CL2009000236A1 - Compuestos derivados de triazolopiridazina, inhibidores de par1,procedimiento de preparacion y uso para profilaxis, prevencion y tratamiento de enfermedades asociadas con trombosis, embolia, hipercoagulabilidad, cambios fibroticos o trastornos inflamatorios. - Google Patents
Compuestos derivados de triazolopiridazina, inhibidores de par1,procedimiento de preparacion y uso para profilaxis, prevencion y tratamiento de enfermedades asociadas con trombosis, embolia, hipercoagulabilidad, cambios fibroticos o trastornos inflamatorios.Info
- Publication number
- CL2009000236A1 CL2009000236A1 CL2009000236A CL2009000236A CL2009000236A1 CL 2009000236 A1 CL2009000236 A1 CL 2009000236A1 CL 2009000236 A CL2009000236 A CL 2009000236A CL 2009000236 A CL2009000236 A CL 2009000236A CL 2009000236 A1 CL2009000236 A1 CL 2009000236A1
- Authority
- CL
- Chile
- Prior art keywords
- triazolopyridazine
- hypercoagulability
- embolism
- thrombosis
- prophylaxis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Neurosurgery (AREA)
- Pain & Pain Management (AREA)
- Emergency Medicine (AREA)
- Urology & Nephrology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Vascular Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
LA INVENCIóN SE REFIERE A COMPUESTOS DERIVADOS DE TRIAZOLOPIRIDAZINAS DE FÓRMULA (I), DONDE<br /> R1-R8 Y 01-03 SE DEFINEN EN LA MEMORIA DESCRIPTIVA, CON ACTIVIDAD ANTITROMBÓTICA, QUE INHIBEN<br /> ESPECIALMENTE EL RECEPTOR 1 ACTIVADO POR PROTEASA , A PROCEDIMIENTOS DE PREPARACIÓN Y A SU USO<br /> PARA PREPARAR MEDICAMENTOS<br />
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08290112 | 2008-02-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2009000236A1 true CL2009000236A1 (es) | 2009-06-05 |
Family
ID=39539711
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2009000236A CL2009000236A1 (es) | 2008-02-05 | 2009-02-03 | Compuestos derivados de triazolopiridazina, inhibidores de par1,procedimiento de preparacion y uso para profilaxis, prevencion y tratamiento de enfermedades asociadas con trombosis, embolia, hipercoagulabilidad, cambios fibroticos o trastornos inflamatorios. |
Country Status (32)
Country | Link |
---|---|
US (2) | US8076336B2 (es) |
EP (1) | EP2240487B1 (es) |
JP (1) | JP5526040B2 (es) |
KR (1) | KR20100114514A (es) |
CN (1) | CN101981034B (es) |
AR (1) | AR070410A1 (es) |
AT (1) | ATE537172T1 (es) |
AU (1) | AU2009211887B2 (es) |
BR (1) | BRPI0907486A2 (es) |
CA (1) | CA2713550C (es) |
CL (1) | CL2009000236A1 (es) |
CO (1) | CO6260083A2 (es) |
CY (1) | CY1113228T1 (es) |
DK (1) | DK2240487T3 (es) |
ES (1) | ES2379447T3 (es) |
HK (1) | HK1149011A1 (es) |
HR (1) | HRP20120230T1 (es) |
IL (1) | IL207205A0 (es) |
MA (1) | MA32061B1 (es) |
MX (1) | MX2010008490A (es) |
MY (1) | MY152040A (es) |
NZ (1) | NZ587141A (es) |
PA (1) | PA8814801A1 (es) |
PE (1) | PE20091455A1 (es) |
PL (1) | PL2240487T3 (es) |
PT (1) | PT2240487E (es) |
RS (1) | RS52264B (es) |
RU (1) | RU2499797C2 (es) |
SI (1) | SI2240487T1 (es) |
TW (1) | TW200946532A (es) |
WO (1) | WO2009097970A1 (es) |
ZA (1) | ZA201004467B (es) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101796056A (zh) * | 2006-09-18 | 2010-08-04 | 沃泰克斯药物股份有限公司 | c-MET的杂环抑制剂及其用途 |
NZ587142A (en) | 2008-02-05 | 2012-04-27 | Sanofi Aventis | Triazolium salts as par1 inhibitors, production thereof, and use as medicaments |
US8673890B2 (en) | 2009-10-29 | 2014-03-18 | Janssen Pharmaceutica Nv | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4578464A (en) | 1983-11-22 | 1986-03-25 | Merrell Dow Pharmaceuticals Inc. | 6-Hydroxyalkylamino-8-methyl-1,2,4-triazolo-[4,3-b]pyridazine and related compounds |
CN1046517C (zh) * | 1994-09-16 | 1999-11-17 | 武田药品工业株式会社 | 三唑并哒嗪,其制备和应用 |
US6063847A (en) | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
US7488742B2 (en) | 2000-06-15 | 2009-02-10 | Schering Corporation | Thrombin receptor antagonists |
EP1614680B1 (en) * | 2001-04-19 | 2011-12-21 | Eisai R&D Management Co., Ltd. | Process for preparing 2-iminopyrrolidine derivatives |
US6956046B2 (en) | 2001-05-25 | 2005-10-18 | Mochida Pharmaceutical Co., Ltd. | 4-hydroxypiperidine derivatives having analgesic activity |
WO2003031442A1 (fr) | 2001-10-05 | 2003-04-17 | Takeda Chemical Industries, Ltd. | Composes heterocycliques, derives oxazole, procede permettant de les presenter et leur utilisation |
PL371948A1 (en) | 2001-10-18 | 2005-07-11 | Schering Corporation | Himbacine analogues as thrombin receptor antagonists |
EP1860106B1 (en) | 2002-04-16 | 2010-01-20 | Schering Corporation | Tricyclic thrombin receptor antagonists |
CN100439336C (zh) | 2003-02-19 | 2008-12-03 | 卫材R&D管理有限公司 | 制备环状苯甲脒衍生物的方法 |
TW200531688A (en) | 2004-03-05 | 2005-10-01 | Hoffmann La Roche | Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents |
EP1813282A4 (en) | 2004-11-09 | 2011-03-02 | Eisai R&D Man Co Ltd | MEANS FOR THE TREATMENT OF ANGIOSPASM IN SUBARACHO-OAL BLOODING WITH THROMBIN RECEPTOR ANTAGONIST AS AN ACTIVE AGENT |
KR101412675B1 (ko) * | 2005-12-21 | 2014-07-03 | 얀센 파마슈티카 엔.브이. | 티로신 키나제 모듈레이터로서의 트리아졸로피리다진 |
DE102006025318A1 (de) * | 2006-05-31 | 2007-12-06 | Bayer Healthcare Ag | Dihydro-pyrrolopyridin-, Dihydro-pyrrolopyridazin- und Dihydro-pyrrolopyrimidin-Derivate und ihre Verwendung |
DE102006036023A1 (de) * | 2006-08-02 | 2008-02-07 | Sanofi-Aventis | Imino-imidazo-pyridinderivate mit antithrombotischer Aktivität |
JP2011511018A (ja) | 2008-02-05 | 2011-04-07 | サノフィ−アベンティス | Par1阻害剤としてのsf5誘導体、その製造、及び薬剤としての使用 |
AU2009211890B2 (en) * | 2008-02-05 | 2014-03-13 | Sanofi-Aventis | Imidazopyridazines as PAR1 inhibitors, production thereof, and use thereof as medicaments |
NZ587142A (en) * | 2008-02-05 | 2012-04-27 | Sanofi Aventis | Triazolium salts as par1 inhibitors, production thereof, and use as medicaments |
WO2009126624A1 (en) | 2008-04-11 | 2009-10-15 | Bristol-Myers Squibb Company | Triazolo compounds useful as dgat1 inhibitors |
US8394823B2 (en) | 2008-04-11 | 2013-03-12 | Bristol-Myers Squibb Company | Triazolopyridine compounds useful as DGAT1 inhibitors |
-
2009
- 2009-01-23 AU AU2009211887A patent/AU2009211887B2/en not_active Ceased
- 2009-01-23 PL PL09708289T patent/PL2240487T3/pl unknown
- 2009-01-23 ES ES09708289T patent/ES2379447T3/es active Active
- 2009-01-23 DK DK09708289.5T patent/DK2240487T3/da active
- 2009-01-23 BR BRPI0907486-4A patent/BRPI0907486A2/pt not_active IP Right Cessation
- 2009-01-23 RS RS20120103A patent/RS52264B/en unknown
- 2009-01-23 KR KR1020107017452A patent/KR20100114514A/ko not_active Application Discontinuation
- 2009-01-23 EP EP09708289A patent/EP2240487B1/de active Active
- 2009-01-23 WO PCT/EP2009/000406 patent/WO2009097970A1/de active Application Filing
- 2009-01-23 RU RU2010136957/04A patent/RU2499797C2/ru not_active IP Right Cessation
- 2009-01-23 AT AT09708289T patent/ATE537172T1/de active
- 2009-01-23 NZ NZ587141A patent/NZ587141A/en not_active IP Right Cessation
- 2009-01-23 CA CA2713550A patent/CA2713550C/en not_active Expired - Fee Related
- 2009-01-23 CN CN2009801115086A patent/CN101981034B/zh not_active Expired - Fee Related
- 2009-01-23 MY MYPI20103226 patent/MY152040A/en unknown
- 2009-01-23 MX MX2010008490A patent/MX2010008490A/es active IP Right Grant
- 2009-01-23 JP JP2010545378A patent/JP5526040B2/ja not_active Expired - Fee Related
- 2009-01-23 SI SI200930192T patent/SI2240487T1/sl unknown
- 2009-01-23 PT PT09708289T patent/PT2240487E/pt unknown
- 2009-02-03 AR ARP090100348A patent/AR070410A1/es not_active Application Discontinuation
- 2009-02-03 TW TW098103334A patent/TW200946532A/zh unknown
- 2009-02-03 PA PA20098814801A patent/PA8814801A1/es unknown
- 2009-02-03 PE PE2009000154A patent/PE20091455A1/es not_active Application Discontinuation
- 2009-02-03 CL CL2009000236A patent/CL2009000236A1/es unknown
-
2010
- 2010-06-24 ZA ZA2010/04467A patent/ZA201004467B/en unknown
- 2010-07-25 IL IL207205A patent/IL207205A0/en unknown
- 2010-08-04 MA MA33059A patent/MA32061B1/fr unknown
- 2010-08-04 CO CO10095026A patent/CO6260083A2/es active IP Right Grant
- 2010-08-05 US US12/851,189 patent/US8076336B2/en not_active Expired - Fee Related
-
2011
- 2011-03-30 HK HK11103239.2A patent/HK1149011A1/xx not_active IP Right Cessation
- 2011-09-23 US US13/243,118 patent/US9079906B2/en not_active Expired - Fee Related
-
2012
- 2012-03-13 HR HR20120230T patent/HRP20120230T1/hr unknown
- 2012-03-14 CY CY20121100256T patent/CY1113228T1/el unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
UY32820A (es) | Composiciones dermatologicas de antagonistas del receptor dp2 | |
CR10309A (es) | "compuestos y composiciones como inhibidores de la actividad del receptor canabinoide 1" | |
CO6450655A2 (es) | Atropisómeros de derivados de 2-purinil-3-tolil-quinazolinona y métodos de uso | |
EA200900983A1 (ru) | Соединения и композиции в качестве ингибиторов киназы | |
CL2009000650A1 (es) | Compuestos derivados de amino-pirazina, inhibidores de cinasa-pi 3; composicion farmaceutica; y uso para el tratamiento de condiciones inflamatorias o alérgicas, tales como enfermedades respiratorias, artritis reumatoide, colitis ulcerativa, entre otras | |
PE20121617A1 (es) | Derivados de oxazina como inhibidores de bace | |
NO20083568L (no) | Hydantoinforbindelser for behandling av inflammatoriske forstyrrelser | |
UY36215A (es) | Espirocicloheptanos como inhibidores de rock | |
MA32393B1 (fr) | Composés et compositions servant d'inhibiteurs de kinases | |
CL2007002641A1 (es) | Compuestos derivados de pirimidinas; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento de trastornos alergicos, autoinmunes, enfermedades inflamatorias. | |
EA201171493A1 (ru) | МОТИВЫ ХИМИЧЕСКИХ МОДИФИКАЦИЙ ДЛЯ ИНГИБИТОРОВ И МИМЕТИКОВ мкРНК | |
TR201901886T4 (tr) | DNA-PK inhibitörleri. | |
PA8848201A1 (es) | Aminotetrahidropiranos como inhibidores de dipeptidil peptidasa-iv para el tratamiento o prevención de diabetes | |
CO6690805A2 (es) | 6-amino-nicotinamidas sustituidas como modulares de kcnq2/3 | |
MX2012010404A (es) | Inhibidores heterociclicos de los receptores de histamina para el tratamiento de enfermedades. | |
EA201071291A3 (ru) | Nmda рецепторные антагонисты для лечения нейропсихиатрических расстройств | |
CO6541569A2 (es) | Inhibidores de n1-pirazoloespirocetona acetil-coa carboxilasa | |
UY33597A (es) | Compuestos y composiciones como inhibidores de la trk | |
SV2008003045A (es) | Aminotetrahidropiranos como inhibidores de dipertidil, peptidasa-iv para el tratamiento o prevencion de diabetes | |
ECSP12012270A (es) | Compuestos de pirazol como inhibidores del receptor sigma | |
ECSP088676A (es) | Pirazolquinolonas como potentes inhibidores de parp | |
CL2007001901A1 (es) | Compuestos derivados de acido carboxilico de naftaleno, quinolina y benzo[b]tiofeno sustituidos, inhibidores de cxcr2; composiicon farmaceutica; y uso para el tratamiento o profilaxis de enfermedades mediadas por quimioquinas, tales como enfermedades inflamatorias agudas y cronicas | |
CR9347A (es) | Derivados de pirimidina para el tratamiento de trastornos hiperproliferativos | |
ATE554084T1 (de) | N-hydroxyacrylamidverbindungen | |
CL2007002427A1 (es) | Compuestos derivados heterociclicos, inhibidores de metaloproteinasa de matriz; proceso de preparacion; composicion farmaceutica, util para el tratamiento o profilaxis de enfermedades inflamatorias o desordenes autoinmunes. |