PT2242740E - Derivados de sf5 como inibidores do par1, sua preparação e utilização como produtos farmacêuticos - Google Patents
Derivados de sf5 como inibidores do par1, sua preparação e utilização como produtos farmacêuticosInfo
- Publication number
- PT2242740E PT2242740E PT97090898T PT09709089T PT2242740E PT 2242740 E PT2242740 E PT 2242740E PT 97090898 T PT97090898 T PT 97090898T PT 09709089 T PT09709089 T PT 09709089T PT 2242740 E PT2242740 E PT 2242740E
- Authority
- PT
- Portugal
- Prior art keywords
- medicaments
- derivatives
- production
- par1 inhibitors
- par1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08290115 | 2008-02-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PT2242740E true PT2242740E (pt) | 2013-02-06 |
Family
ID=39322588
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PT97090898T PT2242740E (pt) | 2008-02-05 | 2009-01-23 | Derivados de sf5 como inibidores do par1, sua preparação e utilização como produtos farmacêuticos |
Country Status (10)
Country | Link |
---|---|
US (1) | US8466169B2 (pt) |
EP (1) | EP2242740B1 (pt) |
JP (1) | JP2011511018A (pt) |
CY (1) | CY1113911T1 (pt) |
DK (1) | DK2242740T3 (pt) |
ES (1) | ES2400322T3 (pt) |
HR (1) | HRP20130160T1 (pt) |
PT (1) | PT2242740E (pt) |
SI (1) | SI2242740T1 (pt) |
WO (1) | WO2009097972A1 (pt) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010007893A (es) | 2008-02-05 | 2010-08-09 | Sanofi Aventis | Sales de triazolio como inhibidores del par1, produccion de las mismas, y uso como medicamentos. |
CN101981034B (zh) * | 2008-02-05 | 2013-08-14 | 赛诺菲-安万特 | 作为par1抑制剂的三唑并哒嗪、其制备及其制备药物的用途 |
US8673890B2 (en) | 2009-10-29 | 2014-03-18 | Janssen Pharmaceutica Nv | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist |
EP2335717A1 (en) * | 2009-11-16 | 2011-06-22 | Institut National De La Recherche Agronomique | PAR-1 antagonists for use in the treatment or prevention of influenza virus type a infections |
EP3527569B1 (en) | 2014-02-03 | 2021-08-25 | Vitae Pharmaceuticals, LLC | Dihydropyrrolopyridine inhibitors of ror-gamma for use in treating drye eye |
PT3207043T (pt) | 2014-10-14 | 2019-03-25 | Vitae Pharmaceuticals Llc | Inibidores de di-hidropirrolopiridina de ror-gama |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
EP3331876B1 (en) | 2015-08-05 | 2020-10-07 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
CN108463458B (zh) | 2015-11-20 | 2022-02-01 | 生命医药有限责任公司 | ROR-γ的调节剂 |
TW202220968A (zh) | 2016-01-29 | 2022-06-01 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
UA126583C2 (uk) | 2017-07-24 | 2022-11-02 | Вітае Фармасьютікалс, Ллс | ІНГІБІТОРИ ROR<font face="Symbol">g</font> |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
WO2022017524A1 (zh) * | 2020-07-23 | 2022-01-27 | 深圳晶泰科技有限公司 | 吡啶酮类化合物及其制备方法和应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063847A (en) | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
US7488742B2 (en) | 2000-06-15 | 2009-02-10 | Schering Corporation | Thrombin receptor antagonists |
US20040242627A1 (en) * | 2001-04-19 | 2004-12-02 | Shuichi Suzuki | 2-Iminoimidazole derivatives (1) |
US6956046B2 (en) | 2001-05-25 | 2005-10-18 | Mochida Pharmaceutical Co., Ltd. | 4-hydroxypiperidine derivatives having analgesic activity |
EP1439178A4 (en) * | 2001-10-05 | 2005-11-16 | Takeda Pharmaceutical | HETEROCYCLIC COMPOUNDS, OXAZOLE DERIVATIVES, PROCESS FOR THEIR PRESENTATION AND USE THEREOF |
US6896942B2 (en) | 2002-04-17 | 2005-05-24 | W. R. Grace & Co. -Conn. | Coating composition comprising colloidal silica and glossy ink jet recording sheets prepared therefrom |
US7375138B2 (en) * | 2002-05-18 | 2008-05-20 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them |
EP1602646A4 (en) | 2003-02-19 | 2010-07-28 | Eisai R&D Man Co Ltd | PROCESS FOR PREPARING CYCLIC BENZAMIDINE DERIVATIVES |
DE10353205A1 (de) | 2003-11-13 | 2005-06-16 | Aventis Pharma Deutschland Gmbh | Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen |
OA13285A (en) | 2003-11-13 | 2007-01-31 | Sanofi Aventis Deutschland | Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same. |
TW200531688A (en) * | 2004-03-05 | 2005-10-01 | Hoffmann La Roche | Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents |
WO2006018955A1 (ja) | 2004-08-16 | 2006-02-23 | Eisai R & D Management Co., Ltd. | イソインドール誘導体の製造方法 |
US7956222B2 (en) | 2004-08-17 | 2011-06-07 | Eisai R&D Management Co., Ltd | Methods for producing dibromofluorobenzene derivatives |
WO2006051623A1 (ja) | 2004-11-09 | 2006-05-18 | Eisai Co., Ltd. | トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤 |
-
2009
- 2009-01-23 EP EP09709089A patent/EP2242740B1/de not_active Not-in-force
- 2009-01-23 ES ES09709089T patent/ES2400322T3/es active Active
- 2009-01-23 DK DK09709089.8T patent/DK2242740T3/da active
- 2009-01-23 JP JP2010545380A patent/JP2011511018A/ja not_active Withdrawn
- 2009-01-23 PT PT97090898T patent/PT2242740E/pt unknown
- 2009-01-23 WO PCT/EP2009/000408 patent/WO2009097972A1/de active Application Filing
- 2009-01-23 SI SI200930522T patent/SI2242740T1/sl unknown
-
2010
- 2010-08-05 US US12/851,229 patent/US8466169B2/en active Active
-
2013
- 2013-02-25 HR HRP20130160AT patent/HRP20130160T1/hr unknown
- 2013-02-27 CY CY20131100184T patent/CY1113911T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK2242740T3 (da) | 2013-03-25 |
JP2011511018A (ja) | 2011-04-07 |
US20110034461A1 (en) | 2011-02-10 |
EP2242740B1 (de) | 2012-12-12 |
US8466169B2 (en) | 2013-06-18 |
SI2242740T1 (sl) | 2013-03-29 |
WO2009097972A1 (de) | 2009-08-13 |
EP2242740A1 (de) | 2010-10-27 |
HRP20130160T1 (hr) | 2013-03-31 |
ES2400322T3 (es) | 2013-04-09 |
CY1113911T1 (el) | 2016-07-27 |
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