DK2242740T3 - SF5-derivater som par1-inhibitorer, deres fremstilling og anvendelse som lægemidler - Google Patents
SF5-derivater som par1-inhibitorer, deres fremstilling og anvendelse som lægemidlerInfo
- Publication number
- DK2242740T3 DK2242740T3 DK09709089.8T DK09709089T DK2242740T3 DK 2242740 T3 DK2242740 T3 DK 2242740T3 DK 09709089 T DK09709089 T DK 09709089T DK 2242740 T3 DK2242740 T3 DK 2242740T3
- Authority
- DK
- Denmark
- Prior art keywords
- drugs
- derivatives
- preparation
- par1 inhibitors
- par1
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Hematology (AREA)
- Rheumatology (AREA)
- Obesity (AREA)
- Child & Adolescent Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Urology & Nephrology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Emergency Medicine (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08290115 | 2008-02-05 | ||
PCT/EP2009/000408 WO2009097972A1 (de) | 2008-02-05 | 2009-01-23 | Sf5-derivate als par1-inhibitoren, ihre herstellung und verwendung als arzneimittel |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2242740T3 true DK2242740T3 (da) | 2013-03-25 |
Family
ID=39322588
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK09709089.8T DK2242740T3 (da) | 2008-02-05 | 2009-01-23 | SF5-derivater som par1-inhibitorer, deres fremstilling og anvendelse som lægemidler |
Country Status (10)
Country | Link |
---|---|
US (1) | US8466169B2 (da) |
EP (1) | EP2242740B1 (da) |
JP (1) | JP2011511018A (da) |
CY (1) | CY1113911T1 (da) |
DK (1) | DK2242740T3 (da) |
ES (1) | ES2400322T3 (da) |
HR (1) | HRP20130160T1 (da) |
PT (1) | PT2242740E (da) |
SI (1) | SI2242740T1 (da) |
WO (1) | WO2009097972A1 (da) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX2010008490A (es) * | 2008-02-05 | 2010-08-18 | Sanofi Aventis | Triazolopiridazinas como inhibidores de par1, su produccion y su uso como medicamentos. |
KR20100120139A (ko) | 2008-02-05 | 2010-11-12 | 사노피-아벤티스 | Par1 억제제로서의 트리아졸륨 염, 이들의 제조방법, 및 약제로서의 용도 |
US8673890B2 (en) | 2009-10-29 | 2014-03-18 | Janssen Pharmaceutica Nv | 2,3-dihydro-1H-isoindol-1-imine derivatives useful as thrombin PAR-1 receptor antagonist |
EP2335717A1 (en) * | 2009-11-16 | 2011-06-22 | Institut National De La Recherche Agronomique | PAR-1 antagonists for use in the treatment or prevention of influenza virus type a infections |
SG11201606080SA (en) | 2014-02-03 | 2016-08-30 | Vitae Pharmaceuticals Inc | Dihydropyrrolopyridine inhibitors of ror-gamma |
HUE042335T2 (hu) | 2014-10-14 | 2019-06-28 | Vitae Pharmaceuticals Inc | ROR-gamma dihidropirrolopiridin inhibitorai |
US9663515B2 (en) | 2014-11-05 | 2017-05-30 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
US9845308B2 (en) | 2014-11-05 | 2017-12-19 | Vitae Pharmaceuticals, Inc. | Isoindoline inhibitors of ROR-gamma |
EP3331876B1 (en) | 2015-08-05 | 2020-10-07 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
EP3377482B1 (en) | 2015-11-20 | 2021-05-12 | Vitae Pharmaceuticals, LLC | Modulators of ror-gamma |
TWI757266B (zh) | 2016-01-29 | 2022-03-11 | 美商維它藥物有限責任公司 | ROR-γ調節劑 |
US9481674B1 (en) | 2016-06-10 | 2016-11-01 | Vitae Pharmaceuticals, Inc. | Dihydropyrrolopyridine inhibitors of ROR-gamma |
WO2019018975A1 (en) | 2017-07-24 | 2019-01-31 | Vitae Pharmaceuticals, Inc. | INHIBITORS OF ROR GAMMA |
MX2020000887A (es) | 2017-07-24 | 2020-07-22 | Vitae Pharmaceuticals Llc | Inhibidores de ror?. |
WO2022017524A1 (zh) * | 2020-07-23 | 2022-01-27 | 深圳晶泰科技有限公司 | 吡啶酮类化合物及其制备方法和应用 |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6063847A (en) | 1997-11-25 | 2000-05-16 | Schering Corporation | Thrombin receptor antagonists |
US7488742B2 (en) | 2000-06-15 | 2009-02-10 | Schering Corporation | Thrombin receptor antagonists |
US20040242627A1 (en) * | 2001-04-19 | 2004-12-02 | Shuichi Suzuki | 2-Iminoimidazole derivatives (1) |
EP1391452A4 (en) | 2001-05-25 | 2005-10-26 | Mochida Pharm Co Ltd | 4-HYDROXPIPERIDIN DERIVATIVE ANALGETIC EFFECT |
US6984653B2 (en) * | 2001-10-05 | 2006-01-10 | Takeda Pharmaceutical Company Limited | Heterocyclic compounds, oxazole derivatives, process for preparation of the same and use thereof |
US6896942B2 (en) | 2002-04-17 | 2005-05-24 | W. R. Grace & Co. -Conn. | Coating composition comprising colloidal silica and glossy ink jet recording sheets prepared therefrom |
US7375138B2 (en) * | 2002-05-18 | 2008-05-20 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them |
AU2004218187C1 (en) | 2003-02-19 | 2011-04-07 | Eisai R&D Management Co., Ltd. | Methods for producing cyclic benzamidine derivatives |
OA13285A (en) | 2003-11-13 | 2007-01-31 | Sanofi Aventis Deutschland | Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same. |
DE10353205A1 (de) | 2003-11-13 | 2005-06-16 | Aventis Pharma Deutschland Gmbh | Ortho-substituierte Pentafluorsulfuranyl-Benzole, Verfahren zu ihrer Herstellung sowie ihre Verwendung als wertvolle Synthese-Zwischenstufen |
TW200531688A (en) * | 2004-03-05 | 2005-10-01 | Hoffmann La Roche | Novel pentafluorosulfanyl compounds, their manufacture and use as pharmaceutical agents |
KR20070062520A (ko) | 2004-08-16 | 2007-06-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 이소인돌 유도체의 제조방법 |
WO2006018954A1 (ja) | 2004-08-17 | 2006-02-23 | Eisai R & D Management Co., Ltd. | ジブロモフルオロベンゼン誘導体の製造方法 |
JPWO2006051623A1 (ja) | 2004-11-09 | 2008-05-29 | エーザイ株式会社 | トロンビン受容体アンタゴニストを有効成分とするくも膜下出血に伴う血管攣縮の治療剤 |
-
2009
- 2009-01-23 ES ES09709089T patent/ES2400322T3/es active Active
- 2009-01-23 JP JP2010545380A patent/JP2011511018A/ja not_active Withdrawn
- 2009-01-23 WO PCT/EP2009/000408 patent/WO2009097972A1/de active Application Filing
- 2009-01-23 DK DK09709089.8T patent/DK2242740T3/da active
- 2009-01-23 SI SI200930522T patent/SI2242740T1/sl unknown
- 2009-01-23 PT PT97090898T patent/PT2242740E/pt unknown
- 2009-01-23 EP EP09709089A patent/EP2242740B1/de not_active Not-in-force
-
2010
- 2010-08-05 US US12/851,229 patent/US8466169B2/en active Active
-
2013
- 2013-02-25 HR HRP20130160AT patent/HRP20130160T1/hr unknown
- 2013-02-27 CY CY20131100184T patent/CY1113911T1/el unknown
Also Published As
Publication number | Publication date |
---|---|
US8466169B2 (en) | 2013-06-18 |
PT2242740E (pt) | 2013-02-06 |
HRP20130160T1 (hr) | 2013-03-31 |
ES2400322T3 (es) | 2013-04-09 |
CY1113911T1 (el) | 2016-07-27 |
EP2242740B1 (de) | 2012-12-12 |
JP2011511018A (ja) | 2011-04-07 |
US20110034461A1 (en) | 2011-02-10 |
WO2009097972A1 (de) | 2009-08-13 |
SI2242740T1 (sl) | 2013-03-29 |
EP2242740A1 (de) | 2010-10-27 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2242740T3 (da) | SF5-derivater som par1-inhibitorer, deres fremstilling og anvendelse som lægemidler | |
DK2303872T3 (da) | Isoxazolderivater og deres anvendelse som metabotrope glutamatreceptorforstærkere | |
DK3421471T3 (da) | Purin- og deazapurinderivater som farmaceutiske forbindelser | |
BRPI0915897A2 (pt) | compostos derivados triazóis, composições farmacêuticas e combinações dos mesmos e seus usos | |
BRPI0822337A2 (pt) | Folatos, composições e usos dos mesmos | |
DK2049557T3 (da) | 1-(-D-glycopyranosyl)-3-(4-cyclopropylphenylmethyl)-4-halogenindolderivater og anvendelse heraf som sglt-inhibitorer | |
DK2099447T3 (da) | Imidazotriaziner og imidazopyrimidiner som kinaseinhibitorer | |
DK2445903T3 (da) | 1,3-Disubstituerede imidazolidin-2-on-derivater som CYP17-inhibitorer | |
NO20091423L (no) | Pyrimidinderivater og deres anvendelse som kinaseinhibitorer | |
DK2073795T3 (da) | Misbrugssikret lægemiddelformulation | |
DK2049525T3 (da) | N-laminoheteroaryl)-1H-indol-2-carboxamid-derivater, og fremstilling og terapeutisk anvendelse deraf | |
BRPI0910503A2 (pt) | compostos, composições farmacêuticas e respectivos usos. | |
DK2327694T3 (da) | Substituerede 4-aminopicolinsyrer og deres anvendelse som herbicider | |
BRPI0906962A2 (pt) | Composto, e, composição farmacêutica | |
DK2252597T3 (da) | Pyrazinderivater og deres anvendelse som proteinkinaseinhibitorer | |
BRPI0906556A2 (pt) | Composto, e, composição farmacêutica | |
DK2229360T3 (da) | Indolinonderivater og fremgangsmåde til deres fremstilling | |
DK2220070T3 (da) | 2-benzylpyridazinonderivater som Met-kinaseinhibitorer | |
DK2078001T3 (da) | Diazepan-acetamidderivater som selektive 11-HSD1-inhibitorer | |
DK2160389T3 (da) | Thioxoquinazolinonderivater som glutaminylcyclaseinhibitorer | |
DK2350026T3 (da) | Sulfoximinsubstituerede anilinopyrimidinderativer som cdk-inhibitorer, fremstilling og anvendelse heraf som lægemiddel | |
DK2160380T3 (da) | Cyano-guanidin derivater som glutaminyl cyclase inhibitorer | |
DK2513105T3 (da) | 2-arylimidazolderivater som pde10a-enzyminhibitorer | |
BRPI0807078A2 (pt) | Composto, e, formulação farmacêutica | |
IL209840A0 (en) | Azacarboline derivatives, preparation thereof, and therapeutic use thereof as kinase inhibitors |