MX2010008490A - Triazolopiridazinas como inhibidores de par1, su produccion y su uso como medicamentos. - Google Patents

Triazolopiridazinas como inhibidores de par1, su produccion y su uso como medicamentos.

Info

Publication number
MX2010008490A
MX2010008490A MX2010008490A MX2010008490A MX2010008490A MX 2010008490 A MX2010008490 A MX 2010008490A MX 2010008490 A MX2010008490 A MX 2010008490A MX 2010008490 A MX2010008490 A MX 2010008490A MX 2010008490 A MX2010008490 A MX 2010008490A
Authority
MX
Mexico
Prior art keywords
medicaments
production
triazolopyridazines
par1 inhibitors
par1
Prior art date
Application number
MX2010008490A
Other languages
English (en)
Inventor
Volkmar Wehner
Uwe Heinelt
Karl Schoenafinger
Matthias Herrmann
Henning Steinhagen
Bodo Scheiper
Original Assignee
Sanofi Aventis
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis filed Critical Sanofi Aventis
Publication of MX2010008490A publication Critical patent/MX2010008490A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Obesity (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Neurosurgery (AREA)
  • Emergency Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Vascular Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La invención se refiere a compuestos de fórmula (I) (ver fórmula I) con actividad antitrombótica, que inhiben especialmente el receptor 1 activado por proteasa, a métodos para su preparación y a su uso como medicamentos.
MX2010008490A 2008-02-05 2009-01-23 Triazolopiridazinas como inhibidores de par1, su produccion y su uso como medicamentos. MX2010008490A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08290112 2008-02-05
PCT/EP2009/000406 WO2009097970A1 (de) 2008-02-05 2009-01-23 Triazolopyridazine als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
MX2010008490A true MX2010008490A (es) 2010-08-18

Family

ID=39539711

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008490A MX2010008490A (es) 2008-02-05 2009-01-23 Triazolopiridazinas como inhibidores de par1, su produccion y su uso como medicamentos.

Country Status (32)

Country Link
US (2) US8076336B2 (es)
EP (1) EP2240487B1 (es)
JP (1) JP5526040B2 (es)
KR (1) KR20100114514A (es)
CN (1) CN101981034B (es)
AR (1) AR070410A1 (es)
AT (1) ATE537172T1 (es)
AU (1) AU2009211887B2 (es)
BR (1) BRPI0907486A2 (es)
CA (1) CA2713550C (es)
CL (1) CL2009000236A1 (es)
CO (1) CO6260083A2 (es)
CY (1) CY1113228T1 (es)
DK (1) DK2240487T3 (es)
ES (1) ES2379447T3 (es)
HK (1) HK1149011A1 (es)
HR (1) HRP20120230T1 (es)
IL (1) IL207205A0 (es)
MA (1) MA32061B1 (es)
MX (1) MX2010008490A (es)
MY (1) MY152040A (es)
NZ (1) NZ587141A (es)
PA (1) PA8814801A1 (es)
PE (1) PE20091455A1 (es)
PL (1) PL2240487T3 (es)
PT (1) PT2240487E (es)
RS (1) RS52264B (es)
RU (1) RU2499797C2 (es)
SI (1) SI2240487T1 (es)
TW (1) TW200946532A (es)
WO (1) WO2009097970A1 (es)
ZA (1) ZA201004467B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2663528A1 (en) * 2006-09-18 2008-03-27 Vertex Pharmaceuticals Incorporated Heterocyclic inhibitors of c-met and uses thereof
CN101981035B (zh) * 2008-02-05 2013-08-28 赛诺菲-安万特 作为par1抑制剂的三唑*盐、其制备及其作为药物的用途
US8673890B2 (en) 2009-10-29 2014-03-18 Janssen Pharmaceutica Nv 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4578464A (en) 1983-11-22 1986-03-25 Merrell Dow Pharmaceuticals Inc. 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds
RU2156252C2 (ru) * 1994-09-16 2000-09-20 Такеда Кемикал Индастриз, Лтд. Триазолопиридазины, способ их получения, фармацевтические композиции на их основе и способ лечения
US6063847A (en) 1997-11-25 2000-05-16 Schering Corporation Thrombin receptor antagonists
US7488742B2 (en) 2000-06-15 2009-02-10 Schering Corporation Thrombin receptor antagonists
WO2002088094A1 (fr) * 2001-04-19 2002-11-07 Eisai Co., Ltd. Derives de 2-iminoimidazole
JPWO2002096875A1 (ja) 2001-05-25 2004-09-09 持田製薬株式会社 鎮痛作用を有する４−ヒドロキシピペリジン誘導体
WO2003031442A1 (fr) 2001-10-05 2003-04-17 Takeda Chemical Industries, Ltd. Composes heterocycliques, derives oxazole, procede permettant de les presenter et leur utilisation
CA2463628A1 (en) 2001-10-18 2003-04-24 Schering Corporation Himbacine analogues as thrombin receptor antagonists
CA2482858C (en) 2002-04-16 2010-11-30 Schering Corporation Tricyclic thrombin receptor antagonists
EP1602646A4 (en) 2003-02-19 2010-07-28 Eisai R&D Man Co Ltd PROCESS FOR PREPARING CYCLIC BENZAMIDINE DERIVATIVES
TW200531688A (en) 2004-03-05 2005-10-01 Hoffmann La Roche Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents
WO2006051648A1 (ja) 2004-11-09 2006-05-18 Eisai R & D Management Co., Ltd. トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤
BRPI0620292B1 (pt) * 2005-12-21 2021-08-24 Janssen Pharmaceutica N. V. Compostos de triazolopiridazinas como moduladores da cinase, composição, uso, combinação e processo de preparo do referido composto
DE102006025318A1 (de) * 2006-05-31 2007-12-06 Bayer Healthcare Ag Dihydro-pyrrolopyridin-, Dihydro-pyrrolopyridazin- und Dihydro-pyrrolopyrimidin-Derivate und ihre Verwendung
DE102006036023A1 (de) * 2006-08-02 2008-02-07 Sanofi-Aventis Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität
PT2242740E (pt) 2008-02-05 2013-02-06 Sanofi Sa Derivados de sf5 como inibidores do par1, sua preparação e utilização como produtos farmacêuticos
CN101981035B (zh) * 2008-02-05 2013-08-28 赛诺菲-安万特 作为par1抑制剂的三唑*盐、其制备及其作为药物的用途
PL2240179T3 (pl) 2008-02-05 2017-08-31 Sanofi Imidazopirydazyny jako inhibitory PAR1, ich wytwarzanie i zastosowanie jako leku
US8324241B2 (en) 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
US8394823B2 (en) 2008-04-11 2013-03-12 Bristol-Myers Squibb Company Triazolopyridine compounds useful as DGAT1 inhibitors

Also Published As

Publication number Publication date
PE20091455A1 (es) 2009-10-22
WO2009097970A1 (de) 2009-08-13
MY152040A (en) 2014-08-15
CN101981034A (zh) 2011-02-23
CL2009000236A1 (es) 2009-06-05
KR20100114514A (ko) 2010-10-25
CN101981034B (zh) 2013-08-14
PL2240487T3 (pl) 2012-05-31
SI2240487T1 (sl) 2012-04-30
EP2240487A1 (de) 2010-10-20
RS52264B (en) 2012-10-31
DK2240487T3 (da) 2012-04-02
RU2499797C2 (ru) 2013-11-27
HRP20120230T1 (hr) 2012-04-30
EP2240487B1 (de) 2011-12-14
US8076336B2 (en) 2011-12-13
MA32061B1 (fr) 2011-02-01
ATE537172T1 (de) 2011-12-15
AU2009211887A1 (en) 2009-08-13
IL207205A0 (en) 2010-12-30
AR070410A1 (es) 2010-04-07
PA8814801A1 (es) 2009-09-17
RU2010136957A (ru) 2012-03-20
BRPI0907486A2 (pt) 2015-07-14
NZ587141A (en) 2012-04-27
CA2713550A1 (en) 2009-08-13
CY1113228T1 (el) 2016-04-13
ES2379447T3 (es) 2012-04-26
CA2713550C (en) 2016-06-14
ZA201004467B (en) 2011-09-28
HK1149011A1 (en) 2011-09-23
CO6260083A2 (es) 2011-03-22
JP2011511016A (ja) 2011-04-07
US9079906B2 (en) 2015-07-14
PT2240487E (pt) 2012-03-08
JP5526040B2 (ja) 2014-06-18
US20120010203A1 (en) 2012-01-12
AU2009211887B2 (en) 2013-09-19
TW200946532A (en) 2009-11-16
US20110034451A1 (en) 2011-02-10

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