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Prostheses (AREA)
- Materials For Medical Uses (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
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| US6623308P | 2008-02-18 | 2008-02-18 | |
| US4934708P | 2008-04-30 | 2008-04-30 | |
| PCT/US2009/000963 WO2009105178A2 (en) | 2008-02-18 | 2009-02-17 | Lacrimal implants and related methods |
Publications (1)
| Publication Number | Publication Date |
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| MX2010008998A true MX2010008998A (es) | 2010-11-26 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2010008998A MX2010008998A (es) | 2008-02-18 | 2009-02-17 | Implantes lagrimales y metodos relacionados. |
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| CA (1) | CA2715489C (enExample) |
| IL (1) | IL207564A0 (enExample) |
| MX (1) | MX2010008998A (enExample) |
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| TW (1) | TW200946093A (enExample) |
| WO (1) | WO2009105178A2 (enExample) |
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Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| CN101052435B (zh) | 2004-07-02 | 2010-12-08 | Qlt塞子传递公司 | 治疗介质递送装置 |
| ES2640458T3 (es) | 2006-03-31 | 2017-11-03 | Mati Therapeutics Inc. | Implantes del sistema de drenaje nasolagrimal para terapia medicamentosa |
| EP3372205A1 (en) | 2007-09-07 | 2018-09-12 | Mati Therapeutics Inc. | Lacrimal implant detection |
| JP5552482B2 (ja) | 2008-04-30 | 2014-07-16 | キュー エル ティー インク． | 複合涙管挿入物および関連する方法 |
| TW201012469A (en) * | 2008-06-24 | 2010-04-01 | Qlt Plug Delivery Inc | Combination treatment of glaucoma |
| TW201006453A (en) * | 2008-07-08 | 2010-02-16 | Qlt Plug Delivery Inc | Lacrimal implant body including comforting agent |
| WO2010071844A1 (en) * | 2008-12-19 | 2010-06-24 | Qlt Plug Delivery, Inc | Substance delivering punctum implants and methods |
| SG173069A1 (en) * | 2009-01-23 | 2011-08-29 | Quadra Logic Tech Inc | Sustained released delivery of one or more agents |
| EP2396070B1 (en) | 2009-02-12 | 2024-12-04 | Incept Llc | Drug delivery through hydrogel plugs |
| JP5937004B2 (ja) | 2009-05-18 | 2016-06-22 | ドーズ メディカル コーポレーションＤｏｓｅ Ｍｅｄｉｃａｌ Ｃｏｒｐｏｒａｔｉｏｎ | 薬剤溶出眼内インプラント |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| WO2012071476A2 (en) | 2010-11-24 | 2012-05-31 | David Haffner | Drug eluting ocular implant |
| CA2781629A1 (en) | 2009-11-27 | 2011-06-03 | Sascha K. Zarins | Lacrimal implants including split and insertable drug core |
| US10245178B1 (en) * | 2011-06-07 | 2019-04-02 | Glaukos Corporation | Anterior chamber drug-eluting ocular implant |
| US9974685B2 (en) | 2011-08-29 | 2018-05-22 | Mati Therapeutics | Drug delivery system and methods of treating open angle glaucoma and ocular hypertension |
| DK3290024T3 (da) | 2011-08-29 | 2019-06-03 | Mati Therapeutics Inc | Vedvarende indgivelse af aktive midler til behandling af glaukom og okulær hypertension |
| US10226417B2 (en) | 2011-09-16 | 2019-03-12 | Peter Jarrett | Drug delivery systems and applications |
| EP3613413A1 (en) | 2011-12-05 | 2020-02-26 | Incept, LLC | Medical organogel processes and compositions |
| US20130220346A1 (en) * | 2012-02-28 | 2013-08-29 | Victor Lust | Balloon punctal plug |
| KR101969594B1 (ko) * | 2012-05-11 | 2019-04-16 | 서강대학교산학협력단 | 안내 약물 전달 임플란트 |
| US10517759B2 (en) | 2013-03-15 | 2019-12-31 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
| CN103349588A (zh) * | 2013-07-15 | 2013-10-16 | 广州卫视博生物科技有限公司 | 泪小管阻芯 |
| EP3148491B1 (en) | 2014-05-29 | 2020-07-01 | Glaukos Corporation | Implants with controlled drug delivery features and manufacturing method for said implants |
| RU2595501C1 (ru) * | 2015-04-17 | 2016-08-27 | федеральное государственное бюджетное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова" Министерства здравоохранения Российской Федерации | Лакримальный обтуратор |
| US11925578B2 (en) | 2015-09-02 | 2024-03-12 | Glaukos Corporation | Drug delivery implants with bi-directional delivery capacity |
| US11564833B2 (en) | 2015-09-25 | 2023-01-31 | Glaukos Corporation | Punctal implants with controlled drug delivery features and methods of using same |
| US11458041B2 (en) * | 2015-10-08 | 2022-10-04 | Ocular Therapeutix, Inc. | Punctal plug and bioadhesives |
| JP7003110B2 (ja) | 2016-04-20 | 2022-01-20 | ドーズ メディカル コーポレーション | 生体吸収性眼球薬物送達デバイス |
| US12233017B2 (en) | 2016-10-14 | 2025-02-25 | Olympic Ophthalmics, Inc. | Quiet handheld devices and methods for treatment of disorders |
| US11351058B2 (en) | 2017-03-17 | 2022-06-07 | W. L. Gore & Associates, Inc. | Glaucoma treatment systems and methods |
| CN107997802B (zh) * | 2018-01-11 | 2020-06-30 | 四川大学华西医院 | 骨间隙精确止血装置 |
| CN108295318B (zh) * | 2018-01-31 | 2021-07-06 | 西安泰科迈医药科技股份有限公司 | 一种温敏可注射型泪道栓及其制备方法 |
| US11147735B2 (en) | 2018-02-26 | 2021-10-19 | Olympic Ophthalmics, Inc. | Therapeutic handheld devices for disorders |
| CN108404225A (zh) * | 2018-03-08 | 2018-08-17 | 广州锐澄医疗技术有限公司 | 一种泪小管栓及其制备方法 |
| US12268632B2 (en) | 2018-05-12 | 2025-04-08 | Goldenbiotech, Llc | Self-retaining implantable drug delivery device |
| EP3806916A1 (en) | 2018-06-14 | 2021-04-21 | W.L. Gore & Associates, Inc. | Epitheliazing microporous biomaterial for use in avascular environments and in corneal implants |
| AU2019333136B2 (en) | 2018-08-29 | 2022-11-17 | W. L. Gore & Associates, Inc. | Drug therapy delivery systems and methods |
| CN109350355B (zh) * | 2018-11-30 | 2023-09-12 | 西安市第四医院 | 一种smile手术来源角膜基质透镜泪道栓及其制备方法 |
| US20240074897A1 (en) * | 2019-10-07 | 2024-03-07 | Glaukos Corporation | Punctal implants, insertion systems and methods of using the same |
| WO2021119353A1 (en) * | 2019-12-10 | 2021-06-17 | Goldenbiotech, Llc | Self-retaining implantable drug delivery device |
| CN111150545A (zh) * | 2020-01-02 | 2020-05-15 | 首都医科大学附属北京同仁医院 | 一种相变降温支架及其制备方法和相变降温组合支架 |
| CA3177005A1 (en) | 2020-04-27 | 2021-11-04 | Michael Goldstein | Methods of treating allergic conjunctivitis |
| CN111821098A (zh) * | 2020-08-20 | 2020-10-27 | 蒋正轩 | 一种泪道插管 |
| KR20240013804A (ko) | 2021-05-27 | 2024-01-30 | 더블유. 엘. 고어 앤드 어소시에이트스, 인코포레이티드 | 약물 치료 전달 시스템 및 방법 |
| CN113288579B (zh) * | 2021-06-21 | 2022-07-12 | 卢国华 | 一种新型人工泪管 |
| CN115531619B (zh) * | 2022-10-30 | 2023-07-21 | 北京医院 | 缓释奥洛他定的泪小管栓及其制备方法 |
| CN115531620B (zh) * | 2022-10-30 | 2023-07-07 | 北京医院 | 缓释氟米龙的泪小管栓及其制备方法 |
Family Cites Families (128)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3659600A (en) * | 1970-02-24 | 1972-05-02 | Estin Hans H | Magnetically operated capsule for administering drugs |
| US3865108A (en) * | 1971-05-17 | 1975-02-11 | Ortho Pharma Corp | Expandable drug delivery device |
| US3949750A (en) * | 1974-10-07 | 1976-04-13 | Freeman Jerre M | Punctum plug and method for treating keratoconjunctivitis sicca (dry eye) and other ophthalmic aliments using same |
| US4014335A (en) * | 1975-04-21 | 1977-03-29 | Alza Corporation | Ocular drug delivery device |
| US4660546A (en) * | 1984-11-07 | 1987-04-28 | Robert S. Herrick | Method for treating for deficiency of tears |
| US5049142A (en) * | 1984-11-07 | 1991-09-17 | Herrick Robert S | Intracanalicular implant for horizontal canalicular blockade treatment of the eye |
| US5053030A (en) * | 1984-11-07 | 1991-10-01 | Herrick Robert S | Intracanalicular implant for horizontal canalicular blockade treatment of the eye |
| US5229128A (en) * | 1986-06-11 | 1993-07-20 | Haddad Heskel M | Drug delivery ophthalmic insert and method of preparing same |
| US5322691A (en) * | 1986-10-02 | 1994-06-21 | Sohrab Darougar | Ocular insert with anchoring protrusions |
| US4886488A (en) * | 1987-08-06 | 1989-12-12 | White Thomas C | Glaucoma drainage the lacrimal system and method |
| US4915684A (en) * | 1988-06-21 | 1990-04-10 | Mackeen Donald L | Method and apparatus for modulating the flow of lacrimal fluid through a punctum and associated canaliculus |
| US5133159A (en) * | 1989-01-13 | 1992-07-28 | Nestle S.A. | Method for polishing silicone products |
| US4959048A (en) * | 1989-01-17 | 1990-09-25 | Helix Medical, Inc. | Lacrimal duct occluder |
| US5128058A (en) * | 1989-05-31 | 1992-07-07 | Hoya Corporation | Contact lens cleaner containing a microcapsular polishing agent |
| IE910450A1 (en) | 1990-02-15 | 1991-08-28 | Bausch & Lomb | Soft contact lens processing aid |
| US5171270A (en) | 1990-03-29 | 1992-12-15 | Herrick Robert S | Canalicular implant having a collapsible flared section and method |
| US5163959A (en) * | 1990-03-29 | 1992-11-17 | Herrick Robert S | Method for treating an eye with a canalicular implant having a collapsible flared section |
| US5041081A (en) * | 1990-05-18 | 1991-08-20 | Odrich Ronald B | Ocular implant for controlling glaucoma |
| US5258042A (en) * | 1991-12-16 | 1993-11-02 | Henry Ford Health System | Intravascular hydrogel implant |
| US5283063A (en) * | 1992-01-31 | 1994-02-01 | Eagle Vision | Punctum plug method and apparatus |
| US5334137A (en) | 1992-02-21 | 1994-08-02 | Eagle Vision, Inc. | Lacrimal fluid control device |
| US5469867A (en) * | 1992-09-02 | 1995-11-28 | Landec Corporation | Cast-in place thermoplastic channel occluder |
| US5318513A (en) * | 1992-09-24 | 1994-06-07 | Leib Martin L | Canalicular balloon fixation stent |
| US5707643A (en) * | 1993-02-26 | 1998-01-13 | Santen Pharmaceutical Co., Ltd. | Biodegradable scleral plug |
| US5417651A (en) * | 1993-07-01 | 1995-05-23 | Guena; Nicolas | Punctum plug and monocanalicular probe for lacrimal pathology |
| US5423777A (en) * | 1993-10-27 | 1995-06-13 | Tajiri; Akira | Punctum plug |
| US5466233A (en) * | 1994-04-25 | 1995-11-14 | Escalon Ophthalmics, Inc. | Tack for intraocular drug delivery and method for inserting and removing same |
| JP3486758B2 (ja) * | 1994-06-24 | 2004-01-13 | 株式会社高研 | 注入可能な涙小管閉鎖剤 |
| US5723005A (en) * | 1995-06-07 | 1998-03-03 | Herrick Family Limited Partnership | Punctum plug having a collapsible flared section and method |
| US6149684A (en) * | 1995-06-07 | 2000-11-21 | Herrick; Robert S. | Punctum plug having a thin elongated lip and a distal starting tip and method of using |
| US5766243A (en) * | 1995-08-21 | 1998-06-16 | Oasis Medical, Inc. | Abrasive polished canalicular implant |
| US5773019A (en) * | 1995-09-27 | 1998-06-30 | The University Of Kentucky Research Foundation | Implantable controlled release device to deliver drugs directly to an internal portion of the body |
| US5824073A (en) * | 1996-03-18 | 1998-10-20 | Peyman; Gholam A. | Macular indentor for use in the treatment of subretinal neovascular membranes |
| JPH1033584A (ja) | 1996-07-26 | 1998-02-10 | M L C:Kk | 涙道挿管器具 |
| US5993407A (en) * | 1996-10-25 | 1999-11-30 | Moazed; Kambiz Thomas | Transnasal lacrimal insert |
| PT935512E (pt) * | 1996-11-01 | 2002-09-30 | Alcon Lab Inc | Metodo de polimero criogenico para artigos acrilicos moles |
| CA2251223A1 (fr) | 1997-02-04 | 1998-08-06 | Alain Fouere | Tampon meatique vissable pour canal lacrymal |
| US6041785A (en) | 1997-03-27 | 2000-03-28 | Eaglevision, Inc. | Punctum plug |
| US6082362A (en) * | 1997-03-27 | 2000-07-04 | Eagle Vision, Inc. | Punctum plug |
| US6016806A (en) | 1997-03-27 | 2000-01-25 | Eaglevision, Inc | Punctum plug |
| US6027470A (en) * | 1998-06-10 | 2000-02-22 | Eagle Vision, Inc. | Punctum plug and method for inserting the same into the punctual opening |
| US5961370A (en) * | 1997-05-08 | 1999-10-05 | Chiron Vision Corporation | Intraocular lens tumbling process using coated beads |
| MY125870A (en) * | 1997-07-25 | 2006-08-30 | Alza Corp | Osmotic delivery system flow modulator apparatus and method |
| US6306426B1 (en) * | 1997-08-11 | 2001-10-23 | Allergan Sales, Inc. | Implant device with a retinoid for improved biocompatibility |
| US5830171A (en) * | 1997-08-12 | 1998-11-03 | Odyssey Medical, Inc. | Punctal occluder |
| US6060439A (en) * | 1997-09-29 | 2000-05-09 | Kyzen Corporation | Cleaning compositions and methods for cleaning resin and polymeric materials used in manufacture |
| NL1008090C2 (nl) | 1998-01-22 | 1999-07-26 | Lubberman Bernardus H M | Plug voor het afsluiten van een traanbuis. |
| US6290684B1 (en) * | 1998-03-02 | 2001-09-18 | Herrick Family Limited Partnership | Punctum plug having a collapsible expanded section and distal tip extending substantially perpendicular thereto and method of inserting same |
| WO1999044553A1 (en) | 1998-03-02 | 1999-09-10 | Herrick Family Limited Partnership | A punctum plug having a collapsible flared section and method |
| US6196993B1 (en) | 1998-04-20 | 2001-03-06 | Eyelab Group, Llc | Ophthalmic insert and method for sustained release of medication to the eye |
| US6306114B1 (en) * | 1998-06-16 | 2001-10-23 | Eagle Vision, Inc. | Valved canalicular plug for lacrimal duct occlusion |
| JP2000070296A (ja) * | 1998-08-27 | 2000-03-07 | M L C:Kk | 涙道内挿管器具 |
| US6095901A (en) * | 1998-12-09 | 2000-08-01 | Alcon Laboratories, Inc. | Polishing method for soft acrylic articles |
| US20040121014A1 (en) * | 1999-03-22 | 2004-06-24 | Control Delivery Systems, Inc. | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
| US6234175B1 (en) * | 1999-03-23 | 2001-05-22 | Medennium, Inc. | Smart ocular plug design and method of insertion for punctal and intracanalicular implants |
| US6383192B1 (en) * | 1999-04-28 | 2002-05-07 | Mlc Limited Company | Apparatus for intubation of lacrimal duct |
| US6428502B1 (en) * | 1999-06-25 | 2002-08-06 | Alcon Manufacturing, Ltd. | Punctal cannula |
| US6706275B1 (en) * | 1999-09-08 | 2004-03-16 | Matthew W. Camp | Scleral plug system |
| US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| US6264971B1 (en) * | 1999-11-04 | 2001-07-24 | Btg International Limited | Ocular insert |
| US7867186B2 (en) * | 2002-04-08 | 2011-01-11 | Glaukos Corporation | Devices and methods for treatment of ocular disorders |
| US6638239B1 (en) * | 2000-04-14 | 2003-10-28 | Glaukos Corporation | Apparatus and method for treating glaucoma |
| US7708711B2 (en) * | 2000-04-14 | 2010-05-04 | Glaukos Corporation | Ocular implant with therapeutic agents and methods thereof |
| EP1195396A4 (en) * | 2000-04-25 | 2003-05-28 | Kansai Paint Co Ltd | AQUEOUS POLYURETHANE GEL, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF |
| US20040175410A1 (en) * | 2000-04-26 | 2004-09-09 | Control Delivery Systems, Inc. | Sustained release device and method for ocular delivery of carbonic anhydrase inhibitors |
| US6375972B1 (en) * | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
| US6371122B1 (en) * | 2000-06-20 | 2002-04-16 | Robert M. Mandelkorn | Gauge/dilator apparatus |
| US6629533B1 (en) * | 2000-06-30 | 2003-10-07 | Eagle Vision, Inc. | Punctum plug with at least one anchoring arm |
| AU2001234337A1 (en) | 2000-08-04 | 2002-02-18 | Medennium, Inc. | Ocular plug for punctal and intracanalicular implants |
| US20020034200A1 (en) * | 2000-09-21 | 2002-03-21 | Randy Wickman | Method of monitoring light from a VCSEL |
| US6756049B2 (en) * | 2000-12-29 | 2004-06-29 | Bausch & Lomb Incorporated | Sustained release drug delivery devices |
| JP2004521882A (ja) * | 2001-01-03 | 2004-07-22 | ボシュ・アンド・ロム・インコーポレイテッド | 組立式透過性プラグを備えた徐放薬剤送達装置 |
| WO2002058667A2 (en) * | 2001-01-26 | 2002-08-01 | Bausch & Lomb Incorporated | Improved process for the production of sustained release drug delivery devices |
| US7431710B2 (en) | 2002-04-08 | 2008-10-07 | Glaukos Corporation | Ocular implants with anchors and methods thereof |
| CA2442652C (en) * | 2001-04-07 | 2011-01-04 | Glaukos Corporation | Glaucoma stent and methods thereof for glaucoma treatment |
| US6605108B2 (en) * | 2001-04-13 | 2003-08-12 | Eagle Vision, Inc. | Monocanalicular stent |
| US6982090B2 (en) * | 2001-05-10 | 2006-01-03 | Gillespie Donald E | More easily visualized punctum plug configurations |
| US7404825B2 (en) * | 2001-06-11 | 2008-07-29 | Herrick Ii Robert S | Implant capable of forming a differential image in an eye |
| FR2829019B3 (fr) | 2001-08-31 | 2003-10-31 | Alain Fouere | Bouchons lacrymaux et methodes de mise en place de ces dispositifs |
| US6729939B2 (en) * | 2001-12-17 | 2004-05-04 | Bausch & Lomb Incorporated | Polishing method for intraocular lens |
| FR2834446B1 (fr) * | 2002-01-08 | 2004-02-13 | Ioltechnologie Production | Clou meatique a expansion |
| US7204995B2 (en) * | 2002-01-31 | 2007-04-17 | El-Sherif Dalia M | Treatment and control of dry eye by use of biodegradable polymer capsules |
| US20040147870A1 (en) * | 2002-04-08 | 2004-07-29 | Burns Thomas W. | Glaucoma treatment kit |
| US9301875B2 (en) | 2002-04-08 | 2016-04-05 | Glaukos Corporation | Ocular disorder treatment implants with multiple opening |
| US6866563B2 (en) * | 2002-06-27 | 2005-03-15 | Bausch & Lomb Incorporated | Apparatus and method for target polishing intraocular lenses |
| FR2841770B1 (fr) | 2002-07-05 | 2004-10-01 | Ioltechnologie Production | Clou meatique d'obturation d'un meat lacrymal |
| FR2844182B1 (fr) | 2002-09-11 | 2004-12-03 | Humanoptics Ag | Bouchon d'obturation d'un canalicule lacrymal |
| US7169163B2 (en) * | 2002-09-30 | 2007-01-30 | Bruce Becker | Transnasal method and catheter for lacrimal system |
| US20050283109A1 (en) | 2003-03-07 | 2005-12-22 | Peyman Gholam A | Method and apparatus for lacrimal canal obstruction |
| AU2004237774B2 (en) * | 2003-05-02 | 2009-09-10 | Surmodics, Inc. | Implantable controlled release bioactive agent delivery device |
| US7017580B2 (en) | 2003-05-22 | 2006-03-28 | Clarity Corporation | Punctum plug system including a punctum plug and passive insertion tool therefor |
| US7204253B2 (en) | 2003-05-22 | 2007-04-17 | Clarity Corporation | Punctum plug |
| US20040260318A1 (en) * | 2003-05-23 | 2004-12-23 | Angiotech International Ag | Anastomotic connector devices |
| JP4104137B2 (ja) * | 2003-05-30 | 2008-06-18 | 有限会社エム・エル・シー | 涙点プラグ |
| JP4339635B2 (ja) | 2003-06-12 | 2009-10-07 | 有限会社エム・エル・シー | 涙点プラグ |
| US6994684B2 (en) | 2003-06-16 | 2006-02-07 | Alphamed Inc. | Punctum plugs having fluid collecting recesses and methods of punctal occlusion |
| US20040265356A1 (en) | 2003-06-30 | 2004-12-30 | Bausch & Lomb Incorporated | Drug delivery device |
| JP4280128B2 (ja) | 2003-08-19 | 2009-06-17 | 有限会社エム・エル・シー | 涙点プラグ |
| US20050181018A1 (en) * | 2003-09-19 | 2005-08-18 | Peyman Gholam A. | Ocular drug delivery |
| JP2005110765A (ja) | 2003-10-03 | 2005-04-28 | M L C:Kk | 涙点プラグセット |
| JP2005110930A (ja) | 2003-10-07 | 2005-04-28 | M L C:Kk | 涙点プラグセット |
| US20050095269A1 (en) * | 2003-11-04 | 2005-05-05 | Ainpour Parviz R. | Gel plug for blockage of the canaliculus |
| US20050197614A1 (en) * | 2004-03-04 | 2005-09-08 | Wilson Pritchard | Occlusive biomedical devices, punctum plugs, and methods of use thereof |
| US20050220882A1 (en) * | 2004-03-04 | 2005-10-06 | Wilson Pritchard | Materials for medical implants and occlusive devices |
| US20050232972A1 (en) * | 2004-04-15 | 2005-10-20 | Steven Odrich | Drug delivery via punctal plug |
| JP2004202276A (ja) | 2004-04-16 | 2004-07-22 | M L C:Kk | 涙道再建用挿管器具 |
| US20050244469A1 (en) * | 2004-04-30 | 2005-11-03 | Allergan, Inc. | Extended therapeutic effect ocular implant treatments |
| JP2005312835A (ja) | 2004-04-30 | 2005-11-10 | M L C:Kk | 糸で補強した涙道ステント |
| JP4644438B2 (ja) | 2004-05-11 | 2011-03-02 | 有限会社エム・エル・シー | ツバつき涙道ステント |
| JP4510511B2 (ja) | 2004-05-18 | 2010-07-28 | 有限会社エム・エル・シー | ツバを円盤で補強した涙道ステント及び涙道プラグ |
| CN101052435B (zh) * | 2004-07-02 | 2010-12-08 | Qlt塞子传递公司 | 治疗介质递送装置 |
| US7117870B2 (en) * | 2004-07-26 | 2006-10-10 | Clarity Corporation | Lacrimal insert having reservoir with controlled release of medication and method of manufacturing the same |
| US20060020253A1 (en) * | 2004-07-26 | 2006-01-26 | Prescott Anthony D | Implantable device having reservoir with controlled release of medication and method of manufacturing the same |
| US20080038317A1 (en) * | 2004-09-10 | 2008-02-14 | Chin-Ming Chang | Therapeutic Lacrimal Canalicular Inserts And Related Methods |
| US20060074370A1 (en) * | 2004-09-24 | 2006-04-06 | Medennium, Inc. | Ocular occluder and method of insertion |
| US20060233858A1 (en) | 2005-03-08 | 2006-10-19 | Allergan, Inc. | Systems and methods providing targeted intraocular drug delivery |
| CA2621993A1 (en) * | 2005-09-16 | 2007-03-29 | Bg Implant, Inc. | Glaucoma treatment devices and methods |
| US7862532B2 (en) * | 2005-10-07 | 2011-01-04 | Delta Life Sciences, Inc. | Punctum plugs having insertion guides and strengthening beams |
| US20070132125A1 (en) * | 2005-12-08 | 2007-06-14 | Bausch & Lomb Incorporated | Use of a super-cooled fluid in lens processing |
| JP4078371B2 (ja) | 2006-01-27 | 2008-04-23 | 章弘 小栗 | 涙点プラグ |
| ES2640458T3 (es) * | 2006-03-31 | 2017-11-03 | Mati Therapeutics Inc. | Implantes del sistema de drenaje nasolagrimal para terapia medicamentosa |
| US9173773B2 (en) * | 2006-06-21 | 2015-11-03 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
| US20080045911A1 (en) | 2006-06-21 | 2008-02-21 | Borgia Maureen J | Punctal plugs for the delivery of active agents |
| US9474645B2 (en) | 2006-06-21 | 2016-10-25 | Johnson & Johnson Vision Care, Inc. | Punctal plugs for the delivery of active agents |
| FR2908042B1 (fr) | 2006-11-08 | 2009-06-05 | Bruno Fayet | Ensemble d'intubation monocanaliculonasal et/ou monocanaliculaire,notamment pour l'imperforation lacrymonasale. |
| EP3372205A1 (en) * | 2007-09-07 | 2018-09-12 | Mati Therapeutics Inc. | Lacrimal implant detection |
| NZ598483A (en) * | 2007-09-07 | 2013-08-30 | Quadra Logic Tech Inc | Drug cores for sustained release of therapeutic agents |
| TWI542338B (zh) * | 2008-05-07 | 2016-07-21 | 壯生和壯生視覺關懷公司 | 用於活性劑之控制釋放的眼用裝置 |
-
2009
- 2009-02-17 RU RU2010136822/14A patent/RU2010136822A/ru not_active Application Discontinuation
- 2009-02-17 BR BRPI0907890-8A patent/BRPI0907890A2/pt not_active IP Right Cessation
- 2009-02-17 SG SG2013011309A patent/SG188155A1/en unknown
- 2009-02-17 NZ NZ587335A patent/NZ587335A/en not_active IP Right Cessation
- 2009-02-17 AU AU2009215897A patent/AU2009215897A1/en not_active Abandoned
- 2009-02-17 CN CN200980109710.5A patent/CN102014816B/zh active Active
- 2009-02-17 CA CA2715489A patent/CA2715489C/en active Active
- 2009-02-17 MX MX2010008998A patent/MX2010008998A/es not_active Application Discontinuation
- 2009-02-17 WO PCT/US2009/000963 patent/WO2009105178A2/en not_active Ceased
- 2009-02-17 EP EP09711554A patent/EP2254536A2/en not_active Withdrawn
- 2009-02-17 US US12/378,710 patent/US9216108B2/en active Active
- 2009-02-17 KR KR1020107019589A patent/KR20100136453A/ko not_active Withdrawn
- 2009-02-17 CN CN201510109774.2A patent/CN104825270B/zh active Active
- 2009-02-17 JP JP2010546796A patent/JP5528356B2/ja active Active
- 2009-02-18 TW TW098105152A patent/TW200946093A/zh unknown
-
2010
- 2010-08-12 IL IL207564A patent/IL207564A0/en unknown
- 2010-08-12 ZA ZA2010/05753A patent/ZA201005753B/en unknown
-
2014
- 2014-04-15 JP JP2014083415A patent/JP5819468B2/ja active Active
-
2015
- 2015-12-14 US US14/967,842 patent/US20160166430A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2254536A2 (en) | 2010-12-01 |
| CA2715489C (en) | 2017-09-19 |
| JP5819468B2 (ja) | 2015-11-24 |
| BRPI0907890A2 (pt) | 2015-07-28 |
| NZ587335A (en) | 2012-05-25 |
| US20160166430A1 (en) | 2016-06-16 |
| IL207564A0 (en) | 2010-12-30 |
| CN104825270B (zh) | 2017-10-24 |
| JP5528356B2 (ja) | 2014-06-25 |
| HK1155937A1 (en) | 2012-06-01 |
| RU2010136822A (ru) | 2012-03-10 |
| JP2014208009A (ja) | 2014-11-06 |
| KR20100136453A (ko) | 2010-12-28 |
| US20090264861A1 (en) | 2009-10-22 |
| CN104825270A (zh) | 2015-08-12 |
| US9216108B2 (en) | 2015-12-22 |
| SG188155A1 (en) | 2013-03-28 |
| CA2715489A1 (en) | 2009-08-27 |
| AU2009215897A2 (en) | 2010-09-16 |
| ZA201005753B (en) | 2011-09-28 |
| TW200946093A (en) | 2009-11-16 |
| CN102014816A (zh) | 2011-04-13 |
| JP2011512194A (ja) | 2011-04-21 |
| CN102014816B (zh) | 2015-04-15 |
| WO2009105178A3 (en) | 2010-06-03 |
| AU2009215897A1 (en) | 2009-08-27 |
| WO2009105178A2 (en) | 2009-08-27 |
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| Date | Code | Title | Description |
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| GB | Transfer or rights |
Owner name: QLT INC. |
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| FA | Abandonment or withdrawal |